Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs

Cancer Research

Volumn 62, Issue 7, 2002, Pages 1935-1938

  Chen, Jie Guang ^a   Horwitz, Susan Band ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; DISCODERMOLIDE; EPOTHILONE B; NOCODAZOLE; PACLITAXEL; VINBLASTINE;

ANEUPLOIDY; ARTICLE; CELL CYCLE G1 PHASE; CELL DIVISION; CELL GROWTH; CENTROSOME; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS RATE; MITOSIS SPINDLE; PRIORITY JOURNAL;

ALKANES; ANEUPLOIDY; ANTINEOPLASTIC AGENTS; CARBAMATES; CARCINOMA, NON-SMALL-CELL LUNG; EPOTHILONES; HUMANS; LACTONES; LUNG NEOPLASMS; MACROLIDES; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; PACLITAXEL; PYRONES; TUMOR CELLS, CULTURED;

EID: 0036531790     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Taxol stabilizes microtubules in mouse fibroblast cells
2. Epothilones, a new class of microtubulestabilizing agents with a Taxol-like mechanism of action
3. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than Taxol
4. Mechanism of mitotic block and inhibition of cell proliferation by Taxol at low concentrations
5. Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis
6. Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits
7. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway
8. Dual cytotoxic mechanisms of submicromolar Taxol on human leukemia HL-60 cells
9. 2 arrest instead of mitotic arrest: Molecular determinants of paclitaxel-induced cytotoxicity
10. Mechanisms of Taxol-induced cell death are concentration dependent
11. Mutations in b-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines
12. Cell cycle and apoptosis: Common pathways to life and death
13. Mitotic forces control a cell-cycle checkpoint
14. Combined antimicrotubule activity of estramustine and Taxol in human prostatic carcinoma cell lines
15. Pulse treatment of interphasic HeLa cells with nanomolar doses of docetaxel affects centrosome organization and leads to catastrophic exit of mitosis
16. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine
17. The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry
18. Supernumerary centrosomes and cancer: Boveri's hypothesis resurrected
19. Measuring the complexity of cell cycle arrest and killing of drugs: Kinetics of phase-specific effects induced by Taxol
20. Taxol and anti-stathmin therapy: A synergistic combination that targets the mitotic spindle
21. 1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase
22. Life, death and genomic change in perturbed cell cycles
23. A mutator phenotype in cancer
24. Centrosome and spindle pole microtubules are main targets of a fluorescent taxoid inducing cell death
25. Centriole distribution during tripolar mitosis in Chinese hamster ovary cells