메뉴 건너뛰기




Volumn 4, Issue 11, 2004, Pages 889-899

Forkhead-box transcription factors and their role in the immune system

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CD4 ANTIGEN; DNA; INTERLEUKIN 2 RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR;

EID: 8544265317     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1488     Document Type: Review
Times cited : (336)

References (79)
  • 1
    • 17344379513 scopus 로고    scopus 로고
    • Five years on the wings of fork head
    • Kaufmann, E. & Knochel, W. Five years on the wings of fork head. Mech. Dev. 57, 3-20 (1996).
    • (1996) Mech. Dev. , vol.57 , pp. 3-20
    • Kaufmann, E.1    Knochel, W.2
  • 2
    • 0024973841 scopus 로고
    • The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo
    • Weigel, D., Jurgens, G., Kuttner, R, Seifert, E, & Jackle, H. The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo. Cell 57, 645-658 (1989).
    • (1989) Cell , vol.57 , pp. 645-658
    • Weigel, D.1    Jurgens, G.2    Kuttner, R.3    Seifert, E.4    Jackle, H.5
  • 3
    • 0025162339 scopus 로고
    • HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally
    • La, E., Prezioso, V. R., Smith, E., Litvin, O., Costa, R. H. & Darnel, J. E. HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes Dev. 4, 1427-1436 (1990).
    • (1990) Genes Dev. , vol.4 , pp. 1427-1436
    • La, E.1    Prezioso, V.R.2    Smith, E.3    Litvin, O.4    Costa, R.H.5    Darnel, J.E.6
  • 4
    • 0342614209 scopus 로고    scopus 로고
    • Unified nomenclature for the winged helix/forkhead transcription factors
    • Kaestner, K. H., Knochel, W. & Martinez, D. E. Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 14, 142-146 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 142-146
    • Kaestner, K.H.1    Knochel, W.2    Martinez, D.E.3
  • 5
    • 0027270989 scopus 로고
    • Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H 5
    • Clark, K. L., Halay, E. D., Lai, E. & Burley, S. K. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364, 412-420 (1993).
    • (1993) Nature , vol.364 , pp. 412-420
    • Clark, K.L.1    Halay, E.D.2    Lai, E.3    Burley, S.K.4
  • 7
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy, K. J. & Powrie, F. Regulatory T cells in the control of immune pathology. Nature Immunol. 2, 816-822 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 8
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers Nature Rev. Immunol. 2, 389-400 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 9
    • 0028171297 scopus 로고
    • + T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse
    • + T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J. Immunol. 153, 3764-3774 (1994).
    • (1994) J. Immunol. , vol.153 , pp. 3764-3774
    • Blair, P.J.1
  • 10
    • 0026043866 scopus 로고
    • Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: Potential model for thymic education
    • Godfrey, V. L., Wilkinson, J. E., Rinchik, E. M. & Russell, L. B. Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education. Proc. Natl Acad. Sci. USA 88, 5528-5532 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5528-5532
    • Godfrey, V.L.1    Wilkinson, J.E.2    Rinchik, E.M.3    Russell, L.B.4
  • 11
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferatrve disorder of the scurfy mouse
    • Brunkow, M. E. et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferatrve disorder of the scurfy mouse. Nature Genet. 27, 68-73 (2001). This study identified the gene that is defective in scurfy mice by combining high-resolution genetic and physical mapping with large-scale sequence analysis. Genetic complementation showed that the protein product of Foxp3 is essential for normal immune homeostasis.
    • (2001) Nature Genet. , vol.27 , pp. 68-73
    • Brunkow, M.E.1
  • 12
    • 0041931076 scopus 로고    scopus 로고
    • Foxp3 and natural regulatory T cells: Key to a cell lineage?
    • Ramsdell, F. Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity 19, 165-168 (2003).
    • (2003) Immunity , vol.19 , pp. 165-168
    • Ramsdell, F.1
  • 13
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin, R. S. et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nature Genet. 27, 18-20 (2001).
    • (2001) Nature Genet. , vol.27 , pp. 18-20
    • Wildin, R.S.1
  • 14
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP 3
    • Bennett, C. L. et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nature Genet. 27, 20-21 (2001).
    • (2001) Nature Genet. , vol.27 , pp. 20-21
    • Bennett, C.L.1
  • 15
    • 0034526617 scopus 로고    scopus 로고
    • JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    • Chatila, T. A. et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J. Clin. Invest. 106, R75-R81 (2000).
