-
1
-
-
0036519363
-
DNA and its associated processes as targets for cancer therapy
-
Hurley, L. H. DNA and its associated processes as targets for cancer therapy. Nature Rev. Cancer 2, 188-200 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 188-200
-
-
Hurley, L.H.1
-
3
-
-
0016633504
-
Different drugs arrest cells at a number of distinct stages in G2
-
Tobey, R. A. Different drugs arrest cells at a number of distinct stages in G2. Nature 254, 245-247 (1975).
-
(1975)
Nature
, vol.254
, pp. 245-247
-
-
Tobey, R.A.1
-
4
-
-
0008158443
-
Radiosensitivity in ataxia-telangiectasia: A new explanation
-
Painter, R. B. & Young, B. R. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl Acad. Sci. USA 77, 7315-7317 (1980).
-
(1980)
Proc. Natl. Acad. Sci. USA
, vol.77
, pp. 7315-7317
-
-
Painter, R.B.1
Young, B.R.2
-
5
-
-
0023712476
-
The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
-
Weinert, T. A. & Hartwell, L. H. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241, 317-322 (1988).
-
(1988)
Science
, vol.241
, pp. 317-322
-
-
Weinert, T.A.1
Hartwell, L.H.2
-
6
-
-
0024425887
-
Checkpoints: Controls that ensure the order of cell cycle events
-
Hartwell, L. H. & Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629-634 (1989).
-
(1989)
Science
, vol.246
, pp. 629-634
-
-
Hartwell, L.H.1
Weinert, T.A.2
-
7
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou, B.-B. & Elledge, S. J. The DNA damage response: putting checkpoints in perspective. Nature 408, 433-439 (2000).
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.-B.1
Elledge, S.J.2
-
8
-
-
0035093737
-
DNA double-strand breaks: Signaling, repair and the cancer connection
-
Khanna, K. K. & Jackson, S. P. DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genet. 27, 247-254 (2001).
-
(2001)
Nature Genet.
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
9
-
-
17444388849
-
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents
-
Chang, B. D. et al. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 59, 3761-3767 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 3761-3767
-
-
Chang, B.D.1
-
10
-
-
0028568315
-
Cell cycle control and cancer
-
Hartwell, L. H. & Kastan, M. B. Cell cycle control and cancer. Science 266, 1821-1828 (1994).
-
(1994)
Science
, vol.266
, pp. 1821-1828
-
-
Hartwell, L.H.1
Kastan, M.B.2
-
11
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nature Rev. Cancer 3, 155-168 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
12
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham, R. T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
13
-
-
0033600182
-
Cell cycle-dependent and ATM-independent expression of human Chk1 kinase
-
Kaneko, Y. et al. Cell cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene 18, 3673-3681 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 3673-3681
-
-
Kaneko, Y.1
-
14
-
-
0035393594
-
DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
-
Lukas, C. et al. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res. 61, 4990-4993 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 4990-4993
-
-
Lukas, C.1
-
15
-
-
0030867582
-
Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
-
Sanchez, Y. et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501 (1997). This paper describes the cloning, and preliminary biochemical characterization of CHK1, particularly its role in the G2-M transition
-
(1997)
Science
, vol.277
, pp. 1497-1501
-
-
Sanchez, Y.1
-
16
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
Liu, Q. et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 14, 1448-1459 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
-
17
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
Zhao, H. & Piwnica-Worms, H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21, 4129-4139 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
18
-
-
0037069326
-
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
-
Zhao, H., Watkins, J. L. & Piwnica-Worms, H. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc. Natl Acad. Sci. USA 99, 14795-14800 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14795-14800
-
-
Zhao, H.1
Watkins, J.L.2
Piwnica-Worms, H.3
-
19
-
-
0012966157
-
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
-
Sorensen, C. S. et al. Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 3, 247-258 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 247-258
-
-
Sorensen, C.S.1
-
20
-
-
0038013782
-
Ataxia-telangiectesia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
-
Gatei, M. et al. Ataxia-telangiectesia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J. Biol. Chem. 278, 14806-14811 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14806-14811
-
-
Gatei, M.1
-
21
-
-
0037484271
-
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents
-
Xiao, Z. et al. Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents. J. Biol. Chem. 278, 21767-21773 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 21767-21773
-
-
Xiao, Z.1
-
22
-
-
0033634679
-
Clespin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
-
Kumegai, A. & Dunphy, W. G. Clespin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol. Cell 6, 839-849 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 839-849
-
-
Kumegai, A.1
Dunphy, W.G.2
-
23
-
-
0043032435
-
Human claspin is required for replication checkpoint control
-
Chini, C. C. & Chert, J. Human claspin is required for replication checkpoint control. J. Biol. Chem. 278, 30057-30062, (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30057-30062
-
-
Chini, C.C.1
Chert, J.2
-
24
-
-
0034717309
-
Rapid destruction of human Cdc25A in response to DNA damage
-
Mailand, N. et al. Rapid destruction of human Cdc25A in response to DNA damage. Science 288, 1425-1429 (2000).
