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Volumn 364, Issue 1517, 2009, Pages 653-665

Non-homologous end joining in class switch recombination: The beginning of the end

Author keywords

Alternative NHEJ; Class switch recombination; Microhomology; Non homologous end joining

Indexed keywords

ENZYME ACTIVITY; HOMOLOGY; PROTEIN; RECOMBINATION;

EID: 60049083261     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2008.0196     Document Type: Conference Paper
Times cited : (47)

References (113)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • doi:10.1101/gad.914401
    • Abraham, R. T. 2001 Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15, 2177-2196. (doi:10.1101/gad.914401)
    • (2001) Genes Dev , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 2
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • doi:10.1074/jbc.M404524200
    • Audebert, M., Salles, B. & Calsou, P. 2004 Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J. Biol. Chem. 279, 55 117-55 126. (doi:10.1074/jbc.M404524200)
    • (2004) J. Biol. Chem , vol.279
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 3
    • 15844426692 scopus 로고    scopus 로고
    • Atm-deficient mice: A paradigm of ataxia telangiectasia
    • doi:10.1016/S0092-8674(00) 80086-0
    • Barlow, C. et al. 1996 Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86, 159-171. (doi:10.1016/S0092-8674(00) 80086-0)
    • (1996) Cell , vol.86 , pp. 159-171
    • Barlow, C.1
  • 4
    • 0034177416 scopus 로고    scopus 로고
    • The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity
    • doi:10.1093/nar/28.7.1506
    • Beamish, H. J., Jessberger, R., Riballo, E., Priestley, A., Blunt, T., Kysela, B. & Jeggo, P. A. 2000 The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity. Nucleic Acids Res. 28, 1506-1513. (doi:10.1093/nar/28.7.1506)
    • (2000) Nucleic Acids Res , vol.28 , pp. 1506-1513
    • Beamish, H.J.1    Jessberger, R.2    Riballo, E.3    Priestley, A.4    Blunt, T.5    Kysela, B.6    Jeggo, P.A.7
  • 5
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • doi:10.1038/ncb1599
    • Berkovich, E., Monnat Jr, R. J. & Kastan, M. B. 2007 Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 9, 683-690. (doi:10.1038/ncb1599)
    • (2007) Nat. Cell Biol , vol.9 , pp. 683-690
    • Berkovich, E.1    Monnat Jr, R.J.2    Kastan, M.B.3
  • 6
    • 0029788520 scopus 로고    scopus 로고
    • Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse
    • doi:10.1073/pnas.93.19.10285
    • Blunt, T., Gell, D., Fox, M., Taccioli, G. E., Lehmann, A. R., Jackson, S. P. & Jeggo, P. A. 1996 Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc. Natl Acad. Sci. USA 93, 10 285-10 290. (doi:10.1073/pnas.93.19.10285)
    • (1996) Proc. Natl Acad. Sci. USA , vol.93
    • Blunt, T.1    Gell, D.2    Fox, M.3    Taccioli, G.E.4    Lehmann, A.R.5    Jackson, S.P.6    Jeggo, P.A.7
  • 7
    • 0037011116 scopus 로고    scopus 로고
    • DNA-dependent protein kinase activity is not required for immunoglobulin class switching
    • doi:10.1084/jem.20001871
    • Bosma, G. C., Kim, J., Urich, T., Fath, D. M., Cotticelli, M. G., Ruetsch, N. R., Radic, M. Z. & Bosma, M. J. 2002 DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J. Exp. Med. 196, 1483-1495. (doi:10.1084/jem.20001871)
    • (2002) J. Exp. Med , vol.196 , pp. 1483-1495
    • Bosma, G.C.1    Kim, J.2    Urich, T.3    Fath, D.M.4    Cotticelli, M.G.5    Ruetsch, N.R.6    Radic, M.Z.7    Bosma, M.J.8
  • 8
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown, E. J. & Baltimore, D. 2000 ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14, 397-402.
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 9
    • 33645532464 scopus 로고    scopus 로고
    • Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
    • doi:10.1093/nar/gkl108
    • Bryant, H. E. & Helleday, T. 2006 Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res. 34, 1685-1691. (doi:10.1093/nar/gkl108)
    • (2006) Nucleic Acids Res , vol.34 , pp. 1685-1691
    • Bryant, H.E.1    Helleday, T.2
  • 10
    • 30944455282 scopus 로고    scopus 로고
    • Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV
    • doi:10.1002/eji.200535401
    • Buck, D. et al. 2006 Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur. J. Immunol. 36, 224-235. (doi:10.1002/eji.200535401)
    • (2006) Eur. J. Immunol , vol.36 , pp. 224-235
    • Buck, D.1
  • 11
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • doi:10.1074/jbc.C100466200
    • Burma, S., Chen, B. P., Murphy, M., Kurimasa, A. & Chen, D. J. 2001 ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276, 42 462-42 467. (doi:10.1074/jbc.C100466200)
    • (2001) J. Biol. Chem , vol.276
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 12
    • 0032522564 scopus 로고    scopus 로고
    • Ku80 is required for immunoglobulin isotype switching
    • doi:10.1093/emboj/17.8. 2404
    • Casellas, R. et al. 1998 Ku80 is required for immunoglobulin isotype switching. EMBO J. 17, 2404-2411. (doi:10.1093/emboj/17.8. 2404)
    • (1998) EMBO J , vol.17 , pp. 2404-2411
    • Casellas, R.1
  • 13
    • 0037012845 scopus 로고    scopus 로고
    • Genomic instability in mice lacking histone H2AX
    • doi:10.1126/science.1069398
    • Celeste, A. et al. 2002 Genomic instability in mice lacking histone H2AX. Science 296, 922-927. (doi:10.1126/science.1069398)
    • (2002) Science , vol.296 , pp. 922-927
    • Celeste, A.1
  • 14
    • 3142765336 scopus 로고    scopus 로고
    • Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair
    • doi:10.1038/nri1395
    • Chaudhuri, J. & Alt, F. W. 2004 Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat. Rev. Immunol. 4, 541-552. (doi:10.1038/nri1395)
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 541-552
    • Chaudhuri, J.1    Alt, F.W.2
  • 15
    • 3242876404 scopus 로고    scopus 로고
    • Ataxia-telangiectasia, an evolving phenotype
    • doi:10.1016/j.dnarep.2004.04. 010
    • Chun, H. H. & Gatti, R. A. 2004 Ataxia-telangiectasia, an evolving phenotype. DNA Repair 3, 1187-1196. (doi:10.1016/j.dnarep.2004.04. 010)
    • (2004) DNA Repair , vol.3 , pp. 1187-1196
    • Chun, H.H.1    Gatti, R.A.2
  • 16
    • 47749141560 scopus 로고    scopus 로고
    • ATR: An essential regulator of genome integrity
    • doi:10.1038/nrm2450
    • Cimprich, K. A. & Cortez, D. 2008 ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 9, 616-627. (doi:10.1038/nrm2450)
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 17
    • 0345735841 scopus 로고    scopus 로고
    • Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions
    • Cook, A. J., Oganesian, L., Harumal, P., Basten, A., Brink, R. & Jolly, C. J. 2003 Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. J. Immunol. 171, 6556-6564.