    • (2000) J. Clin. Invest. , vol.106
    • Chatila, T.A.1
  • 18
    • 0035576221 scopus 로고    scopus 로고
    • The amount of scurfin protein determines peripheral T cell number and responsiveness
    • Khattri, R. et al. The amount of scurfin protein determines peripheral T cell number and responsiveness. J. Immunol. 167, 6312-6320 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 6312-6320
    • Khattri, R.1
  • 19
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L. & Powrie, F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation, J. Exp. Med. 190, 995-1004 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 20
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a represser of transcription and regulates T cell activation
    • Schubert, L. A., Jeffery, E., Zhang, Y., Ramsdell, F. & Ziegler, S. F. Scurfin (FOXP3) acts as a represser of transcription and regulates T cell activation. J. Biol. Chem. 276, 37672-37679 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 23
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194, 629-644 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 24
    • 0348223787 scopus 로고    scopus 로고
    • + regulatory T cells by TGF-β induction of transcription factor Foxp 3
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1
  • 25
    • 2142645808 scopus 로고    scopus 로고
    • - T eels through Foxp3 induction and down-regulation of Smad7
    • - T cells through the induction of FOXP3 expression, which can subsequently inhibit SMAD7 and thereby activate a positive autoregulatory loop of TGF-β signalling.
    • (2004) J. Immunol. , vol.172 , pp. 5149-5153
    • Fantini, M.C.1
  • 27
    • 2942627115 scopus 로고    scopus 로고
    • - regulatory T cells independent of autocrine TGF-β 1
    • - regulatory T cells independent of autocrine TGF-β1. Blood 103, 4594-4601 (2004).
    • (2004) Blood , vol.103 , pp. 4594-4601
    • Mamura, M.1
  • 28
    • 4043071317 scopus 로고    scopus 로고
    • + regulatory T cell compartment
    • + regulatory T cell compartment. J. Immunol. 173, 2227-2230 (2004).
    • (2004) J. Immunol. , vol.173 , pp. 2227-2230
    • Polanczyk, M.J.1
  • 29
    • 1842631137 scopus 로고    scopus 로고
    • Developing a new paradigm for thymus organogenesis
    • Blackburn, C. C. & Manley, N. R. Developing a new paradigm for thymus organogenesis. Nature Rev. Immunol. 4, 278-289 (2004).
    • (2004) Nature Rev. Immunol. , vol.4 , pp. 278-289
    • Blackburn, C.C.1    Manley, N.R.2
  • 30
    • 0028000121 scopus 로고
    • New member of the winged-helix protein family disrupted in mouse and rat nude mutations
    • Nehls, M., Rfeifer, D., Schorpp, M., Hedrich, H. & Boehm, T. New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature 372, 103-107 (1994).
    • (1994) Nature , vol.372 , pp. 103-107
    • Nehls, M.1    Rfeifer, D.2    Schorpp, M.3    Hedrich, H.4    Boehm, T.5
  • 31
    • 0034844763 scopus 로고    scopus 로고
    • Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product
    • Bleul, C. C. & Boehm, T. Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product. Eur. J. Immunol. 31, 2497-2503 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2497-2503
    • Bleul, C.C.1    Boehm, T.2
  • 32
    • 0034610980 scopus 로고    scopus 로고
    • Facilitation of β selection and modification of positive selection in the thymus of PD-1-deficient mice
    • Nishimura, H., Honjo, T. & Minato, N. Facilitation of β selection and modification of positive selection in the thymus of PD-1-deficient mice. J. Exp. Med. 191, 891-898 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 891-898
    • Nishimura, H.1    Honjo, T.2    Minato, N.3
  • 33
    • 0036852151 scopus 로고    scopus 로고
    • Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice
    • Balclunaite, G. et al. Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nature Immunol. 3, 1102-1108 (2002). This paper reported that secreted WNT glycoproteins expressed by TECs and thymocytes can regulate FOXN1 expression in the epithelium through both autocrine and paracrine mechanisms.
    • (2002) Nature Immunol. , vol.3 , pp. 1102-1108
    • Balclunaite, G.1
  • 34
    • 0345689338 scopus 로고    scopus 로고
    • BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis
    • Tsai, P. T., Lee, R. A. & Wu, H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis, Blood 102, 3947-3953 (2003).
