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Volumn 34, Issue 8, 2008, Pages 737-749

Apoptosis and non-apoptotic deaths in cancer development and treatment response

Author keywords

Apoptosis; Autophagy; Mitotic catastrophe; Necrosis; Radiotherapy; Treatment response; Tumorigenesis

Indexed keywords

ANTINEOPLASTIC AGENT; CELECOXIB; FLUOROURACIL; PROTEIN P53; RECOMBINANT SOLUBLE TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; SURVIVIN; TUMOR MARKER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 56249102048     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2008.07.001     Document Type: Review
Times cited : (256)

References (164)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: a link between cancer genetics and chemotherapy
    • Johnstone R.W., Ruefli A.A., and Lowe S.W. Apoptosis: a link between cancer genetics and chemotherapy. Cell 108 (2002) 153-164
    • (2002) Cell , vol.108 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 3
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • Brown J.M., and Attardi L.D. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 5 (2005) 231-237
    • (2005) Nat Rev Cancer , vol.5 , pp. 231-237
    • Brown, J.M.1    Attardi, L.D.2
  • 4
    • 0015383455 scopus 로고
    • Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr J.F., Wyllie A.H., and Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26 (1972) 239-257
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 6
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
    • Wei M.C., Zong W.X., Cheng E.H., et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292 (2001) 727-730
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1    Zong, W.X.2    Cheng, E.H.3
  • 7
    • 0036850312 scopus 로고    scopus 로고
    • Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
    • Kuwana T., Mackey M.R., Perkins G., et al. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111 (2002) 331-342
    • (2002) Cell , vol.111 , pp. 331-342
    • Kuwana, T.1    Mackey, M.R.2    Perkins, G.3
  • 8
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • Letai A., Bassik M.C., Walensky L.D., Sorcinelli M.D., Weiler S., and Korsmeyer S.J. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2 (2002) 183-192
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3    Sorcinelli, M.D.4    Weiler, S.5    Korsmeyer, S.J.6
  • 9
    • 13944277343 scopus 로고    scopus 로고
    • BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
    • Kuwana T., Bouchier-Hayes L., Chipuk J.E., et al. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 17 (2005) 525-535
    • (2005) Mol Cell , vol.17 , pp. 525-535
    • Kuwana, T.1    Bouchier-Hayes, L.2    Chipuk, J.E.3
  • 10
    • 33646354381 scopus 로고    scopus 로고
    • Mitochondria primed by death signals determine cellular addiction to antiapoptotic Bcl-2 family members
    • Certo M., Del G.M., Nishino M., et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic Bcl-2 family members. Cancer Cell 9 (2006) 351-365
    • (2006) Cancer Cell , vol.9 , pp. 351-365
    • Certo, M.1    Del, G.M.2    Nishino, M.3
  • 11
    • 19944432123 scopus 로고    scopus 로고
    • Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    • Chen L., Willis S.N., Wei A., et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17 (2005) 393-403
    • (2005) Mol Cell , vol.17 , pp. 393-403
    • Chen, L.1    Willis, S.N.2    Wei, A.3
  • 13
    • 0037291871 scopus 로고    scopus 로고
    • A unified model for apical caspase activation
    • Boatright K.M., Renatus M., Scott F.L., et al. A unified model for apical caspase activation. Mol Cell 11 (2003) 529-541
    • (2003) Mol Cell , vol.11 , pp. 529-541
    • Boatright, K.M.1    Renatus, M.2    Scott, F.L.3
  • 14
    • 33646024628 scopus 로고    scopus 로고
    • The apoptosome activates caspase-9 by dimerization
    • Pop C., Timmer J., Sperandio S., and Salvesen G.S. The apoptosome activates caspase-9 by dimerization. Mol Cell 22 (2006) 269-275
    • (2006) Mol Cell , vol.22 , pp. 269-275
    • Pop, C.1    Timmer, J.2    Sperandio, S.3    Salvesen, G.S.4
  • 15
    • 0028883850 scopus 로고
    • Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
    • Kischkel F.C., Hellbardt S., Behrmann I., et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 14 (1995) 5579-5588
    • (1995) EMBO J , vol.14 , pp. 5579-5588
    • Kischkel, F.C.1    Hellbardt, S.2    Behrmann, I.3
  • 16
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata S. Apoptosis by death factor. Cell 88 (1997) 355-365
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 17
    • 0037291890 scopus 로고    scopus 로고
    • Insights into the regulatory mechanism for caspase-8 activation
    • Donepudi M., Mac S.A., Briand C., and Grutter M.G. Insights into the regulatory mechanism for caspase-8 activation. Mol Cell 11 (2003) 543-549
    • (2003) Mol Cell , vol.11 , pp. 543-549
    • Donepudi, M.1    Mac, S.A.2    Briand, C.3    Grutter, M.G.4
  • 18
    • 33845501864 scopus 로고    scopus 로고
    • Apoptosome: a platform for the activation of initiator caspases
    • Bao Q., and Shi Y. Apoptosome: a platform for the activation of initiator caspases. Cell Death Differ 14 (2007) 56-65
    • (2007) Cell Death Differ , vol.14 , pp. 56-65
    • Bao, Q.1    Shi, Y.2
  • 19
    • 0030800070 scopus 로고    scopus 로고
    • Inhibition of death receptor signals by cellular FLIP
    • Irmler M., Thome M., Hahne M., et al. Inhibition of death receptor signals by cellular FLIP. Nature 388 (1997) 190-195
    • (1997) Nature , vol.388 , pp. 190-195
    • Irmler, M.1    Thome, M.2    Hahne, M.3
  • 20
    • 0035851189 scopus 로고    scopus 로고
    • Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach
    • Burns T.F., and El Deiry W.S. Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. J Biol Chem 276 (2001) 37879-37886
    • (2001) J Biol Chem , vol.276 , pp. 37879-37886
    • Burns, T.F.1    El Deiry, W.S.2
  • 21
    • 14644406398 scopus 로고    scopus 로고
    • The flip side of FLIP
    • Peter M.E. The flip side of FLIP. Biochem J 382 (2004) e1-e3
    • (2004) Biochem J , vol.382
    • Peter, M.E.1
  • 22
  • 23
    • 0037099678 scopus 로고    scopus 로고
    • c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
    • Chang D.W., Xing Z., Pan Y., et al. c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J 21 (2002) 3704-3714
    • (2002) EMBO J , vol.21 , pp. 3704-3714
    • Chang, D.W.1    Xing, Z.2    Pan, Y.3
  • 24
    • 0037160117 scopus 로고    scopus 로고
    • The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
    • Micheau O., Thome M., Schneider P., et al. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem 277 (2002) 45162-45171
    • (2002) J Biol Chem , vol.277 , pp. 45162-45171
    • Micheau, O.1    Thome, M.2    Schneider, P.3
  • 25
    • 21444446872 scopus 로고    scopus 로고
    • Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis
    • Sharp D.A., Lawrence D.A., and Ashkenazi A. Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis. J Biol Chem 280 (2005) 19401-19409
    • (2005) J Biol Chem , vol.280 , pp. 19401-19409
    • Sharp, D.A.1    Lawrence, D.A.2    Ashkenazi, A.3
  • 26
    • 34250844497 scopus 로고    scopus 로고
    • c-FLIP: a key regulator of colorectal cancer cell death
    • Wilson T.R., McLaughlin K.M., McEwan M., et al. c-FLIP: a key regulator of colorectal cancer cell death. Cancer Res 67 (2007) 5754-5762
    • (2007) Cancer Res , vol.67 , pp. 5754-5762
    • Wilson, T.R.1    McLaughlin, K.M.2    McEwan, M.3
  • 27
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 28
