Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor

Journal of Experimental Medicine

Volumn 187, Issue 9, 1998, Pages 1477-1485

  Vercammen, Dominique ^a   Beyaert, Rudi ^a   Denecker, Geertrui ^a   Goossens, Vera ^a   Van Loo, Geert ^a   Declercq, Wim ^a   Grooten, Johan ^a   Fiers, Walter ^a   Vandenabeele, Peter ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYLATED HYDROXYANISOLE; CASPASE; OXYGEN RADICAL; RECOMBINANT TUMOR NECROSIS FACTOR; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL STRAIN L 929; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; BUTYLATED HYDROXYANISOLE; CASPASE 1; CASPASE 3; CASPASES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; FREE RADICAL SCAVENGERS; MICE; NECROSIS; NF-KAPPA B; OLIGOPEPTIDES; REACTIVE OXYGEN SPECIES; SERPINS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032482169     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.9.1477     Document Type: Article

References (42)

1. Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10:411-452.
2. Fiers, W. 1995. Biologic therapy with TNF: preclinical studies. In Biologic Therapy of Cancer. 2nd ed. V.T. DeVita, Jr., S. Hellman, and S.A. Rosenberg, editors. J.B. Lippincott, Philadelphia. 295-327.
3. Wallach, D., M. Boldin, E. Varfolomeev, R. Beyaert, P. Vandenabeele, and W. Fiers. 1997. Cell death induction by receptors of the TNF family: towards a molecular understanding. FEBS Lett. 410:96-106.
4. Grooten, J., V. Goossens, B. Vanhaesebroeck, and W. Fiers. 1993. Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: early events in tumour necrosis factor-induced cytotoxicity. Cytokine. 5:546-555.
5. Goossens, V., J. Grooten, K. De Vos, and W. Fiers. 1995. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc. Natl. Acad. Sci. USA. 92:8115-8119.
6. Schulze-Osthoff, K., A.C. Bakker, B. Vanhaesebroeck, R. Beyaert, W.A. Jacob, and W. Fiers. 1992. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. J. Biol. Chem. 267:5317-5323.
7. Vercammen, D., P. Vandenabeele, R. Beyaert, W. Declercq, and W. Fiers. 1997. Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells. Cytokine. 9: 801-808.
8. Kroemer, G., P. Petit, N. Zamzami, J.-L. Vayssière, and B. Mignotte. 1995. The biochemistry of programmed cell death. FASEB J. 9:1277-1287.
9. Henkart, P.A. 1996. ICE family proteases: mediators of all apoptotic cell death? Immunity. 4:195-201.
10. Martins, L.M., and W.C. Earnshaw. 1997. Apoptosis: alive and kicking in 1997. Trends Cell Biol. 7:111-114.
11. Nagata, S. 1997. Apoptosis by death factor. Cell. 88:355-365.
12. Boldin, M.P., T.M. Goncharov, Y.V. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell. 85:803-813.
13. Muzio, M., A.M. Chinnaiyan, F.C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J.D. Bretz, M. Zhang, R. Gentz, et al. 1996. FLICE, a novel FADD homologous ICE/ CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex. Cell. 85:817-827.
14. Medema, J.P., C. Scaffidi, F.C. Kischkel, A. Shevchenko, M. Mann, P.H. Krammer, and M.E. Peter. 1997. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO (Eur. Mol. Biol. Organ.) J. 16:2794-2804.
15. Vincenz, C., and V.M. Dixit. 1997. Fas-associated death domain protein interleukin-1B-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95-and p55-mediated death signaling. J. Biol. Chem. 272:6578-6583.
16. Niwa, H., K. Yamamura, and J. Miyazaki. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene. 108:193-200.
17. Southern, P.J., and P. Berg. 1982. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1:327-341.
18. Tada, H., O. Shiho, K. Kuroshima, M. Koyama, and K. Tsukamoto. 1986. An improved colorimetric assay for interleukin 2. J. Immunol. Methods. 93:157-165.
19. Shrieve, D.C., E.A. Bump, and G.C. Rice. 1988. Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis. J. Biol. Chem. 263:14107-14114.
