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Volumn 19, Issue 1, 2010, Pages 11-26

Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: Experimental and genetic evidence

Author keywords

Alzheimer's disease; Genetics; Neurodegeneration; Resveratrol; Review; SIRT1; Sirtuin

Indexed keywords

AMYLOID BETA PROTEIN; RESVERATROL; SIRTUIN;

EID: 75149192820     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-1215     Document Type: Review
Times cited : (107)

References (165)
  • 1
    • 0033887456 scopus 로고    scopus 로고
    • Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    • Frye RA (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273, 739-798.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 739-798
    • Frye, R.A.1
  • 2
    • 0021734287 scopus 로고
    • Characterization of two genes required for the position-effect control of yeast mating-type genes
    • Shore D, Squire M, Nasmyth KA (1984) Characterization of two genes required for the position-effect control of yeast mating-type genes. EMBO J 3, 2817-2823.
    • (1984) EMBO J , vol.3 , pp. 2817-2823
    • Shore, D.1    Squire, M.2    Nasmyth, K.A.3
  • 3
    • 0034048339 scopus 로고    scopus 로고
    • Analysis of Sir2p domains required for rDNA and telomeric silencing in Saccharomyces cerevisiae
    • Cockell MM, Perrod S, Gasser SM(2000) Analysis of Sir2p domains required for rDNA and telomeric silencing in Saccharomyces cerevisiae. Genetics 154, 1069-1083.
    • (2000) Genetics , vol.154 , pp. 1069-1083
    • Cockell, M.M.1    Perrod, S.2    Gasser, S.M.3
  • 4
    • 0035917536 scopus 로고    scopus 로고
    • Crystal structure of a SIR2 homolog-NAD complex
    • Min J, Landry J, Sternglanz R, Xu RM (2001) Crystal structure of a SIR2 homolog-NAD complex. Cell 105, 269-279.
    • (2001) Cell , vol.105 , pp. 269-279
    • Min, J.1    Landry, J.2    Sternglanz, R.3    Xu, R.M.4
  • 6
    • 0029845902 scopus 로고    scopus 로고
    • The nicotinamide dinucleotide binding motif: A comparison of nucleotide binding proteins
    • Bellamacina CR (1996) The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins. FASEB J 10, 1257-1269.
    • (1996) FASEB J , vol.10 , pp. 1257-1269
    • Bellamacina, C.R.1
  • 7
    • 0036008097 scopus 로고    scopus 로고
    • Deacetylase enzymes: Biological functions and the use of small-molecule inhibitors
    • Grozinger CM, Schreiber SL (2002) Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. Chem Biol 9, 3-16.
    • (2002) Chem Biol , vol.9 , pp. 3-16
    • Grozinger, C.M.1    Schreiber, S.L.2
  • 8
    • 0034687694 scopus 로고    scopus 로고
    • Silent information regulator 2 family of NAD- dependent histone/ protein deacetylases generates a unique product, 1-Oacetyl- ADPribose
    • Tanner KG, Landry J, Sternglanz R, Denu JM (2000) Silent information regulator 2 family of NAD- dependent histone/ protein deacetylases generates a unique product, 1-Oacetyl- ADPribose. Proc Natl Acad Sci U S A 97, 14178-14182.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 14178-14182
    • Tanner, K.G.1    Landry, J.2    Sternglanz, R.3    Denu, J.M.4
  • 9
    • 66449123334 scopus 로고    scopus 로고
    • Hydrolase regulates NAD+ metabolites and modulates cellular redox
    • Tong L, Lee S, Denu JM (2009) Hydrolase regulates NAD+ metabolites and modulates cellular redox. J Biol Chem 284, 11256-11266.
    • (2009) J Biol Chem , vol.284 , pp. 11256-11266
    • Tong, L.1    Lee, S.2    Denu, J.M.3
  • 10
    • 65249091951 scopus 로고    scopus 로고
    • Investigating the ADPribosyltransferase activity of sirtuins with NAD analogs and 32P-NAD
    • Du J, Jiang H, Lin H (2009) Investigating the ADPribosyltransferase activity of sirtuins with NAD analogs and 32P-NAD. Biochemistry 48, 2878-2890.
    • (2009) Biochemistry , vol.48 , pp. 2878-2890
    • Du, J.1    Jiang, H.2    Lin, H.3
  • 11
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: Insights into their biological function
    • Michan S, Sinclair D (2007) Sirtuins in mammals: insights into their biological function. Biochem J 404, 1-13.
