Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

Journal of Molecular Biology

Volumn 320, Issue 1, 2002, Pages 85-95

  Wang, Xiaojun ^a   Minasov, George ^a   Shoichet, Brian K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antibiotic resistance; Evolution; Protein stability; TEM 1; lactamase

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAMASE; CEPHALOSPORIN; PENICILLIN G;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ISOLATION; ENZYME PURIFICATION; ENZYME STABILITY; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

EID: 0036295508     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00400-X     Document Type: Article

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