Directed evolution of a genetic circuit

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 26, 2002, Pages 16587-16591

  Yokobayashi, Yohei ^a   Weiss, Ron ^b   Arnold, Frances H ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b Princeton University   (United States)

Author keywords

Biocomputation; Molecular evolution; Random mutagenesis; Repressor gene regulation

Indexed keywords

ARTICLE; GENE CONSTRUCT; GENETIC ENGINEERING; GENETIC REGULATION; IN VIVO STUDY; MOLECULAR EVOLUTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

DNA; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; MUTAGENESIS; PLASMIDS; REPRESSOR PROTEINS;

EID: 0037168510     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.252535999     Document Type: Article

References (22)

1. Gardner, T. S., Cantor, C. R. & Collins, J. J. (2000) Nature 403, 339-342.
2. Elowitz, M. B. & Leibler, S. (2000) Nature 403, 335-338.
3. Becskei, A. & Serrano, L. (2000) Nature 405, 590-593.
4. Guet, C. C., Elowitz, M. B., Hsing, W. & Leibler, S. (2002) Science 296, 1466-1470.
5. Hasty, J., McMillen, D., Isaacs, F. & Collins, J. (2001) Nat. Rev. Genet. 2, 268-279.
6. Weiss, R., Homsy, G. E. & Knight, T. F., Jr. (1999) in Dimacs Workshop on Evolution as Computation (Springer, Princeton), pp. 275-295.
7. Arnold, F. H. (1998) Acc. Chem. Res. 31, 125-131.
8. Weiss, R. & Basu, S. (2002) in First Workshop on Non-Silicon Computing (www.hpcaconf.org/hpca8).
9. Weiss, R. (2001) Ph.D. thesis (Massachusetts Institute of Technology, Cambridge, MA.
10. Cadwell, R. C. & Joyce, G. F. (1992) PCR Methods Appl. 2, 28-33.
11. Cadwell, R. C. & Joyce, G. F. (1994) PCR Methods Appl. 3, S136-S140.
12. Farinas, E. T., Bulter, T. & Arnold, F. H. (2001) Curr. Opin. Biotechnol. 12, 545-551.
13. Schmidt-Dannert, C., Umeno, D. & Arnold, F. H. (2000) Nat. Biotechnol. 18, 750-753.
14. Crameri, A., Dawes, G., Rodriguez, E., Jr., Silver, S. & Stemmer, W. P. (1997) Nat. Biotechnol. 15, 436-438.
15. Jordan, S. R. & Pabo, C. O. (1988) Science 242, 893-899.
16. Beamer, L. J. & Pabo, C. O. (1992) J. Mol. Biol. 227, 177-196.
17. Ptashne, M. (1992) A Genetic Switch: Phage Lambda and Higher Organisms (Blackwell, Cambridge, MA).
18. Ackers, G. K., Johnson, A. D. & Shea, M. A. (1982) Proc. Natl. Acad. Sci. USA 79, 1129-1133.
19. Weiss, M. A., Pabo, C. O., Karplus, M. & Sauer, R. T. (1987) Biochemistry 26, 897-904.
20. Bell, C. E., Frescura, P., Hochschild, A. & Lewis, M. (2000) Cell 101, 801-811.
21. Burz, D. S. & Ackers, G. K. (1994) Biochemistry 33, 8406-8416.
22. Whipple, F. W., Hou, E. F. & Hochschild, A. (1998) Genes Dev. 12, 2791-2802.