    • (2007) Biochem J , vol.404 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 12
    • 26244436281 scopus 로고    scopus 로고
    • Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins
    • Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I (2005) Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell 16, 4623-4635.
    • (2005) Mol Biol Cell , vol.16 , pp. 4623-4635
    • Michishita, E.1    Park, J.Y.2    Burneskis, J.M.3    Barrett, J.C.4    Horikawa, I.5
  • 13
    • 34948883324 scopus 로고    scopus 로고
    • SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    • Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L (2007) SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell 28, 91-106.
    • (2007) Mol Cell , vol.28 , pp. 91-106
    • Li, X.1    Zhang, S.2    Blander, G.3    Tse, J.G.4    Krieger, M.5    Guarente, L.6
  • 19
    • 67649726060 scopus 로고    scopus 로고
    • Growth factors, AGEing, and the diabetes link in Alzheimer's disease
    • Loy CT, Twigg SM (2009) Growth factors, AGEing, and the diabetes link in Alzheimer's disease. J Alzheimers Dis 16, 823-831.
    • (2009) J Alzheimers Dis , vol.16 , pp. 823-831
    • Loy, C.T.1    Twigg, S.M.2
  • 20
    • 53449090280 scopus 로고    scopus 로고
    • Inhibition of transcriptional activity of c-JUN by SIR T1
    • Gao Z, Ye J (2008) Inhibition of transcriptional activity of c-JUN by SIRT1. Biochem Biophys Res Commun 376, 793-796.
    • (2008) Biochem Biophys Res Commun , vol.376 , pp. 793-796
    • Gao, Z.1    Ye, J.2
  • 22
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434, 113-118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 23
    • 34447626095 scopus 로고    scopus 로고
    • SIR T2 deacetylates FOXO3 a in response to oxidative stress and caloric restriction
    • Wang F, Nguyen M, Qin FX, Tong Q (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6, 505-514.
    • (2007) Aging Cell , vol.6 , pp. 505-514
    • Wang, F.1    Nguyen, M.2    Qin, F.X.3    Tong, Q.4
  • 24
    • 34547397081 scopus 로고    scopus 로고
    • SIR T2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
    • Jing E, Gesta S, Kahn CR (2007) SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab 6, 105-114.
    • (2007) Cell Metab , vol.6 , pp. 105-114
    • Jing, E.1    Gesta, S.2    Kahn, C.R.3
  • 28
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • DOI 10.1038/35001622
    • Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800. (Pubitemid 30111843)
    • (2000) Nature , vol.403 , Issue.6771 , pp. 795-800
    • Imai, S.-I.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 29
    • 4944245398 scopus 로고    scopus 로고
    • Human Sir T1 interacts with histone H1 and promotes formation of facultative heterochromatin
    • Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D (2004) Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 16, 93-105.
    • (2004) Mol Cell , vol.16 , pp. 93-105
    • Vaquero, A.1    Scher, M.2    Lee, D.3    Erdjument-Bromage, H.4    Tempst, P.5    Reinberg, D.6
  • 31
    • 0037291214 scopus 로고    scopus 로고
    • The human Sir2 ortholog, SIR T2, is a NAD+-dependent tubulin deacetylase
    • North BJ, Marshall BL, Borra MT, Denu JM,Verdin E (2003) The human Sir2 ortholog, SIRT2, is a NAD+-dependent tubulin deacetylase. Mol Cell 11, 437-444.
    • (2003) Mol Cell , vol.11 , pp. 437-444
    • North, B.J.1    Marshall, B.L.2    Borra, M.T.3    Denu, J.M.4    Verdin, E.5
  • 32
    • 3142548829 scopus 로고    scopus 로고
    • Human histone deacetylase SIR T2 interacts with the homeobox transcription factor HOXA10
    • Bae NS, Swanson MJ, Vassilev A, Howard BH (2004) Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10. J Biochem 135, 695-700.
    • (2004) J Biochem , vol.135 , pp. 695-700
    • Bae, N.S.1    Swanson, M.J.2    Vassilev, A.3    Howard, B.H.4
  • 33
    • 53549105529 scopus 로고    scopus 로고
    • SIR T3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
    • Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP (2008) SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation ofKu70. Mol Cell Biol 28, 6384-6401.
    • (2008) Mol Cell Biol , vol.28 , pp. 6384-6401
    • Sundaresan, N.R.1    Samant, S.A.2    Pillai, V.B.3    Rajamohan, S.B.4    Gupta, M.P.5
  • 34
    • 33745931074 scopus 로고    scopus 로고
    • Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
    • Hallows WC, Lee S, Denu JM (2006) Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci U S A 103, 10230-10235.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10230-10235
    • Hallows, W.C.1    Lee, S.2    Denu, J.M.3
  • 38
    • 33744466971 scopus 로고    scopus 로고
    • Mammalian Sir2 homolog SIR T7 is an activator of RNA polymerase i transcription
    • Ford E, Voit R, Liszt G, Magin C, Grummt I, Guarente L (2006) Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev 20, 1075-1080.