    • (2003) Blood , vol.102 , pp. 3947-3953
    • Tsai, P.T.1    Lee, R.A.2    Wu, H.3
  • 36
    • 0036174684 scopus 로고    scopus 로고
    • Role of the nude gene in epithelial terminal differentiation
    • Baxter, R. M. & Brissette, J. L. Role of the nude gene in epithelial terminal differentiation. J. Invest. Dermatol. 118, 303-309 (2002).
    • (2002) J. Invest. Dermatol. , vol.118 , pp. 303-309
    • Baxter, R.M.1    Brissette, J.L.2
  • 37
    • 0242624627 scopus 로고    scopus 로고
    • A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation
    • Su, D. M., Navarre, S., Oh, W. J., Condie, B. G. & Manley, N. R. A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation. Nature Immunol. 4, 1128-1135 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 1128-1135
    • Su, D.M.1    Navarre, S.2    Oh, W.J.3    Condie, B.G.4    Manley, N.R.5
  • 38
    • 0034601695 scopus 로고    scopus 로고
    • Formation of regulator/target gene relationships during evolution
    • Schlake, T., Schorpp, M. and Boehm, T. Formation of regulator/target gene relationships during evolution. Gene 256, 29-34 (2000).
    • (2000) Gene , vol.256 , pp. 29-34
    • Schlake, T.1    Schorpp, M.2    Boehm, T.3
  • 39
    • 0029013302 scopus 로고
    • Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium
    • Hackett, B.P. et al. Primary structure of hepatocyte nuclear factor/forkhead homologue 4 and characterization of gene expression in the developing respiratory and reproductive epithelium. Proc. Natl Acad. Sci. USA 92, 4249-4253 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4249-4253
    • Hackett, B.P.1
  • 40
    • 0028051755 scopus 로고
    • Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter
    • Clevidence, D. E. et al. Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter. Dev. Biol. 166, 195-209 (1994).
    • (1994) Dev. Biol. , vol.166 , pp. 195-209
    • Clevidence, D.E.1
  • 41
    • 0030967651 scopus 로고    scopus 로고
    • The winged helix transcription factor HFH- 4 is expressed during choroid plexus epithelial development in the mouse embryo
    • Lim, L., Zhou, H. & Costa, R. H. The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Proc. Natl Acad. Sci. USA 94, 3094-3099 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3094-3099
    • Lim, L.1    Zhou, H.2    Costa, R.H.3
  • 42
    • 0032530312 scopus 로고    scopus 로고
    • Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry
    • Chen, J., Knowles, H. J., Hebert, J. L. & Hackett, B. P. Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J. Clin. Invest. 102, 1077-1082(1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 1077-1082
    • Chen, J.1    Knowles, H.J.2    Hebert, J.L.3    Hackett, B.P.4
  • 44
    • 1142286333 scopus 로고    scopus 로고
    • H1 activation and inflammation by the NF-κB repressor Foxj1
    • H1 activation and inflammation by the NF-κB repressor Foxj1. Science 303, 1017-1020 (2004). This study showed that FOXJ1 can inhibit NF-κB signalling through induction of IκB proteins. These results indicate that FOXJ1 might modulate inflammatory reactions and prevent autoimmunity by antagonizing the transcription of genes that encode pro-inflammatory cytokines.
    • (2004) Science , vol.303 , pp. 1017-1020
    • Lin, L.1    Spoor, M.S.2    Gerth, A.J.3    Brody, S.L.4    Peng, S.L.5
  • 45
    • 0030973579 scopus 로고    scopus 로고
    • Transcription factors of the NFAT family: Regulation and function
    • Rao, A., Luo, C. & Hogan, P. G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15, 707-747 (1997).
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 707-747
    • Rao, A.1    Luo, C.2    Hogan, P.G.3
  • 46
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB regulation in the immune system
    • Li, Q. & Verma, I. M. NF-κB regulation in the immune system. Nature Rev. Immunol. 2, 725-734 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 47
    • 0033136283 scopus 로고    scopus 로고
    • An essential role for NF-κB in IL-18-induced IFN-γ expression in KG-1 cells
    • Kojima, H. et al. An essential role for NF-κB in IL-18-induced IFN-γ expression in KG-1 cells. J. Immunol. 162, 5063-5069 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 5063-5069
    • Kojima, H.1
  • 48
    • 0031281421 scopus 로고    scopus 로고
    • Structural characterization of the mouse Hfh4 gene, a developmentally regulated forkhead family member
    • Brody, S. L., Hackett, B. P. & White, R. A. Structural characterization of the mouse Hfh4 gene, a developmentally regulated forkhead family member. Genomics 45, 509-518 (1997).