20. b promoter: enhancer-like sequences and their role in the regulation of class I gene expression. Cell. 44:261-272.
21. Vandenabeele, P., W. Declercq, R. Beyaert, and W. Fiers. 1995. Two tumour necrosis factor receptors: structure and function. Trends Cell Biol. 5:392-399.
22. Zhang, Y., J.-X. Lin, and J. Vilček. 1990. Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a κB-like sequence. Mol. Cell. Biol. 10:3818-3823.
23. Tartaglia, L.A., T.M. Ayres, G.H.W. Wong, and D.V. Goeddel. 1993. A novel domain within the 55 kd TNF receptor signals cell death. Cell. 74:845-853.
24. Song, H.Y., J.D. Dunbar, and D.B. Donner. 1994. Aggregation of the intracellular domain of the type 1 tumor necrosis factor receptor defined by the two-hybrid system. J. Biol. Chem. 269:22492-22495.
25. Boldin, M.P., I.L. Mett, E.E. Varfolomeev, I. Chumakov, Y. Shemer-Avni, J.H. Camonis, and D. Wallach. 1995. Self-association of the "death domains" of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects. J Biol. Chem. 270:387-391.
26. Vandevoorde, V., G. Haegeman, and W. Fiers. 1997. Induced expression of trimerized intracellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effects. J. Cell Biol. 137:1627-1638.
27. Chinnaiyan, A.M., K. O'Rourke, M. Tewari, and V.M. Dixit. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell. 81:505-512.
28. Hsu, H., J. Xiong, and D.V. Goeddel. 1995. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell. 81:495-504.
29. Srinivasula, S.M., M. Ahmad, T. Fernandes-Alnemri, G. Litwack, and E.S. Alnemri. 1996. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. USA. 93:14486-14491.
30. Zhou, Q., S. Snipas, K. Orth, M. Muzio, V.M. Dixit, and G.S. Salvesen. 1997. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J. Biol. Chem. 272:7797-7800.
31. Susin, S.A., N. Zamzami, M. Castedo, T. Hirsch, P. Marchetti, A. Macho, E. Daugas, M. Geuskens, and G. Kroemer. 1996. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J. Exp. Med. 184:1331-1341.
32. Zamzami, N., P. Marchetti, M. Castedo, C. Zanin, J.-L. Vayssière, P.X. Petit, and G. Kroemer. 1995. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181:1661-1672.
33. Rep, M., and L.A. Grivell. 1996. The role of protein degradation in mitochondrial function and biogenesis. Curr. Genet. 30:367-380.
34. Dean, R.T., and J.K. Pollak. 1985. Endogenous free radical generation may influence proteolysis in mitochondria. Biochem. Biophys. Res. Commun. 126:1082-1089.
35. Davies, K.J.A., S.W. Lin, and R.E. Pacifici. 1987. Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein. J. Biol. Chem. 262:9914-9920.
36. Hara, H., R.M. Friedlander, V. Gagliardini, C. Ayata, K. Fink, Z. Huang, M. Shimizu-Sasamata, J. Yuan, and M.A. Moskowitz. 1997. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad. Sci. USA. 94:2007-2012.
37. Rodriguez, I., K. Matsuura, C. Ody, S. Nagata, and P. Vassalli. 1996. Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J. Exp. Med. 184:2067-2072.
38. Friedlander, R.M., R.H. Brown, V. Gagliardini, J. Wang, and J. Yuan. 1997. Inhibition of ICE slows ALS in mice. Nature. 388:31.
39. Kim, T.-W., W.H. Pettingell, Y.-K. Jung, D.M. Kovacs, and R.E. Tanzi. 1997. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science. 277:373-376.
40. Wang, J.H., H.P. Redmond, R.W.G. Watson, S. Duggan, J. McCarthy, M. Barry, and D. Bouchier-Hayes. 1996. Mechanisms involved in the induction of human endothelial cell necrosis. Cell. Immunol. 168:91-99.
41. Rosser, B.G., and G.J. Gores. 1995. Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology. 108:252-275.
42. Maxwell, S.K.J., and G.Y.H. Lip. 1997. Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options. Int. J. Cardiol. 58:95-117.