    • (2003) J. Immunol , vol.171 , pp. 6556-6564
    • Cook, A.J.1    Oganesian, L.2    Harumal, P.3    Basten, A.4    Brink, R.5    Jolly, C.J.6
  • 18
    • 34848843525 scopus 로고    scopus 로고
    • Rag mutations reveal robust alternative end joining
    • doi:10.1038/nature06168
    • Corneo, B. et al. 2007 Rag mutations reveal robust alternative end joining. Nature 449, 483-486. (doi:10.1038/nature06168)
    • (2007) Nature , vol.449 , pp. 483-486
    • Corneo, B.1
  • 19
    • 0036276388 scopus 로고    scopus 로고
    • The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling
    • doi:10.1038/nrm805
    • D'Amours, D. & Jackson, S. P. 2002 The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 3, 317-327. (doi:10.1038/nrm805)
    • (2002) Nat. Rev. Mol. Cell Biol , vol.3 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 20
    • 0029791450 scopus 로고    scopus 로고
    • Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes
    • Danska, J. S., Holland, D. P., Mariathasan, S., Williams, K. M. & Guidos, C. J. 1996 Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol. Cell Biol. 16, 5507-5517.
    • (1996) Mol. Cell Biol , vol.16 , pp. 5507-5517
    • Danska, J.S.1    Holland, D.P.2    Mariathasan, S.3    Williams, K.M.4    Guidos, C.J.5
  • 21
    • 0037124373 scopus 로고    scopus 로고
    • Synapsis of DNA ends by DNA-dependent protein kinase
    • doi:10.1093/emboj/cdf299
    • DeFazio, L. G., Stansel, R. M., Griffith, J. D. & Chu, G. 2002 Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J. 21, 3192-3200. (doi:10.1093/emboj/cdf299)
    • (2002) EMBO J , vol.21 , pp. 3192-3200
    • DeFazio, L.G.1    Stansel, R.M.2    Griffith, J.D.3    Chu, G.4
  • 22
    • 5744246254 scopus 로고    scopus 로고
    • MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder
    • doi:10.1093/hmg/ddh221
    • Delia, D., Piane, M., Buscemi, G., Savio, C., Palmeri, S., Lulli, P., Carlessi, L., Fontanella, E. & Chessa, L. 2004 MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder. Hum. Mol. Genet. 13, 2155-2163. (doi:10.1093/hmg/ddh221)
    • (2004) Hum. Mol. Genet , vol.13 , pp. 2155-2163
    • Delia, D.1    Piane, M.2    Buscemi, G.3    Savio, C.4    Palmeri, S.5    Lulli, P.6    Carlessi, L.7    Fontanella, E.8    Chessa, L.9
  • 23
    • 0037136318 scopus 로고    scopus 로고
    • Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification
    • doi:10.1084/jem. 20020851
    • Difilippantonio, M. J., Petersen, S., Chen, H. T., Johnson, R., Jasin, M., Kanaar, R., Ried, T. & Nussenzweig, A. 2002 Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J. Exp. Med. 196, 469-480. (doi:10.1084/jem. 20020851)
    • (2002) J. Exp. Med , vol.196 , pp. 469-480
    • Difilippantonio, M.J.1    Petersen, S.2    Chen, H.T.3    Johnson, R.4    Jasin, M.5    Kanaar, R.6    Ried, T.7    Nussenzweig, A.8
  • 24
    • 3242892589 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome: Clinical manifestation of defective response to DNA double-strand breaks
    • doi:10.1016/j.dnarep.2004.03.004
    • Digweed, M. & Sperling, K. 2004 Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair 3, 1207-1217. (doi:10.1016/j.dnarep.2004.03.004)
    • (2004) DNA Repair , vol.3 , pp. 1207-1217
    • Digweed, M.1    Sperling, K.2
  • 25
    • 0036902410 scopus 로고    scopus 로고
    • 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
    • doi:10.1038/ncb892
    • DiTullio Jr, R. A., Mochan, T. A., Venere, M., Bartkova, J., Sehested, M., Bartek, J. & Halazonetis, T. D. 2002 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat. Cell Biol. 4, 998-1002. (doi:10.1038/ncb892)
    • (2002) Nat. Cell Biol , vol.4 , pp. 998-1002
    • DiTullio Jr, R.A.1    Mochan, T.A.2    Venere, M.3    Bartkova, J.4    Sehested, M.5    Bartek, J.6    Halazonetis, T.D.7
  • 26
    • 49649117140 scopus 로고    scopus 로고
    • A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation
    • doi:10.1371/journal.pone.0002482
    • Du, L. et al. 2008 A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation. PLoS ONE 3, e2482. (doi:10.1371/journal.pone.0002482)
    • (2008) PLoS ONE , vol.3
    • Du, L.1
  • 27
    • 0035807955 scopus 로고    scopus 로고
    • Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination
    • doi:10.1073/pnas.241525998
    • Ehrenstein, M. R., Rada, C., Jones, A. M., Milstein, C. & Neuberger, M. S. 2001 Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination. Proc. Natl Acad. Sci. USA 98, 14 553-14 558. (doi:10.1073/pnas.241525998)
    • (2001) Proc. Natl Acad. Sci. USA , vol.98
    • Ehrenstein, M.R.1    Rada, C.2    Jones, A.M.3    Milstein, C.4    Neuberger, M.S.5
  • 29
    • 33645785057 scopus 로고    scopus 로고
    • A severe form of human combined immunodeficiency due to mutations in DNA ligase IV
    • Enders, A. et al. 2006 A severe form of human combined immunodeficiency due to mutations in DNA ligase IV. J. Immunol. 176, 5060-5068.
