Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor

Cancer Research

Volumn 58, Issue 24, 1998, Pages 5707-5712

  Ciolino, Henry P ^a,c   Daschner, Phillip J ^b   Yeh, Grace Chao ^a  

^a Basic Research Laboratory   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; MESSENGER RNA; NATURAL PRODUCT; RESERVATROL; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR BINDING; TRANSCRIPTION REGULATION;

ANTICARCINOGENIC AGENTS; CARCINOMA, HEPATOCELLULAR; CYTOCHROME P-450 CYP1A1; CYTOSOL; HUMANS; LIVER NEOPLASMS; PROMOTER REGIONS (GENETICS); RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; STILBENES; TETRACHLORODIBENZODIOXIN; TUMOR CELLS, CULTURED;

EID: 0032535055     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Langcake, P., and Pryce, R. J. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury. Physiol. Plant Pathol., 9: 77-86, 1976.
2. Goldberg, D., Tsang, E., Kanimanchiri, A., Diamandis, E., Soleas, G., and Ng, E. Method to assay the concentrations of phenolic constituents of biological interest in wines. Anal. Chem., 68: 1688-1694, 1996.
3. Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G., and Goldberg, D. M. The red wine phenolies trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin. Chim. Acta, 235: 207-219, 1995.
4. Rotondo, S., Rajtar, G., Manarini, S., Celardo, A., Rotillo, D., de Gaetano, G., Evangelista, V., and Cerletti, C. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br. J. Pharmacol., 123: 1691-1699, 1998.
5. Jayatilake, G. S., Jayasuriya, H., Lee, E. S., Koonchanok, N. M., Geahlen, R. L., Ashendel, C. L., McLaughlin, J. L., and Chang, C. J. Kinase inhibitors from Polygonum cuspidatum. J. Nat. Prod., 56: 1805-1810, 1993.
6. Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. R, Beecher, C. W., Fong, H. H., Farnsworth, N. R., Kinghom, A. D., Mehta, R. G., Moon, R. C., and Pezzuto, J. M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (Washington DC), 275: 218-220, 1997.
7. Hayashi, S., Watanabe, J., Nakachi, K., Eguchi, H., Gotoh, O., and Kawajiri, K. Interindividual difference in expression of human Ah receptor and related P450 genes. Carcinogenesis (Lond.), 15: 801-806, 1994.
8. Rowlands, J. C., and Gustafsson, J. A. Aryl hydrocarbon receptor-mediated signal transduction. Crit. Rev. Toxicol., 27: 109-134, 1997.
9. Whitlock, J. P., Jr., Chichester, C. H., Bedgood, R. M., Okino, S. T., Ko, H. P., Ma, Q., Dong, L., Li, H., and Clarke-Katzenberg, R. Induction of drug-metabolizing enzymes by dioxin. Drug Metab. Rev., 29: 1107-1127, 1997.
10. Peltonen, K., and Dipple, A. Polycyclic aromatic hydrocarbons: chemistry of DNA adduct formation. J. Occup. Environ. Med., 37: 52-58, 1995.
11. Wattenberg, L. W. An overview of chemoprevention: current status and future prospects. Proc. Soc. Exp. Biol. Med., 216: 133-141, 1997.
12. Dohr, O., Vogel, C., and Abel, J. Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells. Arch. Biochem. Biophys., 321: 405-412, 1995.
13. Sogawa, K., Fujisawa-Sehara, A., Yamane, M., and Fujii-Kuriyama, Y. Location of regulatory elements responsible for drug induction in the rat cytochrome P-450c gene. Proc. Natl. Acad. Sci. USA, 83: 8044-8048, 1986.
14. Rosenthal, N. Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol., 152: 704-720, 1987.
15. Kennedy, S., and Jones, S. Simultaneous measurement of cytochrome P4501A catalytic activity and total protein concentration with a fluorescence plate reader. Anal. Biochem., 222: 217-223, 1994.
16. Denison, M. S., Fisher, J. M., and Whitlock, J. P., Jr. The DNA recognition site for the dioxin-Ah receptor complex: nucleotide sequence and functional analysis. J. Biol. Chem., 263: 17221-17224, 1988.
17. Chen, Y. H., and Tukey, R. H. Protein kinase C modulates regulation of the CYP1Al gene by the aryl hydrocarbon receptor. J. Biol. Chem., 277: 26261-26266, 1996.
18. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1976.
19. Raha, A., Reddy, V., Houser, W., and Bresnick, E. J. Binding characteristics of 4S PAH-binding protein and Ah receptor from rats and mice. J. Toxicol. Environ. Health, 29; 339-355, 1990.
20. Singh, S. S., Hord, N. G., and Perdew, G. H. Characterization of the activated form of the aryl hydrocarbon receptor in the nucleus of HeLa cells in the absence of exogenous ligand. Arch. Biochem. Biophys., 329: 47-55, 1996.