Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Cancer Cell

Volumn 2, Issue 3, 2002, Pages 183-192

  Letai, Anthony ^a   Bassik, Michael C ^a   Walensky, Loren D ^a   Sorcinelli, Mia D ^a   Weiler, Solly ^a   Korsmeyer, Stanley J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; CYTOCHROME C; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; APOPTOSIS REGULATORY PROTEIN; BAK1 PROTEIN, HUMAN; BAK1 PROTEIN, MOUSE; BAX PROTEIN, HUMAN; BAX PROTEIN, MOUSE; BCL 2 BINDING PROTEIN, BIM; BCL-2-BINDING PROTEIN, BIM; BID PROTEIN, HUMAN; BID PROTEIN, MOUSE; CARRIER PROTEIN; MEMBRANE PROTEIN; ONCOPROTEIN;

ALPHA HELIX; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL KILLING; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME RELEASE; LEUKEMIA CELL; LIVER MITOCHONDRION; MITOCHONDRIAL DNA DEPLETION; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; GENETIC TRANSDUCTION; GENETICS; HUMAN; LEUKEMIA CELL LINE; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SECRETION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CYTOCHROME C GROUP; HUMANS; JURKAT CELLS; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSDUCTION, GENETIC;

EID: 0036728834     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(02)00127-7     Document Type: Article

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