    • 0030698127 scopus 로고    scopus 로고
    • The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
    • Roy N., Deveraux Q.L., Takahashi R., Salvesen G.S., and Reed J.C. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 16 (1997) 6914-6925
    • (1997) EMBO J , vol.16 , pp. 6914-6925
    • Roy, N.1    Deveraux, Q.L.2    Takahashi, R.3    Salvesen, G.S.4    Reed, J.C.5
  • 29
    • 33645640920 scopus 로고    scopus 로고
    • The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases
    • Eckelman B.P., and Salvesen G.S. The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem 281 (2006) 3254-3260
    • (2006) J Biol Chem , vol.281 , pp. 3254-3260
    • Eckelman, B.P.1    Salvesen, G.S.2
  • 30
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du C., Fang M., Li Y., Li L., and Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102 (2000) 33-42
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 31
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • Verhagen A.M., Ekert P.G., Pakusch M., et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102 (2000) 43-53
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1    Ekert, P.G.2    Pakusch, M.3
  • 32
    • 0034785591 scopus 로고    scopus 로고
    • A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
    • Suzuki Y., Imai Y., Nakayama H., Takahashi K., Takio K., and Takahashi R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 8 (2001) 613-621
    • (2001) Mol Cell , vol.8 , pp. 613-621
    • Suzuki, Y.1    Imai, Y.2    Nakayama, H.3    Takahashi, K.4    Takio, K.5    Takahashi, R.6
  • 34
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower L.A., Harvey M., Slagle B.L., et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356 (1992) 215-221
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 36
    • 0033569423 scopus 로고    scopus 로고
    • INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
    • Schmitt C.A., McCurrach M.E., de Stanchina E., Wallace-Brodeur R.R., and Lowe S.W. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev 13 (1999) 2670-2677
    • (1999) Genes Dev , vol.13 , pp. 2670-2677
    • Schmitt, C.A.1    McCurrach, M.E.2    de Stanchina, E.3    Wallace-Brodeur, R.R.4    Lowe, S.W.5
  • 37
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • Rampino N., Yamamoto H., Ionov Y., et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275 (1997) 967-969
    • (1997) Science , vol.275 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3
  • 38
    • 0034662604 scopus 로고    scopus 로고
    • Mutations of the bak gene in human gastric and colorectal cancers
    • Kondo S., Shinomura Y., Miyazaki Y., et al. Mutations of the bak gene in human gastric and colorectal cancers. Cancer Res 60 (2000) 4328-4330
    • (2000) Cancer Res , vol.60 , pp. 4328-4330
    • Kondo, S.1    Shinomura, Y.2    Miyazaki, Y.3
  • 39
    • 0021679848 scopus 로고
    • Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
    • Tsujimoto Y., Finger L.R., Yunis J., Nowell P.C., and Croce C.M. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226 (1984) 1097-1099
    • (1984) Science , vol.226 , pp. 1097-1099
    • Tsujimoto, Y.1    Finger, L.R.2    Yunis, J.3    Nowell, P.C.4    Croce, C.M.5
  • 40
    • 0024521441 scopus 로고
    • Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    • McDonnell T.J., Deane N., Platt F.M., et al. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57 (1989) 79-88
    • (1989) Cell , vol.57 , pp. 79-88
    • McDonnell, T.J.1    Deane, N.2    Platt, F.M.3
  • 41
    • 0028246885 scopus 로고
    • Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium
    • Moller P., Koretz K., Leithauser F., et al. Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. Int J Cancer 57 (1994) 371-377
    • (1994) Int J Cancer , vol.57 , pp. 371-377
    • Moller, P.1    Koretz, K.2    Leithauser, F.3
  • 42
    • 0033523670 scopus 로고    scopus 로고
    • Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
    • Medema J.P., de Jong J., van Hall T., Melief C.J., and Offringa R. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J Exp Med 190 (1999) 1033-1038
    • (1999) J Exp Med , vol.190 , pp. 1033-1038
    • Medema, J.P.1    de Jong, J.2    van Hall, T.3    Melief, C.J.4    Offringa, R.5
  • 43
    • 18744415186 scopus 로고    scopus 로고
    • Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer
    • Zhou X.D., Yu J.P., Chen H.X., Yu H.G., and Luo H.S. Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer. World J Gastroenterol 11 (2005) 2482-2485
    • (2005) World J Gastroenterol , vol.11 , pp. 2482-2485
    • Zhou, X.D.1    Yu, J.P.2    Chen, H.X.3    Yu, H.G.4    Luo, H.S.5
  • 44
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky D.J., and Emr S.D. Autophagy as a regulated pathway of cellular degradation. Science 290 (2000) 1717-1721
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 45
    • 0041411115 scopus 로고    scopus 로고
    • Autophagic programmed cell death in Drosophila
    • Baehrecke E.H. Autophagic programmed cell death in Drosophila. Cell Death Differ 10 (2003) 940-945
    • (2003) Cell Death Differ , vol.10 , pp. 940-945
    • Baehrecke, E.H.1
  • 46
    • 0032563798 scopus 로고    scopus 로고
    • A protein conjugation system essential for autophagy
    • Mizushima N., Noda T., Yoshimori T., et al. A protein conjugation system essential for autophagy. Nature 395 (1998) 395-398
    • (1998) Nature , vol.395 , pp. 395-398
    • Mizushima, N.1    Noda, T.2    Yoshimori, T.3
  • 47
    • 0032545292 scopus 로고    scopus 로고
    • A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy
    • Mizushima N., Sugita H., Yoshimori T., and Ohsumi Y. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem 273 (1998) 33889-33892
    • (1998) J Biol Chem , vol.273 , pp. 33889-33892
    • Mizushima, N.1    Sugita, H.2    Yoshimori, T.3    Ohsumi, Y.4
  • 48
    • 0035911162 scopus 로고    scopus 로고
    • Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
    • Mizushima N., Yamamoto A., Hatano M., et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 152 (2001) 657-668
    • (2001) J Cell Biol , vol.152 , pp. 657-668
    • Mizushima, N.1    Yamamoto, A.2    Hatano, M.3
  • 50
    • 0038309329 scopus 로고    scopus 로고
    • The molecular mechanism of autophagy
    • Wang C.W., and Klionsky D.J. The molecular mechanism of autophagy. Mol Med 9 (2003) 65-76
    • (2003) Mol Med , vol.9 , pp. 65-76
    • Wang, C.W.1    Klionsky, D.J.2
  • 51
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
    • Petiot A., Ogier-Denis E., Blommaart E.F., Meijer A.J., and Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 275 (2000) 992-998
    • (2000) J Biol Chem , vol.275 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.3    Meijer, A.J.4    Codogno, P.5
  • 52
    • 0035929650 scopus 로고    scopus 로고
    • The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Arico S., Petiot A., Bauvy C., et al. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 276 (2001) 35243-35246
    • (2001) J Biol Chem , vol.276 , pp. 35243-35246
    • Arico, S.1    Petiot, A.2    Bauvy, C.3
  • 53
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of Beclin1 is required for Vps34 binding, autophagy and tumor suppressor function
    • Furuya N., Yu J., Byfield M., Pattingre S., and Levine B. The evolutionarily conserved domain of Beclin1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1 (2005) 46-52
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.4    Levine, B.5
  • 54
    • 4544349386 scopus 로고    scopus 로고
    • Autophagy in human tumors: cell survival or death?
