Resveratrol, sirtuins, and the promise of a DR mimetic

Mechanisms of Ageing and Development

Volumn 131, Issue 4, 2010, Pages 261-269

  Baur, Joseph A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Dietary restriction; Longevity; Mimetic; Resveratrol; Sirtuins

Indexed keywords

ENZYME ACTIVATOR; INSULIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROSTAGLANDIN SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); RESVERATROL; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SRT 1720; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; COGNITIVE DEFECT; DIET RESTRICTION; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; FISH; FLY; HEART PROTECTION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEUKEMIA; LIFESPAN; LONGEVITY; MORTALITY; OBESITY; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; STRUCTURE ANALYSIS; WORM; YEAST;

ADP RIBOSE TRANSFERASES; ANIMALS; DIET; DIET, REDUCING; ENERGY METABOLISM; HUMANS; LONGEVITY; OBESITY; PRIMATES; SACCHAROMYCES CEREVISIAE; SIRTUINS; STILBENES;

PRIMATES; RODENTIA;

EID: 77952549960     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2010.02.007     Document Type: Article

References (128)

1. Alcendor R.R., Gao S., Zhai P., Zablocki D., Holle E., Yu X., Tian B., Wagner T., Vatner S.F., Sadoshima J. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ. Res. 2007, 100:1512-1521.
2. Anderson R.M., Bitterman K.J., Wood J.G., Medvedik O., Sinclair D.A. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 2003, 423:181-185.
3. Anderson R.M., Weindruch R. Calorie restriction: progress during mid-2005-mid-2006. Exp. Gerontol. 2006, 41:1247-1249.
4. Anisimov V.N., Berstein L.M., Egormin P.A., Piskunova T.S., Popovich I.G., Zabezhinski M.A., Kovalenko I.G., Poroshina T.E., Semenchenko A.V., Provinciali M., Re F., Franceschi C. Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp. Gerontol. 2005, 40:685-693.
5. Banks A.S., Kon N., Knight C., Matsumoto M., Gutierrez-Juarez R., Rossetti L., Gu W., Accili D. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 2008, 8:333-341.
6. Barger J.L., Kayo T., Vann J.M., Arias E.B., Wang J., Hacker T.A., Wang Y., Raederstorff D., Morrow J.D., Leeuwenburgh C., Allison D.B., Saupe K.W., Cartee G.D., Weindruch R., Prolla T.A. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE 2008, 3:e2264.
7. Bass T.M., Weinkove D., Houthoofd K., Gems D., Partridge L. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech. Ageing Dev. 2007, 128:546-552.
8. Bauer J.H., Goupil S., Garber G.B., Helfand S.L. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:12980-12985.
9. Baur J.A. Metabolic effects of caloric restriction. Encyclopedia of Life Sciences 2009, John Wiley & Sons, Ltd.
10. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., Pistell P.J., Poosala S., Becker K.G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K.W., Spencer R.G., Lakatta E.G., Le Couteur D., Shaw R.J., Navas P., Puigserver P., Ingram D.K., de Cabo R., Sinclair D.A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
11. Baur J.A., Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 2006, 5:493-506.
12. Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst. Rev. 2008, CD007176.
13. Bluher M., Kahn B.B., Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003, 299:572-574.
14. Boily G., He X.H., Pearce B., Jardine K., McBurney M.W. SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. Oncogene 2009.
15. Bonkowski M.S., Rocha J.S., Masternak M.M., Al Regaiey K.A., Bartke A. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:7901-7905.
16. Bordone L., Cohen D., Robinson A., Motta M.C., van Veen E., Czopik A., Steele A.D., Crowe H., Marmor S., Luo J., Gu W., Guarente L. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007, 6:759-767.
17. Borra M.T., Smith B.C., Denu J.M. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 2005, 280:17187-17195.
18. Bove K., Lincoln D.W., Tsan M.F. Effect of resveratrol on growth of 4T1 breast cancer cells in vitro and in vivo. Biochem. Biophys. Res. Commun. 2002, 291:1001-1005.