-
(2000)
Science
, vol.288
, pp. 1425-1429
-
-
Mailand, N.1
-
25
-
-
0036847320
-
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability
-
Mailand, N. et al. Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J. 21, 5911-5920 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 5911-5920
-
-
Mailand, N.1
-
26
-
-
0030611095
-
Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
-
Pang, C. Y. et al. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505 (1997).
-
(1997)
Science
, vol.277
, pp. 1501-1505
-
-
Pang, C.Y.1
-
27
-
-
0032974109
-
Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site
-
Dalai, S. N., Schweitzer, C. M., Gan, J. & DeCaprio, J. A. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Mol. Cell. Biol. 19, 4465-4479 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4465-4479
-
-
Dalai, S.N.1
Schweitzer, C.M.2
Gan, J.3
DeCaprio, J.A.4
-
28
-
-
0033561439
-
Maintenance of G2 arrest in the Xenopus oocyte: A role for 14-3-3-mediated inhibition of Cdc25 nuclear import
-
Yang, J., Winkler, K., Yoshida, M. & Kornbluth, S. Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. EMBO J. 18, 2174-2183 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 2174-2183
-
-
Yang, J.1
Winkler, K.2
Yoshida, M.3
Kornbluth, S.4
-
29
-
-
0037415735
-
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
-
Zachos, G., Rainey, M. D. & Gillespie, D. A. Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects. EMBO J. 22, 713-723 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 713-723
-
-
Zachos, G.1
Rainey, M.D.2
Gillespie, D.A.3
-
30
-
-
0030615323
-
G1 Phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/sdil in p53-mutated human epidermoid carcinoma A431 cells
-
Akiyama, T. et al. G1 Phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/sdil in p53-mutated human epidermoid carcinoma A431 cells. Cancer Res. 57, 1495-1501 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 1495-1501
-
-
Akiyama, T.1
-
31
-
-
0034053130
-
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
-
Graves, P. R. et al. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J. Biol. Chem. 275, 5600-5605 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5600-5605
-
-
Graves, P.R.1
-
32
-
-
0034655281
-
The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
-
Busby, E. C., Leistritz, D. F., Abraham, R. T., Karnitz, L. M. & Sankaria, J. N. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res. 60, 2108-2112 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 2108-2112
-
-
Busby, E.C.1
Leistritz, D.F.2
Abraham, R.T.3
Karnitz, L.M.4
Sankaria, J.N.5
-
33
-
-
2242421834
-
Structural basis for Chk1 inhibition by UCN-01
-
Zhao, B. et al. Structural basis for Chk1 inhibition by UCN-01. J. Biol. Chem. 277, 46609-46615 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 46609-46615
-
-
Zhao, B.1
-
34
-
-
0037034928
-
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)
-
Sato, S., Fujita, N. & Tsuruo, T. Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). Oncogene 21, 1727-1738 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 1727-1738
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
35
-
-
0034102337
-
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
-
Brown, E. J. & Baltimore, D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14, 397-402 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 397-402
-
-
Brown, E.J.1
Baltimore, D.2
-
36
-
-
0034177408
-
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
-
de Klein, A. et al. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr. Biol. 10, 479-482 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 479-482
-
-
De Klein, A.1
-
37
-
-
0034659341
-
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
-
Takai, H. et al. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev. 14, 1439-1447 (2000). Work described in this reference and reference 16 indicates that Chk1 in mammals might have an essential role during the normal cell cycle.
-
(2000)
Genes Dev.
