Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2

Neurogenetics

Volumn 4, Issue 4, 2003, Pages 213-217

  Finckh, U ^a   Van Hadeln, K ^a   Muller Thomsen T ^a   Alberici, A ^b   Binetti, G ^b   Hock, C ^c   Nitsch, R M ^c   Stoppe, G ^c   Reiss, J ^c   Gal, A ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b Scientific Institute for Research and Patient Care   (Italy)

^c Institut für Humangenetik ^*

Author keywords

Alzheimer disease; APOE; Plasmin; Urokinase gene

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYTOSINE; GENE PRODUCT; PLASMIN; PLASMINOGEN; THYMIDINE; UROKINASE;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 10Q; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC RISK; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PLAU GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; APOLIPOPROTEINS E; CHROMOSOMES, HUMAN, PAIR 10; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PLASMIN; POLYMORPHISM, GENETIC; URINARY PLASMINOGEN ACTIVATOR;

EID: 0141568946     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10048-003-0157-9     Document Type: Article

References (19)

1. Evans DA, Beckett LA, Field TS, Feng L, Albert MS, Bennett DA, Tycko B, Mayeux R (1997) Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons. JAMA 277:822-824
2. Slooter AJ, Cruts M, Kalmijn S, Hofman A, Breteler MM, Van Broeckhoven C, Duijn CM van (1998) Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. Arch Neurol 55:964-968
3. Tol J, Slooter AJC, Duijn CM van (1999) Genetic factors in early- and late-onset Alzheimer's disease. In: Mayeux R, Christen Y (eds) Epidemiology of Alzheimer's disease: from gene to prevention. Springer, Berlin Heidelberg New York, pp 33-39
4. Warwick Daw E, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD, Wijsman EM (2000) The number of trait loci in late-onset Alzheimer disease. Am J Hum Genet 66:196-204
5. Rao VS, Cupples A, Duijn CM van, Kurz A, Green RC, Chui H, Duara R, Auerbach SA, Volicer L, Wells J, Broeckhoven C van, Growdon JH, Haines JL, Farrer LA (1996) Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4. Am J Hum Genet 59:664-675
6. Blacker D, Bertram L, Saunders AJ, Moscarillo TJ, Albert MS, Wiener H, Perry RT, Collins JS, Harrell LE, Go RC, Mahoney A, Beaty T, Fallin MD, Avramopoulos D, Chase GA, Folstein MF, McInnis MG, Bassett SS, Doheny KJ, Pugh EW, Tanzi RE (2003) Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet 12:23-32
7. Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE (2000) Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 290:2302-2303
8. Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin SG (2000) Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 290:2303-2304
9. Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, DeVrieze FW, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, Lillystone S, Kehoe P, Rudrasingham V, Jones L, Lovestone S, Perez-Tur J, Williams J, Owen MJ, Hardy J, Goate AM (2000) Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290:2304-2305
10. Tucker HM, Kihiko M, Caldwell JN, Wright S, Kawarabayashi T, Price D, Walker D, Scheff S, McGillis JP, Rydel RE, Estus S (2000) The plasmin system is induced by and degrades amyloid-beta aggregates. J Neurosci 20:3937-3946
11. Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B, Dotti CG (2000) Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. EMBO Rep 1:530-535
12. Buss S, Muller-Thomsen T, Hock C, Alberici A, Binetti G, Nitsch RM, Gal A, Finckh U (2002) No association between DCP1 genotype and late-onset Alzheimer disease. Am J Med Genet 114:440-445
13. Finckh U, Kammer H von der, Velden J, Michel T, Andresen B, Deng A, Zhang J, Muller-Thomsen T, Zuchowski K, Menzer G, Mann U, Papassotiropoulos A, Heun R, Zurdel J, Holst F, Benussi L, Stoppe G, Reiss J, Miserez AR, Staehelin HB, Rebeck GW, Hyman BT, Binetti G, Hock C, Growdon JH, Nitsch RM (2000) Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease. Arch Neurol 57:1579-1583
14. Menzer G, Muller-Thomsen T, Meins W, Alberici A, Binetti G, Hock C, Nitsch RM, Stoppe G, Reiss J, Finckh U (2001) Non-replication of association between cathepsin D genotype and late onset Alzheimer disease. Am J Med Genet 105:179-182
15. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944
16. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
17. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, Duijn CM van (1997) Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. Jama 278:1349-1356
18. Conne B, Berczy M, Belin D (1997) Detection of polymorphisms in the human urokinase-type plasminogen activator gene. Thromb Haemost 77:434-435
19. Turkmen B, Schmitt M, Schmalfeldt B, Trommler P, Hell W, Creutzburg S, Graeff H, Magdolen V (1997) Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer. Electrophoresis 18:686-689