Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells

Nature Immunology

Volumn 8, Issue 11, 2007, Pages 1255-1265

  Link, Alexander ^a   Vogt, Tobias K ^a   Favre, Stéphanie ^a   Britschgi, Mirjam R ^a   Acha Orbea, Hans ^a   Hinz, Boris ^b   Cyster, Jason G ^c   Luther, Sanjiv A ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b EPFL   (Switzerland)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; MACROPHAGE INFLAMMATORY PROTEIN 3BETA;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DEATH; CELL FUNCTION; CELL PROTECTION; CELL SPECIFICITY; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; GENE TARGETING; HOMEOSTASIS; IMMUNOREGULATION; IN VITRO STUDY; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RETICULOENDOTHELIAL SYSTEM; RETICULUM CELL; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; CELL SURVIVAL; CHEMOKINE CCL19; FIBROBLASTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; HOMEOSTASIS; IN SITU HYBRIDIZATION; INTERLEUKIN-7; LYMPH NODES; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 35548975191     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1513     Document Type: Article

References (50)

1. Marrack, P. & Kappler, J. Control of T cell viability. Annu. Rev. Immunol. 22, 765-787 (2004).
2. Surh, C.D. & Sprent, J. Regulation of mature T cell homeostasis. Semin. Immunol. 17, 183-191 (2005).
3. Freitas, A.A. & Rocha, B. Population biology of lymphocytes: The flight for survival. Annu. Rev. Immunol. 18, 83-111 (2000).
4. Jiang, Q. et al. Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev. 16, 513-533 (2005).
5. Trinder, P.K. & Maeurer, M.J. in The Cytokine Handbook (eds. Thomson, A.W. & Lotze, M.T.) 305-345 (Elsevier Science, London, 2003).
6. Ma, A., Koka, R. & Burkett, P. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu. Rev. Immunol. 24, 657-679 (2006).
7. Cinalli, R.M. et al. T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. Eur. J. Immunol. 35, 786-795 (2005).
8. Dai, Z. & Lakkis, F.G. Cutting edge: Secondary lymphoid organs are essential for maintaining the CD4, but not CD8, naive T cell pool. J. Immunol. 167, 6711-6715 (2001).
9. Dummer, W., Ernst, B., LeRoy, E., Lee, D. & Surh, C. Autologous regulation of naive T cell homeostasis within the T cell compartment. J. Immunol. 166, 2460-2468 (2001).
10. Cyster, J.G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23, 127-159 (2005).
11. von Andrian, U.H. & Mempel, T.R. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 3, 867-878 (2003).
12. Bajenoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989-1001 (2006).
13. Gretz, J.E., Anderson, A.O. & Shaw, S. Cords, channels, corridors and conduits: Critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol. Rev. 156, 11-24 (1997).
14. Katakai, T., Hara, T., Sugai, M., Gonda, H. & Shimizu, A. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J. Exp. Med. 200, 783-795 (2004).
15. Luther, S.A., Tang, H.L., Hyman, P.L., Farr, A.G. & Cyster, J.G. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA 97, 12694-12699 (2000).
16. Lepault, F., Gagnerault, M.C., Faveeuw, C. & Boitard, C. Recirculation, phenotype and functions of lymphocytes in mice treated with monoclonal antibody MEL-14. Eur. J. Immunol. 24, 3106-3112 (1994).
17. Lo, C.G., Xu, Y., Proia, R.L. & Cyster, J.G. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J. Exp. Med. 201, 291-301 (2005).
18. Lo, C.G., Lu, T.T. & Cyster, J.G. Integrin-dependence of lymphocyte entry into the splenic white pulp. J. Exp. Med. 197, 353-361 (2003).
19. Berlin-Rufenach, C. et al. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J. Exp. Med. 189, 1467-1478 (1999).
20. Nakano, H. et al. A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4. Blood 91, 2886-2895 (1998).
21. Gunn, M.D. et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451-460 (1999).
