-
1
-
-
0025875679
-
The PML-RAR α fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
-
de The, H. et al. The PML-RAR α fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66, 675-684 (1991).
-
(1991)
Cell
, vol.66
, pp. 675-684
-
-
De The, H.1
-
2
-
-
0026326963
-
Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia
-
Goddard, A. D., Borrow, J., Freemont, P. S. & Solomon, E. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 254, 1371-1374 (1991).
-
(1991)
Science
, vol.254
, pp. 1371-1374
-
-
Goddard, A.D.1
Borrow, J.2
Freemont, P.S.3
Solomon, E.4
-
3
-
-
0025780876
-
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR α with a novel putative transcription factor, PML
-
Kakizuka, A. et al. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR α with a novel putative transcription factor, PML. Cell 66, 663-674 (1991).
-
(1991)
Cell
, vol.66
, pp. 663-674
-
-
Kakizuka, A.1
-
4
-
-
0028095410
-
PML, a growth suppressor disrupted in acute promyelocytic leukemia
-
Mu, Z. M., Chin, K. V., Liu, J. H., Lozano, G. & Chang, K. S. PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol. Cell. Biol. 14, 6858-6867 (1994).
-
(1994)
Mol. Cell Biol
, vol.14
, pp. 6858-6867
-
-
Mu, Z.M.1
Chin, K.V.2
Liu, J.H.3
Lozano, G.4
Chang, K.S.5
-
5
-
-
0031418659
-
Stable overexpression of PML alters regulation of cell cycle progression in HeLa cells
-
Mu, Z. M., Le, X. F., Vallian, S., Glassman, A. B. & Chang, K. S. Stable overexpression of PML alters regulation of cell cycle progression in HeLa cells. Carcinogenesis 18, 2063-2069 (1997).
-
(1997)
Carcinogenesis
, vol.18
, pp. 2063-2069
-
-
Mu, Z.M.1
Le, X.F.2
Vallian, S.3
Glassman, A.B.4
Chang, K.S.5
-
6
-
-
0032499256
-
Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis
-
Le, X. F., Vallian, S., Mu, Z. M., Hung, M. C. & Chang, K. S. Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis. Oncogene 16, 1839-1849 (1998).
-
(1998)
Oncogene
, vol.16
, pp. 1839-1849
-
-
Le, X.F.1
Vallian, S.2
Mu, Z.M.3
Hung, M.C.4
Chang, K.S.5
-
7
-
-
0031006321
-
Adenovirus-mediated expression of PML suppresses growth and tumorigenicity of prostate cancer cells
-
He, D. et al. Adenovirus-mediated expression of PML suppresses growth and tumorigenicity of prostate cancer cells. Cancer Res. 57, 1868-1872 (1997).
-
(1997)
Cancer Res
, vol.57
, pp. 1868-1872
-
-
He, D.1
-
8
-
-
0000237552
-
Role of PML in cell growth and the retinoic acid pathway
-
Wang, Z. G. et al. Role of PML in cell growth and the retinoic acid pathway. Science 279, 1547-1551 (1998).
-
(1998)
Science
, vol.279
, pp. 1547-1551
-
-
Wang, Z.G.1
-
9
-
-
0033598931
-
A role for PML and the nuclear body in genomic stability
-
Zhong, S. et al. A role for PML and the nuclear body in genomic stability. Oncogene 18, 7941-7947 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 7941-7947
-
-
Zhong, S.1
-
10
-
-
0031791875
-
PML is essential for multiple apoptotic pathways
-
Wang, Z. G. et al. PML is essential for multiple apoptotic pathways. Nature Genet 20, 266-272 (1998).
-
(1998)
Nature Genet
, vol.20
, pp. 266-272
-
-
Wang, Z.G.1
-
11
-
-
0031794632
-
PML induces a novel caspase-independent death process
-
Quignon, F. et al. PML induces a novel caspase-independent death process. Nature Genet. 20, 259-265 (1998).
-
(1998)
Nature Genet
, vol.20
, pp. 259-265
-
-
Quignon, F.1
-
12
-
-
0029808466
-
Cell cycle checkpoints: Preventing an identity crisis
-
Elledge, S. J. Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672 (1996).
-
(1996)
Science
, vol.274
, pp. 1664-1672
-
-
Elledge, S.J.1
-
13
-
-
0032484084
-
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
-
Matsuoka, S., Huang, M. & Elledge, S. J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893-1897 (1998).