    • (2006) J. Immunol , vol.176 , pp. 5060-5068
    • Enders, A.1
  • 30
    • 0036903037 scopus 로고    scopus 로고
    • DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
    • doi:10.1038/ncb884
    • Fernandez-Capetillo, O. et al. 2002 DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol. 4, 993-997. (doi:10.1038/ncb884)
    • (2002) Nat. Cell Biol , vol.4 , pp. 993-997
    • Fernandez-Capetillo, O.1
  • 31
    • 12744273401 scopus 로고    scopus 로고
    • Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder
    • doi:10.1093/hmg/ddi027
    • Fernet, M., Gribaa, M., Salih, M. A., Seidahmed, M. Z., Hall, J. & Koenig, M. 2005 Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder. Hum. Mol. Genet. 14, 307-318. (doi:10.1093/hmg/ddi027)
    • (2005) Hum. Mol. Genet , vol.14 , pp. 307-318
    • Fernet, M.1    Gribaa, M.2    Salih, M.A.3    Seidahmed, M.Z.4    Hall, J.5    Koenig, M.6
  • 32
    • 30744445418 scopus 로고    scopus 로고
    • H2AX prevents DNA breaks from progressing to chromosome breaks and translocations
    • doi:10.1016/j.molcel.2006.01.005
    • Franco, S. et al. 2006 H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol. Cell 21, 201-214. (doi:10.1016/j.molcel.2006.01.005)
    • (2006) Mol. Cell , vol.21 , pp. 201-214
    • Franco, S.1
  • 33
    • 41149099048 scopus 로고    scopus 로고
    • DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination
    • doi:10.1084/jem.20080044
    • Franco, S., Murphy, M. M., Li, G., Borjeson, T., Boboila, C. & Alt, F. W. 2008 DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J. Exp. Med. 205, 557-564. (doi:10.1084/jem.20080044)
    • (2008) J. Exp. Med , vol.205 , pp. 557-564
    • Franco, S.1    Murphy, M.M.2    Li, G.3    Borjeson, T.4    Boboila, C.5    Alt, F.W.6
  • 35
    • 0036404927 scopus 로고    scopus 로고
    • Heterogeneity of humoral immune abnormalities in children with Nijmegen breakage syndrome: An 8-year follow-up study in a single centre
    • doi:10.1046/j.1365-2249.2002. 01971.x
    • Gregorek, H., Chrzanowska, K. H., Michalkiewicz, J., Syczewska, M. & Madalinski, K. 2002 Heterogeneity of humoral immune abnormalities in children with Nijmegen breakage syndrome: an 8-year follow-up study in a single centre. Clin. Exp. Immunol. 130, 319-324. (doi:10.1046/j.1365-2249.2002. 01971.x)
    • (2002) Clin. Exp. Immunol , vol.130 , pp. 319-324
    • Gregorek, H.1    Chrzanowska, K.H.2    Michalkiewicz, J.3    Syczewska, M.4    Madalinski, K.5
  • 36
    • 0031433517 scopus 로고    scopus 로고
    • Growth retardation and leaky SCID phenotype of Ku70-deficient mice
    • doi:10.1016/S1074- 7613(00)80386-6
    • Gu, Y. et al. 1997 Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 7, 653-665. (doi:10.1016/S1074- 7613(00)80386-6)
    • (1997) Immunity , vol.7 , pp. 653-665
    • Gu, Y.1
  • 37
    • 0033603240 scopus 로고    scopus 로고
    • Sir-Ku-itous routes to make ends meet
    • doi:10.1016/S0092-8674(00)80795-3
    • Haber, J. E. 1999 Sir-Ku-itous routes to make ends meet. Cell 97, 829-832. (doi:10.1016/S0092-8674(00)80795-3)
    • (1999) Cell , vol.97 , pp. 829-832
    • Haber, J.E.1
  • 38
    • 25444471892 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
    • Helleday, T., Bryant, H. E. & Schultz, N. 2005 Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. Cell Cycle 4, 1176-1178.
    • (2005) Cell Cycle , vol.4 , pp. 1176-1178
    • Helleday, T.1    Bryant, H.E.2    Schultz, N.3
  • 39
    • 9744271049 scopus 로고    scopus 로고
    • Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
    • doi:10.1158/0008-5472.CAN-04-2727
    • Hickson, I. et al. 2004 Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64, 9152-9159. (doi:10.1158/0008-5472.CAN-04-2727)
    • (2004) Cancer Res , vol.64 , pp. 9152-9159
    • Hickson, I.1
  • 40
    • 0028212789 scopus 로고
    • Molecular analysis of IgA deficiency. Evidence for impaired switching to IgA
    • Islam, K. B., Baskin, B., Nilsson, L., Hammarström, L., Sideras, P. & Smith, C. I. 1994 Molecular analysis of IgA deficiency. Evidence for impaired switching to IgA. J. Immunol. 152, 1442-1452.