, vol.14
, pp. 1439-1447
-
-
Takai, H.1
-
38
-
-
0035979213
-
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation
-
Nghiem, P., Park, P. K., Kim, Y., Vaziri, C. & Schreiber, S. L. ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc. Natl Acad. Sci. USA 98, 9092-9097 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9092-9097
-
-
Nghiem, P.1
Park, P.K.2
Kim, Y.3
Vaziri, C.4
Schreiber, S.L.5
-
39
-
-
0035802112
-
Activation of mammalian Chk1 during DNA replication arrest: A role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
-
Feijoo, C. et al. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. J. Cell Biol. 154, 913-923 (2001).
-
(2001)
J. Cell Biol.
, vol.154
, pp. 913-923
-
-
Feijoo, C.1
-
40
-
-
0031172845
-
The Drosophila grapes gene is related to checkpoint gene chk1/rad 27 and is required for late syncytial division fidelity
-
Fogarty, P. et al. The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity. Curr. Biol. 7, 418-426 (1997).
-
(1997)
Curr. Biol.
, vol.7
, pp. 418-426
-
-
Fogarty, P.1
-
41
-
-
1542754615
-
Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint
-
Chen, Z. et al. Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint. Mol. Cancer Ther. 2, 543-548 (2003).
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 543-548
-
-
Chen, Z.1
-
42
-
-
0035829685
-
Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells
-
Koniaras, K., Cuddihy, A. R., Christopoulos, H., Hogg, A. & O'Connell, M. J. Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells. Oncogene 20, 7453-7463 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 7453-7463
-
-
Koniaras, K.1
Cuddihy, A.R.2
Christopoulos, H.3
Hogg, A.4
O'Connell, M.J.5
-
43
-
-
0036569855
-
Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment
-
Wang, H. et al. Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment. Cancer Res. 62, 2483-2487 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 2483-2487
-
-
Wang, H.1
-
44
-
-
0027232037
-
Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C
-
Akinaga, S., Nomura, K., Gomi, K., and Okabe, M. Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C. Cancer Chemother. Pharmacol. 32, 183-189 (1993).
-
(1993)
Cancer Chemother. Pharmacol.
, vol.32
, pp. 183-189
-
-
Akinaga, S.1
Nomura, K.2
Gomi, K.3
Okabe, M.4
-
45
-
-
0031670310
-
UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in sequence-dependent manner
-
Hsueh, C., Kelsen, D., and Schwartz, G. K. UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in sequence-dependent manner. Clin. Cancer Res. 4, 2201-2206 (1998).
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 2201-2206
-
-
Hsueh, C.1
Kelsen, D.2
Schwartz, G.K.3
-
46
-
-
0029992520
-
Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (ucn-01), a new G2-checkpoint inhibitor
-
Bunch, R. T. & Eastman, A. Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (ucn-01), a new G2-checkpoint inhibitor. Clin. Cancer Res. 2, 791-797 (1996).
-
(1996)
Clin. Cancer Res.
, vol.2
, pp. 791-797
-
-
Bunch, R.T.1
Eastman, A.2
-
47
-
-
0030870632
-
Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function
-
Shao, R. et al. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. Cancer Res. 57, 4029-4035 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 4029-4035
-
-
Shao, R.1
-
48
-
-
0028985932
-
Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells
-
Russell, K. J. et al. Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells. Cancer Res. 55, 1639-1642 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 1639-1642
-
-
Russell, K.J.1
-
49
-
-
0029895439
-
UCN-01: A potent abrogator of G2 checkpoint function in cancer cells with disrupted p53
-
Wang, Q. et al. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J. Natl. Cancer Inst. 88, 956-965 (1996).
-
(1996)
J. Natl. Cancer Inst.
, vol.88
, pp. 956-965
-
-
Wang, Q.1
-
50
-
-
0032404350
-
Splitting the ATM: Distinct repair and checkpoint defects in ataxia-telangiectasia
-
Jeggo, P. A., Carr, A. M. & Lehmann, A. R. Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia. Trends Genet. 14, 312-316 (1998).
-
(1998)
Trends Genet.
, vol.14
, pp. 312-316
-
-
Jeggo, P.A.1
Carr, A.M.2
Lehmann, A.R.3
-
51
-
-
0036146085
-
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation
-
Xu, B., Kim, S. T., Lim, D. S. & Kastan, M. B. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol. Cell. Biol. 22, 1049-1059 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1049-1059
-
-
Xu, B.1
Kim, S.T.2
Lim, D.S.3
Kastan, M.B.4
-
52
-
-
0022625455
-
A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis
-
Lehmann, A. R. et al. A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 49, 639-643 (1986).
