Darwinian evolution can follow only very few mutational paths to fitter proteins

Science

Volumn 312, Issue 5770, 2006, Pages 111-114

  Weinreich, Daniel M ^a   Delaney, Nigel F ^a,b   DePristo, Mark A ^a   Hartl, Daniel L ^a  

^a HARVARD UNIVERSITY   (United States)

^b INTEGRATIVE OCEANOGRAPHY DIVISION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BACTERIOLOGY; ENZYMES; PROTEINS;

BIOPHYSICAL PLEIOTROPY; DARWINIAN EVOLUTION; PROTEIN TAPE; REALIZATION;

GENETIC ENGINEERING;

AMINO ACID; ANTIBIOTIC AGENT; BETA LACTAMASE; CEFOTAXIME;

EVOLUTION; MUTATION; PROTEIN;

ALLELE; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BIOPHYSICS; DRUG HYDROLYSIS; ENZYME STABILITY; MISSENSE MUTATION; MOLECULAR EVOLUTION; NONHUMAN; PLEIOTROPY; POINT MUTATION; PRIORITY JOURNAL; PROBABILITY; TEM GENE; THERMODYNAMICS;

ALLELES; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CEFOTAXIME; DRUG RESISTANCE, BACTERIAL; ENZYME STABILITY; EPISTASIS, GENETIC; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; MODELS, GENETIC; MUTATION; MUTATION, MISSENSE; POINT MUTATION; PROBABILITY; SELECTION (GENETICS);

BACTERIA (MICROORGANISMS);

EID: 33645666942     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1123539     Document Type: Article

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