Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract.

Drug metabolism and pharmacokinetics

Volumn 20, Issue 1, 2005, Pages 34-45

  Iwata, Hiroshi ^a   Tezuka, Yasuhiro ^a   Kadota, Shigetoshi ^a   Hiratsuka, Akira ^a   Watabe, Tadashi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; ENZYME INHIBITOR; EVODIA FRUIT; LIMONIN; LIMONOID; PLANT EXTRACT; RUTAECARPINE;

ARTICLE; DRUG ANTAGONISM; ENZYMOLOGY; FRUIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KINETICS; LIVER MICROSOME; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ALKALOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; EVODIA; FRUIT; HUMANS; KINETICS; LIMONINS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; PLANT EXTRACTS;

EID: 24144432308     PISSN: 13474367     EISSN: None     Source Type: Journal    
DOI: 10.2133/dmpk.20.34     Document Type: Article

References (0)