-
1
-
-
36248996490
-
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
-
Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L (2007) Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 450:420-424.
-
(2007)
Nature
, vol.450
, pp. 420-424
-
-
Adamantidis, A.R.1
Zhang, F.2
Aravanis, A.M.3
Deisseroth, K.4
de Lecea, L.5
-
2
-
-
4043165678
-
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
-
Araki T, Sasaki Y, Milbrandt J (2004) Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305:1010-1013.
-
(2004)
Science
, vol.305
, pp. 1010-1013
-
-
Araki, T.1
Sasaki, Y.2
Milbrandt, J.3
-
3
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK, Lowell BB (2004) Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42:983-991.
-
(2004)
Neuron
, vol.42
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
Kenny, C.D.7
McGovern, R.A.8
Chua Jr, S.C.9
Elmquist, J.K.10
Lowell, B.B.11
-
4
-
-
34249891333
-
Two neurons mediate diet-restriction-induced longevity in C. elegans
-
Bishop NA, Guarente L (2007) Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447:545-549.
-
(2007)
Nature
, vol.447
, pp. 545-549
-
-
Bishop, N.A.1
Guarente, L.2
-
5
-
-
15444377466
-
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
-
Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG (2005) SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem 280:10264-10276.
-
(2005)
J Biol Chem
, vol.280
, pp. 10264-10276
-
-
Bouras, T.1
Fu, M.2
Sauve, A.A.3
Wang, F.4
Quong, A.A.5
Perkins, N.D.6
Hay, R.T.7
Gu, W.8
Pestell, R.G.9
-
6
-
-
0026702956
-
Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius: Detection of POMC mRNA
-
Bronstein DM, Schafer MK, Watson SJ, Akil H (1992) Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA. Brain Res 587:269-275.
-
(1992)
Brain Res
, vol.587
, pp. 269-275
-
-
Bronstein, D.M.1
Schafer, M.K.2
Watson, S.J.3
Akil, H.4
-
7
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A 100:10794-10799.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
Bronson, R.7
Appella, E.8
Alt, F.W.9
Chua, K.F.10
-
8
-
-
0025917542
-
Food deprivation and age modulate neuropeptide gene expression in the murine hypothalamus and adrenal gland
-
Chua SC Jr, Leibel RL, Hirsch J (1991) Food deprivation and age modulate neuropeptide gene expression in the murine hypothalamus and adrenal gland. Brain Res Mol Brain Res 9:95-101.
-
(1991)
Brain Res Mol Brain Res
, vol.9
, pp. 95-101
-
-
Chua Jr, S.C.1
Leibel, R.L.2
Hirsch, J.3
-
9
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390-392.
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
de Cabo, R.9
Sinclair, D.A.10
-
10
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK (1999) Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775-786.
-
(1999)
Neuron
, vol.23
, pp. 775-786
-
-
Elias, C.F.1
Aschkenasi, C.2
Lee, C.3
Kelly, J.4
Ahima, R.S.5
Bjorbaek, C.6
Flier, J.S.7
Saper, C.B.8
Elmquist, J.K.9
-
11
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye RA (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273:793-798.
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
12
-
-
34247259630
-
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
-
Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P (2007) Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J 26:1913-1923.
-
(2007)
EMBO J
, vol.26
, pp. 1913-1923
-
-
Gerhart-Hines, Z.1
Rodgers, J.T.2
Bare, O.3
Lerin, C.4
Kim, S.H.5
Mostoslavsky, R.6
Alt, F.W.7
Wu, Z.8
Puigserver, P.9
-
13
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
14
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M, McVey M, Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13:2570-2580.
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
15
-
-
34447308268
-
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
-
Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH (2007) SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J 26:3169-3179.
-
(2007)
EMBO J
, vol.26
, pp. 3169-3179
-
-
Kim, D.1
Nguyen, M.D.2
Dobbin, M.M.3
Fischer, A.4
Sananbenesi, F.5
Rodgers, J.T.6
Delalle, I.7
Baur, J.A.8
Sui, G.9
Armour, S.M.10
Puigserver, P.11
Sinclair, D.A.12
Tsai, L.H.13
-
16
-
-
35349011726
-
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
-
Kim EJ, Kho JH, Kang MR, Um SJ (2007) Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol Cell 28:277-290.
-
(2007)
Mol Cell
, vol.28
, pp. 277-290
-
-
Kim, E.J.1
Kho, J.H.2
Kang, M.R.3
Um, S.J.4
-
17
-
-
0030001086
-
Chronic food restriction and acute food deprivation decrease mRNA levels of opioid peptides in arcuate nucleus
-
Kim EM, Welch CC, Grace MK, Billington CJ, Levine AS (1996) Chronic food restriction and acute food deprivation decrease mRNA levels of opioid peptides in arcuate nucleus. Am J Physiol 270:R1019-R1024.
