메뉴 건너뛰기




Volumn 34, Issue 6, 2006, Pages 1685-1691

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 1,8 NAPHTHALAMIDE; ATM PROTEIN; DNA DEPENDENT PROTEIN KINASE; KU 55933; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NU 7026; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; 1 NAPHTHYLAMINE; 4 AMINO 1,8 NAPHTHALIMIDE; 4-AMINO-1,8-NAPHTHALIMIDE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; DRUG DERIVATIVE; ENZYME INHIBITOR; NAPHTHALIMIDE DERIVATIVE; POLY(ADP RIBOSE)POLYMERASE 1, MOUSE; POLY(ADP-RIBOSE)POLYMERASE-1, MOUSE; PROTEIN SERINE THREONINE KINASE; QUINOLONE DERIVATIVE; TUMOR SUPPRESSOR PROTEIN;

EID: 33645532464     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl108     Document Type: Article
Times cited : (172)

References (55)
  • 1
    • 0028865245 scopus 로고
    • Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
    • Lindahl,T,, Satoh,M.S., Poirier,G.G. and Klungland,A. (1995) Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem. Sci., 20, 405-411.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 405-411
    • Lindahl, T.1    Satoh, M.S.2    Poirier, G.G.3    Klungland, A.4
  • 2
    • 0033198919 scopus 로고    scopus 로고
    • Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
    • D'Amours,D., Desnoyers,S., D'Silva,I. and Poirier,G.G. (1999) Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem. J., 342, 249-268.
    • (1999) Biochem. J. , vol.342 , pp. 249-268
    • D'Amours, D.1    Desnoyers, S.2    D'Silva, I.3    Poirier, G.G.4
  • 4
    • 0029957245 scopus 로고    scopus 로고
    • XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick- sensor' in vitro
    • Caldecott,K., Aoufouchi,S., Johnson,P. and Shall,S. (1996) XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick- sensor' in vitro. Nucleic Acids Res., 24, 4387-4394.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4387-4394
    • Caldecott, K.1    Aoufouchi, S.2    Johnson, P.3    Shall, S.4
  • 5
    • 0031844311 scopus 로고    scopus 로고
    • XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
    • Masson,M., Niedergang,C., Schreiber,V., Muller,S., Menissier-de Murcia,J. and de Murcia,G. (1998) XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol. Cell Biol., 18, 3563-3571.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 3563-3571
    • Masson, M.1    Niedergang, C.2    Schreiber, V.3    Muller, S.4    Menissier-de Murcia, J.5    de Murcia, G.6
  • 7
    • 0344875495 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
    • Schultz,N., Lopez,E., Saleh-Gohari,N. and Helleday,T. (2003) Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids. Res., 31, 4959-4964.
    • (2003) Nucleic Acids. Res. , vol.31 , pp. 4959-4964
    • Schultz, N.1    Lopez, E.2    Saleh-Gohari, N.3    Helleday, T.4
  • 8
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • Audebert,M., Salles,B. and Calsou,P. (2004) Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J. Biol. Chem., 279, 55117-55126.
    • (2004) J. Biol. Chem. , vol.279 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 9
    • 0035796476 scopus 로고    scopus 로고
    • Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice
    • Conde,C., Mark,M., Oliver,F.J., Huber,A., de Murcia,G. and Menissier-de Murcia,J. (2001) Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice. EMBO J., 20, 3535-3543.
    • (2001) EMBO J. , vol.20 , pp. 3535-3543
    • Conde, C.1    Mark, M.2    Oliver, F.J.3    Huber, A.4    de Murcia, G.5    Menissier-de Murcia, J.6
  • 10
    • 0025921994 scopus 로고
    • Effects of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in chinese hamster V79 Cells
    • Arundel-Suto,C.M., Scavone,S.V., Turner,W.R., Suto,M.J. and Sebolt-Leopold,J.S. (1991) Effects of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on X-ray-induced cellular recovery processes in chinese hamster V79 Cells. Radiation Res., 126, 367-371.
    • (1991) Radiation Res. , vol.126 , pp. 367-371
    • Arundel-Suto, C.M.1    Scavone, S.V.2    Turner, W.R.3    Suto, M.J.4    Sebolt-Leopold, J.S.5
  • 11
    • 0031762817 scopus 로고    scopus 로고
    • Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064
    • Bowman,K.J., White,A., Golding,B.T., Griffin,R.J. and Curtin,N.J. (1998) Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br. J. Cancer, 78, 1269-1277.