19. Brown-Borg H.M., Borg K.E., Meliska C.J., Bartke A. Dwarf mice and the ageing process. Nature 1996, 384:33.
20. Buryanovskyy L., Fu Y., Boyd M., Ma Y., Hsieh T.C., Wu J.M., Zhang Z. Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry 2004, 43:11417-11426.
21. Chen D., Bruno J., Easlon E., Lin S.J., Cheng H.L., Alt F.W., Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 2008, 22:1753-1757.
22. Chen D., Steele A.D., Lindquist S., Guarente L. Increase in activity during calorie restriction requires Sirt1. Science 2005, 310:1641.
23. Chung H.Y., Kim H.J., Kim K.W., Choi J.S., Yu B.P. Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc. Res. Technol. 2002, 59:264-272.
24. Ciolino H.P., Daschner P.J., Yeh G.C. Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res. 1998, 58:5707-5712.
25. Civitarese A.E., Carling S., Heilbronn L.K., Hulver M.H., Ukropcova B., Deutsch W.A., Smith S.R., Ravussin E. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 2007, 4:e76.
26. Colman R.J., Anderson R.M., Johnson S.C., Kastman E.K., Kosmatka K.J., Beasley T.M., Allison D.B., Cruzen C., Simmons H.A., Kemnitz J.W., Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009, 325:201-204.
27. Csiszar A., Labinskyy N., Pinto J.T., Ballabh P., Zhang H., Losonczy G., Pearson K., de Cabo R., Pacher P., Zhang C., Ungvari Z. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am. J. Physiol. Heart. Circ. Physiol. 2009, 297:H13-H20.
28. Dali-Youcef N., Lagouge M., Froelich S., Koehl C., Schoonjans K., Auwerx J. Sirtuins: the 'magnificent seven', function, metabolism and longevity. Ann. Med. 2007, 39:335-345.
29. Dasgupta B., Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:7217-7222.
30. Dhahbi J.M., Mote P.L., Fahy G.M., Spindler S.R. Identification of potential caloric restriction mimetics by microarray profiling. Physiol. Genomics 2005, 23:343-350.
31. Dilman V.M., Anisimov V.N. Effect of treatment with phenformin, diphenylhydantoin or l-dopa on life span and tumour incidence in C3H/Sn mice. Gerontology 1980, 26:241-246.
32. Dixit V.D. Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. J. Leukoc. Biol. 2008, 84:882-892.
33. Doll R., Peto R., Boreham J., Sutherland I. Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ 2004, 328:1519.
34. Everitt A.V., Le Couteur D.G. Life extension by calorie restriction in humans. Ann. N. Y. Acad. Sci. 2007, 1114:428-433.
35. Feige J.N., Lagouge M., Canto C., Strehle A., Houten S.M., Milne J.C., Lambert P.D., Mataki C., Elliott P.J., Auwerx J. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 2008, 8:347-358.
36. Flurkey K., Papaconstantinou J., Harrison D.E. The Snell dwarf mutation Pit1(dw) can increase life span in mice. Mech. Ageing Dev. 2002, 123:121-130.
37. Flurkey K., Papaconstantinou J., Miller R.A., Harrison D.E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:6736-6741.
38. Franco O.H., de Laet C., Peeters A., Jonker J., Mackenbach J., Nusselder W. Effects of physical activity on life expectancy with cardiovascular disease. Arch. Intern. Med. 2005, 165:2355-2360.
39. Friedman D.B., Johnson T.E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 1988, 118:75-86.
40. Fulco M., Cen Y., Zhao P., Hoffman E.P., McBurney M.W., Sauve A.A., Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev. Cell 2008, 14:661-673.
41. Gao X., Xu Y.X., Divine G., Janakiraman N., Chapman R.A., Gautam S.C. Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes. J. Nutr. 2002, 132:2076-2081.
42. Gehm B.D., McAndrews J.M., Chien P.Y., Jameson J.L. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:14138-14143.
43. Gonzalez A.A., Kumar R., Mulligan J.D., Davis A.J., Weindruch R., Saupe K.W. Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E1032-E1037.