-
(1996)
Am J Physiol
, vol.270
-
-
Kim, E.M.1
Welch, C.C.2
Grace, M.K.3
Billington, C.J.4
Levine, A.S.5
-
18
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
Kim JE, Chen J, Lou Z (2008) DBC1 is a negative regulator of SIRT1. Nature 451:583-586.
-
(2008)
Nature
, vol.451
, pp. 583-586
-
-
Kim, J.E.1
Chen, J.2
Lou, Z.3
-
19
-
-
33646590947
-
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
-
Kitamura T, Feng Y, Kitamura YI, Chua SC Jr, Xu AW, Barsh GS, Rossetti L, Accili D (2006) Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med 12:534-540.
-
(2006)
Nat Med
, vol.12
, pp. 534-540
-
-
Kitamura, T.1
Feng, Y.2
Kitamura, Y.I.3
Chua Jr, S.C.4
Xu, A.W.5
Barsh, G.S.6
Rossetti, L.7
Accili, D.8
-
20
-
-
27744518040
-
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
-
Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W, Accili D (2005) FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab 2:153-163.
-
(2005)
Cell Metab
, vol.2
, pp. 153-163
-
-
Kitamura, Y.I.1
Kitamura, T.2
Kruse, J.P.3
Raum, J.C.4
Stein, R.5
Gu, W.6
Accili, D.7
-
21
-
-
0034455592
-
Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats
-
Korner J, Wardlaw SL, Liu SM, Conwell IM, Leibel RL, Chua SC Jr (2000) Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats. Endocrinology 141:2465-2471.
-
(2000)
Endocrinology
, vol.141
, pp. 2465-2471
-
-
Korner, J.1
Wardlaw, S.L.2
Liu, S.M.3
Conwell, I.M.4
Leibel, R.L.5
Chua Jr, S.C.6
-
22
-
-
0037312020
-
How does calorie restriction work?
-
Koubova J, Guarente L (2003) How does calorie restriction work? Genes Dev 17:313-321.
-
(2003)
Genes Dev
, vol.17
, pp. 313-321
-
-
Koubova, J.1
Guarente, L.2
-
23
-
-
24944559665
-
HST2 mediates SIR2-independent lifespan extension by calorie restriction
-
Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA (2005) HST2 mediates SIR2-independent lifespan extension by calorie restriction. Science 309:1861-1864.
-
(2005)
Science
, vol.309
, pp. 1861-1864
-
-
Lamming, D.W.1
Latorre-Esteves, M.2
Medvedik, O.3
Wong, S.N.4
Tsang, F.A.5
Wang, C.6
Lin, S.J.7
Sinclair, D.A.8
-
24
-
-
0037093346
-
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
-
Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, Minucci S, Pelicci PG, Kouzarides T (2002) Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J 21:2383-2396.
-
(2002)
EMBO J
, vol.21
, pp. 2383-2396
-
-
Langley, E.1
Pearson, M.2
Faretta, M.3
Bauer, U.M.4
Frye, R.A.5
Minucci, S.6
Pelicci, P.G.7
Kouzarides, T.8
-
25
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin SJ, Defossez PA, Guarente L (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289:2126-2128.
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
26
-
-
0041624549
-
Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter
-
Liu H, Kishi T, Roseberry AG, Cai X, Lee CE, Montez JM, Friedman JM, Elmquist JK (2003) Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 23:7143-7154.
-
(2003)
J Neurosci
, vol.23
, pp. 7143-7154
-
-
Liu, H.1
Kishi, T.2
Roseberry, A.G.3
Cai, X.4
Lee, C.E.5
Montez, J.M.6
Friedman, J.M.7
Elmquist, J.K.8
-
27
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107:137-148.
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
28
-
-
34249083199
-
Sirtuins in mammals: Insights into their biological function
-
Michan S, Sinclair D (2007) Sirtuins in mammals: insights into their biological function. Biochem J 404:1-13.
-
(2007)
Biochem J
, vol.404
, pp. 1-13
-
-
Michan, S.1
Sinclair, D.2
-
29
-
-
0032915413
-
Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
-
Mizuno TM, Mobbs CV (1999) Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140:814-817.
-
(1999)
Endocrinology
, vol.140
, pp. 814-817
-
-
Mizuno, T.M.1
Mobbs, C.V.2
-
30
-
-
0031888157
-
Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin
-
Mizuno TM, Kleopoulos SP, Bergen HT, Roberts JL, Priest CA, Mobbs CV (1998) Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47:294-297.
-
(1998)
Diabetes
, vol.47
, pp. 294-297
-
-
Mizuno, T.M.1
Kleopoulos, S.P.2
Bergen, H.T.3
Roberts, J.L.4
Priest, C.A.5
Mobbs, C.V.6
-
31
-
-
25144454432
-
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
-
Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Méneur C, Permutt MA, Imai S (2005) Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab 2:105-117.
