Pml is essential for multiple apoptotic pathways

Nature Genetics

Volumn 20, Issue 3, 1998, Pages 266-272

  Wang, Zhu Gang ^a   Ruggero, Davide ^a   Ronchetti, Simona ^a   Zhong, Sue ^a   Gaboli, Mirella ^a   Rivi, Roberta ^a   Pandolfi, Pier Paolo ^a  

^a Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CASPASE; CASPASE 3; CERAMIDE; CONCANAVALIN A; FAS ANTIGEN; INTERLEUKIN 1BETA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE ISOLATION; INTRAPERITONEAL DRUG ADMINISTRATION; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CASPASES; CERAMIDES; DNA DAMAGE; ENZYME ACTIVATION; FEMALE; INTERFERONS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MALE; MICE; MICE, KNOCKOUT; NEOPLASM PROTEINS; NUCLEAR PROTEINS; ONCOGENE PROTEINS, FUSION; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEINS;

EID: 0031791875     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/3073     Document Type: Article

References (41)

1. Pandolfi, P.P. et al. Structure and origin of the acute promyelocytic leukaemia myl/RARα cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene 6, 1285-1292 (1991).
2. de The, H. et al. The PML/RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukaemia encodes a functionally altered RAR. Cell 66, 675-684 (1991).
3. Kakizuka, A. et al. Chromosomal translocation t(15;17) in human acute promyelocytic leukaemia fuses RARα with a novel putative transcription factor, PML Cell 66, 663-674 (1991).
4. Goddard, A.D., Borrow, J., Freemont, I. & Solomon, E. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 254, 1371-1374 (1991).
5. Kalantry, S. et al. Gene rearrangements in the molecular pathogenesis of acute promyelocytic leukemia. J. Cell. Phys. 173, 288-296 (1997).
6. Kastner, P. et al. Structure, localization and transcriptional properties of two classes of retinoic acid receptor a fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J. 11, 629-642 (1992).
7. Perez, A. et al. PML/RAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR. EMBO J. 12, 3171-3182 (1993).
8. Freemont, P.S., Hanson, I.M. & Trowsdale, J. A novel cysteine-rich sequence motif. Cell 64, 483-484 (1991).
9. Borden, K.L. & Freemont, P.S. The RING finger domain: a recent example of a sequence-structure family. Curr. Opin. Struct. Biol. 6, 395-401 (1996).
10. Borden, K.L. et al. The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML EMBO J. 14, 1532-1541 (1995).
11. Lamond, A.I. & Earnshaw, W.C. Structure and function in the nucleus. Science 280, 547-553 (1998).
12. Hodges, M., Tissot, C., Howe, K., Grimwade, D. & Freemont, P.S. Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies. Am. J. Hum. Genet. 63, 297-304 (1998).
13. Stadler, M. et al. Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and GAS element. Oncogene 11, 2565-2573 (1995).
14. Lavau, C. et al. The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene 11, 871-876 (1995).
15. Nason-Burchenal, K. et al. Interferon augments PML and PML/RARα expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid resistant promyelocytic cell line. Blood 88, 3926-3936 (1996).
16. Wang, Z.G. et al. Role of PML in cell growth and the retinoic acid pathway. Science 279, 1547-1551 (1998).
17. Koken, M.H.M. et al. The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J. 13, 1073-1083 (1994).
18. Dyck, J. et al. A novel macromolecular structure is a target of the promyelocyteretinoic acid receptor oncoprotein. Cell 76, 333-343 (1994).
19. Weis, K. et al. Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemic cells. Cell 76, 345-356 (1994).
20. Grignani, F. et al. The acute promyelocytic leukaemia specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74, 423-431 (1993).
21. Strasser, A., Harris, A.W., Jacks, T. & Cory, S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 79, 329-339 (1994).
22. Reap, E.A. et al. Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions. Proc. Natl Acad. Sci. USA 94, 5750-5755 (1997).
23. Nagata, S. Apoptosis by death factors. Cell 88, 355-365 (1997).
24. Enari, M., Hug, H. & Nagata, S. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375, 78-81 (1995).
25. Ogasawara, J. et al. Lethal effect of the anti-Fas antibody in mice. Nature 364, 805-809 (1993).
26. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A. & Nagata, S. Lymphoproliferative disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317 (1992).
27. Enari, M., Talanian, R.V., Wong, W.W. & Nagata, S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380, 723-726 (1996).
28. Tamura T. et al. An IRF-1 dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376, 596-599 (1995).
29. Kolesnick, R.N. & Krönke, M. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60, 643-665 (1998).
30. Smyth, M.J. et al. prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem. J. 316, 25-28 (1996).
31. Chinnaiyan A.M. et al. FADD/MORT1 is a common mediator of CD95 (Fas/Apo-1) and tumor necrosis factor receptor induced apoptosis. J. Biol. Chem. 271, 4961-4965 (1996).
32. Selleri, C. et al. Interferon-γ and tumor necrosis factor-α suppress both early and late stages of hematopoiesis and induce programmed cell death. J. Cell. Phys. 165, 538-546 (1995).
33. + human marrow cells is induced by interferon-γ and tumor necrosis factor-α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood 85, 3183-3190 (1995).
34. He, L.Z. et al. Acute leukemia with promyelocytic features in PML-RARα transgenic mice. Proc. Natl Acad. Sci. USA 94, 5302-5307 (1997).
35. He, L.Z. et al. Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL. Nature Genet. 18, 126-135 (1998).
36. Quignon, F. et al. PML induces a caspase-independent death associated with BAX recruitment to nuclear bodies. Nature Genet. 20, 259-265 (1998).
37. Penninger, J.M. & Kroemer, G. Molecular and cellular mechanisms of T lymphocyte apoptosis. Adv. Immunol. 68, 51-144 (1998).
38. Lenardo, M.J. The molecular regulation of lymphocyte apoptosis. Semin. Immunol. 9, 1-5 (1997).
39. Hong, S.H. et al. SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia. Proc. Natl Acad. Sci. USA 94, 9038-9033 (1997).
40. Grignani, F. et al. Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia. Nature 391, 815-818 (1998).
41. Lin, R.J. et al. Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391, 811-814 (1998).