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Volumn 4, Issue 11, 2002, Pages 865-870

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; PHOSPHOTRANSFERASE; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

EID: 0036847998     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb869     Document Type: Article
Times cited : (204)

References (40)
  • 1
    • 0025875679 scopus 로고
    • The PML-RAR α fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
    • de The, H. et al. The PML-RAR α fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66, 675-684 (1991).
    • (1991) Cell , vol.66 , pp. 675-684
    • De The, H.1
  • 2
    • 0026326963 scopus 로고
    • Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia
    • Goddard, A. D., Borrow, J., Freemont, P. S. & Solomon, E. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 254, 1371-1374 (1991).
    • (1991) Science , vol.254 , pp. 1371-1374
    • Goddard, A.D.1    Borrow, J.2    Freemont, P.S.3    Solomon, E.4
  • 3
    • 0025780876 scopus 로고
    • Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR α with a novel putative transcription factor, PML
    • Kakizuka, A. et al. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR α with a novel putative transcription factor, PML. Cell 66, 663-674 (1991).
    • (1991) Cell , vol.66 , pp. 663-674
    • Kakizuka, A.1
  • 4
    • 0028095410 scopus 로고
    • PML, a growth suppressor disrupted in acute promyelocytic leukemia
    • Mu, Z. M., Chin, K. V., Liu, J. H., Lozano, G. & Chang, K. S. PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol. Cell. Biol. 14, 6858-6867 (1994).
    • (1994) Mol. Cell Biol , vol.14 , pp. 6858-6867
    • Mu, Z.M.1    Chin, K.V.2    Liu, J.H.3    Lozano, G.4    Chang, K.S.5
  • 5
    • 0031418659 scopus 로고    scopus 로고
    • Stable overexpression of PML alters regulation of cell cycle progression in HeLa cells
    • Mu, Z. M., Le, X. F., Vallian, S., Glassman, A. B. & Chang, K. S. Stable overexpression of PML alters regulation of cell cycle progression in HeLa cells. Carcinogenesis 18, 2063-2069 (1997).
    • (1997) Carcinogenesis , vol.18 , pp. 2063-2069
    • Mu, Z.M.1    Le, X.F.2    Vallian, S.3    Glassman, A.B.4    Chang, K.S.5
  • 6
    • 0032499256 scopus 로고    scopus 로고
    • Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis
    • Le, X. F., Vallian, S., Mu, Z. M., Hung, M. C. & Chang, K. S. Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis. Oncogene 16, 1839-1849 (1998).
    • (1998) Oncogene , vol.16 , pp. 1839-1849
    • Le, X.F.1    Vallian, S.2    Mu, Z.M.3    Hung, M.C.4    Chang, K.S.5
  • 7
    • 0031006321 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of PML suppresses growth and tumorigenicity of prostate cancer cells
    • He, D. et al. Adenovirus-mediated expression of PML suppresses growth and tumorigenicity of prostate cancer cells. Cancer Res. 57, 1868-1872 (1997).
    • (1997) Cancer Res , vol.57 , pp. 1868-1872
    • He, D.1
  • 8
    • 0000237552 scopus 로고    scopus 로고
    • Role of PML in cell growth and the retinoic acid pathway
    • Wang, Z. G. et al. Role of PML in cell growth and the retinoic acid pathway. Science 279, 1547-1551 (1998).
    • (1998) Science , vol.279 , pp. 1547-1551
    • Wang, Z.G.1
  • 9
    • 0033598931 scopus 로고    scopus 로고
    • A role for PML and the nuclear body in genomic stability
    • Zhong, S. et al. A role for PML and the nuclear body in genomic stability. Oncogene 18, 7941-7947 (1999).
    • (1999) Oncogene , vol.18 , pp. 7941-7947
    • Zhong, S.1
  • 10
    • 0031791875 scopus 로고    scopus 로고
    • PML is essential for multiple apoptotic pathways
    • Wang, Z. G. et al. PML is essential for multiple apoptotic pathways. Nature Genet 20, 266-272 (1998).
    • (1998) Nature Genet , vol.20 , pp. 266-272
    • Wang, Z.G.1
  • 11
    • 0031794632 scopus 로고    scopus 로고
    • PML induces a novel caspase-independent death process
    • Quignon, F. et al. PML induces a novel caspase-independent death process. Nature Genet. 20, 259-265 (1998).
    • (1998) Nature Genet , vol.20 , pp. 259-265
    • Quignon, F.1
  • 12
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge, S. J. Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672 (1996).
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 13
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • Matsuoka, S., Huang, M. & Elledge, S. J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893-1897 (1998).