    • (1994) J. Immunol , vol.152 , pp. 1442-1452
    • Islam, K.B.1    Baskin, B.2    Nilsson, L.3    Hammarström, L.4    Sideras, P.5    Smith, C.I.6
  • 41
    • 0028242909 scopus 로고
    • Two cellular proteins that bind to wild-type but not mutant p53
    • doi:10.1073/pnas.91.13.6098
    • Iwabuchi, K., Bartel, P. L., Li, B., Marraccino, R. & Fields, S. 1994 Two cellular proteins that bind to wild-type but not mutant p53. Proc. Natl Acad. Sci. USA 91, 6098-6102. (doi:10.1073/pnas.91.13.6098)
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 6098-6102
    • Iwabuchi, K.1    Bartel, P.L.2    Li, B.3    Marraccino, R.4    Fields, S.5
  • 42
    • 33847276659 scopus 로고    scopus 로고
    • The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination
    • doi:10.1073/pnas.0611359104
    • Kiefer, K., Oshinsky, J., Kim, J., Nakajima, P. B., Bosma, G. C. & Bosma, M. J. 2007 The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc. Natl Acad. Sci. USA 104, 2843-2848. (doi:10.1073/pnas.0611359104)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 2843-2848
    • Kiefer, K.1    Oshinsky, J.2    Kim, J.3    Nakajima, P.B.4    Bosma, G.C.5    Bosma, M.J.6
  • 43
    • 13444281917 scopus 로고    scopus 로고
    • Nibrin functions in Ig class-switch recombination
    • doi:10.1073/pnas.0409191102
    • Kracker, S. et al. 2005 Nibrin functions in Ig class-switch recombination. Proc. Natl Acad. Sci. USA 102, 1584-1589. (doi:10.1073/pnas.0409191102)
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1584-1589
    • Kracker, S.1
  • 44
    • 47249106520 scopus 로고    scopus 로고
    • Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing
    • doi:10.1021/bi702325t
    • Kusumoto, R., Dawut, L., Marchetti, C., Wan Lee, J., Vindigni, A., Ramsden, D. & Bohr, V. A. 2008 Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing. Biochemistry 47, 7548-7556. (doi:10.1021/bi702325t)
    • (2008) Biochemistry , vol.47 , pp. 7548-7556
    • Kusumoto, R.1    Dawut, L.2    Marchetti, C.3    Wan Lee, J.4    Vindigni, A.5    Ramsden, D.6    Bohr, V.A.7
  • 45
    • 1942437416 scopus 로고    scopus 로고
    • Delineation of the role of the Mre11 complex in class switch recombination
    • doi:10.1074/jbc.M312796200
    • Lahdesmaki, A., Taylor, A. M., Chrzanowska, K. H. & Pan-Hammarstrom, Q. 2004 Delineation of the role of the Mre11 complex in class switch recombination. J. Biol. Chem. 279, 16 479-16 487. (doi:10.1074/jbc.M312796200)
    • (2004) J. Biol. Chem , vol.279
    • Lahdesmaki, A.1    Taylor, A.M.2    Chrzanowska, K.H.3    Pan-Hammarstrom, Q.4
  • 46
    • 36949013395 scopus 로고    scopus 로고
    • ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks
    • doi:10.1038/sj.onc.1210880
    • Lavin, M. F. 2007 ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Oncogene 26, 7749-7758. (doi:10.1038/sj.onc.1210880)
    • (2007) Oncogene , vol.26 , pp. 7749-7758
    • Lavin, M.F.1
  • 47
    • 34247483506 scopus 로고    scopus 로고
    • ATM activation and DNA damage response
    • Lavin, M. F. & Kozlov, S. 2007 ATM activation and DNA damage response. Cell Cycle 6, 931-942.
    • (2007) Cell Cycle , vol.6 , pp. 931-942
    • Lavin, M.F.1    Kozlov, S.2
  • 48
    • 0002799923 scopus 로고    scopus 로고
    • Ataxia-telangiectasia
    • eds H. D. Ochs, C. I. E. Smith & J. M. Puck, pp, New York, NY: Oxford University Press
    • Lavin, M. & Shiloh, Y. 1999 Ataxia-telangiectasia. In Primary immunodeficiency diseases (eds H. D. Ochs, C. I. E. Smith & J. M. Puck), pp. 306-323. New York, NY: Oxford University Press.
    • (1999) Primary immunodeficiency diseases , pp. 306-323
    • Lavin, M.1    Shiloh, Y.2
  • 49
    • 0034665971 scopus 로고    scopus 로고
    • Functional interaction between Ku and theWerner syndrome protein in DNA end processing
    • Li, B. & Comai, L. 2000 Functional interaction between Ku and theWerner syndrome protein in DNA end processing. J. Biol. Chem. 275, 39 800.
    • (2000) J. Biol. Chem , vol.275 , pp. 39-800
    • Li, B.1    Comai, L.2
  • 50
    • 45549094090 scopus 로고    scopus 로고
    • Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks
    • doi:10.1093/nar/gkn184
    • Liang, L., Deng, L., Nguyen, S. C., Zhao, X., Maulion, C. D., Shao, C. & Tischfield, J. A. 2008 Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks. Nucleic Acids Res. 36, 3297-3310. (doi:10.1093/nar/gkn184)
    • (2008) Nucleic Acids Res , vol.36 , pp. 3297-3310
    • Liang, L.1    Deng, L.2    Nguyen, S.C.3    Zhao, X.4    Maulion, C.D.5    Shao, C.6    Tischfield, J.A.7
  • 51
    • 0032904693 scopus 로고    scopus 로고
    • The biochemistry and biological significance of nonhomologous DNA end joining: An essential repair process in multicellular eukaryotes
    • doi:10.1046/j.1365-2443.1999. 00245.x
    • Lieber, M. R. 1999 The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes. Genes Cells 4, 77-85. (doi:10.1046/j.1365-2443.1999. 00245.x)
    • (1999) Genes Cells , vol.4 , pp. 77-85
    • Lieber, M.R.1
  • 52
    • 38049115657 scopus 로고    scopus 로고
    • The mechanism of human nonhomologous DNA end joining
    • doi:10.1074/jbc.R700039200
    • Lieber, M. R. 2008 The mechanism of human nonhomologous DNA end joining. J. Biol. Chem. 283, 1-5. (doi:10.1074/jbc.R700039200)
    • (2008) J. Biol. Chem , vol.283 , pp. 1-5
    • Lieber, M.R.1
  • 53
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human non-homologous DNA end-joining
    • doi:10.1038/nrm1202
    • Lieber, M. R., Ma, Y., Pannicke, U. & Schwarz, K. 2003 Mechanism and regulation of human non-homologous DNA end-joining. Nat. Rev. Mol. Cell Biol. 4, 712-720. (doi:10.1038/nrm1202)
    • (2003) Nat. Rev. Mol. Cell Biol , vol.4 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 54
    • 0037468232 scopus 로고    scopus 로고
    • MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
    • doi:10.1038/nature01447