44. Gonzalez-Suarez E., Geserick C., Flores J.M., Blasco M.A. Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice. Oncogene 2005, 24:2256-2270.
45. Greer E.L., Dowlatshahi D., Banko M.R., Villen J., Hoang K., Blanchard D., Gygi S.P., Brunet A. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr. Biol. 2007, 17:1646-1656.
46. Haigis M.C., Mostoslavsky R., Haigis K.M., Fahie K., Christodoulou D.C., Murphy A.J., Valenzuela D.M., Yancopoulos G.D., Karow M., Blander G., Wolberger C., Prolla T.A., Weindruch R., Alt F.W., Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006, 126:941-954.
47. Harrison D.E., Archer J.R., Astle C.M. Effects of food restriction on aging: separation of food intake and adiposity. Proc. Natl. Acad. Sci. U.S.A. 1984, 81:1835-1838.
48. Hempenstall S., Picchio L., Mitchell S.E., Speakman J.R., Selman C. The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice. Mech. Ageing Dev. 2010.
49. Holloszy J.O., Smith E.K., Vining M., Adams S. Effect of voluntary exercise on longevity of rats. J. Appl. Physiol. 1985, 59:826-831.
50. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., Sinclair D.A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425:191-196.
51. Imai S., Armstrong C.M., Kaeberlein M., Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000, 403:795-800.
52. Ingram D.K., Zhu M., Mamczarz J., Zou S., Lane M.A., Roth G.S., deCabo R. Calorie restriction mimetics: an emerging research field. Aging Cell 2006, 5:97-108.
53. Jang M., Cai L., Udeani G.O., Slowing K.V., Thomas C.F., Beecher C.W., Fong H.H., Farnsworth N.R., Kinghorn A.D., Mehta R.G., Moon R.C., Pezzuto J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997, 275:218-220.
54. Jarolim S., Millen J., Heeren G., Laun P., Goldfarb D.S., Breitenbach M. A novel assay for replicative lifespan in Saccharomyces cerevisiae. FEMS Yeast Res. 2004, 5:169-177.
55. Jonker J.T., De Laet C., Franco O.H., Peeters A., Mackenbach J., Nusselder W.J. Physical activity and life expectancy with and without diabetes: life table analysis of the Framingham Heart Study. Diabetes Care 2006, 29:38-43.
56. Kaeberlein M., Hu D., Kerr E.O., Tsuchiya M., Westman E.A., Dang N., Fields S., Kennedy B.K. Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet. 2005, 1:e69.
57. Kaeberlein M., Kirkland K.T., Fields S., Kennedy B.K. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol. 2004, 2:E296.
58. Kaeberlein M., McDonagh T., Heltweg B., Hixon J., Westman E.A., Caldwell S., Napper A., Curtis R., Distefano P.S., Fields S., Bedalov A., Kennedy B.K. Substrate specific activation fo sirtuins by resveratrol. J. Biol. Chem. 2005.
59. Katic M., Kennedy A.R., Leykin I., Norris A., McGettrick A., Gesta S., Russell S.J., Bluher M., Maratos-Flier E., Kahn C.R. Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell 2007, 6:827-839.
60. Kawahara T.L., Michishita E., Adler A.S., Damian M., Berber E., Lin M., McCord R.A., Ongaigui K.C., Boxer L.D., Chang H.Y., Chua K.F. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009, 136:62-74.
61. Kim D., Nguyen M.D., Dobbin M.M., Fischer A., Sananbenesi F., Rodgers J.T., Delalle I., Baur J.A., Sui G., Armour S.M., Puigserver P., Sinclair D.A., Tsai L.H. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007, 26:3169-3179.
62. Kwong S.C., Brubacher J. Phenformin and lactic acidosis: a case report and review. J. Emerg. Med. 1998, 16:881-886.
63. Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127:1109-1122.
64. Lamming D.W., Latorre-Esteves M., Medvedik O., Wong S.N., Tsang F.A., Wang C., Lin S.J., Sinclair D.A. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 2005, 309:1861-1864.
65. Lan F., Cacicedo J.M., Ruderman N., Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J. Biol. Chem. 2008, 283:27628-27635.
