FcγRIIB as a modulator of autoimmune disease susceptibility

Autoimmunity

Volumn 40, Issue 6, 2007, Pages 409-417

  Tarasenko, Tatyana ^a   Dean, Jonathan A ^a   Bolland, Silvia ^a  

^a Laboratory of Immunogenetics   (United States)

Author keywords

Fc gamma receptors (Fc R); Fc RIIB; SLE; Susceptibility

Indexed keywords

ANTINUCLEAR ANTIBODY; B LYMPHOCYTE RECEPTOR; CD16 ANTIGEN; CD32 ANTIGEN; CD64 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DOUBLE STRANDED DNA ANTIBODY; FC RECEPTOR; FC RECEPTOR IA; FC RECEPTOR IB; FC RECEPTOR IC; FC RECEPTOR IIA; FC RECEPTOR IIB; FC RECEPTOR IIC; FC RECEPTOR IIIA; FC RECEPTOR IIIB; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN RECEPTOR; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; FCGR2B PROTEIN, HUMAN; FCGR2B PROTEIN, MOUSE;

ALLERGIC ENCEPHALOMYELITIS; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTATION; AUTOIMMUNE DISEASE; AUTOIMMUNE HEMOLYTIC ANEMIA; BULLOUS PEMPHIGOID; CYTOKINE RELEASE; DISEASE PREDISPOSITION; DISEASE RESISTANCE; DRUG EFFICACY; DRUG RESPONSE; GENE DELETION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; HUMORAL IMMUNITY; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNOGENETICS; IMMUNOPATHOGENESIS; IMMUNOREGULATION; IMMUNOTHERAPY; LUPUS ERYTHEMATOSUS NEPHRITIS; LUPUS LIKE SYNDROME; MOLECULAR CLONING; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; AUTOIMMUNITY; B LYMPHOCYTE; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; B-LYMPHOCYTES; DISEASE SUSCEPTIBILITY; HUMANS; IMMUNOTHERAPY; MICE; POLYMORPHISM, GENETIC; RECEPTORS, IGG; SIGNAL TRANSDUCTION;

EID: 34548303252     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930701464665     Document Type: Review

References (113)