    • Lou, Z., Minter-Dykhouse, K., Wu, X. & Chen, J. 2003 MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421, 957-961. (doi:10.1038/nature01447)
    • (2003) Nature , vol.421 , pp. 957-961
    • Lou, Z.1    Minter-Dykhouse, K.2    Wu, X.3    Chen, J.4
  • 55
    • 30744465308 scopus 로고    scopus 로고
    • MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
    • doi:10.1016/j.molcel.2005.11.025
    • Lou, Z. et al. 2006 MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol. Cell 21, 187-200. (doi:10.1016/j.molcel.2005.11.025)
    • (2006) Mol. Cell , vol.21 , pp. 187-200
    • Lou, Z.1
  • 56
    • 8644242383 scopus 로고    scopus 로고
    • Immunoglobulin class switch recombination is impaired in Atm-deficient mice
    • doi:10.1084/jem.20041074
    • Lumsden, J. M. et al. 2004 Immunoglobulin class switch recombination is impaired in Atm-deficient mice. J. Exp. Med. 200, 1111-1121. (doi:10.1084/jem.20041074)
    • (2004) J. Exp. Med , vol.200 , pp. 1111-1121
    • Lumsden, J.M.1
  • 57
    • 0033594904 scopus 로고    scopus 로고
    • Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
    • doi:10.1073/pnas.96.13.7376
    • Luo, G., Yao, M. S., Bender, C. F., Mills, M., Bladl, A. R., Bradley, A. & Petrini, J. H. 1999 Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc. Natl Acad. Sci. USA 96, 7376-7381. (doi:10.1073/pnas.96.13.7376)
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 7376-7381
    • Luo, G.1    Yao, M.S.2    Bender, C.F.3    Mills, M.4    Bladl, A.R.5    Bradley, A.6    Petrini, J.H.7
  • 58
    • 0032526290 scopus 로고    scopus 로고
    • Ku70 is required for late B cell development and immunoglobulin heavy chain class switching
    • doi:10.1084/jem.187.12.2081
    • Manis, J. P., Gu, Y., Lansford, R., Sonoda, E., Ferrini, R., Davidson, L., Rajewsky, K. & Alt, F. W. 1998 Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J. Exp. Med. 187, 2081-2089. (doi:10.1084/jem.187.12.2081)
    • (1998) J. Exp. Med , vol.187 , pp. 2081-2089
    • Manis, J.P.1    Gu, Y.2    Lansford, R.3    Sonoda, E.4    Ferrini, R.5    Davidson, L.6    Rajewsky, K.7    Alt, F.W.8
  • 59
    • 0036224604 scopus 로고    scopus 로고
    • IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells
    • doi:10.1016/S1074-7613(02)00306-0
    • Manis, J. P., Dudley, D., Kaylor, L. & Alt, F. W. 2002 IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 16, 607-617. (doi:10.1016/S1074-7613(02)00306-0)
    • (2002) Immunity , vol.16 , pp. 607-617
    • Manis, J.P.1    Dudley, D.2    Kaylor, L.3    Alt, F.W.4
  • 60
    • 2442707746 scopus 로고    scopus 로고
    • 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
    • doi:10.1038/ni1067
    • Manis, J. P., Morales, J. C., Xia, Z., Kutok, J. L., Alt, F. W. & Carpenter, P. B. 2004 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat. Immunol. 5, 481-487. (doi:10.1038/ni1067)
    • (2004) Nat. Immunol , vol.5 , pp. 481-487
    • Manis, J.P.1    Morales, J.C.2    Xia, Z.3    Kutok, J.L.4    Alt, F.W.5    Carpenter, P.B.6
  • 61
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • doi:10.1126/science.1140321
    • Matsuoka, S. et al. 2007 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166. (doi:10.1126/science.1140321)
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1
  • 62
    • 0025674706 scopus 로고
    • Sequences of human immunoglobulin switch regions: Implications for recombination and transcription
    • doi:10.1093/nar/18.24.7305
    • Mills, F. C., Brooker, J. S. & Camerini-Otero, R. D. 1990 Sequences of human immunoglobulin switch regions: implications for recombination and transcription. Nucleic Acids Res. 18, 7305-7316. (doi:10.1093/nar/18.24.7305)
    • (1990) Nucleic Acids Res , vol.18 , pp. 7305-7316
    • Mills, F.C.1    Brooker, J.S.2    Camerini-Otero, R.D.3
  • 63
    • 3242884087 scopus 로고    scopus 로고
    • 53BP1, an activator of ATM in response to DNA damage
    • doi:10.1016/j.dnarep.2004.03.017
    • Mochan, T. A., Venere, M., DiTullio Jr, R. A. & Halazonetis, T. D. 2004 53BP1, an activator of ATM in response to DNA damage. DNA Repair 3, 945-952. (doi:10.1016/j.dnarep.2004.03.017)
    • (2004) DNA Repair , vol.3 , pp. 945-952
    • Mochan, T.A.1    Venere, M.2    DiTullio Jr, R.A.3    Halazonetis, T.D.4
  • 64
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • doi:10.1016/S0092-8674(00)00078-7
    • Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y. & Honjo, T. 2000 Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102, 553-563. (doi:10.1016/S0092-8674(00)00078-7)
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 65
    • 35348821296 scopus 로고    scopus 로고
    • A backup DNA repair pathway moves to the forefront
    • doi:10.1016/j.cell. 2007.10.005
    • Nussenzweig, A. & Nussenzweig, M. C. 2007 A backup DNA repair pathway moves to the forefront. Cell 131, 223-225. (doi:10.1016/j.cell. 2007.10.005)
    • (2007) Cell , vol.131 , pp. 223-225
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 67
    • 18244362081 scopus 로고    scopus 로고
    • DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency
    • doi:10.1016/S1097-2765(01)00408-7
    • O'Driscoll, M. et al. 2001 DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol. Cell 8, 1175-1185. (doi:10.1016/S1097-2765(01)00408-7)
    • (2001) Mol. Cell , vol.8 , pp. 1175-1185
    • O'Driscoll, M.1
  • 68
    • 0345073699 scopus 로고    scopus 로고
    • A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
    • doi:10.1038/ng1129
    • O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A. & Goodship, J. A. 2003 A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33, 497-501. (doi:10.1038/ng1129)
    • (2003) Nat. Genet , vol.33 , pp. 497-501
    • O'Driscoll, M.1    Ruiz-Perez, V.L.2    Woods, C.G.3    Jeggo, P.A.4    Goodship, J.A.5
  • 69
    • 0035666864 scopus 로고    scopus 로고
