Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein

Nature

Volumn 444, Issue 7121, 2006, Pages 929-932

  Bershtein, Shimon ^a   Segal, Michal ^a   Bekerman, Roy ^a   Tokuriki, Nobuhiko ^a   Tawfik, Dan S ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; BETA LACTAMASE; CHLORAMPHENICOL; PLASMID DNA;

BACTERIUM; ENZYME ACTIVITY; EPISTASIS; FITNESS; MUTATION; PROTEIN;

ARTICLE; CORRELATION ANALYSIS; ENZYME ACTIVITY; EPISTASIS; ESCHERICHIA COLI; GENE; GENE MUTATION; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; NONHUMAN; PHYSICOCHEMICAL MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; TEM 1 GENE;

BACTERIA (MICROORGANISMS);

EID: 33845864966     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05385     Document Type: Article

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