    • (1998) Br. J. Cancer , vol.78 , pp. 1269-1277
    • Bowman, K.J.1    White, A.2    Golding, B.T.3    Griffin, R.J.4    Curtin, N.J.5
  • 12
    • 0031474597 scopus 로고    scopus 로고
    • Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose) polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells
    • Weltin,D., Holl,V., Hyun,J.W., Dufour,P., Marchal,J. and Bischoff,P. (1997) Effect of 6(5H)-phenanthridinone, a poly (ADP-ribose) polymerase inhibitor, and ionizing radiation on the growth of cultured lymphoma cells. Int. J. Radiat. Biol., 72, 685-692.
    • (1997) Int. J. Radiat. Biol. , vol.72 , pp. 685-692
    • Weltin, D.1    Holl, V.2    Hyun, J.W.3    Dufour, P.4    Marchal, J.5    Bischoff, P.6
  • 13
    • 0035137364 scopus 로고    scopus 로고
    • Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro
    • Bowman,K.J., Newell,D.R., Calvert,A.H. and Curtin,N.J. (2001) Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro. Br. J. Cancer, 84, 106-112.
    • (2001) Br. J. Cancer , vol.84 , pp. 106-112
    • Bowman, K.J.1    Newell, D.R.2    Calvert, A.H.3    Curtin, N.J.4
  • 14
    • 0033941729 scopus 로고    scopus 로고
    • Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines
    • Delaney,C.A., Wang,L.Z., Kyle,S., White,A.W., Calvert,A.H., Curtin,N.J., Durkacz,B.W., Hostomsky,Z. and Newell,D.R. (2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin. Cancer Res., 6, 2860-2867.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2860-2867
    • Delaney, C.A.1    Wang, L.Z.2    Kyle, S.3    White, A.W.4    Calvert, A.H.5    Curtin, N.J.6    Durkacz, B.W.7    Hostomsky, Z.8    Newell, D.R.9
  • 15
    • 0036447366 scopus 로고    scopus 로고
    • Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors
    • Tentori,L., Portarena,I. and Graziani,G. (2002) Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors. Pharmacol. Res., 45, 73-85.
    • (2002) Pharmacol. Res. , vol.45 , pp. 73-85
    • Tentori, L.1    Portarena, I.2    Graziani, G.3
  • 16
    • 0028826231 scopus 로고
    • Potentiation of temozolomide-induced cytotoxicity: A comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors
    • Boulton,S., Pemberton,L.C., Porteous,J.K., Curtin,N.J., Griffin,R.J., Golding,B.T. and Durkacz,B.W. (1995) Potentiation of temozolomide-induced cytotoxicity: A comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors. Br. J. Cancer, 72, 849-856.
    • (1995) Br. J. Cancer , vol.72 , pp. 849-856
    • Boulton, S.1    Pemberton, L.C.2    Porteous, J.K.3    Curtin, N.J.4    Griffin, R.J.5    Golding, B.T.6    Durkacz, B.W.7
  • 17
    • 31044446360 scopus 로고    scopus 로고
    • PARP inhibitors for cancer therapy
    • Curtin,N.J. (2005) PARP inhibitors for cancer therapy. Expert Rev. Mol. Med., 7, 1-20.
    • (2005) Expert Rev. Mol. Med. , vol.7 , pp. 1-20
    • Curtin, N.J.1
  • 22
    • 0032928476 scopus 로고    scopus 로고
    • 4-Amino-1,8-naphthalimide: A novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer
    • Schlicker,A., Peschke,P., Burkle,A., Hahn,E.W. and Kim,J.H. (1999) 4-Amino-1,8-naphthalimide: A novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int. J. Radiat. Biol., 75, 91-100.
    • (1999) Int. J. Radiat. Biol. , vol.75 , pp. 91-100
    • Schlicker, A.1    Peschke, P.2    Burkle, A.3    Hahn, E.W.4    Kim, J.H.5
  • 24
    • 6044261241 scopus 로고    scopus 로고
    • Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair
    • Veuger,S.J., Curtin,N.J., Smith,G.C. and Durkacz,B.W. (2004) Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair. Oncogene, 23, 7322-7329.
    • (2004) Oncogene , vol.23 , pp. 7322-7329
    • Veuger, S.J.1    Curtin, N.J.2    Smith, G.C.3    Durkacz, B.W.4
  • 25
    • 0028922462 scopus 로고
    • Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
    • Wang,Z.-Q., Auer,B., Stingl,L., Berghammer,H., Haidacher,D., Schweiger,M. and Wagner,E.F. (1995) Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev., 9, 509-520.