    • (1997) Genomics , vol.45 , pp. 509-518
    • Brody, S.L.1    Hackett, B.P.2    White, R.A.3
  • 49
    • 2442542309 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinases 1/2 function as integrators of TCR signal strength
    • Schade, A. E. & Levine, A. D. Extracellular signal-regulated kinases 1/2 function as integrators of TCR signal strength. J. Immunol. 172, 5828-5832 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5828-5832
    • Schade, A.E.1    Levine, A.D.2
  • 51
    • 0038003956 scopus 로고    scopus 로고
    • Decisions on life and death: FOXO forkhead transcription factors are in command when PKB/Akt is off duty
    • Burgering, B. M. & Medema, R. H. Decisions on life and death: FOXO forkhead transcription factors are in command when PKB/Akt is off duty. J. Leukoc. Biol. 73, 689-701 (2003).
    • (2003) J. Leukoc. Biol. , vol.73 , pp. 689-701
    • Burgering, B.M.1    Medema, R.H.2
  • 52
    • 0042591476 scopus 로고    scopus 로고
    • FOXO transcription factors as regulators of immune homeostasis: Molecules to die for?
    • Birkenkamp, K. U. & Coffer, P. J. FOXO transcription factors as regulators of immune homeostasis: molecules to die for? J. Immunol. 171, 1623-1629 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 1623-1629
    • Birkenkamp, K.U.1    Coffer, P.J.2
  • 53
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • Accili, D. & Arden, K. C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421-426 (2004).
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 54
    • 4143129696 scopus 로고    scopus 로고
    • H activation, and autoinflammation by the forkhead transcription factor Foxo3a
    • H activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 21, 203-213 (2004). This was the first study that identified a role for FOXO transcription factors in immune homeostasis in vivo. FOXO3A can inhibit NF-κB activation and maintain T-cell tolerance through an undefined mechanism.
    • (2004) Immunity , vol.21 , pp. 203-213
    • Lin, L.1    Hron, J.D.2    Peng, S.L.3
  • 55
    • 0038152845 scopus 로고    scopus 로고
    • Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
    • Castrillon, D. H., Miao, L., Kollipara, R., Horner, J. W. & DePinho, R. A. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301, 215-218 (2003).
    • (2003) Science , vol.301 , pp. 215-218
    • Castrillon, D.H.1    Miao, L.2    Kollipara, R.3    Horner, J.W.4    DePinho, R.A.5
  • 57
    • 0036120725 scopus 로고    scopus 로고
    • Control of cell cycle exit and entry by protein kinase B-reguiated forkhead transcription factors
    • Kops, G. J. et al. Control of cell cycle exit and entry by protein kinase B-reguiated forkhead transcription factors. Mol. Cell. Biol. 22, 2025-2036 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2025-2036
    • Kops, G.J.1
  • 59
    • 0037136563 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO 3a protects quiescent cells from oxidative stress
    • Kops, G. J. et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316-321 (2002).
    • (2002) Nature , vol.419 , pp. 316-321
    • Kops, G.J.1
  • 62
    • 0037094096 scopus 로고    scopus 로고
    • Kip1 and Bim in response to IL-2
    • Kip1 and Bim in response to IL-2. J. Immunol. 168, 5024-5031 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 5024-5031
    • Stahl, M.1
  • 65
    • 2342653278 scopus 로고    scopus 로고
    • Control of cyclin G2 mRNA expression by forkhead transcription factors; mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead
    • Martinez-Gac, L., Marques, M., Garcia, Z., Campanero, M. R. & Carrera, A. C. Control of cyclin G2 mRNA expression by forkhead transcription factors; mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Mol. Cell. Biol. 24, 2181-2189 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 2181-2189
    • Martinez-Gac, L.1    Marques, M.2    Garcia, Z.3    Campanero, M.R.4    Carrera, A.C.5
  • 66
    • 0030987302 scopus 로고    scopus 로고
    • Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest
    • Horne, M. C. et al. Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest J. Biol. Chem. 272, 12650-12661 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 12650-12661
    • Horne, M.C.1
  • 67
    • 0037017396 scopus 로고    scopus 로고
    • FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: Protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity
    • Dijkers, P. F. et al. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156, 531-542 (2002). This paper showed that activation of FOXO3A alone can recapitulate all known elements of the apoptotic programme that are normally induced in lymphocytes by cytokine withdrawal.