    • Alva A.S., Gultekin S.H., and Baehrecke E.H. Autophagy in human tumors: cell survival or death?. Cell Death Differ 11 (2004) 1046-1048
    • (2004) Cell Death Differ , vol.11 , pp. 1046-1048
    • Alva, A.S.1    Gultekin, S.H.2    Baehrecke, E.H.3
  • 55
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by Beclin1
    • Liang X.H., Jackson S., Seaman M., et al. Induction of autophagy and inhibition of tumorigenesis by Beclin1. Nature 402 (1999) 672-676
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3
  • 56
    • 0345166111 scopus 로고    scopus 로고
    • Beclin1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z., Jin S., Yang C., Levine A.J., and Heintz N. Beclin1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100 (2003) 15077-15082
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 58
    • 33745885329 scopus 로고    scopus 로고
    • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    • Crighton D., Wilkinson S., O'Prey J., et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126 (2006) 121-134
    • (2006) Cell , vol.126 , pp. 121-134
    • Crighton, D.1    Wilkinson, S.2    O'Prey, J.3
  • 59
    • 2542628931 scopus 로고    scopus 로고
    • Ras is involved in the negative control of autophagy through the class I PI3-kinase
    • Furuta S., Hidaka E., Ogata A., Yokota S., and Kamata T. Ras is involved in the negative control of autophagy through the class I PI3-kinase. Oncogene 23 (2004) 3898-3904
    • (2004) Oncogene , vol.23 , pp. 3898-3904
    • Furuta, S.1    Hidaka, E.2    Ogata, A.3    Yokota, S.4    Kamata, T.5
  • 60
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw R.J., and Cantley L.C. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441 (2006) 424-430
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 61
    • 0346998038 scopus 로고    scopus 로고
    • Defective autophagy leads to cancer
    • Edinger A.L., and Thompson C.B. Defective autophagy leads to cancer. Cancer Cell 4 (2003) 422-424
    • (2003) Cancer Cell , vol.4 , pp. 422-424
    • Edinger, A.L.1    Thompson, C.B.2
  • 62
    • 33846244269 scopus 로고    scopus 로고
    • Role of autophagy in cancer: management of metabolic stress
    • Jin S., and White E. Role of autophagy in cancer: management of metabolic stress. Autophagy 3 (2007) 28-31
    • (2007) Autophagy , vol.3 , pp. 28-31
    • Jin, S.1    White, E.2
  • 63
    • 34249863298 scopus 로고    scopus 로고
    • Autophagy suppresses tumor progression by limiting chromosomal instability
    • Mathew R., Kongara S., Beaudoin B., et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 21 (2007) 1367-1381
    • (2007) Genes Dev , vol.21 , pp. 1367-1381
    • Mathew, R.1    Kongara, S.2    Beaudoin, B.3
  • 64
    • 37549063395 scopus 로고    scopus 로고
    • Expression of Beclin-1, an autophagy-related protein, in gastric and colorectal cancers
    • Ahn C.H., Jeong E.G., Lee J.W., et al. Expression of Beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS 115 (2007) 1344-1349
    • (2007) APMIS , vol.115 , pp. 1344-1349
    • Ahn, C.H.1    Jeong, E.G.2    Lee, J.W.3
  • 65
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum J.J., Bauer D.E., Kong M., et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120 (2005) 237-248
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3
  • 66
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    • Amaravadi R.K., Yu D., Lum J.J., et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117 (2007) 326-336
    • (2007) J Clin Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1    Yu, D.2    Lum, J.J.3
  • 67
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • Klionsky D.J., Abeliovich H., Agostinis P., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4 (2008) 151-175
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3
  • 68
    • 0024709822 scopus 로고
    • CDC2 and the regulation of mitosis: six interacting mcs genes
    • Molz L., Booher R., Young P., and Beach D. CDC2 and the regulation of mitosis: six interacting mcs genes. Genetics 122 (1989) 773-782
    • (1989) Genetics , vol.122 , pp. 773-782
    • Molz, L.1    Booher, R.2    Young, P.3    Beach, D.4
  • 69
    • 0035736138 scopus 로고    scopus 로고
    • If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
    • Roninson I.B., Broude E.V., and Chang B.D. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat 4 (2001) 303-313
    • (2001) Drug Resist Updat , vol.4 , pp. 303-313
    • Roninson, I.B.1    Broude, E.V.2    Chang, B.D.3
  • 71
    • 23044467656 scopus 로고    scopus 로고
    • Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype
    • Eom Y.W., Kim M.A., Park S.S., et al. Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. Oncogene 24 (2005) 4765-4777
    • (2005) Oncogene , vol.24 , pp. 4765-4777
    • Eom, Y.W.1    Kim, M.A.2    Park, S.S.3
  • 72
    • 33847293264 scopus 로고    scopus 로고
    • Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells
    • Chen T., Hevi S., Gay F., et al. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet 39 (2007) 391-396
    • (2007) Nat Genet , vol.39 , pp. 391-396
    • Chen, T.1    Hevi, S.2    Gay, F.3
  • 73
    • 33846821915 scopus 로고    scopus 로고
    • p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
    • Reinhardt H.C., Aslanian A.S., Lees J.A., and Yaffe M.B. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 11 (2007) 175-189
    • (2007) Cancer Cell , vol.11 , pp. 175-189
    • Reinhardt, H.C.1    Aslanian, A.S.2    Lees, J.A.3    Yaffe, M.B.4
  • 74
    • 34047257880 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines
    • Strauss S.J., Higginbottom K., Juliger S., et al. The proteasome inhibitor bortezomib acts independently of p53 and induces cell death via apoptosis and mitotic catastrophe in B-cell lymphoma cell lines. Cancer Res 67 (2007) 2783-2790
    • (2007) Cancer Res , vol.67 , pp. 2783-2790
    • Strauss, S.J.1    Higginbottom, K.2    Juliger, S.3
  • 75
    • 0031749011 scopus 로고    scopus 로고
    • Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
    • Jin P., Hardy S., and Morgan D.O. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol 141 (1998) 875-885
    • (1998) J Cell Biol , vol.141 , pp. 875-885
    • Jin, P.1    Hardy, S.2    Morgan, D.O.3
  • 76
    • 0033533612 scopus 로고    scopus 로고
    • 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
