HIV-1 proviral DNA excision using an evolved recombinase

Science

Volumn 316, Issue 5833, 2007, Pages 1912-1915

  Sarkar, Indrani ^a   Hauber, Ilona ^b   Hauber, Joachim ^b   Buchholz, Frank ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINASE; VIRUS DNA;

CHROMOSOME; DNA; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS;

ARTICLE; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; EXCISION REPAIR; GENOME; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; TRANSACTIVATION; VIRUS DNA CELL DNA INTERACTION;

AMINO ACID SEQUENCE; BASE SEQUENCE; DIRECTED MOLECULAR EVOLUTION; DNA SHUFFLING; DNA, VIRAL; ESCHERICHIA COLI; GENE LIBRARY; GENOME, HUMAN; HELA CELLS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; INTEGRASES; MOLECULAR SEQUENCE DATA; MUTATION; PROVIRUSES; RECOMBINATION, GENETIC; VIRUS INTEGRATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 34347398120     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1141453     Document Type: Article

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25. We thank A. Bunk for technical assistance and A. F. Stewart for critical reading of the manuscript. The Max Planck Society supported this work. The Heinrich-Pette-Institute is a member of the Leibniz Gemeinschaft (WGL) and is supported by the Free and Hanseatic City of Hamburg and the Federal Ministry of Health.