66. Lane M.A., Ingram D.K., Roth G.S. 2-Deoxy-d-glucose feeding in rats mimics physiological effects of caloric restriction. J. Anti-Aging Med. 1998, 1:327-337.
67. Lefevre M., Redman L.M., Heilbronn L.K., Smith J.V., Martin C.K., Rood J.C., Greenway F.L., Williamson D.A., Smith S.R., Ravussin E. Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Atherosclerosis 2009, 203:206-213.
68. Leverve X.M., Guigas B., Detaille D., Batandier C., Koceir E.A., Chauvin C., Fontaine E., Wiernsperger N.F. Mitochondrial metabolism and type-2 diabetes: a specific target of metformin. Diabetes Metab. 2003, 29:S88-S94. 6.
69. Li T., Fan G.X., Wang W., Yuan Y.K. Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo. Int. Immunopharmacol. 2007, 7:1221-1231.
70. Li Y., Xu W., McBurney M.W., Longo V.D. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab. 2008, 8:38-48.
71. Lin S.J., Defossez P.A., Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000, 289:2126-2128.
72. Lin S.J., Ford E., Haigis M., Liszt G., Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 2004, 18:12-16.
73. Masoro E.J. Overview of caloric restriction and ageing. Mech. Ageing Dev. 2005, 126:913-922.
74. Mayers J.R., Iliff B.W., Swoap S.J. Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction. FASEB J. 2009, 23:1032-1040.
75. McBurney M.W., Yang X., Jardine K., Hixon M., Boekelheide K., Webb J.R., Lansdorp P.M., Lemieux M. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell. Biol. 2003, 23:38-54.
76. McCay C.M., Crowell M.F., Maynard L.A. The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr. 1935, 10:63-79.
77. McShane T.M., Wise P.M. Life-long moderate caloric restriction prolongs reproductive life span in rats without interrupting estrous cyclicity: effects on the gonadotropin-releasing hormone/luteinizing hormone axis. Biol. Reprod. 1996, 54:70-75.
78. Milne J.C., Lambert P.D., Schenk S., Carney D.P., Smith J.J., Gagne D.J., Jin L., Boss O., Perni R.B., Vu C.B., Bemis J.E., Xie R., Disch J.S., Ng P.Y., Nunes J.J., Lynch A.V., Yang H., Galonek H., Israelian K., Choy W., Iffland A., Lavu S., Medvedik O., Sinclair D.A., Olefsky J.M., Jirousek M.R., Elliott P.J., Westphal C.H. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007, 450:712-716.
79. Mostoslavsky R., Chua K.F., Lombard D.B., Pang W.W., Fischer M.R., Gellon L., Liu P., Mostoslavsky G., Franco S., Murphy M.M., Mills K.D., Patel P., Hsu J.T., Hong A.L., Ford E., Cheng H.L., Kennedy C., Nunez N., Bronson R., Frendewey D., Auerbach W., Valenzuela D., Karow M., Hottiger M.O., Hursting S., Barrett J.C., Guarente L., Mulligan R., Demple B., Yancopoulos G.D., Alt F.W. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006, 124:315-329.
80. Moynihan K.A., Grimm A.A., Plueger M.M., Bernal-Mizrachi E., Ford E., Cras-Meneur C., Permutt M.A., Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab. 2005, 2:105-117.
81. Nakagawa T., Lomb D.J., Haigis M.C., Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 2009, 137:560-570.
82. Nisoli E., Tonello C., Cardile A., Cozzi V., Bracale R., Tedesco L., Falcone S., Valerio A., Cantoni O., Clementi E., Moncada S., Carruba M.O. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 2005, 310:314-317.
83. Oberdoerffer P., Michan S., McVay M., Mostoslavsky R., Vann J., Park S.K., Hartlerode A., Stegmuller J., Hafner A., Loerch P., Wright S.M., Mills K.D., Bonni A., Yankner B.A., Scully R., Prolla T.A., Alt F.W., Sinclair D.A. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 2008, 135:907-918.
84. Olshansky S.J., Carnes B.A., Cassel C. In search of Methuselah: estimating the upper limits to human longevity. Science 1990, 250:634-640.
