Apoptosis in rectal cancer: Prognostic significance in comparison with clinical, histopathologic, and immunohistochemical variables

Diseases of the Colon and Rectum

Volumn 43, Issue 9, 2000, Pages 1227-1236

  Schwandner, O ^a   Schiedeck, T H K ^a   Bruch, H P ^a   Duchrow, M ^a   Windhoevel, U ^a   Broll, R ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Apoptosis; bcl 2; p53; Prognosis; Rectal cancer; Recurrence; Survival

Indexed keywords

PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER RECURRENCE; CANCER SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; RECTUM CANCER;

EID: 0033812746     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02237426     Document Type: Article

References (36)

1. Recurrence and survival after total mesorectal excision for rectal cancer
2. Abdominoperineal excision of the rectum - An endangered operation
3. Inhibition of apoptosis during development of colorectal cancer
4. Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas
5. Apoptosis is inhibited early in the dysplasia-carcinoma sequence of Barrett esophagus
6. The p53 tumour suppressor gene
7. Bcl-2 and the regulation of programmed cell death
8. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
9. Molecular thanatopsis: A discourse on the BCL2 family and cell death
10. Down-regulation of bcl-2 by p53 in nasopharyngeal carcinoma and lack of detection of its specific t(14;18) chromosomal translocation in fixed tissues
11. p53- Dependent apoptosis modulates the cytoxicity of anti-cancer agents
12. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
13. Activating mutations for transformation by p53 produce a gene product that forms an hsc 700-p53 complex with an altered half-life
14. The p53 tumor suppressor gene
15. Coexpression of Bcl-2, c-Myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma
16. Apoptosis in colorectal carcinoma occurring in patients aged 45 years and under: Relationship to prognosis, mitosis, and immunohistochemical demonstration of p53, c-myc and bcl-2 protein products
17. Prognostic significance of bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma
18. Immunohistochemical detection of p53 and Bcl-2 in colorectal carcinoma: No evidence for prognostic significance
19. Chirurgische Therapie des Rektumkarzinoms: Standard und TME
20. Apoptosis in breast carcinomas detected with monoclonal antibody to single-stranded DANN: Relation to bcl-2 expression, hormone receptors, and lymph node metastases
21. Bcl-2 initiates a new category of oncogenes: Regulators of cell death
22. Apoptosis, mitosis, PCNA, and bcl-2 in normal, leukoplakic and malignant epithelia of the human oral cavity: Prospective, in vivo study
23. bcl-2 Oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas
24. Proliferating cell nuclear antigen expression and its relationship to malignancy potential in invasive colorectal carcinomas
25. Incidence and patterns of recurrence following curative resection for colorectal carcinoma
26. DCC protein as a predictor of distant metastases after curative surgery for rectal cancer
27. DNA index as a significant predictor of recurrence in colorectal cancer
28. Patterns of recurrence after curative resection of carcinoma of the colon and rectum
29. Local recurrence after curative resection of colorectal adenocarcinoma
30. Multivariate analysis of prognostic factors for operable rectal cancer
31. Survival and recurrence after low anterior resection and abdominoperineal resection for rectal cancer: The results of a long-term study with a review of the literature
32. Local recurrence following total mesorectal excision for rectal cancer
33. Actual standards and controversies on operative technique and lymph-node dissection in colorectal cancer
34. Factors affecting survival after excision of the rectum for cancer: A multivariate analysis
35. Bcl-2 protein expression: Association with p53 and prognosis in colorectal cancer