    • (1995) Genes Dev. , vol.9 , pp. 509-520
    • Wang, Z.-Q.1    Auer, B.2    Stingl, L.3    Berghammer, H.4    Haidacher, D.5    Schweiger, M.6    Wagner, E.F.7
  • 27
    • 0035131124 scopus 로고    scopus 로고
    • Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development
    • Menisser-de Murcia,J., Mark,M., Wendling,O., Wynshaw-Boris,A. and de Murcia,G. (2001) Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development. Mol. Cell Biol., 21, 1828-1832.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 1828-1832
    • Menisser-de Murcia, J.1    Mark, M.2    Wendling, O.3    Wynshaw-Boris, A.4    de Murcia, G.5
  • 29
    • 0030679762 scopus 로고    scopus 로고
    • Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
    • Morrison,C., Smith,G.C., Stingl,L., Jackson,S.P., Wagner,E.F. and Wang,Z.Q. (1997) Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nature Genet., 17, 479-482.
    • (1997) Nature Genet. , vol.17 , pp. 479-482
    • Morrison, C.1    Smith, G.C.2    Stingl, L.3    Jackson, S.P.4    Wagner, E.F.5    Wang, Z.Q.6
  • 30
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar,A., Lindsey-Boltz,L.A., Unsal-Kacmaz,K. and Linn,S. (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem., 73, 39-85.
    • (2004) Annu Rev Biochem. , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 31
    • 0344875495 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
    • Schultz,N., Lopez,E., Saleh-Gohari,N. and Helleday,T. (2003) Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res., 31, 4959-4964.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 4959-4964
    • Schultz, N.1    Lopez, E.2    Saleh-Gohari, N.3    Helleday, T.4
  • 32
    • 23344444636 scopus 로고    scopus 로고
    • Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
    • Saleh-Gohari,N., Bryant,H.E., Schultz,N., Parker,K.M., Cassel,T.N. and Helleday,T. (2005) Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol. Cell Biol., 25, 7158-7169.
    • (2005) Mol. Cell Biol. , vol.25 , pp. 7158-7169
    • Saleh-Gohari, N.1    Bryant, H.E.2    Schultz, N.3    Parker, K.M.4    Cassel, T.N.5    Helleday, T.6
  • 33
    • 0035853295 scopus 로고    scopus 로고
    • DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
    • Arnaudeau,C., Lundin,C. and Helleday,T. (2001) DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J. Mol. Biol., 307, 1235-1245.
    • (2001) J. Mol. Biol. , vol.307 , pp. 1235-1245
    • Arnaudeau, C.1    Lundin, C.2    Helleday, T.3
  • 34
    • 0032546733 scopus 로고    scopus 로고
    • A partial hprt gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination
    • Helleday,T., Arnaudeau,C. and Jenssen,D. (1998) A partial hprt gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination. J. Mol. Biol., 279, 687-694.
    • (1998) J. Mol. Biol. , vol.279 , pp. 687-694
    • Helleday, T.1    Arnaudeau, C.2    Jenssen, D.3
  • 36
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham,R.T. (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev., 15, 2177-2196.
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 37
    • 9744284973 scopus 로고    scopus 로고
    • ATM is required for the cellular response to thymidine induced replication fork stress
    • Bolderson,E., Scorah,J., Helleday,T., Smythe,C. and Meuth,M. (2004) ATM is required for the cellular response to thymidine induced replication fork stress. Hum. Mol. Genet., 31, 2937-2945.
    • (2004) Hum. Mol. Genet. , vol.31 , pp. 2937-2945
    • Bolderson, E.1    Scorah, J.2    Helleday, T.3    Smythe, C.4    Meuth, M.5
  • 38
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signaling, repair and the cancer connection
    • Khanna,K.K. and Jackson,S.P. (2001) DNA double-strand breaks: Signaling, repair and the cancer connection. Nature Genet., 27, 247-254.
    • (2001) Nature Genet. , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 39
    • 27644479719 scopus 로고    scopus 로고
    • Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis
    • Kurose,A., Tanaka,T., Huang,X., Halicka,H.D., Traganos,F., Dai,W. and Darzynkiewicz,Z. (2005) Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis. Cytometry A, 68, 1-9.
    • (2005) Cytometry A , vol.68 , pp. 1-9
    • Kurose, A.1    Tanaka, T.2    Huang, X.3    Halicka, H.D.4    Traganos, F.5    Dai, W.6    Darzynkiewicz, Z.7
  • 40
    • 0034124053 scopus 로고    scopus 로고
    • Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff
    • Strumberg,D., Pilon,A.A., Smith,M., Hickey,R., Malkas,L. and Pommier,Y. (2000) Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5′-phosphorylated DNA double-strand breaks by replication runoff. Mol. Cell Biol., 20, 3977-3987.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 3977-3987
    • Strumberg, D.1    Pilon, A.A.2    Smith, M.3    Hickey, R.4    Malkas, L.5    Pommier, Y.6
  • 41
    • 0034141562 scopus 로고    scopus 로고
    • The controlling role of ATM in homologous recombinational repair of DNA damage
    • Morrison,C., Sonoda,E., Takao,N., Shinohara,A., Yamamoto,K. and Takeda,S. (2000) The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J., 19, 463-471.