-
(1986)
Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.
, vol.49
, pp. 639-643
-
-
Lehmann, A.R.1
-
53
-
-
0028844502
-
Fission yeast rad17: A homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins
-
Griffiths, D. J., Barbet, N. C., McCready, S., Lehmann, A. R. & Carr, A. M. Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins. EMBO J. 14, 5812-5823 (1995).
-
(1995)
EMBO J.
, vol.14
, pp. 5812-5823
-
-
Griffiths, D.J.1
Barbet, N.C.2
McCready, S.3
Lehmann, A.R.4
Carr, A.M.5
-
54
-
-
0028825202
-
Separation of phenotypes in mutant alleles of the Schizosaccharomyces pombe cell-cycle checkpoint gene rad1+
-
Kanter-Smoler, G., Knudsen, K. E., Jimenez, G., Sunnerhagen, P. & Subramani, S. Separation of phenotypes in mutant alleles of the Schizosaccharomyces pombe cell-cycle checkpoint gene rad1+. Mol. Biol. Cell 6, 793-805 (1995).
-
(1995)
Mol. Biol. Cell
, vol.6
, pp. 793-805
-
-
Kanter-Smoler, G.1
Knudsen, K.E.2
Jimenez, G.3
Sunnerhagen, P.4
Subramani, S.5
-
55
-
-
0028198383
-
Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast
-
al-Khodairy, F. et al. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol. Biol. Cell 5, 147-160 (1994).
-
(1994)
Mol. Biol. Cell
, vol.5
, pp. 147-160
-
-
Al-Khodairy, F.1
-
56
-
-
0037386947
-
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint
-
Groth, A. et al. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J. 22, 1676-1687 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 1676-1687
-
-
Groth, A.1
-
57
-
-
0141730324
-
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1
-
Krause, D. R. et al. Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene 22, 5927-5937 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 5927-5937
-
-
Krause, D.R.1
-
58
-
-
0035871444
-
Phase trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms
-
Sausville, E. A. et al. Phase trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms. J. Clin. Oncol. 19, 2319-2333 (2001).
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 2319-2333
-
-
Sausville, E.A.1
-
59
-
-
0032484084
-
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
-
Matsuoka, S., Huang, M. & Elledge, S. J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893-1897 (1998). Work in this reference, and in references 60, 62 and 63, describes the cloning and preliminary biochemical characterization of CHK2.
-
(1998)
Science
, vol.282
, pp. 1893-1897
-
-
Matsuoka, S.1
Huang, M.2
Elledge, S.J.3
-
60
-
-
0033566082
-
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
-
Chaturvedi, P. et al. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene 18, 4047-4054 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 4047-4054
-
-
Chaturvedi, P.1
-
61
-
-
0037013243
-
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach
-
O'Neill, T. et al. Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J. Biol. Chem. 277, 16102-16115 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 16102-16115
-
-
O'Neill, T.1
-
62
-
-
0033552873
-
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
-
Blasina, A. et al. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr. Biol. 9, 1-10 (1999).
-
(1999)
Curr. Biol.
, vol.9
, pp. 1-10
-
-
Blasina, A.1
-
63
-
-
0033616828
-
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
-
Brown, A. L. et al. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc. Natl Acad. Sci. USA 96, 3745-3750 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3745-3750
-
-
Brown, A.L.1
-
64
-
-
0034142325
-
D Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
-
Chehab, N. H., Malikzay, A., Appel, M. & Halazonetis, T. D Chk2/ hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 14, 278-288 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.4
-
65
-
-
0035848819
-
The ATM-Chk2-Cdc 25A checkpoint pathway guards against radioresistant DNA synthesis
-
Falck, J., Mailand, N., Syljuasen, R. G., Bartek, J. & Lukas, J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847 (2001).
-
(2001)
Nature
, vol.410
, pp. 842-847
-
-
Falck, J.1
Mailand, N.2
Syljuasen, R.G.3
Bartek, J.4
Lukas, J.5
-
66
-
-
0036510055
-
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
-
Falck, J., Petrini, J. H., Williams, B. R., Lukas, J. & Bartek, J. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nature Genet. 30, 290-294 (2002). References 65 and 66 describe the first signalling and effector cascade that provided a mechanistic insight into the ionizing-radiation-induced intra-S-phase checkpoint in terms of its direct impact on cell-cycle machinery.