    • Pan, Q., Petit-Frere, C., Dai, S., Huang, P., Morton, H. C., Brandtzaeg, P. & Hammarstrom, L. 2001 Regulation of switching and production of IgA in human B cells in donors with duplicated alpha1 genes. Eur. J. Immunol. 31, 3622-3630. (doi:10.1002/1521-4141(200112)31:12〈3622::AID- IMMU3622〉3.0.CO;2-H)
    • Pan, Q., Petit-Frere, C., Dai, S., Huang, P., Morton, H. C., Brandtzaeg, P. & Hammarstrom, L. 2001 Regulation of switching and production of IgA in human B cells in donors with duplicated alpha1 genes. Eur. J. Immunol. 31, 3622-3630. (doi:10.1002/1521-4141(200112)31:12〈3622::AID- IMMU3622〉3.0.CO;2-H)
  • 70
    • 0036105322 scopus 로고    scopus 로고
    • Pan, Q., Petit-Frere, C., Lahdesmaki, A., Gregorek, H., Chrzanowska, K. H. & Hammarstrom, L. 2002 Alternative end joining during switch recombination in patients with ataxia-telangiectasia. Eur. J. Immunol. 32, 1300-1308. (doi:10.1002/1521-4141(200205)32:5〈1300::AID- IMMU1300〉3.0.CO;2-L)
    • Pan, Q., Petit-Frere, C., Lahdesmaki, A., Gregorek, H., Chrzanowska, K. H. & Hammarstrom, L. 2002 Alternative end joining during switch recombination in patients with ataxia-telangiectasia. Eur. J. Immunol. 32, 1300-1308. (doi:10.1002/1521-4141(200205)32:5〈1300::AID- IMMU1300〉3.0.CO;2-L)
  • 71
    • 42249109412 scopus 로고    scopus 로고
    • Antibody deficiency diseases
    • doi:10.1002/eji. 200737927
    • Pan-Hammarstrom, Q. & Hammarstrom, L. 2008 Antibody deficiency diseases. Eur. J. Immunol. 38, 327-333. (doi:10.1002/eji. 200737927)
    • (2008) Eur. J. Immunol , vol.38 , pp. 327-333
    • Pan-Hammarstrom, Q.1    Hammarstrom, L.2
  • 72
    • 13244268505 scopus 로고    scopus 로고
    • Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells
    • doi:10.1084/jem.20040772
    • Pan-Hammarstrom, Q., Jones, A. M., Lahdesmaki, A., Zhou, W., Gatti, R. A., Hammarstrom, L., Gennery, A. R. & Ehrenstein, M. R. 2005 Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells. J. Exp. Med. 201, 189-194. (doi:10.1084/jem.20040772)
    • (2005) J. Exp. Med , vol.201 , pp. 189-194
    • Pan-Hammarstrom, Q.1    Jones, A.M.2    Lahdesmaki, A.3    Zhou, W.4    Gatti, R.A.5    Hammarstrom, L.6    Gennery, A.R.7    Ehrenstein, M.R.8
  • 73
    • 31344465936 scopus 로고    scopus 로고
    • Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
    • doi:10.1084/jem.20050595
    • Pan-Hammarstrom, Q. et al. 2006 Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation. J. Exp. Med. 203, 99-110. (doi:10.1084/jem.20050595)
    • (2006) J. Exp. Med , vol.203 , pp. 99-110
    • Pan-Hammarstrom, Q.1
  • 74
    • 33947327732 scopus 로고    scopus 로고
    • Class switch recombination: A comparison between mouse and human
    • doi:10.1016/S0065-2776(06)93001-6
    • Pan-Hammarstrom, Q., Zhao, Y. & Hammarstrom, L. 2007 Class switch recombination: a comparison between mouse and human. Adv. Immunol. 93, 1-61. (doi:10.1016/S0065-2776(06)93001-6)
    • (2007) Adv. Immunol , vol.93 , pp. 1-61
    • Pan-Hammarstrom, Q.1    Zhao, Y.2    Hammarstrom, L.3
  • 75
    • 0034612307 scopus 로고    scopus 로고
    • A mechanistic basis for Mre11-directed DNA joining at microhomologies
    • doi:10.1073/pnas.110144297
    • Paull, T. T. & Gellert, M. 2000 A mechanistic basis for Mre11-directed DNA joining at microhomologies. Proc. Natl Acad. Sci. USA 97, 6409-6414. (doi:10.1073/pnas.110144297)
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 6409-6414
    • Paull, T.T.1    Gellert, M.2
  • 76
    • 34249058024 scopus 로고    scopus 로고
    • A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair
    • doi:10.1084/jem.20070087
    • Peron, S. et al. 2007 A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair. J. Exp. Med. 204, 1207-1216. (doi:10.1084/jem.20070087)
    • (2007) J. Exp. Med , vol.204 , pp. 1207-1216
    • Peron, S.1
  • 77
    • 0035818990 scopus 로고    scopus 로고
    • AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching
    • doi:10.1038/414660a
    • Petersen, S. et al. 2001 AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature 414, 660-665. (doi:10.1038/414660a)
    • (2001) Nature , vol.414 , pp. 660-665
    • Petersen, S.1
  • 78
    • 0037866984 scopus 로고    scopus 로고
    • H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation
    • doi:10.1084/jem.20030569
    • Reina-San-Martin, B., Difilippantonio, S., Hanitsch, L., Masilamani, R. F., Nussenzweig, A. & Nussenzweig, M. C. 2003 H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J. Exp. Med. 197, 1767-1778. (doi:10.1084/jem.20030569)
    • (2003) J. Exp. Med , vol.197 , pp. 1767-1778
    • Reina-San-Martin, B.1    Difilippantonio, S.2    Hanitsch, L.3    Masilamani, R.F.4    Nussenzweig, A.5    Nussenzweig, M.C.6
  • 79
    • 8644238314 scopus 로고    scopus 로고
    • ATM is required for efficient recombination between immunoglobulin switch regions
    • doi:10.1084/jem. 20041162
    • Reina-San-Martin, B., Chen, H. T., Nussenzweig, A. & Nussenzweig, M. C. 2004 ATM is required for efficient recombination between immunoglobulin switch regions. J. Exp. Med. 200, 1103-1110. (doi:10.1084/jem. 20041162)
    • (2004) J. Exp. Med , vol.200 , pp. 1103-1110
    • Reina-San-Martin, B.1    Chen, H.T.2    Nussenzweig, A.3    Nussenzweig, M.C.4
  • 80
    • 13444309097 scopus 로고    scopus 로고
    • Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1
    • doi:10.1073/pnas.0406289102
    • Reina-San-Martin, B., Nussenzweig, M. C., Nussenzweig, A. & Difilippantonio, S. 2005 Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc. Natl Acad. Sci. USA 102, 1590-1595. (doi:10.1073/pnas.0406289102)
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1590-1595
    • Reina-San-Martin, B.1    Nussenzweig, M.C.2    Nussenzweig, A.3    Difilippantonio, S.4
  • 82
    • 0034264851 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
    • doi:10.1016/S0092-8674(00)00079-9
    • Revy, P. et al. 2000 Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell 102, 565-575. (doi:10.1016/S0092-8674(00)00079-9)
    • (2000) Cell , vol.102 , pp. 565-575
