The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells

Nature Immunology

Volumn 10, Issue 2, 2009, Pages 158-166

  Park, Sung Gyoo ^a   Schulze Luehrman, Jan ^a   Hayden, Matthew S ^a   Hashimoto, Naoko ^b   Ogawa, Wataru ^b   Kasuga, Masato ^b   Ghosh, Sankar ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD28 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN CARMA1; PROTEIN KINASE C THETA; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD28; CARD SIGNALING ADAPTOR PROTEINS; CELL SURVIVAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOPRECIPITATION; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 58549094896     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1687     Document Type: Article

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