Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 1, 2011, Pages 236-241

  Liang, Si Cheng ^a   Ge, Guang Bo ^a   Liu, Hui Xin ^a   Shang, Hai Tao ^b   Wei, Hong ^b   Fang, Zhong Ze ^a   Zhu, Liang Liang ^a   Mao, Yu Xi ^a   Yang, Ling ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hepatic microsomes; Human individual difference; Interspecies difference; Propofol O glucuronide; Ultra fast liquid chromatography

Indexed keywords

ANDROSTERONE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; PHENYLBUTAZONE; PROPOFOL; PROPOFOL O GLUCURONIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ACCURACY; ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; GLUCURONIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; ION MONITORING; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SCREENING; SPECIES DIFFERENCE; VALIDATION PROCESS;

ACETIC ACID; ANIMALS; CALIBRATION; DOGS; GLUCURONOSYLTRANSFERASE; HAPLORHINI; HUMANS; HYMECROMONE; KINETICS; MASS SPECTROMETRY; MICE; MICROSOMES, LIVER; MODELS, CHEMICAL; PROPOFOL; RATS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77957018120     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.07.049     Document Type: Article

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