    • (2002) J. Cell Biol. , vol.156 , pp. 531-542
    • Dijkers, P.F.1
  • 68
    • 1642305625 scopus 로고    scopus 로고
    • H2 cells against activation-induced cell death by a mechanism requiring PI 3 kinase function
    • H2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function. J. Exp. Med. 199, 831-842 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 831-842
    • Pandiyan, P.1
  • 69
    • 0034658320 scopus 로고    scopus 로고
    • L levels in vivo
    • L levels in vivo. J. Exp. Med. 191, 1721-1734 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1721-1734
    • Jones, R.G.1
  • 70
    • 0037134491 scopus 로고    scopus 로고
    • The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional represser
    • Tang, T. T. et al. The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional represser. J. Biol. Chem. 277, 14255-14265 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 14255-14265
    • Tang, T.T.1
  • 71
    • 11144357466 scopus 로고    scopus 로고
    • IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a
    • Hu, M. C. et al. IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117, 225-237 (2004).
    • (2004) Cell , vol.117 , pp. 225-237
    • Hu, M.C.1
  • 72
    • 0037119628 scopus 로고    scopus 로고
    • IκB kinase signaling is essential for maintenance of mature B cells
    • Pasparakis, M., Schmidt-Supprian, M. & Rajewsky, K. IκB kinase signaling is essential for maintenance of mature B cells. J. Exp. Med. 196, 743-752 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 743-752
    • Pasparakis, M.1    Schmidt-Supprian, M.2    Rajewsky, K.3
  • 73
    • 2342622123 scopus 로고    scopus 로고
    • Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factor
    • Yusuf, I., Zhu, X., Kharas, M. G., Chen, J. & Fruman, D. A. Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factor. Blood 104, 784-787 (2004).
    • (2004) Blood , vol.104 , pp. 784-787
    • Yusuf, I.1    Zhu, X.2    Kharas, M.G.3    Chen, J.4    Fruman, D.A.5
  • 74
    • 1642580499 scopus 로고    scopus 로고
    • FoxO3a regulates erythroid differentiation and induces BTG 1, an activator of protein arginine methyl transferase 1
    • Bakker, W. J. et al., FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J. Cell Biol. 164, 175-184 (2004).
    • (2004) J. Cell Biol. , vol.164 , pp. 175-184
    • Bakker, W.J.1
  • 75
    • 0033535507 scopus 로고    scopus 로고
    • Exposing the human nude phenotype
    • Frank, J. et al. Exposing the human nude phenotype. Nature 398, 473-474 (1999).
    • (1999) Nature , vol.398 , pp. 473-474
    • Frank, J.1
  • 76
    • 2442676466 scopus 로고    scopus 로고
    • FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins
    • Scheijen, B., Ngo, H. T., Kang, H. & Griffin, J. D. FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins. Oncogene 23, 3338-3349 (2004).
    • (2004) Oncogene , vol.23 , pp. 3338-3349
    • Scheijen, B.1    Ngo, H.T.2    Kang, H.3    Griffin, J.D.4
  • 77
    • 0037458609 scopus 로고    scopus 로고
    • A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells
    • Komatsu, N. et al. A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells. J. Biol. Chem. 278, 6411-6419 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 6411-6419
    • Komatsu, N.1
  • 78
    • 0036651790 scopus 로고    scopus 로고
    • A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
    • Ramaswamy, S., Nakamura, N. Sansal, I., Bergeron, L. & Sellers, W. R. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2, 81-91 (2002).
    • (2002) Cancer Cell , vol.2 , pp. 81-91
    • Ramaswamy, S.1    Nakamura, N.2    Sansal, I.3    Bergeron, L.4    Sellers, W.R.5
  • 79
    • 0036387193 scopus 로고    scopus 로고
    • Forkhead transcription factors: Key players in development and metabolism
    • Carlsson, P. & Mahlapuu, M. Forkhead transcription factors: key players in development and metabolism. Dev. Biol. 250, 1-23 (2002).
    • (2002) Dev. Biol. , vol.250 , pp. 1-23
    • Carlsson, P.1    Mahlapuu, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.