-
(2002)
Nature Genet.
, vol.30
, pp. 290-294
-
-
Falck, J.1
Petrini, J.H.2
Williams, B.R.3
Lukas, J.4
Bartek, J.5
-
67
-
-
0036724625
-
Chk2 is a tumor suppressor that regulates apoptosis in both an ATM-dependent and ATM-independent manner
-
Hirao, A. et al. Chk2 is a tumor suppressor that regulates apoptosis in both an ATM-dependent and ATM-independent manner. Mol. Cell. Biol. 22, 6521-6532 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6521-6532
-
-
Hirao, A.1
-
68
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai, H. et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21, 5195-5205 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
-
69
-
-
0037162506
-
Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response
-
Jack, M. T. et al. Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response. Proc. Natl Acad. Sci. USA 99, 9825-9829 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 9825-9829
-
-
Jack, M.T.1
-
70
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek, J. & Lukas, J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell. 3, 421-429 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
71
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao, A. et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287, 1824-1827 (2000). Work described in this reference and references 67-69 show that CHK2 is crucial for IR-induced apoptosis and indicates that CHK2 could be a radioprotection target.
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
-
72
-
-
0033598754
-
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
-
Chehab, N. H., Malikzay, A., Stavridi, E. S. & Halazonetis, T. D. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc. Natl Acad. Sci. USA 96, 13777-13782 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13777-13782
-
-
Chehab, N.H.1
Malikzay, A.2
Stavridi, E.S.3
Halazonetis, T.D.4
-
73
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
-
Shieh, S. Y., Ahn, J., Tamai, K., Taya, Y. & Prives, C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289-300 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 289-300
-
-
Shieh, S.Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
74
-
-
0042854721
-
Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain
-
Craig, A. et al. Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. EMBO Rep. 4, 787-792 (2003).
-
(2003)
EMBO Rep.
, vol.4
, pp. 787-792
-
-
Craig, A.1
-
75
-
-
0036205321
-
Mutation of mouse p53 Ser23 and the response to DNA damage
-
Wu, Z. et al. Mutation of mouse p53 Ser23 and the response to DNA damage. Mol. Cell. Biol. 22, 2441-2449 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2441-2449
-
-
Wu, Z.1
-
76
-
-
0038392762
-
Questioning the role of checkpoint kinase 2 in the p53 DNA damage response
-
Ahn, J., Urist, M. & Prives, C. Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. J. Biol. Chem. 278, 20480-20489 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20480-20489
-
-
Ahn, J.1
Urist, M.2
Prives, C.3
-
77
-
-
0038054343
-
The Chk2 tumor suppressor is not required for p53 responses in human cancer cells
-
Jallepalli, P. V., Lengauer, C., Vogelstein, B. & Bunz, F. The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J. Biol. Chem. 278, 20475-20479 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20475-20479
-
-
Jallepalli, P.V.1
Lengauer, C.2
Vogelstein, B.3
Bunz, F.4
-
78
-
-
0037226473
-
The mismatch repair system is required for S-phase checkpoint activation
-
Brown, K. D. et al. The mismatch repair system is required for S-phase checkpoint activation. Nature Genet. 33, 80-84 (2003).
-
(2003)
Nature Genet.
, vol.33
, pp. 80-84
-
-
Brown, K.D.1
-
79
-
-
18344395671
-
Human MRE11 is inactivated in mismatch repair-deficient cancers
-
Giannini, G. et al. Human MRE11 is inactivated in mismatch repair-deficient cancers. EMBO Rep. 3, 248-254 (2002).
-
(2002)
EMBO Rep.
, vol.3
, pp. 248-254
-
-
Giannini, G.1
-
80
-
-
0141509882
-
ATM can regulate p53 and neuronal death independent of Chk2 in response to DNA damage
-
Keramaris, E., Hirao, A., Slack, R. S., Mak, T. W. & Park, D. S. ATM can regulate p53 and neuronal death independent of Chk2 in response to DNA damage. J. Biol. Chem. 278, 37782-87789 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37782-87789
-
-
Keramaris, E.1
Hirao, A.2
Slack, R.S.3
Mak, T.W.4
Park, D.S.5
-
81
-
-
0036847998
-
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
-
Yang, S., Kuo, C., Bisi, J. E. & Kim, M. K. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nature Cell Biol. 4, 865-870 (2002).