    • (2000) EMBO J. , vol.19 , pp. 463-471
    • Morrison, C.1    Sonoda, E.2    Takao, N.3    Shinohara, A.4    Yamamoto, K.5    Takeda, S.6
  • 42
    • 6044261241 scopus 로고    scopus 로고
    • Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair
    • Veuger,S.J., Curtin,N.J., Smith,G.C. and Durkacz,B.W. (2004) Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair. Oncogene, 23, 7322-7329.
    • (2004) Oncogene , vol.23 , pp. 7322-7329
    • Veuger, S.J.1    Curtin, N.J.2    Smith, G.C.3    Durkacz, B.W.4
  • 44
    • 20644463916 scopus 로고    scopus 로고
    • The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
    • Ma,Y., Schwarz,K. and Lieber,M.R. (2005) The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps. DNA Repair (Amst), 4, 845-851.
    • (2005) DNA Repair (Amst) , vol.4 , pp. 845-851
    • Ma, Y.1    Schwarz, K.2    Lieber, M.R.3
  • 45
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou,L. and Elledge,S.J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science, 300, 1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 46
    • 3543112227 scopus 로고    scopus 로고
    • Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms
    • Siu,W.Y., Lau,A., Arooz,T., Chow,J.P., Ho,H.T. and Poon,R.Y. (2004) Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms. Mol. Cancer Ther., 3, 621-632.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 621-632
    • Siu, W.Y.1    Lau, A.2    Arooz, T.3    Chow, J.P.4    Ho, H.T.5    Poon, R.Y.6
  • 47
    • 0037059331 scopus 로고    scopus 로고
    • S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function
    • Cliby,W.A., Lewis,K.A., Lilly,K.K. and Kaufmann,S.H. (2002) S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function. J. Biol. Chem., 277, 1599-1606.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1599-1606
    • Cliby, W.A.1    Lewis, K.A.2    Lilly, K.K.3    Kaufmann, S.H.4
  • 50
    • 9144247813 scopus 로고    scopus 로고
    • Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses
    • Stankovic,T., Hubank,M., Cronin,D., Stewart,G.S., Fletcher,D., Bignell,C.R., Alvi,A.J., Austen,B., Weston,V.J., Fegan,C., Byrd,P.J., Moss,P.A.H. and Taylor,A.M.R. (2004) Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses. Blood, 103, 291-300.
    • (2004) Blood , vol.103 , pp. 291-300
    • Stankovic, T.1    Hubank, M.2    Cronin, D.3    Stewart, G.S.4    Fletcher, D.5    Bignell, C.R.6    Alvi, A.J.7    Austen, B.8    Weston, V.J.9    Fegan, C.10    Byrd, P.J.11    Moss, P.A.H.12    Taylor, A.M.R.13
  • 53
    • 27644450586 scopus 로고    scopus 로고
    • Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
    • Austen,B., Powell,J.E., Alvi,A., Edwards,I., Hooper,L., Starczynski,J., Taylor,A.M.R., Fegan,C., Moss,P. and Stankovic,T. (2005) Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL. Blood, 106, 3175-3182.
    • (2005) Blood , vol.106 , pp. 3175-3182
    • Austen, B.1    Powell, J.E.2    Alvi, A.3    Edwards, I.4    Hooper, L.5    Starczynski, J.6    Taylor, A.M.R.7    Fegan, C.8    Moss, P.9    Stankovic, T.10
  • 54
    • 0036096157 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage
    • Stankovic,T., Stewart,G.S., Fegan,C., Biggs,P., Last,J., Byrd,P.J., Keenan,R.D., Moss,P.A.H. and Taylor,A.M.R. (2002) Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage. Blood, 99, 300-309.
    • (2002) Blood , vol.99 , pp. 300-309
    • Stankovic, T.1    Stewart, G.S.2    Fegan, C.3    Biggs, P.4    Last, J.5    Byrd, P.J.6    Keenan, R.D.7    Moss, P.A.H.8    Taylor, A.M.R.9
  • 55
    • 0033566329 scopus 로고    scopus 로고
    • Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia
    • Schaffner,C., Stilgenbauer,S., Rappold,G.A., Dohner,H. and Lichter,P. (1999) Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. Blood, 94, 748-753.
    • (1999) Blood , vol.94 , pp. 748-753
    • Schaffner, C.1    Stilgenbauer, S.2    Rappold, G.A.3    Dohner, H.4    Lichter, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.