Strategies for the in vitro evolution of protein function: Enzyme evolution by random recombination of improved sequences

Journal of Molecular Biology

Volumn 272, Issue 3, 1997, Pages 336-347

  Moore, Jeffrey C ^a,b   Jin, Hua Ming ^a,b   Kuchner, Olga ^a,c   Arnold, Frances H ^c  

^a California Institute of Technology   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Directed evolution; DNA shuffling; Paranitrobenzyl esterase; Random mutagenesis

Indexed keywords

ESTERASE; LORACARBEF; PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DNA DETERMINATION; DNA SEQUENCE; ENZYME ACTIVITY; GENETIC ENGINEERING; GENETIC RECOMBINATION; MUTAGENESIS; POINT MUTATION; PRIORITY JOURNAL;

EID: 0031587291     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1252     Document Type: Article

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