    • (2006) Genes Dev , vol.20 , pp. 1075-1080
    • Ford, E.1    Voit, R.2    Liszt, G.3    Magin, C.4    Grummt, I.5    Guarente, L.6
  • 44
    • 38349112898 scopus 로고    scopus 로고
    • Ageassociated loss of Sirt1-mediated enhancement of glucosestimulated insulin secretion in beta cell-specific Sirt1- overexpressing (BESTO) mice
    • Ramsey KM, Mills KF, Satoh A, Imai S (2008) Ageassociated loss of Sirt1-mediated enhancement of glucosestimulated insulin secretion in beta cell-specific Sirt1- overexpressing (BESTO) mice. Aging Cell 7, 78-88.
    • (2008) Aging Cell , vol.7 , pp. 78-88
    • Ramsey, K.M.1    Mills, K.F.2    Satoh, A.3    Imai, S.4
  • 47
    • 65249087389 scopus 로고    scopus 로고
    • SIR T5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
    • Nakagawa T, Lomb DJ, Haigis MC, Guarente L (2009) SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137, 560-570.
    • (2009) Cell , vol.137 , pp. 560-570
    • Nakagawa, T.1    Lomb, D.J.2    Haigis, M.C.3    Guarente, L.4
  • 49
    • 41449083867 scopus 로고    scopus 로고
    • Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
    • Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E (2008) Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res 102, 703-710.
    • (2008) Circ Res , vol.102 , pp. 703-710
    • Vakhrusheva, O.1    Smolka, C.2    Gajawada, P.3    Kostin, S.4    Boettger, T.5    Kubin, T.6    Braun, T.7    Bober, E.8
  • 50
    • 64049090625 scopus 로고    scopus 로고
    • Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging
    • Vakhrusheva O, Braeuer D, Liu Z, Braun T, Bober E (2008) Sirt7-dependent inhibition of cell growth and proliferation might be instrumental to mediate tissue integrity during aging. J Physiol Pharmacol 59, 201-212.
    • (2008) J Physiol Pharmacol , vol.59 , pp. 201-212
    • Vakhrusheva, O.1    Braeuer, D.2    Liu, Z.3    Braun, T.4    Bober, E.5
  • 51
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5, 493-506.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 57
    • 34547875773 scopus 로고    scopus 로고
    • Sirtuins: Critical regulators at the crossroads between cancer and aging
    • Saunders LR, Verdin E (2007) Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 26, 5489-5504.
    • (2007) Oncogene , vol.26 , pp. 5489-5504
    • Saunders, L.R.1    Verdin, E.2
  • 58
    • 53249121556 scopus 로고    scopus 로고
    • Sirtuins - Novel therapeutic targets to treat age-associated diseases
    • Lavu S, Boss O, Elliott PJ, Lambert PD (2008) Sirtuins - novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov 7, 841-853.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 841-853
    • Lavu, S.1    Boss, O.2    Elliott, P.J.3    Lambert, P.D.4
  • 59
    • 40849135481 scopus 로고    scopus 로고
    • The Sirtuin family: Therapeutic targets to treat diseases of aging
    • Milne JC, Denu JM (2008) The Sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 12, 11-17.
    • (2008) Curr Opin Chem Biol , vol.12 , pp. 11-17
    • Milne, J.C.1    Denu, J.M.2
  • 60
    • 9444296057 scopus 로고    scopus 로고
    • High absorption but very low bioavailability of oral resveratrol in humans
    • Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32, 1377-1382.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1377-1382
    • Walle, T.1    Hsieh, F.2    Delegge, M.H.3    Oatis, J.E.4    Walle, U.K.5
  • 62
    • 41949118209 scopus 로고    scopus 로고
    • Sirtuins: Novel targets for metabolic disease
    • Elliott PJ, Jirousek M (2008) Sirtuins: novel targets for metabolic disease. Curr Opin Invest Drugs 9, 371-378.
    • (2008) Curr Opin Invest Drugs , vol.9 , pp. 371-378
    • Elliott, P.J.1    Jirousek, M.2
  • 64
    • 34248146970 scopus 로고    scopus 로고
    • Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat
    • Mokni M, Elkahoui S, Limam F, Amri M, Aouani E (2007) Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat. Neurochem Res 32, 981-987.
