Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes

Journal of Nutrition

Volumn 132, Issue 7, 2002, Pages 2076-2081

  Gao, Xiaohua ^a   Xu, Yong X ^a   Divine, George ^a   Janakiraman, Nalini ^a   Chapman, Robert A ^a   Gautam, Subhash C ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

Antileukemic activity; Apoptosis; Resveratrol

Indexed keywords

CASPASE 3; DNA FRAGMENT; POLYPHENOL DERIVATIVE; RESVERATROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLOOD DISEASE; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; GRAPE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MYELOID LEUKEMIA; NONHUMAN;

ANIMALIA; VITACEAE; VITIS SP.;

EID: 0036307853     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.7.2076     Document Type: Article

References (42)

1. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence
2. Diet and health: What should we eat?
3. Diet and cancer: A review
4. Inhibition of carcinogenesis by minor dietary constituents
5. Dietary fat intake and the risk of coronary heart disease in women
6. Dietary flavonoid and cancer prevention: Evidence and potential mechanism
7. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances
8. Alcohol, ischemic heart disease, and the French paradox
9. Wine, alcohol, platelets, and the French paradox for coronary heart disease
10. Mortality associated with moderate intakes of wine, bear, or spirits
11. Interaction of transresveratrol with plasma lipoproteins
12. Inhibition of human LDL oxidation by resveratrol
13. The red wine phenolics trans-reversatrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implication for protection against coronary heart disease
14. Effects of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function
15. Effects of stilbenes on arachidonate metabolism in leukocytes
16. Resveratrol inhibits metal ion dependent and independent peroxidation of porcine low density lipoproteins
17. Antiplatelet activity of cis resveratrol
18. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway
19. Resveratrol modulates arachidonic acid release, prostaglandin sysnthesis, and 3T6 fibroblast growth factor
20. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
21. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells
22. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells
23. Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostrate cancer cell lines
24. Anti-proliferative effect of resveratrol, a natural component of grapes, wine, on human colonic cancer cells
25. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes
26. Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats
27. Resveratrol selectively inhibits leukemia cells: A prospective agent for ex vivo bone marrow purging
28. Immunomodulatory activity of resveratrol: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production
29. Beyond alcohol: Beverage consumption and cardiovascular mortality
30. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection and injury
31. Resveratrol, a remarkable inhibitor of ribonucleotide reductase
32. DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia
33. Resveratrol arrests the cell division cycle at S/G2 phase transition
34. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells
35. Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells
36. Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21 (WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2
37. Resveratrol as a new type of DNA-cleaving agent
38. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2
39. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models
40. Resveratrol isolated from Polygonum cuspidatum root prevent tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice
41. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes
42. Antileukemic activity of TNF-gene therapy with myeloid progenitor cells against minimal residual disease