    • Revy, P.1
  • 83
    • 9744220428 scopus 로고    scopus 로고
    • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
    • doi:10.1016/j.molcel.2004.10.029
    • Riballo, E. et al. 2004 A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol. Cell 16, 715-724. (doi:10.1016/j.molcel.2004.10.029)
    • (2004) Mol. Cell , vol.16 , pp. 715-724
    • Riballo, E.1
  • 84
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • doi:10.1083/jcb.146.5.905
    • Rogakou, E. P., Boon, C., Redon, C. & Bonner, W. M. 1999 Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146, 905-916. (doi:10.1083/jcb.146.5.905)
    • (1999) J. Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 85
    • 0030273141 scopus 로고    scopus 로고
    • The SCID but not the RAG-2 gene product is required for Sm-Se heavy chain class switching
    • doi:10.1016/S1074-7613(00)80258-7
    • Rolink, A., Melchers, F. & Andersson, J. 1996 The SCID but not the RAG-2 gene product is required for Sm-Se heavy chain class switching. Immunity 5, 319-330. (doi:10.1016/S1074-7613(00)80258-7)
    • (1996) Immunity , vol.5 , pp. 319-330
    • Rolink, A.1    Melchers, F.2    Andersson, J.3
  • 86
    • 14044253569 scopus 로고    scopus 로고
    • Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development
    • doi:10.1073/pnas.0409857102
    • Rooney, S., Alt, F. W., Sekiguchi, J. & Manis, J. P. 2005 Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proc. Natl Acad. Sci. USA 102, 2471-2475. (doi:10.1073/pnas.0409857102)
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 2471-2475
    • Rooney, S.1    Alt, F.W.2    Sekiguchi, J.3    Manis, J.P.4
  • 87
    • 51649128895 scopus 로고    scopus 로고
    • Up-regulation of WRN and DNA ligase IIIα in chronic myeloid leukemia: Consequences for the repair of DNA double strand breaks
    • doi:10.1182/blood-2007-07-104257
    • Sallmyr, A., Tomkinson, A. E. & Rassool, F. V. 2008 Up-regulation of WRN and DNA ligase IIIα in chronic myeloid leukemia: consequences for the repair of DNA double strand breaks. Blood 112, 1413-1423. (doi:10.1182/blood-2007-07-104257)
    • (2008) Blood , vol.112 , pp. 1413-1423
    • Sallmyr, A.1    Tomkinson, A.E.2    Rassool, F.V.3
  • 88
    • 0037017390 scopus 로고    scopus 로고
    • Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions
    • doi:10.1084/jem.20011877
    • Schrader, C. E., Vardo, J. & Stavnezer, J. 2002 Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J. Exp. Med. 195, 367-373. (doi:10.1084/jem.20011877)
    • (2002) J. Exp. Med , vol.195 , pp. 367-373
    • Schrader, C.E.1    Vardo, J.2    Stavnezer, J.3
  • 89
    • 36549008815 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair
    • Schrader, C. E., Guikema, J. E., Linehan, E. K., Selsing, E. & Stavnezer, J. 2007 Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. J. Immunol. 179, 6064-6071.
    • (2007) J. Immunol , vol.179 , pp. 6064-6071
    • Schrader, C.E.1    Guikema, J.E.2    Linehan, E.K.3    Selsing, E.4    Stavnezer, J.5
  • 90
    • 0034739853 scopus 로고    scopus 로고
    • p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
    • doi:10.1083/jcb.151.7.1381
    • Schultz, L. B., Chehab, N. H., Malikzay, A. & Halazonetis, T. D. 2000 p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell Biol. 151, 1381-1390. (doi:10.1083/jcb.151.7.1381)
    • (2000) J. Cell Biol , vol.151 , pp. 1381-1390
    • Schultz, L.B.1    Chehab, N.H.2    Malikzay, A.3    Halazonetis, T.D.4
  • 91
    • 34249850294 scopus 로고    scopus 로고
    • Role for Msh5 in the regulation of Ig class switch recombination
    • doi:10.1073/pnas.0700815104
    • Sekine, H. et al. 2007 Role for Msh5 in the regulation of Ig class switch recombination. Proc. Natl Acad. Sci. USA 104, 7193-7198. (doi:10.1073/pnas.0700815104)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 7193-7198
    • Sekine, H.1
  • 92
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • doi:10.1038/nrc1011
    • Shiloh, Y. 2003 ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168. (doi:10.1038/nrc1011)
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 93
    • 0027141893 scopus 로고
    • Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching
    • Shockett, P. & Stavnezer, J. 1993 Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching. J. Immunol. 151, 6962-6976.
    • (1993) J. Immunol , vol.151 , pp. 6962-6976
    • Shockett, P.1    Stavnezer, J.2
  • 95
    • 0030022218 scopus 로고    scopus 로고
    • Antibody class switching
    • doi:10.1016/S0065-2776(08)60866-4
    • Stavnezer, J. 1996 Antibody class switching. Adv. Immunol. 61, 79-146. (doi:10.1016/S0065-2776(08)60866-4)
    • (1996) Adv. Immunol , vol.61 , pp. 79-146
    • Stavnezer, J.1
  • 96
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • doi:10.1146/annurev.immunol.26.021607.090248
    • Stavnezer, J., Guikema, J. E. & Schrader, C. E. 2008 Mechanism and regulation of class switch recombination. Annu. Rev. Immunol. 26, 261-292. (doi:10.1146/annurev.immunol.26.021607.090248)
    • (2008) Annu. Rev. Immunol , vol.26 , pp. 261-292
    • Stavnezer, J.1    Guikema, J.E.2    Schrader, C.E.3
  • 97
    • 0033544724 scopus 로고    scopus 로고
    • The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
    • doi:10.1016/S0092-8674(00)81547-0
    • Stewart, G. S. et al. 1999 The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99, 577-587. (doi:10.1016/S0092-8674(00)81547-0)
    • (1999) Cell , vol.99 , pp. 577-587
    • Stewart, G.S.1
  • 98
    • 0037468192 scopus 로고    scopus 로고
    • MDC1 is a mediator of the mammalian DNA damage checkpoint
    • doi:10.1038/nature01446
    • Stewart, G. S., Wang, B., Bignell, C. R., Taylor, A. M. & Elledge, S. J. 2003 MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421, 961-966. (doi:10.1038/nature01446)
    • (2003) Nature , vol.421 , pp. 961-966
    • Stewart, G.S.1    Wang, B.2    Bignell, C.R.3    Taylor, A.M.4    Elledge, S.J.5