    • (2007) Neurochem Res , vol.32 , pp. 981-987
    • Mokni, M.1    Elkahoui, S.2    Limam, F.3    Amri, M.4    Aouani, E.5
  • 65
    • 0035914304 scopus 로고    scopus 로고
    • Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
    • Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276, 38837-38843.
    • (2001) J Biol Chem , vol.276 , pp. 38837-38843
    • Grozinger, C.M.1    Chao, E.D.2    Blackwell, H.E.3    Moazed, D.4    Schreiber, S.L.5
  • 70
    • 0037069290 scopus 로고    scopus 로고
    • Amount and type of alcohol and risk of dementia: The Copenhagen City Heart Study
    • Copenhagen City Heart Study
    • Truelsen T, Thudium D, Grønbaek M, Copenhagen City Heart Study (2002) Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study. Neurology 59, 1313-1319.
    • (2002) Neurology , vol.59 , pp. 1313-1319
    • Truelsen, T.1    Thudium, D.2    Grønbaek, M.3
  • 71
    • 27744593088 scopus 로고    scopus 로고
    • Epidemiology of and risk factors for psychosis of Alzheimer's disease: A review of 55 studies published from 1990 to 2003
    • Ropacki SA, Jeste DV (2005) Epidemiology of and risk factors for psychosis of Alzheimer's disease: a review of 55 studies published from 1990 to 2003. Am J Psychiatry 162, 2022-2030.
    • (2005) Am J Psychiatry , vol.162 , pp. 2022-2030
    • Ropacki, S.A.1    Jeste, D.V.2
  • 72
    • 0021077610 scopus 로고
    • Senile dementia of the Alzheimer type
    • Terry RD, Katzman R (1983) Senile dementia of the Alzheimer type. Ann Neurol 14, 497-506.
    • (1983) Ann Neurol , vol.14 , pp. 497-506
    • Terry, R.D.1    Katzman, R.2
  • 74
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 75
    • 0037446328 scopus 로고    scopus 로고
    • Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death
    • Jang JH, Surh YJ (2003) Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death. Free Radic Biol Med 34, 1100-1110.
    • (2003) Free Radic Biol Med , vol.34 , pp. 1100-1110
    • Jang, J.H.1    Surh, Y.J.2
  • 77
    • 0037432493 scopus 로고    scopus 로고
    • Red wine micronutrients as protective agents in Alzheimer-like induced insult
    • Russo A, Palumbo M, Aliano C, Lempereur L, Scoto G, RenisM(2003) Red wine micronutrients as protective agents in Alzheimer-like induced insult. Life Sci 72, 2369-2379.
    • (2003) Life Sci , vol.72 , pp. 2369-2379
    • Russo, A.1    Palumbo, M.2    Aliano, C.3    Lempereur, L.4    Renism, S.G.5
  • 78
    • 2342468058 scopus 로고    scopus 로고
    • Effect of resveratrol and catechin on PC12 tyrosine kinase activities and their synergistic protection from beta-amyloid toxicity
    • Conte A, Pellegrini S, Tagliazucchi D(2003) Effect of resveratrol and catechin on PC12 tyrosine kinase activities and their synergistic protection from beta-amyloid toxicity. Drugs Exp Clin Res 29, 243-255.
    • (2003) Drugs Exp Clin Res , vol.29 , pp. 243-255
    • Conte, A.1    Pellegrini, S.2    Tagliazucchi, D.3
  • 79
    • 0037314445 scopus 로고    scopus 로고
    • Meal size and frequency affect neuronal plasticity and vulnerability to disease: Cellular and molecular mechanisms
    • Mattson MP, DuanW, Guo Z (2003) Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J Neurochem 84, 417-431.
    • (2003) J Neurochem , vol.84 , pp. 417-431
    • Mattson, M.P.1    Duan, W.2    Guo, Z.3
  • 83
    • 34347338702 scopus 로고    scopus 로고
    • Adiponectin secretion is regulated by SIR T1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha
    • Qiang L, Wang H, Farmer SR (2007) Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol 27, 4698-4707.
    • (2007) Mol Cell Biol , vol.27 , pp. 4698-4707
    • Qiang, L.1    Wang, H.2    Farmer, S.R.3
  • 84
    • 34547906123 scopus 로고    scopus 로고
    • Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
    • Rodgers JT, Puigserver P (2007) Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A 104, 12861-12866.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12861-12866
    • Rodgers, J.T.1    Puigserver, P.2
  • 86
    • 0031947574 scopus 로고    scopus 로고
    • Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease
    • Draczynska-Lusiak B, Doung A, Sun AY (1998) Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease. Mol Chem Neuropathol 33, 139-148.