-
(1998)
Science
, vol.282
, pp. 1893-1897
-
-
Matsuoka, S.1
Huang, M.2
Elledge, S.J.3
-
14
-
-
0033616828
-
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
-
Brown, A. L. et al. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc. Natl Acad. Sci. USA 96, 3745-3750 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3745-3750
-
-
Brown, A.L.1
-
15
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao, A. et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287, 1824-1827 (2000).
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
-
16
-
-
0034142325
-
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
-
Chehab, N. H., Malikzay, A., Appel, M. & Halazonetis, T. D. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 14, 278-288 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
17
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
-
erratum in Genes Dev, 14, 750 (2000)
-
Shieh, S. Y., Ahn, J., Tamai, K., Taya, Y. & Prives, C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289-300 (2000); erratum in Genes Dev, 14, 750 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 289-300
-
-
Shieh, S.Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
18
-
-
0033563010
-
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis
-
Ruiter, G. A., Zerp, S. F., Bartelink, H., van Blitterswijk, W. J. & Verheij, M. Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis. Cancer Res. 59, 2457-2463 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 2457-2463
-
-
Ruiter, G.A.1
Zerp, S.F.2
Bartelink, H.3
Van Blitterswijk, W.J.4
Verheij, M.5
-
19
-
-
0030812174
-
Apoptosis in small intestinal epithelial from p53-null mice: Evidence for a delayed, p53-independent G2/M-associated cell death after γ-irradiation
-
Merritt, A. J., Allen, T. D., Potten, C. S. & Hickman, J. A. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after γ-irradiation. Oncogene 14, 2759-2766 (1997).
-
(1997)
Oncogene
, vol.14
, pp. 2759-2766
-
-
Merritt, A.J.1
Allen, T.D.2
Potten, C.S.3
Hickman, J.A.4
-
20
-
-
0028072523
-
DNA damage can induce apoptosis in proliferating lymphoid cells through p53-independent mechanisms inhibitable by Bcl-2
-
Strasser, A., Harris, A. W., Jacks, T. & Cory, S. DNA damage can induce apoptosis in proliferating lymphoid cells through p53-independent mechanisms inhibitable by Bcl-2. Cell 79, 329-339 (1994).
-
(1994)
Cell
, vol.79
, pp. 329-339
-
-
Strasser, A.1
Harris, A.W.2
Jacks, T.3
Cory, S.4
-
21
-
-
0029144891
-
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
-
Tamura, T. et al. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376, 596-599 (1995).
-
(1995)
Nature
, vol.376
, pp. 596-599
-
-
Tamura, T.1
-
22
-
-
0035656415
-
CHK2 kinase - A busy messenger
-
Bartek, J., Falck, J. & Lukas, J. CHK2 kinase - a busy messenger. Nature Rev. Mol. Cell Biol. 2, 877-886 (2001).
-
(2001)
Nature Rev. Mol. Cell Biol
, vol.2
, pp. 877-886
-
-
Bartek, J.1
Falck, J.2
Lukas, J.3
-
23
-
-
0034624718
-
Hcds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
-
Lee, J. S., Collins, K. M., Brown, A. L., Lee, C. H. & Chung, J. H. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-204 (2000).
-
(2000)
Nature
, vol.404
, pp. 201-204
-
-
Lee, J.S.1
Collins, K.M.2
Brown, A.L.3
Lee, C.H.4
Chung, J.H.5
-
24
-
-
0026578112
-
Alternative splicing of PML transcripts predicts co-expression of several carboxy-terminally different protein isoforms
-
Fagioli, M. et al. Alternative splicing of PML transcripts predicts co-expression of several carboxy-terminally different protein isoforms. Oncogene 7, 1083-1091 (1992).
-
(1992)
Oncogene
, vol.7
, pp. 1083-1091
-
-
Fagioli, M.1
-
25
-
-
0029803774
-
Interferon augments PML and PML/RAR α expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line
-
Nason-Burchenal, K. et al. Interferon augments PML and PML/RAR α expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. Blood 88, 3926-3936 (1996).
-
(1996)
Blood
, vol.88
, pp. 3926-3936
-
-
Nason-Burchenal, K.1
-
26
-
-
0032522962
-
Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML-and PLZF-RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia
-
Guidez, F. et al. Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML-and PLZF-RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. Blood 91, 2634-2642 (1998).
-
(1998)
Blood
, vol.91
, pp. 2634-2642
-
-
Guidez, F.1
-
27
-
-
0035855627
-
Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
-
Bartkova, J. et al. Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours. Oncogene 20, 5897-5902 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 5897-5902
-
-
Bartkova, J.1
-
28
-
-
0035393594
-
DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
-
Lukas, C. et al. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Res. 61, 4990-4993 (2001).