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 14
    • 0033616828 scopus 로고    scopus 로고
    • A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
    • Brown, A. L. et al. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc. Natl Acad. Sci. USA 96, 3745-3750 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3745-3750
    • Brown, A.L.1
  • 15
    • 0034629072 scopus 로고    scopus 로고
    • DNA damage-induced activation of p53 by the checkpoint kinase Chk2
    • Hirao, A. et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287, 1824-1827 (2000).
    • (2000) Science , vol.287 , pp. 1824-1827
    • Hirao, A.1
  • 16
    • 0034142325 scopus 로고    scopus 로고
    • Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
    • Chehab, N. H., Malikzay, A., Appel, M. & Halazonetis, T. D. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 14, 278-288 (2000).
    • (2000) Genes Dev , vol.14 , pp. 278-288
    • Chehab, N.H.1    Malikzay, A.2    Appel, M.3    Halazonetis, T.D.4
  • 17
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • erratum in Genes Dev, 14, 750 (2000)
    • Shieh, S. Y., Ahn, J., Tamai, K., Taya, Y. & Prives, C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289-300 (2000); erratum in Genes Dev, 14, 750 (2000).
    • (2000) Genes Dev , vol.14 , pp. 289-300
    • Shieh, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 18
    • 0033563010 scopus 로고    scopus 로고
    • Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis
    • Ruiter, G. A., Zerp, S. F., Bartelink, H., van Blitterswijk, W. J. & Verheij, M. Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis. Cancer Res. 59, 2457-2463 (1999).
    • (1999) Cancer Res , vol.59 , pp. 2457-2463
    • Ruiter, G.A.1    Zerp, S.F.2    Bartelink, H.3    Van Blitterswijk, W.J.4    Verheij, M.5
  • 19
    • 0030812174 scopus 로고    scopus 로고
    • Apoptosis in small intestinal epithelial from p53-null mice: Evidence for a delayed, p53-independent G2/M-associated cell death after γ-irradiation
    • Merritt, A. J., Allen, T. D., Potten, C. S. & Hickman, J. A. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after γ-irradiation. Oncogene 14, 2759-2766 (1997).
    • (1997) Oncogene , vol.14 , pp. 2759-2766
    • Merritt, A.J.1    Allen, T.D.2    Potten, C.S.3    Hickman, J.A.4
  • 20
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells through p53-independent mechanisms inhibitable by Bcl-2
    • Strasser, A., Harris, A. W., Jacks, T. & Cory, S. DNA damage can induce apoptosis in proliferating lymphoid cells through p53-independent mechanisms inhibitable by Bcl-2. Cell 79, 329-339 (1994).
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4
  • 21
    • 0029144891 scopus 로고
    • An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
    • Tamura, T. et al. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376, 596-599 (1995).
    • (1995) Nature , vol.376 , pp. 596-599
    • Tamura, T.1
  • 23
    • 0034624718 scopus 로고    scopus 로고
    • Hcds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
    • Lee, J. S., Collins, K. M., Brown, A. L., Lee, C. H. & Chung, J. H. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-204 (2000).
    • (2000) Nature , vol.404 , pp. 201-204
    • Lee, J.S.1    Collins, K.M.2    Brown, A.L.3    Lee, C.H.4    Chung, J.H.5
  • 24
    • 0026578112 scopus 로고
    • Alternative splicing of PML transcripts predicts co-expression of several carboxy-terminally different protein isoforms
    • Fagioli, M. et al. Alternative splicing of PML transcripts predicts co-expression of several carboxy-terminally different protein isoforms. Oncogene 7, 1083-1091 (1992).
    • (1992) Oncogene , vol.7 , pp. 1083-1091
    • Fagioli, M.1
  • 25
    • 0029803774 scopus 로고    scopus 로고
    • Interferon augments PML and PML/RAR α expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line
    • Nason-Burchenal, K. et al. Interferon augments PML and PML/RAR α expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. Blood 88, 3926-3936 (1996).
    • (1996) Blood , vol.88 , pp. 3926-3936
    • Nason-Burchenal, K.1
  • 26
    • 0032522962 scopus 로고    scopus 로고
    • Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML-and PLZF-RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia
    • Guidez, F. et al. Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML-and PLZF-RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. Blood 91, 2634-2642 (1998).
    • (1998) Blood , vol.91 , pp. 2634-2642
    • Guidez, F.1
  • 27
    • 0035855627 scopus 로고    scopus 로고
    • Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
    • Bartkova, J. et al. Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours. Oncogene 20, 5897-5902 (2001).
    • (2001) Oncogene , vol.20 , pp. 5897-5902
    • Bartkova, J.1
  • 28
    • 0035393594 scopus 로고    scopus 로고
    • DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
    • Lukas, C. et al. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res. 61, 4990-4993 (2001).