  • 99
    • 36749029369 scopus 로고    scopus 로고
    • RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling
    • doi:10.1073/pnas.0708408104
    • Stewart, G. S. et al. 2007 RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc. Natl Acad. Sci. USA 104, 16 910-16 915. (doi:10.1073/pnas.0708408104)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104
    • Stewart, G.S.1
  • 100
    • 33646106590 scopus 로고    scopus 로고
    • GammaH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
    • doi:10.1016/j.dnarep.2006.01.012
    • Stucki, M. & Jackson, S. P. 2006 GammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair 5, 534-543. (doi:10.1016/j.dnarep.2006.01.012)
    • (2006) DNA Repair , vol.5 , pp. 534-543
    • Stucki, M.1    Jackson, S.P.2
  • 101
    • 31044446450 scopus 로고    scopus 로고
    • A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation
    • doi:10.1172/JCI26121
    • van der Burg, M. et al. 2006 A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation. J. Clin. Invest. 116, 137-145. (doi:10.1172/JCI26121)
    • (2006) J. Clin. Invest , vol.116 , pp. 137-145
    • van der Burg, M.1
  • 102
    • 0032076190 scopus 로고    scopus 로고
    • Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
    • doi:10.1016/S0092-8674(00)81174-5
    • Varon, R. et al. 1998 Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93, 467-476. (doi:10.1016/S0092-8674(00)81174-5)
    • (1998) Cell , vol.93 , pp. 467-476
    • Varon, R.1
  • 103
    • 0037112212 scopus 로고    scopus 로고
    • 53BP1, a mediator of the DNA damage checkpoint
    • doi:10.1126/science.1076182
    • Wang, B., Matsuoka, S., Carpenter, P. B. & Elledge, S. J. 2002 53BP1, a mediator of the DNA damage checkpoint. Science 298, 1435-1438. (doi:10.1126/science.1076182)
    • (2002) Science , vol.298 , pp. 1435-1438
    • Wang, B.1    Matsuoka, S.2    Carpenter, P.B.3    Elledge, S.J.4
  • 104
    • 20144363082 scopus 로고    scopus 로고
    • DNA ligase III as a candidate component of backup pathways of nonhomologous end joining
    • doi:10.1158/0008-5472.CAN-04-3055
    • Wang, H., Rosidi, B., Perrault, R., Wang, M., Zhang, L., Windhofer, F. & Iliakis, G. 2005 DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res. 65, 4020-4030. (doi:10.1158/0008-5472.CAN-04-3055)
    • (2005) Cancer Res , vol.65 , pp. 4020-4030
    • Wang, H.1    Rosidi, B.2    Perrault, R.3    Wang, M.4    Zhang, L.5    Windhofer, F.6    Iliakis, G.7
  • 105
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • doi:10.1093/nar/gkl840
    • Wang, M., Wu, W., Wu, W., Rosidi, B., Zhang, L., Wang, H. & Iliakis, G. 2006 PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 34, 6170-6182. (doi:10.1093/nar/gkl840)
    • (2006) Nucleic Acids Res , vol.34 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Wu, W.3    Rosidi, B.4    Zhang, L.5    Wang, H.6    Iliakis, G.7
  • 106
    • 0037378527 scopus 로고    scopus 로고
    • p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
    • doi:10.1128/MCB.23.7.2556- 2563.2003
    • Ward, I. M., Minn, K., van Deursen, J. & Chen, J. 2003 p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol. Cell Biol. 23, 2556-2563. (doi:10.1128/MCB.23.7.2556- 2563.2003)
    • (2003) Mol. Cell Biol , vol.23 , pp. 2556-2563
    • Ward, I.M.1    Minn, K.2    van Deursen, J.3    Chen, J.4
  • 107
    • 2542463148 scopus 로고    scopus 로고
    • 53BP1 is required for class switch recombination
    • doi:10.1083/jcb. 200403021
    • Ward, I. M. et al. 2004 53BP1 is required for class switch recombination. J. Cell Biol. 165, 459-464. (doi:10.1083/jcb. 200403021)
    • (2004) J. Cell Biol , vol.165 , pp. 459-464
    • Ward, I.M.1
  • 108
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
    • doi:10.1093/nar/25.15.2985
    • Xiao, Y. & Weaver, D. T. 1997 Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 25, 2985-2991. (doi:10.1093/nar/25.15.2985)
    • (1997) Nucleic Acids Res , vol.25 , pp. 2985-2991
    • Xiao, Y.1    Weaver, D.T.2
  • 109
    • 37349096996 scopus 로고    scopus 로고
    • Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
    • doi:10.1016/j.molcel.2007.12.005
    • Xie, A. et al. 2007 Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol. Cell 28, 1045-1057. (doi:10.1016/j.molcel.2007.12.005)
    • (2007) Mol. Cell , vol.28 , pp. 1045-1057
    • Xie, A.1
  • 110
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • doi:10.1101/gad.10.19.2411
    • Xu, Y., Ashley, T., Brainerd, E. E., Bronson, R. T., Meyn, M. S. & Baltimore, D. 1996 Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10, 2411-2422. (doi:10.1101/gad.10.19.2411)
    • (1996) Genes Dev , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6
  • 111
    • 34748863465 scopus 로고    scopus 로고
    • IgH class switching and translocations use a robust non-classical end-joining pathway
    • doi:10.1038/nature06020
    • Yan, C. T. et al. 2007 IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 449, 478-482. (doi:10.1038/nature06020)
    • (2007) Nature , vol.449 , pp. 478-482
    • Yan, C.T.1
  • 112
    • 15844409553 scopus 로고    scopus 로고
    • Positional cloning of the Werner's syndrome gene
    • doi:10.1126/science.272.5259.258
    • Yu, C. E. et al. 1996 Positional cloning of the Werner's syndrome gene. Science 272, 258-262. (doi:10.1126/science.272.5259.258)
    • (1996) Science , vol.272 , pp. 258-262
    • Yu, C.E.1
  • 113
    • 0035936554 scopus 로고    scopus 로고
    • Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
    • doi:10.1016/S0960- 9822(01)00019-7
    • Zhu, J., Petersen, S., Tessarollo, L. & Nussenzweig, A. 2001 Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr. Biol. 11, 105-109. (doi:10.1016/S0960- 9822(01)00019-7)
    • (2001) Curr. Biol , vol.11 , pp. 105-109
    • Zhu, J.1    Petersen, S.2    Tessarollo, L.3    Nussenzweig, A.4


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