-
(2001)
Cancer Res
, vol.61
, pp. 4990-4993
-
-
Lukas, C.1
-
29
-
-
0035848819
-
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
-
Falck, J., Mailand, N., Syljuasen, R. G., Bartek, J. & Lukas, J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410, 842-847 (2001).
-
(2001)
Nature
, vol.410
, pp. 842-847
-
-
Falck, J.1
Mailand, N.2
Syljuasen, R.G.3
Bartek, J.4
Lukas, J.5
-
30
-
-
0035951809
-
Characterization of tumor-associated Chk2 mutations
-
Wu, X., Webster, S. R. & Chen, J. Characterization of tumor-associated Chk2 mutations. J. Biol. Chem. 276, 2971-2974 (2000).
-
(2000)
J. Biol. Chem
, vol.276
, pp. 2971-2974
-
-
Wu, X.1
Webster, S.R.2
Chen, J.3
-
31
-
-
0035930536
-
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks
-
Ward, I. M., Wu, X. & Chen, J. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J. Biol. Chem. 276, 47755-47758 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 47755-47758
-
-
Ward, I.M.1
Wu, X.2
Chen, J.3
-
32
-
-
0026747613
-
Frequent mutations in the p53 gene in human myeloid leukemia cell lines
-
Sugimoto, K. et al. Frequent mutations in the p53 gene in human myeloid leukemia cell lines. Blood 79, 2378-2383 (1992).
-
(1992)
Blood
, vol.79
, pp. 2378-2383
-
-
Sugimoto, K.1
-
33
-
-
0001606206
-
Major deletions in the gene encoding the p53 tumour antigen cause lack of p53 expression in HL-60 cells
-
Wolf, D. & Rotter, V. Major deletions in the gene encoding the p53 tumour antigen cause lack of p53 expression in HL-60 cells. Proc. Natl Acad. Sci. USA 82, 790-794 (1985).
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 790-794
-
-
Wolf, D.1
Rotter, V.2
-
34
-
-
0037023726
-
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP
-
Gotoh, T., Oyadomari, S., Mori, K. & Mori, M. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J. Biol. Chem. 277, 12343-12350 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 12343-12350
-
-
Gotoh, T.1
Oyadomari, S.2
Mori, K.3
Mori, M.4
-
35
-
-
0035886009
-
TNFα enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide through ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation
-
Guidarelli, A., Clementi, E., De Nadai, C., Bersacchi, R. & Cantoni, O. TNFα enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide through ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation. Exp. Cell Res. 270, 56-65 (2001).
-
(2001)
Exp. Cell Res
, vol.270
, pp. 56-65
-
-
Guidarelli, A.1
Clementi, E.2
De Nadai, C.3
Bersacchi, R.4
Cantoni, O.5
-
36
-
-
0027055037
-
Potentiation of topoisomerase I and II inhibitors cell killing by tumour necrosis factor: Relationship to DNA strand breakage formation
-
Orengo, G. et al. Potentiation of topoisomerase I and II inhibitors cell killing by tumour necrosis factor: relationship to DNA strand breakage formation. Jpn J. Cancer Res. 83, 1132-1136 (1992).
-
(1992)
Jpn. J. Cancer Res
, vol.83
, pp. 1132-1136
-
-
Orengo, G.1
-
37
-
-
0034695883
-
Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis
-
Zhong, S. et al. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. 191, 631-640 (2000).
-
(2000)
J. Exp. Med
, vol.191
, pp. 631-640
-
-
Zhong, S.1
-
38
-
-
0033601346
-
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
-
Bell, D. W. et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286, 2528-2531 (1999).
-
(1999)
Science
, vol.286
, pp. 2528-2531
-
-
Bell, D.W.1
-
39
-
-
0034306019
-
The function of PML in p53-dependent apoptosis
-
Guo, A. et al. The function of PML in p53-dependent apoptosis. Nature Cell Biol. 2, 730-736 (2000).
-
(2000)
Nature Cell Biol
, vol.2
, pp. 730-736
-
-
Guo, A.1
-
40
-
-
0034520085
-
Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function
-
Cogswell, J. P., Brown, C. E., Bisi, J. E. & Neill, S. D. Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function. Cell Growth Differ 11, 615-623 (2000).
-
(2000)
Cell Growth Differ
, vol.11
, pp. 615-623
-
-
Cogswell, J.P.1
Brown, C.E.2
Bisi, J.E.3
Neill, S.D.4
|