85. Pacholec M., Chrunyk B.A., Cunningham D., Flynn D., Griffith D.A., Griffor M., Loulakis P., Pabst B., Qiu X., Stockman B., Thanabal V., Varghese A., Ward J., Withka J., Ahn K. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. 2010.
86. Pani G., Fusco S., Galeotti T. Smaller, hungrier mice. Science 2006, 311:1553-1554. (author reply 1553-4).
87. Panowski S.H., Wolff S., Aguilaniu H., Durieux J., Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 2007, 447:550-555.
88. Pearson K.J., Baur J.A., Lewis K.N., Peshkin L., Price N.L., Labinskyy N., Swindell W.R., Kamara D., Minor R.K., Perez E., Jamieson H.A., Zhang Y., Dunn S.R., Sharma K., Pleshko N., Woollett L.A., Csiszar A., Ikeno Y., Le Couteur D., Elliott P.J., Becker K.G., Navas P., Ingram D.K., Wolf N.S., Ungvari Z., Sinclair D.A., de Cabo R. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008, 8:157-168.
89. Pfluger P.T., Herranz D., Velasco-Miguel S., Serrano M., Tschop M.H. Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:9793-9798.
90. Phelan J.P., Rose M.R. Why dietary restriction substantially increases longevity in animal models but won't in humans. Ageing Res. Rev. 2005, 4:339-350.
91. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004, 429:771-776.
92. Purushotham A., Schug T.T., Xu Q., Surapureddi S., Guo X., Li X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 2009, 9:327-338.
93. Ramsey K.M., Mills K.F., Satoh A., Imai S. Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. Aging Cell 2008, 7:78-88.
94. Ritz B.W., Aktan I., Nogusa S., Gardner E.M. Energy restriction impairs natural killer cell function and increases the severity of influenza infection in young adult male C57BL/6 mice. J. Nutr. 2008, 138:2269-2275.
95. Robb E.L., Winkelmolen L., Visanji N., Brotchie J., Stuart J.A. Dietary resveratrol administration increases MnSOD expression and activity in mouse brain. Biochem. Biophys. Res. Commun. 2008, 372:254-259.
96. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005, 434:113-118.
97. Rodgers J.T., Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:12861-12866.
98. Rogina B., Helfand S.L. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:15998-16003.
99. Rose G., Dato S., Altomare K., Bellizzi D., Garasto S., Greco V., Passarino G., Feraco E., Mari V., Barbi C., BonaFe M., Franceschi C., Tan Q., Boiko S., Yashin A.I., De Benedictis G. Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp. Gerontol. 2003, 38:1065-1070.
100. Roth G.S., Ingram D.K., Lane M.A. Caloric restriction in primates and relevance to humans. Ann. N. Y. Acad. Sci. 2001, 928:305-315.
101. Sale S., Verschoyle R.D., Boocock D., Jones D.J., Wilsher N., Ruparelia K.C., Potter G.A., Farmer P.B., Steward W.P., Gescher A.J. Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4′-tetramethoxystilbene. Br. J. Cancer 2004, 90:736-744.
102. Shakibaei M., Harikumar K.B., Aggarwal B.B. Resveratrol addiction: to die or not to die. Mol. Nutr. Food Res. 2009, 53:115-128.
103. Sharma M., Gupta Y.K. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci. 2002, 71:2489-2498.
104. Smith J.J., Kenney R.D., Gagne D.J., Frushour B.P., Ladd W., Galonek H.L., Israelian K., Song J., Razvadauskaite G., Lynch A.V., Carney D.P., Johnson R.J., Lavu S., Iffland A., Elliott P.J., Lambert P.D., Elliston K.O., Jirousek M.R., Milne J.C., Boss O. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst. Biol. 2009, 3:31.
105. Smith J.S., Brachmann C.B., Celic I., Kenna M.A., Muhammad S., Starai V.J., Avalos J.L., Escalante-Semerena J.C., Grubmeyer C., Wolberger C., Boeke J.D. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:6658-6663.