    • Chan T.A., Hermeking H., Lengauer C., Kinzler K.W., and Vogelstein B. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401 (1999) 616-620
    • (1999) Nature , vol.401 , pp. 616-620
    • Chan, T.A.1    Hermeking, H.2    Lengauer, C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 77
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown E.J., and Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 14 (2000) 397-402
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 78
    • 0034659341 scopus 로고    scopus 로고
    • Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
    • Takai H., Tominaga K., Motoyama N., et al. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev 14 (2000) 1439-1447
    • (2000) Genes Dev , vol.14 , pp. 1439-1447
    • Takai, H.1    Tominaga, K.2    Motoyama, N.3
  • 79
    • 28244497051 scopus 로고    scopus 로고
    • Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe
    • Niida H., Tsuge S., Katsuno Y., Konishi A., Takeda N., and Nakanishi M. Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe. J Biol Chem 280 (2005) 39246-39252
    • (2005) J Biol Chem , vol.280 , pp. 39246-39252
    • Niida, H.1    Tsuge, S.2    Katsuno, Y.3    Konishi, A.4    Takeda, N.5    Nakanishi, M.6
  • 80
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F., Dutriaux A., Lengauer C., et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282 (1998) 1497-1501
    • (1998) Science , vol.282 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3
  • 81
    • 0038376119 scopus 로고    scopus 로고
    • Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension
    • Lens S.M., Wolthuis R.M., Klompmaker R., et al. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J 22 (2003) 2934-2947
    • (2003) EMBO J , vol.22 , pp. 2934-2947
    • Lens, S.M.1    Wolthuis, R.M.2    Klompmaker, R.3
  • 82
    • 1842486792 scopus 로고    scopus 로고
    • The spindle checkpoint, aneuploidy, and cancer
    • Bharadwaj R., and Yu H. The spindle checkpoint, aneuploidy, and cancer. Oncogene 23 (2004) 2016-2027
    • (2004) Oncogene , vol.23 , pp. 2016-2027
    • Bharadwaj, R.1    Yu, H.2
  • 83
    • 0242551545 scopus 로고    scopus 로고
    • The cellular geography of aurora kinases
    • Carmena M., and Earnshaw W.C. The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 4 (2003) 842-854
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 842-854
    • Carmena, M.1    Earnshaw, W.C.2
  • 84
    • 33750827351 scopus 로고    scopus 로고
    • The case for Survivin as mitotic regulator
    • Lens S.M., Vader G., and Medema R.H. The case for Survivin as mitotic regulator. Curr Opin Cell Biol 18 (2006) 616-622
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 616-622
    • Lens, S.M.1    Vader, G.2    Medema, R.H.3
  • 85
    • 3543092021 scopus 로고    scopus 로고
    • Pathways of apoptotic and non-apoptotic death in tumour cells
    • Okada H., and Mak T.W. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer 4 (2004) 592-603
    • (2004) Nat Rev Cancer , vol.4 , pp. 592-603
    • Okada, H.1    Mak, T.W.2
  • 86
    • 0036531790 scopus 로고    scopus 로고
    • Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs
    • Chen J.G., and Horwitz S.B. Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. Cancer Res 62 (2002) 1935-1938
    • (2002) Cancer Res , vol.62 , pp. 1935-1938
    • Chen, J.G.1    Horwitz, S.B.2
  • 87
    • 33846424957 scopus 로고    scopus 로고
    • Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation
    • Vogel C., Hager C., and Bastians H. Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation. Cancer Res 67 (2007) 339-345
    • (2007) Cancer Res , vol.67 , pp. 339-345
    • Vogel, C.1    Hager, C.2    Bastians, H.3
  • 88
    • 14944359615 scopus 로고    scopus 로고
    • Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of Survivin Cys84Ala mutant
    • Tu S.P., Cui J.T., Liston P., et al. Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of Survivin Cys84Ala mutant. Gastroenterology 128 (2005) 361-375
    • (2005) Gastroenterology , vol.128 , pp. 361-375
    • Tu, S.P.1    Cui, J.T.2    Liston, P.3
  • 90
    • 0035370777 scopus 로고    scopus 로고
    • Expression of Survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis
    • Kawasaki H., Toyoda M., Shinohara H., et al. Expression of Survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis. Cancer 91 (2001) 2026-2032
    • (2001) Cancer , vol.91 , pp. 2026-2032
    • Kawasaki, H.1    Toyoda, M.2    Shinohara, H.3
  • 91
    • 0030746636 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene, Survivin, expressed in cancer and lymphoma
    • Ambrosini G., Adida C., and Altieri D.C. A novel anti-apoptosis gene, Survivin, expressed in cancer and lymphoma. Nat Med 3 (1997) 917-921
    • (1997) Nat Med , vol.3 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 92
    • 0033923368 scopus 로고    scopus 로고
    • Structure of the human anti-apoptotic protein Survivin reveals a dimeric arrangement
    • Verdecia M.A., Huang H., Dutil E., Kaiser D.A., Hunter T., and Noel J.P. Structure of the human anti-apoptotic protein Survivin reveals a dimeric arrangement. Nat Struct Biol 7 (2000) 602-608
    • (2000) Nat Struct Biol , vol.7 , pp. 602-608
    • Verdecia, M.A.1    Huang, H.2    Dutil, E.3    Kaiser, D.A.4    Hunter, T.5    Noel, J.P.6
  • 93
    • 0032533494 scopus 로고    scopus 로고
    • Inhibition of apoptosis by Survivin predicts shorter survival rates in colorectal cancer
    • Kawasaki H., Altieri D.C., Lu C.D., Toyoda M., Tenjo T., and Tanigawa N. Inhibition of apoptosis by Survivin predicts shorter survival rates in colorectal cancer. Cancer Res 58 (1998) 5071-5074
    • (1998) Cancer Res , vol.58 , pp. 5071-5074
    • Kawasaki, H.1    Altieri, D.C.2    Lu, C.D.3    Toyoda, M.4    Tenjo, T.5    Tanigawa, N.6
  • 94
    • 0036338868 scopus 로고    scopus 로고
    • High Survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection
    • Rodel F., Hoffmann J., Grabenbauer G.G., et al. High Survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection. Strahlenther Onkol 178 (2002) 426-435
    • (2002) Strahlenther Onkol , vol.178 , pp. 426-435
    • Rodel, F.1    Hoffmann, J.2    Grabenbauer, G.G.3
  • 95
    • 19644370614 scopus 로고    scopus 로고
    • Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer
    • Rodel F., Hoffmann J., Distel L., et al. Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res 65 (2005) 4881-4887
    • (2005) Cancer Res , vol.65 , pp. 4881-4887
    • Rodel, F.1    Hoffmann, J.2    Distel, L.3
  • 96
    • 0032482169 scopus 로고    scopus 로고
    • Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor
    • Vercammen D., Beyaert R., Denecker G., et al. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 187 (1998) 1477-1485
    • (1998) J Exp Med , vol.187 , pp. 1477-1485
    • Vercammen, D.1    Beyaert, R.2    Denecker, G.3
  • 97
    • 0032494143 scopus 로고    scopus 로고
    • Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways
    • Vercammen D., Brouckaert G., Denecker G., et al. Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J Exp Med 188 (1998) 919-930
    • (1998) J Exp Med , vol.188 , pp. 919-930
    • Vercammen, D.1    Brouckaert, G.2    Denecker, G.3
  • 98
    • 5944233768 scopus 로고    scopus 로고
    • Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
    • Holler N., Zaru R., Micheau O., et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1 (2000) 489-495
    • (2000) Nat Immunol , vol.1 , pp. 489-495
    • Holler, N.1    Zaru, R.2    Micheau, O.3
  • 100
    • 1642299768 scopus 로고    scopus 로고
    • Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation
    • Lin Y., Choksi S., Shen H.M., et al. Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem 279 (2004) 10822-10828
    • (2004) J Biol Chem , vol.279 , pp. 10822-10828
    • Lin, Y.1    Choksi, S.2    Shen, H.M.3
  • 101
    • 33846986842 scopus 로고    scopus 로고
    • Mitochondrial c-Jun NH2-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support
    • Lopez-Sanchez N., Rodriguez J.R., and Frade J.M. Mitochondrial c-Jun NH2-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support. Mol Cancer Res 5 (2007) 47-60
    • (2007) Mol Cancer Res , vol.5 , pp. 47-60
    • Lopez-Sanchez, N.1    Rodriguez, J.R.2    Frade, J.M.3
  • 102
    • 34147223377 scopus 로고    scopus 로고
    • Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells
    • Kim C.H., Han S.I., Lee S.Y., et al. Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells. J Cell Physiol 211 (2007) 371-385
    • (2007) J Cell Physiol , vol.211 , pp. 371-385
    • Kim, C.H.1    Han, S.I.2    Lee, S.Y.3
  • 103
    • 0033598713 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
    • Ha H.C., and Snyder S.H. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion. Proc Natl Acad Sci USA 96 (1999) 13978-13982
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13978-13982
    • Ha, H.C.1    Snyder, S.H.2
  • 104
    • 20444454999 scopus 로고    scopus 로고
    • Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction
    • Cipriani G., Rapizzi E., Vannacci A., Rizzuto R., Moroni F., and Chiarugi A. Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction. J Biol Chem 280 (2005) 17227-17234
    • (2005) J Biol Chem , vol.280 , pp. 17227-17234
    • Cipriani, G.1    Rapizzi, E.2    Vannacci, A.3    Rizzuto, R.4    Moroni, F.5    Chiarugi, A.6
  • 105
    • 0037067317 scopus 로고    scopus 로고
    • Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
    • Yu S.W., Wang H., Poitras M.F., et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297 (2002) 259-263
    • (2002) Science , vol.297 , pp. 259-263
    • Yu, S.W.1    Wang, H.2    Poitras, M.F.3
  • 106
    • 33646827842 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation
    • Xu Y., Huang S., Liu Z.G., and Han J. Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem 281 (2006) 8788-8795
    • (2006) J Biol Chem , vol.281 , pp. 8788-8795
    • Xu, Y.1    Huang, S.2    Liu, Z.G.3    Han, J.4
  • 107
    • 34247383146 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation
    • Zhang S., Lin Y., Kim Y.S., Hande M.P., Liu Z.G., and Shen H.M. c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation. Cell Death Differ 14 (2007) 1001-1010
    • (2007) Cell Death Differ , vol.14 , pp. 1001-1010
    • Zhang, S.1    Lin, Y.2    Kim, Y.S.3    Hande, M.P.4    Liu, Z.G.5    Shen, H.M.6
  • 108
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: from caspases to alternative mechanisms
    • Leist M., and Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2 (2001) 589-598
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 110
    • 0034684651 scopus 로고    scopus 로고
    • Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice
    • Knight B., Yeoh G.C., Husk K.L., et al. Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice. J Exp Med 192 (2000) 1809-1818
    • (2000) J Exp Med , vol.192 , pp. 1809-1818
    • Knight, B.1    Yeoh, G.C.2    Husk, K.L.3
  • 111
    • 1842586795 scopus 로고    scopus 로고
    • Expression of both TNFα receptor subtypes is essential for optimal skin tumour development
    • Arnott C.H., Scott K.A., Moore R.J., Robinson S.C., Thompson R.G., and Balkwill F.R. Expression of both TNFα receptor subtypes is essential for optimal skin tumour development. Oncogene 23 (2004) 1902-1910
    • (2004) Oncogene , vol.23 , pp. 1902-1910
    • Arnott, C.H.1    Scott, K.A.2    Moore, R.J.3    Robinson, S.C.4    Thompson, R.G.5    Balkwill, F.R.6
  • 112
    • 14644429135 scopus 로고    scopus 로고
    • Colorectal cancer in patients with inflammatory bowel disease
    • Vagefi P.A., and Longo W.E. Colorectal cancer in patients with inflammatory bowel disease. Clin Colorectal Cancer 4 (2005) 313-319
    • (2005) Clin Colorectal Cancer , vol.4 , pp. 313-319
    • Vagefi, P.A.1    Longo, W.E.2
  • 113
    • 17744418769 scopus 로고    scopus 로고
    • The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
    • Steinbach G., Lynch P.M., Phillips R.K., et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 342 (2000) 1946-1952
    • (2000) N Engl J Med , vol.342 , pp. 1946-1952
    • Steinbach, G.1    Lynch, P.M.2    Phillips, R.K.3
  • 114
    • 34247272614 scopus 로고    scopus 로고
    • Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: two steps forward, one step back
    • Bertagnolli M.M. Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: two steps forward, one step back. Lancet Oncol 8 (2007) 439-443
    • (2007) Lancet Oncol , vol.8 , pp. 439-443
    • Bertagnolli, M.M.1
  • 115
    • 1542472979 scopus 로고    scopus 로고
    • Apoptosis genes and resistance to cancer therapy: what does the experimental and clinical data tell us?