    • (1998) Mol Chem Neuropathol , vol.33 , pp. 139-148
    • Draczynska-Lusiak, B.1    Doung, A.2    Sun, A.Y.3
  • 87
    • 0032536359 scopus 로고    scopus 로고
    • Oxidized lipoproteins activate NF-kappa B binding activity and apoptosis in PC12 cells
    • Draczynska-Lusiak B, Chen YM, Sun AY (1998) Oxidized lipoproteins activate NF-kappaB binding activity and apoptosis in PC12 cells. Neuroreport 9, 527-532.
    • (1998) Neuroreport , vol.9 , pp. 527-532
    • Draczynska-Lusiak, B.1    Chen, Y.M.2    Sun, A.Y.3
  • 88
    • 0035235476 scopus 로고    scopus 로고
    • Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons
    • Bastianetto S, Zheng WH, Quirion R (2000) Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br J Pharmacol 131, 711-720.
    • (2000) Br J Pharmacol , vol.131 , pp. 711-720
    • Bastianetto, S.1    Zheng, W.H.2    Quirion, R.3
  • 89
    • 0034795205 scopus 로고    scopus 로고
    • Oxidized lipoproteins, beta amyloid peptides and Alzheimer's disease
    • Sun AY, Draczynska-Lusiak B, Sun GY (2001) Oxidized lipoproteins, beta amyloid peptides and Alzheimer's disease. Neurotox Res 3, 167-178.
    • (2001) Neurotox Res , vol.3 , pp. 167-178
    • Sun, A.Y.1    Draczynska-Lusiak, B.2    Sun, G.Y.3
  • 90
    • 41649112271 scopus 로고    scopus 로고
    • Antioxidants prevent ethanolassociated apoptosis in fetal rhombencephalic neurons
    • Antonio AM, Druse MJ (2008) Antioxidants prevent ethanolassociated apoptosis in fetal rhombencephalic neurons. Brain Res 1204, 16-23.
    • (2008) Brain Res , vol.1204 , pp. 16-23
    • Antonio, A.M.1    Druse, M.J.2
  • 92
    • 27844497059 scopus 로고    scopus 로고
    • Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides
    • Marambaud P, Zhao H, Davies P (2005) Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem 280, 37377-37382.
    • (2005) J Biol Chem , vol.280 , pp. 37377-37382
    • Marambaud, P.1    Zhao, H.2    Davies, P.3
  • 93
    • 34249988863 scopus 로고    scopus 로고
    • Resveratrol oligomers from Vitis amurensis attenuate beta-amyloid-induced oxidative stress in PC12 cells
    • Jang MH, Piao XL, Kim HY, Cho EJ, Baek SH, Kwon SW, Park JH (2007) Resveratrol oligomers from Vitis amurensis attenuate beta-amyloid-induced oxidative stress in PC12 cells. Biol Pharm Bull 30, 1130-1134.
    • (2007) Biol Pharm Bull , vol.30 , pp. 1130-1134
    • Jang, M.H.1    Piao, X.L.2    Kim, H.Y.3    Cho, E.J.4    Baek, S.H.5    Kwon, S.W.6    Park, J.H.7
  • 94
    • 34247874522 scopus 로고    scopus 로고
    • Protective effects of piceatannol against beta-amyloid-induced neuronal cell death
    • Kim HJ, Lee KW, Lee HJ (2007) Protective effects of piceatannol against beta-amyloid-induced neuronal cell death. Ann N Y Acad Sci 1095, 473-482.
    • (2007) Ann N y Acad Sci , vol.1095 , pp. 473-482
    • Kim, H.J.1    Lee, K.W.2    Lee, H.J.3
  • 96
    • 57749112087 scopus 로고    scopus 로고
    • Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity
    • Ono K, Condron MM, Ho L,Wang J, ZhaoW, Pasinetti GM, Teplow DB (2008) Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J Biol Chem 283, 32176-32187.
    • (2008) J Biol Chem , vol.283 , pp. 32176-32187
    • Ono, K.1    Condron, M.M.2    Ho, L.3    Wang, J.4    Zhao, W.5    Pasinetti, G.M.6    Teplow, D.B.7
  • 97
    • 45549095784 scopus 로고    scopus 로고
    • Polyphenols as potential inhibitors of amyloid aggregation and toxicity: Possible significance to Alzheimer's disease
    • Bastianetto S, Krantic S, QuirionR(2008) Polyphenols as potential inhibitors of amyloid aggregation and toxicity: possible significance to Alzheimer's disease. Mini Rev Med Chem 8, 429-435.
