Protein stability promotes evolvability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 15, 2006, Pages 5869-5874

  Bloom, Jesse D ^a   Labthavikul, Sy T ^a   Otey, Christopher R ^b   Arnold, Frances H ^a  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

CYP102A1; Cytochrome P450; Directed evolution; Lattice protein; Mutational robustness

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOCHROME P450; CYTOCHROME P450 BM3; ENZYME VARIANT; MUTANT PROTEIN; NAPROXEN; UNCLASSIFIED DRUG;

ARTICLE; DRUG HYDROXYLATION; EVOLUTION; MOLECULAR MODEL; MUTATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; SIMULATION; THERMOSTABILITY;

BASE PAIRING; BASE SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; EVOLUTION, MOLECULAR; FRAMESHIFT MUTATION; KINETICS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEINS; THERMODYNAMICS;

EID: 33645811495     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510098103     Document Type: Article

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