Surveying a local fitness landscape of a protein with epistatic sites for the study of directed evolution

Biopolymers

Volumn 64, Issue 2, 2002, Pages 95-105

  Aita, Takuyo ^a,b   Hamamatsu, Norio ^a   Nomiya, Yukiko ^a   Uchiyama, Hidefumi ^c   Shibanaka, Yasuhiko ^a   Husimi, Yuzuru ^b  

^a NOVARTIS PHARMA K K   (Japan)

^b SAITAMA UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Epistasis; Mutation scrambling; Mutational additivity; Sequence space; Thermostability

Indexed keywords

CLONING; MUTAGENESIS; STABILITY;

LOCAL FITNESS LANDSCAPES;

PROTEINS;

BIOPOLYMER; PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; DIRECTED MOLECULAR EVOLUTION; EPISTASIS; MOLECULAR MODEL; POINT MUTATION; THERMOSTABILITY;

DIRECTED MOLECULAR EVOLUTION; HALF-LIFE; MODELS, MOLECULAR; MUTATION; SERINE ENDOPEPTIDASES; THERMODYNAMICS;

EID: 0037025118     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10126     Document Type: Article

References (13)