1. Tivol, EA, Borriello, F., Schweitzer, AN, Lynch, WP, Bluestone, JA and Sharpe, AH (1995) Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity, 3:5, pp. 541-547.
2. Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H. and Minato, N. (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science, 291:5502, pp. 319-322.
3. O'Keefe, TL, Williams, GT, Batista, FD and Neuberger, MS (1999) Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med, 189:8, pp. 1307-1313.
4. Nimmerjahn, F. and Ravetch, JV (2006) Fcgamma receptors: Old friends and new family members. Immunity, 24:1, pp. 19-28.
5. Nimmerjahn, F., Bruhns, P., Horiuchi, K. and Ravetch, JV (2005) FcgammaRIV: A novel FcR with distinct IgG subclass specificity. Immunity, 23:1, pp. 41-51.
6. Takai, T. (2002) Roles of Fc receptors in autoimmunity. Nat Rev Immunol, 2:8, pp. 580-592.
7. Takai, T. (2005) Fc receptors and their role in immune regulation and autoimmunity. J Clin Immunol, 25:1, pp. 1-18.
8. Stefanescu, RN, Olferiev, M., Liu, Y. and Pricop, L. (2004) Inhibitory Fc gamma receptors: From gene to disease. J Clin Immunol, 24:4, pp. 315-326.
9. Ravetch, JV and Kinet, JP (1991) Fc receptors. Annu Rev Immunol, 9, pp. 457-492.
10. Daeron, M. (1997) Fc receptor biology. Annu Rev Immunol, 15, pp. 203-234.
11. Yada, A., Ebihara, S., Matsumura, K., Endo, S., Maeda, T., Nakamura, A., Akiyama, K., Aiba, S. and Takai, T. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell Immunol, 225:1, pp. 21-32.
12. Fridman, WH, Bonnerot, C., Daeron, M., Amigorena, S., Teillaud, JL and Sautes, C. (1992) Structural bases of Fc gamma receptor functions. Immunol Rev, 125, pp. 49-76.
13. Regnault, A., Lankar, D., Lacabanne, V., Rodriguez, A., Thery, C., Rescigno, M., Saito, T., Verbeek, S., Bonnerot, C. and Ricciardi-Castagnoli, P. (1999) Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J Exp Med, 189:2, pp. 371-380.
14. Wines, BD, Gavin, A., Powell, MS, Steinitz, M., Buchanan, RR and Hogarth, P Mark (2003) Soluble FcgammaRIIa inhibits rheumatoid factor binding to immune complexes. Immunology, 109:2, pp. 246-254.
15. Pearse, RN, Kawabe, T., Bolland, S., Guinamard, R., Kurosaki, T. and Ravetch, JV (1999) SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis. Immunity, 10:6, pp. 753-760.
16. Brauweiler, AM and Cambier, JC (2004) Autonomous SHIP-dependent FcgammaR signaling in pre-B cells leads to inhibition of cell migration and induction of cell death. Immunol Lett, 92:1, pp. 75-81.
17. Ashman, RF, Peckham, D. and Stunz, LL (1996) Fc receptor off-signal in the B cell involves apoptosis. J Immunol, 157:1, pp. 5-11.
18. Aydar, Y., Song, J., Szakal, AK and Tew, JG (2004) FcgammaRII expression on follicular dendritic cells and immunoreceptor tyrosine-based inhibition motif signaling in B cells. Eur J Immunol, 34:1, pp. 98-107.
19. Stuart, SG, Trounstine, ML, Vaux, DJ, Koch, T., Martens, CL, Mellman, I. and Moore, KW (1987) Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII). J Exp Med, 166:6, pp. 1668-1684.
20. Ravetch, JV, Luster, AD, Weinshank, R., Kochan, J., Pavlovec, A., Portnoy, DA, Hulmes, J., Pan, YC and Unkeless, JC (1986) Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science, 234:4777, pp. 718-725.
21. Lewis, VA, Koch, T., Plutner, H. and Mellman, I. (1986) A complementary DNA clone for a macrophage-lymphocyte Fc receptor. Nature, 324:6095, pp. 372-375.
22. Hibbs, ML, Bonadonna, L., Scott, BM, McKenzie, IF and Hogarth, PM (1988) Molecular cloning of a human immunoglobulin G Fc receptor. Proc Natl Acad Sci USA, 85:7, pp. 2240-2244.
23. Hogarth, PM, Hibbs, ML, Bonadonna, L., Scott, BM, Witort, E., Pietersz, GA and McKenzie, IF (1987) The mouse Fc receptor for IgG (Ly-17): Molecular cloning and specificity. Immunogenetics, 26:3, pp. 161-168.
24. Brooks, DG, Qiu, WQ, Luster, AD and Ravetch, JV (1989) Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J Exp Med, 170:4, pp. 1369-1385.
25. Stengelin, S., Stamenkovic, I. and Seed, B. (1988) Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning. EMBO J, 7:4, pp. 1053-1059.
26. Perussia, B., Tutt, MM, Qiu, WQ, Kuziel, WA, Tucker, PW, Trinchieri, G., Bennett, M., Ravetch, JV and Kumar, V. (1989) Murine natural killer cells express functional Fc gamma receptor II encoded by the Fc gamma R alpha gene. J Exp Med, 170:1, pp. 73-86.