-
(2002)
Nature Cell Biol.
, vol.4
, pp. 865-870
-
-
Yang, S.1
Kuo, C.2
Bisi, J.E.3
Kim, M.K.4
-
82
-
-
0038752083
-
Chk2 activates E2F-1 in response to DNA damage
-
Stevens, C., Smith, L. & La Thangue, N. B. Chk2 activates E2F-1 in response to DNA damage. Nature Cell Biol. 5, 401-409 (2003).
-
(2003)
Nature Cell Biol.
, vol.5
, pp. 401-409
-
-
Stevens, C.1
Smith, L.2
La Thangue, N.B.3
-
83
-
-
0033543728
-
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
-
Komarov, P. G. et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285, 1733-1737 (1999). This reference describes the identification - by chemical library screening - and in vitro and in vivo testing of a p53 inhibitor, and indicates that inhibition of the p53 pathway could reduce IR-induced DNA damage and lead to radioprotection.
-
(1999)
Science
, vol.285
, pp. 1733-1737
-
-
Komarov, P.G.1
-
84
-
-
0037317521
-
The role of p53 in determining sensitivity to radiotherapy
-
Gudkov, A. V. & Komarova, E. A. The role of p53 in determining sensitivity to radiotherapy. Nature Rev. Cancer. 3, 117-129 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 117-129
-
-
Gudkov, A.V.1
Komarova, E.A.2
-
85
-
-
0034665162
-
p53 is essential for chemotherapy-induced hair loss
-
Botchkarev, V. A. et al. p53 is essential for chemotherapy-induced hair loss. Cancer Res. 60, 5002-5006 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 5002-5006
-
-
Botchkarev, V.A.1
-
86
-
-
0035808599
-
Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors
-
Davis, S. T. et al. Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. Science 291, 134-137 (2001).
-
(2001)
Science
, vol.291
, pp. 134-137
-
-
Davis, S.T.1
-
87
-
-
0036500555
-
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
-
Kim, S. T., Xu, B. & Kastan, M. B. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16, 560-570 (2002).
-
(2002)
Genes Dev.
, vol.16
, pp. 560-570
-
-
Kim, S.T.1
Xu, B.2
Kastan, M.B.3
-
88
-
-
0034601420
-
Different impact of p53 and p21 on the radiation response of mouse tissues
-
Komarova, E. A., Christov, K., Faerman, A. I. & Gudkov, A. V. Different impact of p53 and p21 on the radiation response of mouse tissues. Oncogene 19, 3791-3798 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 3791-3798
-
-
Komarova, E.A.1
Christov, K.2
Faerman, A.I.3
Gudkov, A.V.4
-
89
-
-
0034624718
-
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
-
Lee, J. S., Collins, K. M., Brown, A. L., Lee, C. H. & Chung, J. H. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-204 (2000).
-
(2000)
Nature
, vol.404
, pp. 201-204
-
-
Lee, J.S.1
Collins, K.M.2
Brown, A.L.3
Lee, C.H.4
Chung, J.H.5
-
90
-
-
0346095320
-
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair
-
Zhang, J. et al. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol. Cell. Biol. 24, 708-718 (2004).
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 708-718
-
-
Zhang, J.1
-
91
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou, L. & Elledge, S. J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300, 1542-1548 (2003).
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
92
-
-
0037178748
-
Interfaces between the detection, signaling, and repair of DNA damage
-
Rouse, J. & Jackson, S. P. Interfaces between the detection, signaling, and repair of DNA damage. Science 297, 547-551 (2002).
-
(2002)
Science
, vol.297
, pp. 547-551
-
-
Rouse, J.1
Jackson, S.P.2
-
93
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist, C. J. & Kastan, M. B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (2003).
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
94
-
-
0036276388
-
The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling
-
D'Amours, D. & Jackson, S. P. The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nature Rev. Mol. Cell Biol. 3, 317-327 (2002).
-
(2002)
Nature Rev. Mol. Cell Biol.
, vol.3
, pp. 317-327
-
-
D'Amours, D.1
Jackson, S.P.2
-
95
-
-
0142011461
-
The cellular response to DNA double strand breaks: Defining the sensors and mediators
-
Petrini, H. J. & Stracker, T. H. The cellular response to DNA double strand breaks: defining the sensors and mediators. Trends Cell Biol. 13, 458-462 (2003).