    • Brown J.M., and Wilson G. Apoptosis genes and resistance to cancer therapy: what does the experimental and clinical data tell us?. Cancer Biol Ther 2 (2003) 477-490
    • (2003) Cancer Biol Ther , vol.2 , pp. 477-490
    • Brown, J.M.1    Wilson, G.2
  • 116
  • 117
    • 0033812746 scopus 로고    scopus 로고
    • Apoptosis in rectal cancer: prognostic significance in comparison with clinical histopathologic, and immunohistochemical variables
    • Schwandner O., Schiedeck T.H., Bruch H.P., Duchrow M., Windhoevel U., and Broll R. Apoptosis in rectal cancer: prognostic significance in comparison with clinical histopathologic, and immunohistochemical variables. Dis Colon Rectum 43 (2000) 1227-1236
    • (2000) Dis Colon Rectum , vol.43 , pp. 1227-1236
    • Schwandner, O.1    Schiedeck, T.H.2    Bruch, H.P.3    Duchrow, M.4    Windhoevel, U.5    Broll, R.6
  • 118
    • 30444437631 scopus 로고    scopus 로고
    • The significance of tumor markers for proliferation and apoptosis in predicting survival in colorectal cancer
    • Hilska M., Collan Y.U., VJ O.L., et al. The significance of tumor markers for proliferation and apoptosis in predicting survival in colorectal cancer. Dis Colon Rectum 48 (2005) 2197-2208
    • (2005) Dis Colon Rectum , vol.48 , pp. 2197-2208
    • Hilska, M.1    Collan, Y.U.2    VJ, O.L.3
  • 119
    • 0035873139 scopus 로고    scopus 로고
    • Apoptosis in rectal carcinoma: prognosis and recurrence after preoperative radiotherapy
    • Adell G.C., Zhang H., Evertsson S., Sun X.F., Stal O.H., and Nordenskjold B.A. Apoptosis in rectal carcinoma: prognosis and recurrence after preoperative radiotherapy. Cancer 91 (2001) 1870-1875
    • (2001) Cancer , vol.91 , pp. 1870-1875
    • Adell, G.C.1    Zhang, H.2    Evertsson, S.3    Sun, X.F.4    Stal, O.H.5    Nordenskjold, B.A.6
  • 120
    • 33751271180 scopus 로고    scopus 로고
    • Prognostic value of apoptosis in rectal cancer patients of the dutch total mesorectal excision trial: radiotherapy is redundant in intrinsically high-apoptotic tumors
    • de Bruin E.C., van de Velde C.J., van de P.S., et al. Prognostic value of apoptosis in rectal cancer patients of the dutch total mesorectal excision trial: radiotherapy is redundant in intrinsically high-apoptotic tumors. Clin Cancer Res 12 (2006) 6432-6436
    • (2006) Clin Cancer Res , vol.12 , pp. 6432-6436
    • de Bruin, E.C.1    van de Velde, C.J.2    van de, P.S.3
  • 121
    • 0036471058 scopus 로고    scopus 로고
    • Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer
    • Rodel C., Grabenbauer G.G., Papadopoulos T., et al. Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer. Int J Radiat Oncol Biol Phys 52 (2002) 294-303
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 294-303
    • Rodel, C.1    Grabenbauer, G.G.2    Papadopoulos, T.3
  • 122
    • 0344701057 scopus 로고    scopus 로고
    • Apoptosis, proliferation, Bax, Bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer
    • Tannapfel A., Nusslein S., Fietkau R., Katalinic A., Kockerling F., and Wittekind C. Apoptosis, proliferation, Bax, Bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 41 (1998) 585-591
    • (1998) Int J Radiat Oncol Biol Phys , vol.41 , pp. 585-591
    • Tannapfel, A.1    Nusslein, S.2    Fietkau, R.3    Katalinic, A.4    Kockerling, F.5    Wittekind, C.6
  • 123
    • 0030742170 scopus 로고    scopus 로고
    • Apoptosis in colorectal carcinoma occurring in patients aged 45 years and under: relationship to prognosis, mitosis, and immunohistochemical demonstration of p53, c-myc and Bcl-2 protein products
    • Langlois N.E., Lamb J., Eremin O., and Heys S.D. Apoptosis in colorectal carcinoma occurring in patients aged 45 years and under: relationship to prognosis, mitosis, and immunohistochemical demonstration of p53, c-myc and Bcl-2 protein products. J Pathol 182 (1997) 392-397
    • (1997) J Pathol , vol.182 , pp. 392-397
    • Langlois, N.E.1    Lamb, J.2    Eremin, O.3    Heys, S.D.4
  • 124
    • 0032781795 scopus 로고    scopus 로고
    • Apoptotic and mitotic indices predict survival rates in lymph node-negative colon carcinomas
    • Sinicrope F.A., Hart J., Hsu H.A., Lemoine M., Michelassi F., and Stephens L.C. Apoptotic and mitotic indices predict survival rates in lymph node-negative colon carcinomas. Clin Cancer Res 5 (1999) 1793-1804
    • (1999) Clin Cancer Res , vol.5 , pp. 1793-1804
    • Sinicrope, F.A.1    Hart, J.2    Hsu, H.A.3    Lemoine, M.4    Michelassi, F.5    Stephens, L.C.6
  • 125
    • 0035060624 scopus 로고    scopus 로고
    • Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status
    • Michael-Robinson J.M., Biemer-Huttmann A., Purdie D.M., et al. Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status. Gut 48 (2001) 360-366
    • (2001) Gut , vol.48 , pp. 360-366
    • Michael-Robinson, J.M.1    Biemer-Huttmann, A.2    Purdie, D.M.3
  • 126
    • 0034860818 scopus 로고    scopus 로고
    • Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival
    • Elkablawy M.A., Maxwell P., Williamson K., Anderson N., and Hamilton P.W. Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival. J Pathol 194 (2001) 436-443
    • (2001) J Pathol , vol.194 , pp. 436-443
    • Elkablawy, M.A.1    Maxwell, P.2    Williamson, K.3    Anderson, N.4    Hamilton, P.W.5
  • 127
    • 1542682345 scopus 로고    scopus 로고
    • Prognostic significance of p27/kip1 and apoptosis in patients with colorectal carcinoma
    • Noguchi T., Kikuchi R., Ono K., Takeno S., Moriyama H., and Uchida Y. Prognostic significance of p27/kip1 and apoptosis in patients with colorectal carcinoma. Oncol Rep 10 (2003) 827-831
    • (2003) Oncol Rep , vol.10 , pp. 827-831
    • Noguchi, T.1    Kikuchi, R.2    Ono, K.3    Takeno, S.4    Moriyama, H.5    Uchida, Y.6
  • 128
    • 0037694849 scopus 로고    scopus 로고
    • Simultaneous detection of apoptosis and proliferation in colorectal carcinoma by multiparameter flow cytometry allows separation of high and low-turnover tumors with distinct clinical outcome