    • (2008) Mini Rev Med Chem , vol.8 , pp. 429-435
    • Bastianetto, S.1    Quirionr, K.S.2
  • 98
    • 34347228616 scopus 로고    scopus 로고
    • Novel method for quantitative determination of amyloid fibrils of alphasynuclein and amyloid beta/A4 protein by using resveratrol
    • Ahn JS, Lee JH, Kim JH, Paik SR (2007) Novel method for quantitative determination of amyloid fibrils of alphasynuclein and amyloid beta/A4 protein by using resveratrol. Anal Biochem 367, 259-265.
    • (2007) Anal Biochem , vol.367 , pp. 259-265
    • Ahn, J.S.1    Lee, J.H.2    Kim, J.H.3    Paik, S.R.4
  • 99
    • 33745727518 scopus 로고    scopus 로고
    • Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells
    • Kim YA, Lim SY, Rhee SH, Park KY, Kim CH, Choi BT, Lee SJ, Park YM, Choi YH (2006) Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells. Int J Mol Med 17, 1069-1075.
    • (2006) Int J Mol Med , vol.17 , pp. 1069-1075
    • Kim, Y.A.1    Lim, S.Y.2    Rhee, S.H.3    Park, K.Y.4    Kim, C.H.5    Choi, B.T.6    Lee, S.J.7    Park, Y.M.8    Choi, Y.H.9
  • 100
    • 28844474597 scopus 로고    scopus 로고
    • SIR T1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappa B signaling
    • Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L (2005) SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 280, 40364-40374.
    • (2005) J Biol Chem , vol.280 , pp. 40364-40374
    • Chen, J.1    Zhou, Y.2    Mueller-Steiner, S.3    Chen, L.F.4    Kwon, H.5    Yi, S.6    Mucke, L.7    Gan, L.8
  • 103
    • 34250860632 scopus 로고    scopus 로고
    • Comparative analysis of the effects of resveratrol in two apoptotic models: Inhibition of complex i and potassium deprivation in cerebellar neurons
    • Alvira D, Yeste-Velasco M, Folch J, Verdaguer E, Canudas AM, Pall̀as M, Camins A (2007) Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons. Neuroscience 147, 746-756.
    • (2007) Neuroscience , vol.147 , pp. 746-756
    • Alvira, D.1    Yeste-Velasco, M.2    Folch, J.3    Verdaguer, E.4    Canudas, A.M.5    Pall̀as, M.6    Camins, A.7
  • 104
    • 65249173918 scopus 로고    scopus 로고
    • Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIR T1 may endanger energetically compromised neurons
    • Liu D, Gharavi R, Pitta M, Gleichmann M, Mattson MP (2009) Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med 11, 28-42.
    • (2009) Neuromolecular Med , vol.11 , pp. 28-42
    • Liu, D.1    Gharavi, R.2    Pitta, M.3    Gleichmann, M.4    Mattson, M.P.5
  • 105
    • 58149339917 scopus 로고    scopus 로고
    • Opposing effects of sirtuins on neuronal survival: SIR T1-mediated neuroprotection is independent of its deacetylase activity
    • Pfister JA, Ma C, Morrison BE, D'Mello SR (2008) Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS ONE 3, e4090.
    • (2008) PLoS ONE , vol.3
    • Pfister, J.A.1    Ma, C.2    Morrison, B.E.3    D'Mello, S.R.4
  • 107
    • 34247502715 scopus 로고    scopus 로고
    • Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
    • Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C (2007) Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell 129, 473-484.
    • (2007) Cell , vol.129 , pp. 473-484
    • Belenky, P.1    Racette, F.G.2    Bogan, K.L.3    McClure, J.M.4    Smith, J.S.5    Brenner, C.6
  • 108
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum, Guarente (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230.
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, G.1
  • 109
    • 17144429302 scopus 로고    scopus 로고
    • Calorie restriction, SIR T1 and metabolism: Understanding longevity
    • Bordone, Guarente (2005) Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 6, 298-305.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 298-305
    • Bordone, G.1
  • 110
    • 28844469898 scopus 로고    scopus 로고
    • Medicine: Increase in activity during calorie restriction requires Sirt1
    • DOI 10.1126/science.1118357
    • Chen D, Steele AD, Lindquist S, Guarente L (2005) Increase in activity during calorie restriction requires Sirt1. Science 310, 1641. (Pubitemid 41780779)
    • (2005) Science , vol.310 , Issue.5754 , pp. 1641
    • Chen, D.1    Steele, A.D.2    Lindquist, S.3    Guarente, L.4
  • 111
    • 57649155899 scopus 로고    scopus 로고
    • Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration
    • Qin W, Zhao W, Ho L, Wang J, Walsh K, Gandy S, Pasinetti GM (2008) Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration. Ann N Y Acad Sci 1147, 335-347.