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 458-462
-
-
Petrini, H.J.1
Stracker, T.H.2
-
96
-
-
0024164649
-
Fluorouracil: Biochemistry and pharmacology
-
Pinedo, H. M. & Peters, G. P. Fluorouracil: biochemistry and pharmacology. J. Clin. Oncol. 6, 1653-1664 (1988).
-
(1988)
J. Clin. Oncol.
, vol.6
, pp. 1653-1664
-
-
Pinedo, H.M.1
Peters, G.P.2
-
97
-
-
0038387494
-
5-Fluorouracil: Mechanisms of action and clinical strategies
-
Longley, D. B., Harkin, D. P. & Johnston, P. G. 5-fluorouracil: mechanisms of action and clinical strategies. Nature Rev. Cancer 3, 330-338 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 330-338
-
-
Longley, D.B.1
Harkin, D.P.2
Johnston, P.G.3
-
98
-
-
0026721532
-
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
-
Advanced Colorectal Cancer Meta-Analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J. Clin. Oncol. 10, 896-903 (1992).
-
(1992)
J. Clin. Oncol.
, vol.10
, pp. 896-903
-
-
-
99
-
-
0029090540
-
Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (WR-2721): Preclinical aspects
-
Peters, G. J. & van der Vijgh, W. J. Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (WR-2721): preclinical aspects. Eur. J. Cancer. 31A, S1-S7 (1995).
-
(1995)
Eur. J. Cancer
, vol.31 A
-
-
Peters, G.J.1
Van Der Vijgh, W.J.2
-
100
-
-
0029745368
-
Amifostine: The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies
-
Capizzi, R. Amifostine: the preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies. Semin. Oncol. 23, 2-17 (1996).
-
(1996)
Semin. Oncol.
, vol.23
, pp. 2-17
-
-
Capizzi, R.1
-
101
-
-
0030826795
-
Randomized trial of carboplatin plus amifostine versus carboplatin alone in patients with advanced solid tumors
-
Budd, G. T. et al. Randomized trial of carboplatin plus amifostine versus carboplatin alone in patients with advanced solid tumors. Cancer 80, 1134-1140 (1997).
-
(1997)
Cancer
, vol.80
, pp. 1134-1140
-
-
Budd, G.T.1
-
102
-
-
0032734957
-
The potential of amifostine: From cytoprotectant to therapeutic agent
-
Santini, V. & Giles, P. J. The potential of amifostine: from cytoprotectant to therapeutic agent. Haematologica 84, 1035-1042 (1999).
-
(1999)
Haematologica
, vol.84
, pp. 1035-1042
-
-
Santini, V.1
Giles, P.J.2
-
103
-
-
0030013080
-
Amifostine, cisplatin, and vinblastine in metastatic non-small-cell lung cancer: A report of high response rates and prolonged survival
-
Schiller, J. H. et al. Amifostine, cisplatin, and vinblastine in metastatic non-small-cell lung cancer: a report of high response rates and prolonged survival. J. Clin. Oncol. 14, 1913-1921 (1996).
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 1913-1921
-
-
Schiller, J.H.1
-
104
-
-
0037268373
-
Chemical radioprotection: A critical review of amifostine as a cytoprotector in radiotherapy
-
Andreassen, C. N., Grau, C. & Lindegaard, J. C. Chemical radioprotection: a critical review of amifostine as a cytoprotector in radiotherapy. Semin. Radiat. Oncol. 13, 62-72 (2003).
-
(2003)
Semin. Radiat. Oncol.
, vol.13
, pp. 62-72
-
-
Andreassen, C.N.1
Grau, C.2
Lindegaard, J.C.3
-
105
-
-
0344406759
-
Selective killing of cancer cells by β-lapachone: Direct checkpoint activation as a strategy against cancer
-
Li, Y., Sun, X., LaMont, J. T., Pardee, A. B. & Li, C. J. Selective killing of cancer cells by β-lapachone: direct checkpoint activation as a strategy against cancer. Proc. Natl Acad. Sci. USA 100, 2674-2678 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 2674-2678
-
-
Li, Y.1
Sun, X.2
LaMont, J.T.3
Pardee, A.B.4
Li, C.J.5
|