Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan

Experimental Gerontology

Volumn 43, Issue 12, 2008, Pages 1044-1051

  Yen, Kelvin ^a   Steinsaltz, David ^b   Mobbs, Charles Vernon ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Aging; Gompertz; Lifespan; Mortality; Senescence

Indexed keywords

ARTICLE; CONTROLLED STUDY; GENETIC EPIDEMIOLOGY; HUMAN; LIFESPAN; LINEAR REGRESSION ANALYSIS; MORTALITY; PRIORITY JOURNAL; SENESCENCE; SURVIVAL TIME;

AGING; HUMANS; LONGEVITY; LONGITUDINAL STUDIES; MODELS, THEORETICAL; MORTALITY; REGRESSION ANALYSIS; SURVIVAL RATE;

MUS;

EID: 56349133531     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2008.09.006     Document Type: Article

References (56)

1. Adachi H., and Ishii N. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 55 (2000) B280-B285
2. Arking R. The Biology of Aging: Observations and Principles (2006), Oxford University Press, New York
3. Baker D.J., Jeganathan K.B., Cameron J.D., Thompson M., Juneja S., Kopecka A., Kumar R., Jenkins R.B., de Groen P.C., Roche P., and van Deursen J.M. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat. Genet. 36 (2004) 744-749
4. Bartke A. Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology 78 (2003) 210-216
5. Bartke A., Wright J.C., Mattison J.A., Ingram D.K., Miller R.A., and Roth G.S. Longevity: extending the lifespan of long-lived mice. Nature 414 (2001) 412
6. Bergman A., Atzmon G., Ye K., MacCarthy T., and Barzilai N. Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. PLoS Comput. Biol. 3 (2007) e170
7. Bluher M., Kahn B.B., and Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 (2003) 572-574
8. Brown-Borg H.M., Borg K.E., Meliska C.J., and Bartke A. Dwarf mice and the ageing process. Nature 384 (1996) 33
9. Carpenter J., and Bithell J. Bootstrap confidence intervals: when, which, what? A practical guide for medical statisticians. Stat. Med. 19 (2000) 1141-1164
10. Chang S., Multani A.S., Cabrera N.G., Naylor M.L., Laud P., Lombard D., Pathak S., Guarente L., and DePinho R.A. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat. Genet. 36 (2004) 877-882
11. Chiu C.-H., Lin W.-D., Huang S.-Y., and Lee Y.-H. Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. Genes Dev. 18 (2004) 1970-1975
12. Conde C., Weller S., Gilfillan S., Marcellin L., Martin T., and Pasquali J.-L. Terminal deoxynucleotidyl transferase deficiency reduces the incidence of autoimmune nephritis in (New Zealand black New Zealand white) F1 mice. J. Immunol. 161 (1998) 7023-7030
13. Conti B., Sanchez-Alavez M., Winsky-Sommerer R., Morale M.C., Lucero J., Brownell S., Fabre V., Huitron-Resendiz S., Henriksen S., Zorrilla E.P., de Lecea L., and Bartfai T. Transgenic mice with a reduced core body temperature have an increased life span. Science 314 (2006) 825-828
14. Coschigano K.T., Holland A.N., Riders M.E., List E.O., Flyvbjerg A., and Kopchick J.J. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 144 (2003) 3799-3810
15. de Magalhaes J.P., Cabral J.A.S., and Magalhaes D. The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics 169 (2005) 265-274
16. Eakin T., Shouman R., Qi Y., Liu G., and Witten M. Estimating parametric survival model parameters in gerontological aging studies: methodological problems and insights. J. Gerontol. A Biol. Sci. Med. Sci. 50 (1995) B166-B176
17. Efron B., and Tibshirani R.J. An Introduction to the Bootstrap (1994), Chapman and Hall/CRC
18. Eliason S.R. Maximum Likelihood Estimation Logic and Practice (1993), Sage Publications, Newbury Park
19. Finch C.E. Longevity Senescence and the Genome (1990), The University of Chicago Press, Chicago
20. Finch C.E., and Pike M.C. Maximum life span predictions from the Gompertz mortality model. J. Gerontol. A Biol. Sci. Med. Sci. 51 (1996) B183-B794
21. Flurkey K., Papaconstantinou J., Miller R.A., and Harrison D.E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. USA 98 (2001) 6736-6741
22. Garg M.L., Rao B.R., and Redmond C.K. Maximum-likelihood estimation of the parameters of the Gompertz survival function. Appl. Stat. 19 (1970) 152-159
23. Harper J.M., Leathers C.W., and Austad S.N. Does caloric restriction extend life in wild mice?. Aging Cell 5 (2006) 441-449
24. Holzenberger M., Dupont J., Ducos B., Leneuve P., Geloen A., Even P.C., Cervera P., and Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421 (2003) 182-187
25. Jolly C.A., Muthukumar A., Avula C.P.R., Troyer D., and Fernandes G. Life span is prolonged in food-restricted autoimmune-prone (NZB NZW)F(1) mice fed a diet enriched with (n - 3) fatty acids. J. Nutr. 131 (2001) 2753-2760
26. Johnson T.E. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science 249 (1990) 908-912
27. Jones J.B. The relation of the human health to age, place, and time. In: Birren J.E. (Ed). Handbook of Aging and the Individual (1959), The University of Chicago Press, Chicago 336-337