    • (2008) Ann N y Acad Sci , vol.1147 , pp. 335-347
    • Qin, W.1    Zhao, W.2    Ho, L.3    Wang, J.4    Walsh, K.5    Gandy, S.6    Pasinetti, G.M.7
  • 115
    • 27644457456 scopus 로고    scopus 로고
    • Effect of alpha lipoic acid, melatonin and trans resveratrol on intracerebroventricular streptozotocin induced spatial memory deficit in rats
    • Sharma M, Briyal S, Gupta YK (2005) Effect of alpha lipoic acid, melatonin and trans resveratrol on intracerebroventricular streptozotocin induced spatial memory deficit in rats. Indian J Physiol Pharmacol 49, 395-402.
    • (2005) Indian J Physiol Pharmacol , vol.49 , pp. 395-402
    • Sharma, M.1    Briyal, S.2    Gupta, Y.K.3
  • 116
    • 0037063709 scopus 로고    scopus 로고
    • Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats
    • Sharma M, Gupta YK (2002) Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci 71, 2489-2498.
    • (2002) Life Sci , vol.71 , pp. 2489-2498
    • Sharma, M.1    Gupta, Y.K.2
  • 117
    • 33845917602 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats
    • DOI 10.1159/000097511
    • Kumar A, Naidu PS, Seghal N, Padi SS (2007) Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Pharmacology 79, 17-26. (Pubitemid 46034173)
    • (2007) Pharmacology , vol.79 , Issue.1 , pp. 17-26
    • Kumar, A.1    Naidu, P.S.2    Seghal, N.3    Padi, S.S.V.4
  • 119
    • 46749123053 scopus 로고    scopus 로고
    • Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease
    • Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen L, Humala N, Teplow DB, Pasinetti GM (2008) Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease. J Neurosci 28, 6388-6392.
    • (2008) J Neurosci , vol.28 , pp. 6388-6392
    • Wang, J.1    Ho, L.2    Zhao, W.3    Ono, K.4    Rosensweig, C.5    Chen, L.6    Humala, N.7    Teplow, D.B.8    Pasinetti, G.M.9
  • 121
    • 18144411313 scopus 로고    scopus 로고
    • SIR T1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
    • Nemoto S, Fergusson MM, Finkel T (2005) SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem 280, 16456-16460.
    • (2005) J Biol Chem , vol.280 , pp. 16456-16460
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 122
    • 52049096152 scopus 로고    scopus 로고
    • Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons
    • Hasegawa K, Yoshikawa K (2008) Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. J Neurosci 28, 8772-8784.
    • (2008) J Neurosci , vol.28 , pp. 8772-8784
    • Hasegawa, K.1    Yoshikawa, K.2
  • 123
    • 0035913911 scopus 로고    scopus 로고
    • Negative control of p53 by Sir2 alpha promotes cell survival under stress
    • Luo J, NikolaevAY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107, 137-148.
    • (2001) Cell , vol.107 , pp. 137-148
    • Luo, J.1    Nikolaevay Imai, S.2    Chen, D.3    Su, F.4    Shiloh, A.5    Guarente, L.6    Gu, W.7
  • 124
    • 60249098801 scopus 로고    scopus 로고
    • Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
    • Karuppagounder SS, Pinto JT,XuH, Chen HL, BealMF, Gibson GE (2009) Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int 54, 111-118.
    • (2009) Neurochem Int , vol.54 , pp. 111-118
    • Karuppagounder, S.S.1    Pinto, J.T.2    Xu, H.3    Chen, H.L.4    Beal, M.F.5    Gibson, G.E.6
  • 126
    • 58149267462 scopus 로고    scopus 로고
    • Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
    • Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM (2008) Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci 28, 11500-11510.
    • (2008) J Neurosci , vol.28 , pp. 11500-11510
    • Green, K.N.1    Steffan, J.S.2    Martinez-Coria, H.3    Sun, X.4    Schreiber, S.S.5    Thompson, L.M.6    Laferla, F.M.7
  • 128
    • 32144443685 scopus 로고    scopus 로고
    • Software for tag single nucleotide polymorphism selection
    • Stram DO (2005) Software for tag single nucleotide polymorphism selection. Hum Genomics 2, 144-151.