    • Rupa J.D., de Bruine A.P., Gerbers A.J., et al. Simultaneous detection of apoptosis and proliferation in colorectal carcinoma by multiparameter flow cytometry allows separation of high and low-turnover tumors with distinct clinical outcome. Cancer 97 (2003) 2404-2411
    • (2003) Cancer , vol.97 , pp. 2404-2411
    • Rupa, J.D.1    de Bruine, A.P.2    Gerbers, A.J.3
  • 129
    • 0038312248 scopus 로고    scopus 로고
    • Apoptotic index and Bcl-2 expression as prognostic factors in colorectal carcinoma
    • Bendardaf R., Ristamaki R., Kujari H., et al. Apoptotic index and Bcl-2 expression as prognostic factors in colorectal carcinoma. Oncology 64 (2003) 435-442
    • (2003) Oncology , vol.64 , pp. 435-442
    • Bendardaf, R.1    Ristamaki, R.2    Kujari, H.3
  • 130
    • 30844433043 scopus 로고    scopus 로고
    • Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy
    • Smith F.M., Reynolds J.V., Miller N., Stephens R.B., and Kennedy M.J. Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy. Eur J Surg Oncol 32 (2006) 55-64
    • (2006) Eur J Surg Oncol , vol.32 , pp. 55-64
    • Smith, F.M.1    Reynolds, J.V.2    Miller, N.3    Stephens, R.B.4    Kennedy, M.J.5
  • 131
    • 34249801768 scopus 로고    scopus 로고
    • Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy
    • de Heer P., Gosens M.J., de Bruin E.C., et al. Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy. Clin Cancer Res 13 (2007) 2955-2960
    • (2007) Clin Cancer Res , vol.13 , pp. 2955-2960
    • de Heer, P.1    Gosens, M.J.2    de Bruin, E.C.3
  • 132
    • 0033826530 scopus 로고    scopus 로고
    • Genetic analysis of chemoresistance in primary murine lymphomas
    • Schmitt C.A., Rosenthal C.T., and Lowe S.W. Genetic analysis of chemoresistance in primary murine lymphomas. Nat Med 6 (2000) 1029-1035
    • (2000) Nat Med , vol.6 , pp. 1029-1035
    • Schmitt, C.A.1    Rosenthal, C.T.2    Lowe, S.W.3
  • 133
    • 23844534812 scopus 로고    scopus 로고
    • Correlation between expression of orotate phosphoribosyl transferase and 5-fluorouracil sensitivity, as measured by apoptosis index in colorectal cancer tissue
    • Kawai K., Watabe S., Matsuda M., Sakamoto K., and Kamano T. Correlation between expression of orotate phosphoribosyl transferase and 5-fluorouracil sensitivity, as measured by apoptosis index in colorectal cancer tissue. Int J Gastrointest Cancer 35 (2005) 197-203
    • (2005) Int J Gastrointest Cancer , vol.35 , pp. 197-203
    • Kawai, K.1    Watabe, S.2    Matsuda, M.3    Sakamoto, K.4    Kamano, T.5
  • 134
    • 0037317521 scopus 로고    scopus 로고
    • The role of p53 in determining sensitivity to radiotherapy
    • Gudkov A.V., and Komarova E.A. The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 3 (2003) 117-129
    • (2003) Nat Rev Cancer , vol.3 , pp. 117-129
    • Gudkov, A.V.1    Komarova, E.A.2
  • 135
    • 0034657818 scopus 로고    scopus 로고
    • Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation
    • Ruth A.C., and Roninson I.B. Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res 60 (2000) 2576-2578
    • (2000) Cancer Res , vol.60 , pp. 2576-2578
    • Ruth, A.C.1    Roninson, I.B.2
  • 136
    • 0742304431 scopus 로고    scopus 로고
    • Reasons to reconsider the significance of apoptosis for cancer therapy
    • Abend M. Reasons to reconsider the significance of apoptosis for cancer therapy. Int J Radiat Biol 79 (2003) 927-941
    • (2003) Int J Radiat Biol , vol.79 , pp. 927-941
    • Abend, M.1
  • 137
    • 0035863399 scopus 로고    scopus 로고
    • A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
    • Paglin S., Hollister T., Delohery T., et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 61 (2001) 439-444
    • (2001) Cancer Res , vol.61 , pp. 439-444
    • Paglin, S.1    Hollister, T.2    Delohery, T.3
  • 138
    • 0038743077 scopus 로고    scopus 로고
    • Induction of autophagic cell death in malignant glioma cells by arsenic trioxide
    • Kanzawa T., Kondo Y., Ito H., Kondo S., and Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 63 (2003) 2103-2108
    • (2003) Cancer Res , vol.63 , pp. 2103-2108
    • Kanzawa, T.1    Kondo, Y.2    Ito, H.3    Kondo, S.4    Germano, I.5
  • 139
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • Kondo Y., Kanzawa T., Sawaya R., and Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5 (2005) 726-734
    • (2005) Nat Rev Cancer , vol.5 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 140
    • 21444442926 scopus 로고    scopus 로고
    • Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells
    • Ito H., Daido S., Kanzawa T., Kondo S., and Kondo Y. Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. Int J Oncol 26 (2005) 1401-1410
    • (2005) Int J Oncol , vol.26 , pp. 1401-1410
    • Ito, H.1    Daido, S.2    Kanzawa, T.3    Kondo, S.4    Kondo, Y.5
  • 142
    • 33847026354 scopus 로고    scopus 로고
    • Autophagy delays apoptotic death in breast cancer cells following DNA damage
    • Abedin M.J., Wang D., McDonnell M.A., Lehmann U., and Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ 14 (2007) 500-510
    • (2007) Cell Death Differ , vol.14 , pp. 500-510
    • Abedin, M.J.1    Wang, D.2    McDonnell, M.A.3    Lehmann, U.4    Kelekar, A.5
  • 143
    • 33750565745 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
    • Cao C., Subhawong T., Albert J.M., et al. Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res 66 (2006) 10040-10047
    • (2006) Cancer Res , vol.66 , pp. 10040-10047
    • Cao, C.1    Subhawong, T.2    Albert, J.M.3
  • 144
    • 33845974091 scopus 로고    scopus 로고
    • Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling
    • Kim K.W., Mutter R.W., Cao C., et al. Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling. J Biol Chem 281 (2006) 36883-36890
    • (2006) J Biol Chem , vol.281 , pp. 36883-36890
    • Kim, K.W.1    Mutter, R.W.2    Cao, C.3
  • 145
    • 33947417275 scopus 로고    scopus 로고
    • Crosstalk between Bak/Bax and mTOR signaling regulates radiation-induced autophagy
    • Moretti L., Attia A., Kim K.W., and Lu B. Crosstalk between Bak/Bax and mTOR signaling regulates radiation-induced autophagy. Autophagy 3 (2007) 142-144
    • (2007) Autophagy , vol.3 , pp. 142-144