106. Sohal R.S., Ferguson M., Sohal B.H., Forster M.J. Life span extension in mice by food restriction depends on an energy imbalance. J. Nutr. 2009, 139:533-539.
107. Streppel M.T., Ocke M.C., Boshuizen H.C., Kok F.J., Kromhout D. Long-term wine consumption is related tocardiovascular mortality and life expectancyindependently of moderate alcohol intake: theZutphen Study. J. Epidemiol. Commun. Health 2009.
108. Su J.L., Yang C.Y., Zhao M., Kuo M.L., Yen M.L. Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. J. Biol. Chem. 2007, 282:19385-19398.
109. Tatsumi S., Ito M., Asaba Y., Tsutsumi K., Ikeda K. Life-long caloric restriction reveals biphasic and dimorphic effects on bone metabolism in rodents. Endocrinology 2008, 149:634-641.
110. Taylor D.H., Hasselblad V., Henley S.J., Thun M.J., Sloan F.A. Benefits of smoking cessation for longevity. Am. J. Public Health 2002, 92:990-996.
111. Tomas-Loba A., Flores I., Fernandez-Marcos P.J., Cayuela M.L., Maraver A., Tejera A., Borras C., Matheu A., Klatt P., Flores J.M., Vina J., Serrano M., Blasco M.A. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell 2008, 135:609-622.
112. Tsuchiya M., Dang N., Kerr E.O., Hu D., Steffen K.K., Oakes J.A., Kennedy B.K., Kaeberlein M. Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell 2006, 5:505-514.
113. Um J.H., Park S.J., Kang H., Yang S., Foretz M., McBurney M.W., Kim M.K., Viollet B., Chung J.H. AMPK-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 2009.
114. Vakhrusheva O., Smolka C., Gajawada P., Kostin S., Boettger T., Kubin T., Braun T., Bober E. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 2008, 102:703-710.
115. Valenzano D.R., Terzibasi E., Genade T., Cattaneo A., Domenici L., Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr. Biol. 2006, 16:296-300.
116. Viswanathan M., Kim S.K., Berdichevsky A., Guarente L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 2005, 9:605-615.
117. Volk M.J., Pugh T.D., Kim M., Frith C.H., Daynes R.A., Ershler W.B., Weindruch R. Dietary restriction from middle age attenuates age-associated lymphoma development and interleukin 6 dysregulation in C57BL/6 mice. Cancer Res. 1994, 54:3054-3061.
118. Wang Y., Tissenbaum H.A. Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech. Ageing Dev. 2006, 127:48-56.
119. Weindruch R., Walford R.L. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 1982, 215:1415-1418.
120. Weindruch R., Walford R.L. The retardation of aging and disease by dietary restriction 1988, Springfield, IL, USA, p. xvii, 436 p. C.C. Thomas (Ed.).
121. Weindruch R., Walford R.L., Fligiel S., Guthrie D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J. Nutr. 1986, 116:641-654.
122. Weiss E.P., Racette S.B., Villareal D.T., Fontana L., Steger-May K., Schechtman K.B., Klein S., Holloszy J.O. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am. J. Clin. Nutr. 2006, 84:1033-1042.
123. Whitlock G., Lewington S., Sherliker P., Clarke R., Emberson J., Halsey J., Qizilbash N., Collins R., Peto R. Body-mass index and cause-specific mortality in 900000 adults: collaborative analyses of 57 prospective studies. Lancet 2009, 373:1083-1096.
124. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M., Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004, 430:686-689.
125. Yang H., Baur J.A., Chen A., Miller C., Adams J.K., Kisielewski A., Howitz K.T., Zipkin R.E., Sinclair D.A. Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell 2007, 6:35-43.
126. Yen K., Steinsaltz D., Mobbs C.V. Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan. Exp. Gerontol. 2008, 43:1044-1051.
127. Zang M., Xu S., Maitland-Toolan K.A., Zuccollo A., Hou X., Jiang B., Wierzbicki M., Verbeuren T.J., Cohen R.A. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 2006, 55:2180-2191.
128. Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M.F., Goodyear L.J., Moller D.E. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 2001, 108:1167-1174.