-
(2005)
Cell Metab
, vol.2
, pp. 105-117
-
-
Moynihan, K.A.1
Grimm, A.A.2
Plueger, M.M.3
Bernal-Mizrachi, E.4
Ford, E.5
Cras-Méneur, C.6
Permutt, M.A.7
Imai, S.8
-
32
-
-
34548604499
-
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
-
Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB (2007) Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449:228-232.
-
(2007)
Nature
, vol.449
, pp. 228-232
-
-
Parton, L.E.1
Ye, C.P.2
Coppari, R.3
Enriori, P.J.4
Choi, B.5
Zhang, C.Y.6
Xu, C.7
Vianna, C.R.8
Balthasar, N.9
Lee, C.E.10
Elmquist, J.K.11
Cowley, M.A.12
Lowell, B.B.13
-
33
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429:771-776.
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
Machado De Oliveira, R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
34
-
-
42349085704
-
Sirt1 contributes critically to the redox-dependent fate of neural progenitors
-
Prozorovski T, Schulze-Topphoff U, Glumm R, Baumgart J, Schröter F, Ninnemann O, Siegert E, Bendix I, Brüstle O, Nitsch R, Zipp F, Aktas O (2008) Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol 10:385-394.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 385-394
-
-
Prozorovski, T.1
Schulze-Topphoff, U.2
Glumm, R.3
Baumgart, J.4
Schröter, F.5
Ninnemann, O.6
Siegert, E.7
Bendix, I.8
Brüstle, O.9
Nitsch, R.10
Zipp, F.11
Aktas, O.12
-
35
-
-
33746824192
-
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
-
Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem 281:21745-21754.
-
(2006)
J Biol Chem
, vol.281
, pp. 21745-21754
-
-
Qin, W.1
Yang, T.2
Ho, L.3
Zhao, Z.4
Wang, J.5
Chen, L.6
Zhao, W.7
Thiyagarajan, M.8
MacGrogan, D.9
Rodgers, J.T.10
Puigserver, P.11
Sadoshima, J.12
Deng, H.13
Pedrini, S.14
Gandy, S.15
Sauve, A.A.16
Pasinetti, G.M.17
-
36
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434:113-118.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
37
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B, Helfand SL (2004) Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A 101:15998-16003.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
38
-
-
0025072899
-
Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation
-
Sanacora G, Kershaw M, Finkelstein JA, White JD (1990) Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 127:730-737.
-
(1990)
Endocrinology
, vol.127
, pp. 730-737
-
-
Sanacora, G.1
Kershaw, M.2
Finkelstein, J.A.3
White, J.D.4
-
39
-
-
20244363653
-
Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus
-
Segal JP, Stallings NR, Lee CE, Zhao L, Socci N, Viale A, Harris TM, Soares MB, Childs G, Elmquist JK, Parker KL, Friedman JM (2005) Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus. J Neurosci 25:4181-4188.
-
(2005)
J Neurosci
, vol.25
, pp. 4181-4188
-
-
Segal, J.P.1
Stallings, N.R.2
Lee, C.E.3
Zhao, L.4
Socci, N.5
Viale, A.6
Harris, T.M.7
Soares, M.B.8
Childs, G.9
Elmquist, J.K.10
Parker, K.L.11
Friedman, J.M.12
-
40
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
-
Tontonoz P, Hu E, Spiegelman BM (1994) Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79:1147-1156.
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
41
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107:149-159.
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
42
-
-
0038392755
-
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
-
Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6:736-742.
-
(2003)
Nat Neurosci
, vol.6
, pp. 736-742
-
-
Xu, B.1
Goulding, E.H.2
Zang, K.3
Cepoi, D.4
Cone, R.D.5
Jones, K.R.6
Tecott, L.H.7
Reichardt, L.F.8
-
43
-
-
0032863468
-
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
-
Yaswen L, Diehl N, Brennan MB, Hochgeschwender U (1999) Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 5:1066-1070.
-
(1999)
Nat Med
, vol.5
, pp. 1066-1070
-
-
Yaswen, L.1
Diehl, N.2
Brennan, M.B.3
Hochgeschwender, U.4
-
44
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB (2001) Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105:745-755.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, P.3
Krauss, S.4
Peroni, O.5
Grujic, D.6
Hagen, T.7
Vidal-Puig, A.J.8
Boss, O.9
Kim, Y.B.10
Zheng, X.X.11
Wheeler, M.B.12
Shulman, G.I.13
Chan, C.B.14
Lowell, B.B.15
-
45
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
46
-
-
38749132992
-
Negative regulation of the deacetylase SIRT1 by DBC1
-
Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (2008) Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451:587-590.
-
(2008)
Nature
, vol.451
, pp. 587-590
-
-
Zhao, W.1
Kruse, J.P.2
Tang, Y.3
Jung, S.Y.4
Qin, J.5
Gu, W.6
|