    • Moretti, L.1    Attia, A.2    Kim, K.W.3    Lu, B.4
  • 146
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins M.B., Hidalgo M., Stadler W.M., et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 22 (2004) 909-918
    • (2004) J Clin Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3
  • 147
    • 33750884079 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors in combination with letrozole in breast cancer
    • Chollet P., Abrial C., Tacca O., et al. Mammalian target of rapamycin inhibitors in combination with letrozole in breast cancer. Clin Breast Cancer 7 (2006) 336-338
    • (2006) Clin Breast Cancer , vol.7 , pp. 336-338
    • Chollet, P.1    Abrial, C.2    Tacca, O.3
  • 148
    • 33846866035 scopus 로고    scopus 로고
    • The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer
    • Cho D., Signoretti S., Regan M., Mier J.W., and Atkins M.B. The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer. Clin Cancer Res 13 (2007) 758s-763s
    • (2007) Clin Cancer Res , vol.13
    • Cho, D.1    Signoretti, S.2    Regan, M.3    Mier, J.W.4    Atkins, M.B.5
  • 149
    • 28044444535 scopus 로고    scopus 로고
    • Polo-like kinase 1 expression is a prognostic factor in human colon cancer
    • Weichert W., Kristiansen G., Schmidt M., et al. Polo-like kinase 1 expression is a prognostic factor in human colon cancer. World J Gastroenterol 11 (2005) 5644-5650
    • (2005) World J Gastroenterol , vol.11 , pp. 5644-5650
    • Weichert, W.1    Kristiansen, G.2    Schmidt, M.3
  • 150
    • 0034212635 scopus 로고    scopus 로고
    • Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma
    • Takemasa I., Yamamoto H., Sekimoto M., et al. Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma. Cancer Res 60 (2000) 3043-3050
    • (2000) Cancer Res , vol.60 , pp. 3043-3050
    • Takemasa, I.1    Yamamoto, H.2    Sekimoto, M.3
  • 152
    • 0034021068 scopus 로고    scopus 로고
    • Expression of the antiapoptosis gene, Survivin, predicts death from recurrent colorectal carcinoma
    • Sarela A.I., Macadam R.C., Farmery S.M., Markham A.F., and Guillou P.J. Expression of the antiapoptosis gene, Survivin, predicts death from recurrent colorectal carcinoma. Gut 46 (2000) 645-650
    • (2000) Gut , vol.46 , pp. 645-650
    • Sarela, A.I.1    Macadam, R.C.2    Farmery, S.M.3    Markham, A.F.4    Guillou, P.J.5
  • 153
    • 34247577611 scopus 로고    scopus 로고
    • Significant impact of Survivin on myeloma cell growth
    • Romagnoli M., Trichet V., David C., et al. Significant impact of Survivin on myeloma cell growth. Leukemia 21 (2007) 1070-1078
    • (2007) Leukemia , vol.21 , pp. 1070-1078
    • Romagnoli, M.1    Trichet, V.2    David, C.3
  • 154
    • 0032546360 scopus 로고    scopus 로고
    • Mutations of mitotic checkpoint genes in human cancers
    • Cahill D.P., Lengauer C., Yu J., et al. Mutations of mitotic checkpoint genes in human cancers. Nature 392 (1998) 300-303
    • (1998) Nature , vol.392 , pp. 300-303
    • Cahill, D.P.1    Lengauer, C.2    Yu, J.3
  • 157
    • 0030812174 scopus 로고    scopus 로고
    • Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation
    • Merritt A.J., Allen T.D., Potten C.S., and Hickman J.A. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation. Oncogene 14 (1997) 2759-2766
    • (1997) Oncogene , vol.14 , pp. 2759-2766
    • Merritt, A.J.1    Allen, T.D.2    Potten, C.S.3    Hickman, J.A.4
  • 158
    • 2642536197 scopus 로고    scopus 로고
    • Alkylating DNA damage stimulates a regulated form of necrotic cell death
    • Zong W.X., Ditsworth D., Bauer D.E., Wang Z.Q., and Thompson C.B. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Gene Dev 18 (2004) 1272-1282
    • (2004) Gene Dev , vol.18 , pp. 1272-1282
    • Zong, W.X.1    Ditsworth, D.2    Bauer, D.E.3    Wang, Z.Q.4    Thompson, C.B.5
  • 159
    • 0035866393 scopus 로고    scopus 로고
    • DNA fragments in the blood plasma of cancer patients: quantitation and evidence for their origin from apoptotic and necrotic cells
    • Jahr S., Hentze H., Englisch S., et al. DNA fragments in the blood plasma of cancer patients: quantitation and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61 (2001) 1659-1665
    • (2001) Cancer Res , vol.61 , pp. 1659-1665
    • Jahr, S.1    Hentze, H.2    Englisch, S.3
  • 160
    • 4344576754 scopus 로고    scopus 로고
    • Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker
    • Linder S., Havelka A.M., Ueno T., and Shoshan M.C. Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker. Cancer Lett 214 (2004) 1-9
    • (2004) Cancer Lett , vol.214 , pp. 1-9
    • Linder, S.1    Havelka, A.M.2    Ueno, T.3    Shoshan, M.C.4
  • 161
    • 12144290503 scopus 로고    scopus 로고
    • Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18
    • Kramer G., Erdal H., Mertens H.J., et al. Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res 64 (2004) 1751-1756
    • (2004) Cancer Res , vol.64 , pp. 1751-1756
    • Kramer, G.1    Erdal, H.2    Mertens, H.J.3
  • 162
    • 34250643551 scopus 로고    scopus 로고
    • Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy
    • Olofsson M.H., Ueno T., Pan Y., et al. Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy. Clin Cancer Res 13 (2007) 3198-3206
    • (2007) Clin Cancer Res , vol.13 , pp. 3198-3206
    • Olofsson, M.H.1    Ueno, T.2    Pan, Y.3
  • 163
    • 33747829837 scopus 로고    scopus 로고
    • Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo
    • Marini P., Denzinger S., Schiller D., et al. Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo. Oncogene 25 (2006) 5145-5154
    • (2006) Oncogene , vol.25 , pp. 5145-5154
    • Marini, P.1    Denzinger, S.2    Schiller, D.3
  • 164
    • 20444486559 scopus 로고    scopus 로고
    • An inhibitor of Bcl-2 family proteins induces regression of solid tumours
    • Oltersdorf T., Elmore S.W., Shoemaker A.R., et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435 (2005) 677-681
    • (2005) Nature , vol.435 , pp. 677-681
    • Oltersdorf, T.1    Elmore, S.W.2    Shoemaker, A.R.3


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