    • (2005) Hum Genomics , vol.2 , pp. 144-151
    • Stram, D.O.1
  • 129
    • 33748804424 scopus 로고    scopus 로고
    • A tutorial on statistical methods for population association studies
    • Balding DJ (2006) A tutorial on statistical methods for population association studies. Nat Rev Genet 7, 781-791.
    • (2006) Nat Rev Genet , vol.7 , pp. 781-791
    • Balding, D.J.1
  • 148
    • 62249110887 scopus 로고    scopus 로고
    • Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1 - Uncoupling protein 2 pathway
    • Della-Morte D, Dave KR, Defazio RA, Bao YC, Raval AP, Perez-Pinzon MA (2009) Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1 - uncoupling protein 2 pathway. Neuroscience 159, 993-1002.
    • (2009) Neuroscience , vol.159 , pp. 993-1002
    • Della-Morte, D.1    Dave, K.R.2    Defazio, R.A.3    Bao, Y.C.4    Raval, A.P.5    Perez-Pinzon, M.A.6
  • 149
    • 64749083797 scopus 로고    scopus 로고
    • Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIR T1
    • Wang L, Zhang L, Chen ZB, Wu JY, Zhang X, Xu Y (2009) Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. Eur J Pharmacol 609, 40-44.
    • (2009) Eur J Pharmacol , vol.609 , pp. 40-44
    • Wang, L.1    Zhang, L.2    Chen, Z.B.3    Wu, J.Y.4    Zhang, X.5    Xu, Y.6
  • 154
    • 51549098145 scopus 로고    scopus 로고
    • Dietary oxyresveratrol prevents parkinsonian mimetic 6- hydroxydopamine neurotoxicity
    • Chao J, Yu MS, Ho YS, Wang M, Chang RC (2008) Dietary oxyresveratrol prevents parkinsonian mimetic 6- hydroxydopamine neurotoxicity. Free Radic Biol Med 45, 1019-1026.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1019-1026
    • Chao, J.1    Yu, M.S.2    Ho, Y.S.3    Wang, M.4    Chang, R.C.5
  • 156
    • 4043165678 scopus 로고    scopus 로고
    • Increased nuclear NAD biosynthesis and SIR T1 activation prevent axonal degeneration
    • Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305, 1010-1013.
    • Science , vol.305 , pp. 1010-1013
    • Araki, T.1    Sasaki, Y.2    Milbrandt, J.3
  • 157
    • 33748174151 scopus 로고    scopus 로고
    • Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy
    • Sasaki Y, Araki T, Milbrandt J (2006) Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. J Neurosci 26, 8484-8491.
    • (2006) J Neurosci , vol.26 , pp. 8484-8491
    • Sasaki, Y.1    Araki, T.2    Milbrandt, J.3
  • 160
    • 48749102434 scopus 로고    scopus 로고
    • Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease
    • Pasinetti GM, Eberstein JA (2008) Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease. J Neurochem 106, 1503-1514.
    • (2008) J Neurochem , vol.106 , pp. 1503-1514
    • Pasinetti, G.M.1    Eberstein, J.A.2
  • 161
    • 0037248470 scopus 로고    scopus 로고
    • Absorption of three wine-related polyphenols in three different matrices by healthy subjects
    • Goldberg DM, Yan J, Soleas GJ (2003) Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 36, 79-87.
    • (2003) Clin Biochem , vol.36 , pp. 79-87
    • Goldberg, D.M.1    Yan, J.2    Soleas, G.J.3
  • 162
    • 20344364428 scopus 로고    scopus 로고
    • Metabolism and bioavailability of trans-resveratrol
    • Wenzel E, Somoza V (2005) Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res 49, 472-481.
    • (2005) Mol Nutr Food Res , vol.49 , pp. 472-481
    • Wenzel, E.1    Somoza, V.2
  • 164
    • 75149113800 scopus 로고    scopus 로고
    • ClinicalTrials.gov; http://www.clinicaltrials.gov/ct2/results? term=resveratrol+alzheimer%27s+disease.
  • 165
    • 61849085876 scopus 로고    scopus 로고
    • The forkhead transcription factor FOXO3 a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3
    • Shang YC, Chong ZZ, Hou J, Maiese K (2009) The forkhead transcription factor FOXO3a controls microglial inflammatory activation and eventual apoptotic injury through caspase 3. Curr Neurovasc Res 6, 20-31.
    • (2009) Curr Neurovasc Res , vol.6 , pp. 20-31
    • Shang, Y.C.1    Chong, Z.Z.2    Hou, J.3    Maiese, K.4


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