27. Sondermann, P., Huber, R., Oosthuizen, V. and Jacob, U. (2000) The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex. Nature, 406:6793, pp. 267-273.
28. Hulett, MD and Hogarth, PM (1994) Molecular basis of Fc receptor function. Adv Immunol, 57, pp. 1-127.
29. Ravetch, JV and Clynes, RA (1998) Divergent roles for Fc receptors and complement in vivo. Annu Rev Immunol, 16, pp. 421-432.
30. Ravetch, JV and Lanier, LL (2000) Immune inhibitory receptors. Science, 290:5489, pp. 84-89.
31. Shushakova, N., Skokowa, J., Schulman, J., Baumann, U., Zwirner, J., Schmidt, RE and Gessner, JE (2002) C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease. J Clin Invest, 110:12, pp. 1823-1830.
32. Ravetch, JV (2002) A full complement of receptors in immune complex diseases. J Clin Invest, 110:12, pp. 1759-1761.
33. Fossati-Jimack, L., Ioan-Facsinay, A., Reininger, L., Chicheportiche, Y., Watanabe, N., Saito, T., Hofhuis, FM, Gessner, JE, Schiller, C. and Schmidt, RE (2000) Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III. J Exp Med, 191:8, pp. 1293-1302.
34. Kaneko, Y., Nimmerjahn, F., Madaio, MP and Ravetch, JV (2006) Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors. J Exp Med, 203:3, pp. 789-797.
35. Nimmerjahn, F. and Ravetch, JV (2005) Divergent immunoglobulin g subclass activity through selective Fc receptor binding. Science, 310:5753, pp. 1510-1512.
36. Miettinen, HM, Rose, JK and Mellman, I. (1989) Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity. Cell, 58:2, pp. 317-327.
37. Ono, M., Bolland, S., Tempst, P. and Ravetch, JV (1996) Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature, 383:6597, pp. 263-266.
38. Clynes, R., Maizes, JS, Guinamard, R., Ono, M., Takai, T. and Ravetch, JV (1999) Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med, 189:1, pp. 179-185.
39. Muta, T., Kurosaki, T., Misulovin, Z., Sanchez, M., Nussenzweig, MC and Ravetch, JV (1994) A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling. Nature, 369:6478, p. 340.
40. Samuelsson, A., Towers, TL and Ravetch, JV (2001) Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. Science, 291:5503, pp. 484-486.
41. Kepley, CL, Taghavi, S., Mackay, G., Zhu, D., Morel, PA, Zhang, K., Ryan, JJ, Satin, LS, Zhang, M. and Pandolfi, PP (2004) Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes. J Biol Chem, 279:34, pp. 35139-35149.
42. Daeron, M., Latour, S., Malbec, O., Espinosa, E., Pina, P., Pasmans, S. and Fridman, WH (1995) The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity, 3:5, pp. 635-646.
43. Nakamura, K., Brauweiler, A. and Cambier, JC (2000) Effects of Src homology domain 2 (SH2)-containing inositol phosphatase (SHIP), SH2-containing phosphotyrosine phosphatase (SHP)-1, and SHP-2 SH2 decoy proteins on Fc gamma RIIB1-effector interactions and inhibitory functions. J Immunol, 164:2, pp. 631-638.
44. Damen, JE, Liu, L., Rosten, P., Humphries, RK, Jefferson, AB, Majerus, PW and Krystal, G. (1996) The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci USA, 93:4, pp. 1689-1693.
45. Gupta, N., Scharenberg, AM, Fruman, DA, Cantley, LC, Kinet, JP and Long, EO (1999) The SH2 domain-containing inositol 5′-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling. J Biol Chem, 274:11, pp. 7489-7494.
46. Scharenberg, AM, El-Hillal, O., Fruman, DA, Beitz, LO, Lin, S., Gout, I., Cantley, LC, Rawlings, DJ and Kinet, JP (1998) Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals. Embo J, 17:7, pp. 1961-1972.
47. Fluckiger, AC, Kato, RM, Wahl, MI, Ochs, HD, Longnecker, R., Kinet, JP, Witte, ON, Scharenberg, AM and Rawlings, DJ (1998) Btk/Tec kinases regulate sustained increases in intracellular Ca2 + following B-cell receptor activation. Embo J, 17:7, pp. 1973-1985.
48. Bolland, S., Pearse, RN, Kurosaki, T. and Ravetch, JV (1998) SHIP modulates immune receptor responses by regulating membrane association of Btk. Immunity, 8:4, pp. 509-516.
49. Ono, M., Okada, H., Bolland, S., Yanagi, S., Kurosaki, T. and Ravetch, JV (1997) Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell, 90:2, pp. 293-301.