22. Farr, A.G. et al. Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J. Exp. Med. 176, 1477-1482 (1992).
23. Kriehuber, E. et al. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J. Exp. Med. 194, 797-808 (2001).
24. Honda, K. et al. Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. J. Exp. Med. 193, 621-630 (2001).
25. Sixt, M. et al. The conduit system transports soluble antigens from the afferent lmph to resident dendritic cells in the T cell area of the lymph node. Immunity 22, 19-29 (2005).
26. Ngo, V.N. et al. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189, 403-412 (1999).
27. Gretz, J.E., Norbury, C.C., Anderson, A.O., Proudfoot, A.E. & Shaw, S. Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J. Exp. Med. 192, 1425-1440 (2000).
28. Bergers, G. & Song, S. The role of pericytes in blood-vessel formation and maintenance. Neuro. Oncol. 7, 452-464 (2005).
29. Mazzucchelli, R. & Durum, S.K. Interleukin-7 receptor expression: intelligent design. Nat. Rev. Immunol. 7, 144-154 (2007).
30. Hinz, B. & Gabbiani, G. Mechanisms of force generation and transmission by myofibroblasts. Curr. Opin. Biotechnol. 14, 538-546 (2003).
31. Gabbiani, G. The myofibroblast in wound healing and fibrocontractive diseases. J. Pathol. 200, 500-503 (2003).
32. Hinz, B., Celetta, G., Tomasek, J.J., Gabbiani, G. & Chaponnier, C. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol. Biol. Cell 12, 2730-2741 (2001).
33. Sanchez-Sanchez, N. et al. Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Blood 104, 619-625 (2004).
34. Endharti, A.T., Zhou, Y.W., Nakashima, I. & Suzuki, H. Galectin-1 supports survival of naive T cells without promoting cell proliferation. Eur. J. Immunol. 35, 86-97 (2005).
35. Kimura, K. et al. Role of glycosaminoglycans in the regulation of T cell proliferation induced by thymic stroma-derived T cell growth factor. J. Immunol. 146, 2618-2624 (1991).
36. Ueno, T. et al. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity 16 205-218 (2002).
37. Mackay, F. & Ambrose, C. The TNF family members BAFF and APRIL: The growing complexity. Cytokine Growth Factor Rev. 14, 311-324 (2003).
38. Schluns, K.S., Kieper, W.C., Jameson, S.C. & Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1, 426-432 (2000).
39. Zhou, Y.W. et al. Murine lymph node-derived stromal cells effectively support survival but induce no activation/proliferation of peripheral resting T cells in vitro. Immunology 109, 496-503 (2003).
40. + T cells. Eur J. Immunol. 35, 2563-2572 (2005).
41. Hara, T. et al. A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. Int. Immunol. 18, 301-311 (2006).
42. Forster, R. et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99, 23-33 (1999).
43. Luther, S.A. et al. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J. Immunol. 169, 424-433 (2002).
44. Ploix, C., Lo, D. & Carson, M.J. A ligand for the chemokine receptor CCR7 can influence the homeostatic proliferation of CD4 T cells and progression of autoimmunity. J. Immunol. 167, 6724-6730 (2001).
45. + T lymphocytes from apoptosis. Clin. Cancer Res. 11, 7901-7910 (2005).
46. Sanchez-Sanchez, N., Riol-Blanco, L. & Rodriguez-Fernandez, J.L. The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J. Immunol. 176, 5153-5159 (2006).
47. Okada, T. & Cyster, J.G. CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J. Immunol. 178 2973-2978 (2007).
48. Worbs, T., Mempel, T.R., Bolter, J., von Andrian, U.H. & Forster, R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J. Exp. Med. 204, 489-495 (2007).
49. Zamisch, M. et al. Ontogeny and regulation of IL-7-expressing thymic epithelial cells. J. Immunol. 174, 60-67 (2005).
50. Goffin J.M. et al. Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers. J. Cell Biol. 172, 259-268 (2006).