28. Keyfitz N., and Caswell H. Applied Mathematical Demography. third ed. (2005), Springer, Cambridge, MA
29. Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., Shiraki-Iida T., Nishikawa S., Nagai R., and Nabeshima Y.-i. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390 (1997) 45-51
30. Kwan K.Y., and Wang J.C. Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. Proc. Natl. Acad. Sci. USA 98 (2001) 5717-5721
31. Lee E.T., and Wang J.W. Statistical Methods for Survival Data Analysis (2003), Wiley John and Sons, Incorporated, New York, NY
32. Lindgren B.W. Statistical Theory. fourth ed. (1993), Chapman and Hall/CRC, Boca Raton, FL
33. Mair W., Goymer P., Pletcher S.D., and Partridge L. Demography of dietary restriction and death in Drosophila. Science 301 (2003) 1731-1733
34. Migliaccio E., Giorgio M., Mele S., Pelicci G., Reboldi P., Pandolfi P.P., Lanfrancone L., and Pelicci P.G. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402 (1999) 309-313
35. Miskin R., and Masos T. Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity. J. Gerontol. A Biol. Sci. Med. Sci. 52 (1997) B118-B124
36. Mitsui A., Hamuro J., Nakamura H., Kondo N., Hirabayashi Y., Ishizaki-Koizumi S., Hirakawa T., Inoue T., and Yodoi J. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxid. Redox Signal. 4 (2002) 693-696
37. Moskovitz J., Bar-Noy S., Williams W.M., Requena J., Berlett B.S., and Stadtman E.R. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc. Natl. Acad. Sci. USA 98 (2001) 12920-12925
38. Mounkes L.C., Kozlov S., Hernandez L., Sullivan T., and Stewart C.L. A progeroid syndrome in mice is caused by defects in A-type lamins. Nature 423 (2003) 298-301
39. Mueller L.D., Nusbaum T.J., and Rose M.R. The Gompertz equation as a predictive tool in demography. Exp. Gerontol. 30 (1995) 553-569
40. Neumann C.A., Krause D.S., Carman C.V., Das S., Dubey D.P., Abraham J.L., Bronson R.T., Fujiwara Y., Orkin S.H., and Van Etten R.A. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 424 (2003) 561-565
41. Olshansky S.J., and Carnes B.A. Ever since Gompertz. Demography 34 (1997) 1-15
42. Promislow D.E.L., Tatar M., Pletcher S., and Carey J.R. Below-threshold mortality: implications for studies in evolution, ecology and demography. J. Evol. Biol. 12 (1999) 314-328
43. Promislow D.E.L., Tatar M., Khazaeli A.A., and Curtsinger J.W. Age-specific patterns of genetic variance in Drosophila melanogaster. I. Mortality. Genetics 143 (1996) 839-848
44. Quick K.L., Ali S.S., Arch R., Xiong C., Wozniak D., and Dugan L.L. A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. Neurobiol. Aging 29 (2008) 117-128
45. Rice J.A. Mathematical Statistics and Data Analysis. second ed. (1995), Duxbury Press, Belmont, CA
46. Rikke B.A., Yerg III J.E., Battaglia M.E., Nagy T.R., Allison D.B., and Johnson T.E. Quantitative trait loci specifying the response of body temperature to dietary restriction. J. Gerontol. A Biol. Sci. Med. Sci. 59 (2004) B118-B125
47. Schriner S.E., Linford N.J., Martin G.M., Treuting P., Ogburn C.E., Emond M., Coskun P.E., Ladiges W., Wolf N., Van Remmen H., Wallace D.C., and Rabinovitch P.S. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308 (2005) 1909-1911
48. Spencer C.C., and Promislow D.E.L. Age-specific changes in epistatic effects on mortality rate in Drosophila melanogaster. J. Hered. 96 (2005) 513-521
49. Takeda T., Hosokawa M., Takeshita S., Irino M., Higuchi K., Matsushita T., Tomita Y., Yasuhira K., Hamamoto H., and Shimizu K. A new murine model of accelerated senescence. Mech. Ageing Dev. 17 (1981) 183-194
50. Trifunovic A., Wredenberg A., Falkenberg M., Spelbrink J.N., Rovio A.T., Bruder C.E., Bohlooly-Y M., Gidlof S., Oldfors A., Wibom R., Tornell J., Jacobs H.T., and Larsson N.-G. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429 (2004) 417-423
51. Turturro A., Duffy P., Hass B., Kodell R., and Hart R. Survival characteristics and age-adjusted disease incidences in C57BL/6 mice fed a commonly used cereal-based diet modulated by dietary restriction. J. Gerontol. A Biol. Sci. Med. Sci. 57 (2002) B379-B389
52. Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Igelmann H., Lu X., Soron G., Cooper B., Brayton C., Hee Park S., Thompson T., Karsenty G., Bradley A., and Donehower L.A. p53 mutant mice that display early ageing-associated phenotypes. Nature 415 (2002) 45-53
53. Weindruch R., and Walford R.L. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 215 (1982) 1415-1418
54. Wilson D.L. A comparison of methods for estimating mortality parameters from survival data. Mech. Ageing Dev. 66 (1993) 269-281
55. Wong K.-K., Maser R.S., Bachoo R.M., Menon J., Carrasco D.R., Gu Y., Alt F.W., and DePinho R.A. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421 (2003) 643-648
56. Yu B.P., Masoro E.J., Murata I., Bertrand H.A., and Lynd F.T. Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: longevity, growth, lean body mass and disease. J. Gerontol. 37 (1982) 130-141