50. Aman, MJ, Lamkin, TD, Okada, H., Kurosaki, T. and Ravichandran, KS (1998) The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells. J Biol Chem, 273:51, pp. 33922-33928.
51. Tamir, I., Stolpa, JC, Helgason, CD, Nakamura, K., Bruhns, P., Daeron, M. and Cambier, JC (2000) The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Immunity, 12:3, pp. 347-358.
52. Isnardi, I., Lesourne, R., Bruhns, P., Fridman, WH, Cambier, JC and Daeron, M. (2004) Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap. J Biol Chem, 279:50, pp. 51931-51938.
53. Helgason, CD, Kalberer, CP, Damen, JE, Chappel, SM, Pineault, N., Krystal, G. and Humphries, RK (2000) A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: Aberrant development and enhanced function of b lymphocytes in ship -/-mice. J Exp Med, 191:5, pp. 781-794.
54. Liu, Q., Oliveira-Dos-Santos, AJ, Mariathasan, S., Bouchard, D., Jones, J., Sarao, R., Kozieradzki, I., Ohashi, PS, Penninger, JM and Dumont, DJ (1998) The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med, 188:7, pp. 1333-1342.
55. Lesourne, R., Fridman, WH and Daeron, M. (2005) Dynamic interactions of Fc gamma receptor IIB with filamin-bound SHIP1 amplify filamentous actin-dependent negative regulation of Fc epsilon receptor I signaling. J Immunol, 174:3, pp. 1365-1373.
56. Tzeng, SJ, Bolland, S., Inabe, K., Kurosaki, T. and Pierce, SK (2005) The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathway. J Biol Chem, 280:42, pp. 35247-35254.
57. Takai, T., Sylvestre, D., Clynes, R. and Ravetch, JV (1994) FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell, 76:3, pp. 519-529.
58. Sylvestre, DL and Ravetch, JV (1994) Fc receptors initiate the Arthus reaction: Redefining the inflammatory cascade. Science, 265:5175, pp. 1095-1098.
59. Clynes, R., Dumitru, C. and Ravetch, JV (1998) Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science, 279:5353, pp. 1052-1054.
60. Clynes, R. and Ravetch, JV (1995) Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity, 3:1, pp. 21-26.
61. Watanabe, N., Akikusa, B., Park, SY, Ohno, H., Fossati, L., Vecchietti, G., Gessner, JE, Schmidt, RE, Verbeek, JS and Ryffel, B. (1999) Mast cells induce autoantibody-mediated vasculitis syndrome through tumor necrosis factor production upon triggering Fcgamma receptors. Blood, 94:11, pp. 3855-3863.
62. Barnes, N., Gavin, AL, Tan, PS, Mottram, P., Koentgen, F. and Hogarth, PM (2002) FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. Immunity, 16:3, pp. 379-389.
63. Hazenbos, WL, Gessner, JE, Hofhuis, FM, Kuipers, H., Meyer, D., Heijnen, IA, Schmidt, RE, Sandor, M., Capel, PJ and Daeron, M. (1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity, 5:2, pp. 181-188.
64. Hazenbos, WL, Heijnen, IA, Meyer, D., Hofhuis, FM, de Lavalette, CR Renardel, Schmidt, RE, Schmidt, RE, Capel, PJ, van de Winkel, JG, Gessner, JE and Berg, TK van den (1998) Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16). J Immunol, 161:6, pp. 3026-3032.
65. Meyer, D., Schiller, C., Westermann, J., Izui, S., Hazenbos, WL, Verbeek, JS, Schmidt, RE and Gessner, JE (1998) FcgammaRIII (CD16)-deficient mice show IgG isotype-dependent protection to experimental autoimmune hemolytic anemia. Blood, 92:11, pp. 3997-4002.
66. Takai, T., Ono, M., Hikida, M., Ohmori, H. and Ravetch, JV (1996) Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature, 379:6563, pp. 346-349.
67. Bolland, S. and Ravetch, JV (2000) Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. Immunity, 13:2, pp. 277-285.
68. Okazaki, T., Otaka, Y., Wang, J., Hiai, H., Takai, T., Ravetch, JV and Honjo, T. (2005) Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/-mice. J Exp Med, 202:12, pp. 1643-1648.
69. Bolland, S., Yim, YS, Tus, K., Wakeland, EK and Ravetch, JV (2002) Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med, 195:9, pp. 1167-1174.
70. Yajima, K., Nakamura, A., Sugahara, A. and Takai, T. (2003) FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease. Eur J Immunol, 33:4, pp. 1020-1029.
71. Fukuyama, H., Nimmerjahn, F. and Ravetch, JV (2005) The inhibitory Fcgamma receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G + anti-DNA plasma cells. Nat Immunol, 6:1, pp. 99-106.
