Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002

Journal of Biological Chemistry

Volumn 280, Issue 14, 2005, Pages 13728-13734

  Jacobs, Marc D ^a,b   Black, James ^a   Futer, Olga ^a   Swenson, Lora ^a   Hare, Brian ^a   Fleming, Mark ^a   Saxena, Kumkum ^a  

^a VERTEX PHARMACEUTICALS   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; GENES; HYDROGEN BONDS; VAN DER WAALS FORCES; VIRUSES;

GERM CELL LINES; LIGANDS; PIM-1 LIGAND-BOUND STRUCTURES; T-CELL LYMPHOMAS;

CELLS;

2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE; ADENOSINE TRIPHOSPHATE; ENDOPEPTIDASE LA; LIGAND; PHOSPHATIDYLINOSITOL 3 KINASE; PROLINE; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; STAUROSPORINE;

ARTICLE; CONFORMATION; CRYSTAL STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STRUCTURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE; AMINO ACID SEQUENCE; BINDING SITES; CHROMONES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MORPHOLINES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-PIM-1; SEQUENCE ALIGNMENT; STAUROSPORINE;

EID: 17144422830     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413155200     Document Type: Article

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