    • (2001) Cancer Res , vol.61 , pp. 4990-4993
    • Lukas, C.1
  • 29
    • 0035848819 scopus 로고    scopus 로고
    • The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    • Falck, J., Mailand, N., Syljuasen, R. G., Bartek, J. & Lukas, J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847 (2001).
    • (2001) Nature , vol.410 , pp. 842-847
    • Falck, J.1    Mailand, N.2    Syljuasen, R.G.3    Bartek, J.4    Lukas, J.5
  • 30
    • 0035951809 scopus 로고    scopus 로고
    • Characterization of tumor-associated Chk2 mutations
    • Wu, X., Webster, S. R. & Chen, J. Characterization of tumor-associated Chk2 mutations. J. Biol. Chem. 276, 2971-2974 (2000).
    • (2000) J. Biol. Chem , vol.276 , pp. 2971-2974
    • Wu, X.1    Webster, S.R.2    Chen, J.3
  • 31
    • 0035930536 scopus 로고    scopus 로고
    • Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks
    • Ward, I. M., Wu, X. & Chen, J. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J. Biol. Chem. 276, 47755-47758 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 47755-47758
    • Ward, I.M.1    Wu, X.2    Chen, J.3
  • 32
    • 0026747613 scopus 로고
    • Frequent mutations in the p53 gene in human myeloid leukemia cell lines
    • Sugimoto, K. et al. Frequent mutations in the p53 gene in human myeloid leukemia cell lines. Blood 79, 2378-2383 (1992).
    • (1992) Blood , vol.79 , pp. 2378-2383
    • Sugimoto, K.1
  • 33
    • 0001606206 scopus 로고
    • Major deletions in the gene encoding the p53 tumour antigen cause lack of p53 expression in HL-60 cells
    • Wolf, D. & Rotter, V. Major deletions in the gene encoding the p53 tumour antigen cause lack of p53 expression in HL-60 cells. Proc. Natl Acad. Sci. USA 82, 790-794 (1985).
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 790-794
    • Wolf, D.1    Rotter, V.2
  • 34
    • 0037023726 scopus 로고    scopus 로고
    • Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP
    • Gotoh, T., Oyadomari, S., Mori, K. & Mori, M. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J. Biol. Chem. 277, 12343-12350 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 12343-12350
    • Gotoh, T.1    Oyadomari, S.2    Mori, K.3    Mori, M.4
  • 35
    • 0035886009 scopus 로고    scopus 로고
    • TNFα enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide through ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation
    • Guidarelli, A., Clementi, E., De Nadai, C., Bersacchi, R. & Cantoni, O. TNFα enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide through ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation. Exp. Cell Res. 270, 56-65 (2001).
    • (2001) Exp. Cell Res , vol.270 , pp. 56-65
    • Guidarelli, A.1    Clementi, E.2    De Nadai, C.3    Bersacchi, R.4    Cantoni, O.5
  • 36
    • 0027055037 scopus 로고
    • Potentiation of topoisomerase I and II inhibitors cell killing by tumour necrosis factor: Relationship to DNA strand breakage formation
    • Orengo, G. et al. Potentiation of topoisomerase I and II inhibitors cell killing by tumour necrosis factor: relationship to DNA strand breakage formation. Jpn J. Cancer Res. 83, 1132-1136 (1992).
    • (1992) Jpn. J. Cancer Res , vol.83 , pp. 1132-1136
    • Orengo, G.1
  • 37
    • 0034695883 scopus 로고    scopus 로고
    • Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis
    • Zhong, S. et al. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. 191, 631-640 (2000).
    • (2000) J. Exp. Med , vol.191 , pp. 631-640
    • Zhong, S.1
  • 38
    • 0033601346 scopus 로고    scopus 로고
    • Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
    • Bell, D. W. et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286, 2528-2531 (1999).
    • (1999) Science , vol.286 , pp. 2528-2531
    • Bell, D.W.1
  • 39
    • 0034306019 scopus 로고    scopus 로고
    • The function of PML in p53-dependent apoptosis
    • Guo, A. et al. The function of PML in p53-dependent apoptosis. Nature Cell Biol. 2, 730-736 (2000).
    • (2000) Nature Cell Biol , vol.2 , pp. 730-736
    • Guo, A.1
  • 40
    • 0034520085 scopus 로고    scopus 로고
    • Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function
    • Cogswell, J. P., Brown, C. E., Bisi, J. E. & Neill, S. D. Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function. Cell Growth Differ 11, 615-623 (2000).
    • (2000) Cell Growth Differ , vol.11 , pp. 615-623
    • Cogswell, J.P.1    Brown, C.E.2    Bisi, J.E.3    Neill, S.D.4


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