72. Ehlers, M., Fukuyama, H., McGaha, TL, Aderem, A. and Ravetch, JV (2006) TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med, 203:3, pp. 553-561.
73. Christensen, SR, Shupe, J., Nickerson, K., Kashgarian, M., Flavell, RA and Shlomchik, MJ (2006) Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity, 25:3, pp. 417-428.
74. Peng, SL (2006) Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum, 54:1, pp. 336-342.
75. Xiang, Z., Cutler, AJ, Brownlie, RJ, Fairfax, K., Lawlor, KE, Severinson, E., Walker, EU, Manz, RA, Tarlinton, DM and Smith, KG (2007) FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immunol, 8:4, pp. 419-429.
76. Pritchard, NR, Cutler, AJ, Uribe, S., Chadban, SJ, Morley, BJ and Smith, KG (2000) Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII. Curr Biol, 10:4, pp. 227-230.
77. Jiang, Y., Hirose, S., Abe, M., Sanokawa-Akakura, R., Ohtsuji, M., Xiu, Y., Zhang, D. and Shirai, J. (2000) Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility. Immunogenetics, 51:6, pp. 429-435.
78. Jiang, Y., Hirose, S., Sanokawa-Akakura, R., Abe, M., Miura, Y., Shirai, J., Zhang, D. and Hamano, Y. (1999) Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus. Int Immunol, 11:10, pp. 1685-1691.
79. Lin, Q., Xiu, Y., Jiang, Y., Tsurui, H., Nakamura, K., Kodera, S., Ohtsuji, M., Ohtsuji, N., Shiroiwa, W. and Tsukamoto, K. (2006) Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol, 177:3, pp. 1646-1654.
80. Kumar, KR, Yan, M., Bhaskarabhatla, M., Mobley, AB, Nguyen, C., Mooney, JM, Schatzle, JD, Wakeland, EK and Mohan, C. (2006) Regulation of B cell tolerance by the lupus susceptibility gene Ly108. Science, 312:5780, pp. 1665-1669.
81. McGaha, TL, Sorrentino, B. and Ravetch, JV (2005) Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science, 307:5709, pp. 590-593.
82. Nakamura, A., Yuasa, T., Ujike, A., Ono, M., Nukiwa, T., Ravetch, JV and Takai, T. (2000) Fcgamma receptor IIB-deficient mice develop Good pasture's syndrome upon immunization with type IV collagen: A novel murine model for autoimmune glomerular basement membrane disease. J Exp Med, 191:5, pp. 899-906.
83. Martinsson, K. and Hultman, P. (2006) The role of Fc-receptors in murine mercury-induced systemic autoimmunity. Clin Exp Immunol, 144:2, pp. 309-318.
84. Park, SY, Ueda, S., Ohno, H., Hamano, Y., Tanaka, M., Shiratori, T., Yamazaki, T., Arase, H., Arase, N. and Karasawa, A. (1998) Resistance of Fc receptor-deficient mice to fatal glomerulonephritis. J Clin Invest, 102:6, pp. 1229-1238.
85. Coxon, A., Cullere, X., Knight, S., Sethi, S., Wakelin, MW, Stavrakis, G., Luscinskas, FW and Mayadas, TN (2001) Fc gamma RIII mediates neutrophil recruitment to immune complexes. A mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity, 14:6, pp. 693-704.
86. Matsumoto, K., Watanabe, N., Akikusa, B., Kurasawa, K., Matsumura, R., Saito, Y., Iwamoto, I. and Saito, T. (2003) Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. Arthritis Rheum, 48:2, pp. 486-494.
87. Clynes, R., Calvani, N., Croker, BP and Richards, HB (2005) Modulation of the immune response in pristane-induced lupus by expression of activation and inhibitory Fc receptors. Clin Exp Immunol, 141:2, pp. 230-237.
88. Kleinau, S., Martinsson, P. and Heyman, B. (2000) Induction and suppression of collagen-induced arthritis is dependent on distinct Fcgamma receptors. J Exp Med, 191:9, pp. 1611-1616.
89. Nandakumar, KS, Andren, M., Martinsson, P., Bajtner, E., Hellstrom, S., Holmdahl, R. and Kleinau, S. (2003) Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB. Eur J Immunol, 33:8, pp. 2269-2277.
90. Kagari, T., Tanaka, D., Doi, H. and Shimozato, T. (2003) Essential role of Fc gamma receptors in anti-type II collagen antibody-induced arthritis. J Immunol, 170:8, pp. 4318-4324.
91. Yuasa, T., Kubo, S., Yoshino, T., Ujike, A., Matsumura, K., Ono, M., Ravetch, JV and Takai, T. (1999) Deletion of Fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis. J Exp Med, 189:1, pp. 187-194.
92. Petkova, SB, Konstantinov, KN, Sproule, TJ, Lyons, BL, Awwami, MA and Roopenian, DC (2006) Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor Fc gamma RIIB. J Exp Med, 203:2, pp. 275-280.
93. Szalai, AJ and Barnum, SR (2004) Fc receptors and the common gamma-chain in experimental autoimmune encephalomyelitis. J Neurosci Res, 75:5, pp. 597-602.
94. Abdul-Majid, KB, Stefferl, A., Bourquin, C., Lassmann, H., Linington, C., Olsson, T., Kleinau, S. and Harris, RA (2002) Fc receptors are critical for autoimmune inflammatory damage to the central nervous system in experimental autoimmune encephalomyelitis. Scand J Immunol, 55:1, pp. 70-81.
95. Zhao, M., Trimbeger, ME, Diaz, LA, Shapiro, SD and Liu, Z. (2006) Role of FcRs in animal model of autoimmune bullous pemphigoid. J Immunol, 177:5, pp. 3398-3405.
96. Mestas, J. and Hughes, CC (2004) Of mice and not men: Differences between mouse and human immunology. J Immunol, 172:5, pp. 2731-2738.
97. Blank, MC, Stefanescu, RN, Masuda, E., Marti, F., King, PD, Redecha, PB, Wurzburger, RJ, Peterson, MG, Tanaka, S. and Pricop, L. (2005) Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus. Hum Genet, 117:2, pp. 220-227.
98. Edberg, JC, Ferguson, P. and Kimberly, RP (2004) A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function. J Immunol, 172:11, pp. 7192-7199.
99. Edberg, JC, Ferguson, P., Cooper, GS, Langefeld, CD and Kimberly, RP (2004) A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus. J Immunol, 172:11, pp. 7186-7191.
100. Kyogoku, C., Dijstelbloem, HM, Tsuchiya, N., Hatta, Y., Kato, H., Yamaguchi, A., Fukazawa, T., Jansen, MD, Hashimoto, H. and van de Winkel, JG (2002) Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution of FCGR2B to genetic susceptibility. Arthritis Rheum, 46:5, pp. 1242-1254.
101. Chu, ZT, Tsuchiya, N., Kyogoku, C., Ohashi, J., Qian, YP, Xu, SB, Mao, CZ, Chu, JY and Tokunaga, K. (2004) Association of Fcgamma receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: A common susceptibility gene in the Asian populations. Tissue Antigens, 63:1, pp. 21-27.
102. Siriboonrit, U., Tsuchiya, N., Sirikong, M., Kyogoku, C., Bejrachandra, S., Suthipinittharm, P., Luangtrakool, K., Srinak, D., Thongpradit, R. and Fujiwara, K. (2003) Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens, 61:5, pp. 374-383.
103. Carter, RH, Edberg, JC, Cooper, GS and Kimberly, RP (2003) A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling. Arthritis Rheum, 48:11, pp. 3242-3252.
104. Floto, RA, Clatworthy, MR, Heilbronn, KR, Rosner, DR, MacAry, PA, Rankin, A., Lehner, PJ, Ouwehand, WH, Allen, JM and Watkins, NA (2005) Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts. Nat Med, 11:10, pp. 1056-1058.
105. Kono, H., Kyogoku, C., Suzuki, T., Tsuchiya, N., Honda, H., Yamamoto, K., Tokunaga, K. and Honda, Z. (2005) FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Hum Mol Genet, 14:19, pp. 2881-2892.
106. Tsuchiya, N. and Kyogoku, C. (2005) Role of Fc gamma receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: Insights from Asia. Autoimmunity, 38:5, pp. 347-352.
107. Mackay, M., Stanevsky, A., Wang, T., Aranow, C., Koenig, S., Ravetch, JV and Diamond, B. (2006) Selective dysregulation of the Fc gamma IIB receptor on memory B cells in SLE. J Exp Med, 203:9, pp. 2157-2164.
108. Yurasov, S., Tiller, T., Tsuiji, M., Velinzon, K., Pascual, V., Wardemann, H. and Nussenzweig, MC (2006) Persistent expression of autoantibodies in SLE patients in remission. J Exp Med, 203:10, pp. 2255-2261.
109. Baechler, EC, Gregersen, PK and Behrens, TW (2004) The emerging role of interferon in human systemic lupus erythematosus. Curr Opin Immunol, 16:6, pp. 801-807.
110. Sapir, T., Blank, M. and Shoenfeld, Y. (2005) Immunomodulatory effects of intravenous immunoglobulins as a treatment for autoimmune diseases, cancer, and recurrent pregnancy loss. Ann N Y Acad Sci, 1051, pp. 743-778.
111. Park-Min, KH, Serbina, NV, Yang, W., Krystal, G., Neel, BG, Nutt, SL and Ivashkiv, LB (2007) FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity, 26:1, pp. 67-78.
112. Kaneko, Y., Nimmerjahn, F. and Ravetch, JV (2006) Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science, 313:5787, pp. 670-673.
113. Ruderman, EM and Pope, RM (2006) Drug insight: Abatacept for the treatment of rheumatoid arthritis. Nat Clin Pract Rheumatol, 2:12, pp. 654-660.