If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

Drug Resistance Updates

Volumn 4, Issue 5, 2001, Pages 303-313

  Roninson, Igor B ^a   Broude, Eugenia V ^a   Chang, Bey Dih ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; CYTOSTATIC AGENT; CYTOTOXIC AGENT; DOXORUBICIN; ETOPOSIDE; PACLITAXEL; PROTEIN P21; PROTEIN P53;

APOPTOSIS; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CLONOGENESIS; DRUG EFFICACY; DRUG EXPOSURE; HUMAN; HUMAN CELL; INTERPHASE; IONIZING RADIATION; MICRONUCLEUS; MITOSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; REVIEW; SENESCENCE; TUMOR CELL LINE;

EID: 0035736138     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1054/drup.2001.0213     Document Type: Review

References (104)

1. Does resistance to apoptosis affect response to antitumor drugs?
2. Programmed cell death is critical for drug response in vivo
3. Apoptosis: Mediator or mode of cell killing by anticancer agents?
4. Apoptosis, p53, and tumor cell sensitivity to anticancer agents
5. Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation
6. Human MDR I protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts
7. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis
8. Apoptosis signaling
9. The serial cultivation of human diploid cell strains
10. Cancer, aging and cellular senescence
11. Cellular senescence as a tumor-protection mechanism: The essential role of counting
12. Cell senescence in human aging: A review of the theory
13. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells
14. Lack of replicative senescence in normal rodent glia
15. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
16. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
17. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
18. The cat and mouse games that genes, viruses, and cells play
19. DNA topoisomerase inhibitors induce reversible senescence in normal human fibroblasts
20. Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening
21. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
22. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
23. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
24. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
25. CDK inhibitors: Positive and negative regulators of G-phase progression
26. p21(WAF1/Cip1): More than a break to the cell cycle?
27. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
28. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
29. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
30. Involvement of RB-1, p53, p16INK4 and telomerase in immortalisation of human cells
31. Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts
32. Role of the INK4a locus in tumor suppression and cell mortality
33. Nucleolar Arf sequesters Mdm2 and activates p53
34. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
35. p16INK4A and p19ARF act in overlapping pathways in cellular immortalization
36. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
37. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
38. Regulation of a senescence checkpoint response by the E2FI transcription factor and p14(ARF) tumor suppressor
39. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
40. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
41. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
42. Induction of senescence in human malignant glioma cells by p16INK4A
43. Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts
44. p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
45. Role of p53 and p21Waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
46. p16INK4a can initiate an autonomous senescence program
47. Rapid induction of senescence in human cervical carcinoma cells
48. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents
49. Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells
50. Cisplatin-induced p53-independent growth arrest and cell death in cancer cells
51. Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell
52. Stable cell membrane labelling
53. Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts
54. From cells to organisms: Can we learn about aging from cells in culture?
55. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
56. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
57. Transforming growth factor-beta I induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
58. Transforming growth factor-beta I promotes the morphological and functional differentiation of the myofibroblast
59. Transforming growth factor beta triggers two independent-senescence programs in cancer cells
60. 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts
61. Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
62. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
63. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
64. Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light
65. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases
66. Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells
67. How does radiation kill cells?
68. Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized
69. Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival
70. Mechanisms of Taxol-induced cell death are concentration dependent
71. The occurrence of apoptosis, abnormal mitoses, cells dying in mitosis and micronuclei in a human melanoma xenograft exposed to single dose irradiation
72. The role of cell cycle progression in cisplatin-induced apoptosis in Chinese hamster ovary cells
73. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
74. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
75. Chfr defines a mitotic stress checkpoint that delays entry into metaphase
76. Mutations of mitotic checkpoint genes in human cancers
77. G2 checkpoint and anticancer therapy
78. Requirement for p53 and p21 to sustain G2 arrest after DNA damage
79. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
80. Nuclear envelope formation around metaphase chromosomes: Chromosome decondensation and nuclear envelope reconstitution during mitosis
81. The use and action of drugs in analyzing mitosis
82. Spontaneous premature chromosome condensation, micronucleus formation, and non-apoptotic cell death in heated HeLa S3 cells. Ultrastructural observations
83. Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells
84. Mammalian cell fusion: Induction of premature chromosome condensation in interphase nuclei
85. Cellular mechanisms associated with the lack of chronic thermotolerance expression in HeLa S3 cells
86. Uncoupling of M-phase kinase activation from the completion of S-phase by heat shock
87. Human wee 1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
88. Nuclear localization of cyclin BI controls mitotic entry after DNA damage
89. Centrosome duplication. A centriolar pas de deux
90. Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells
91. Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function
92. Specific phosphorylation of nucleophosmin on Thr 199 by CDK2/cyclin E, and its role in centrosome duplication
93. p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
94. Mitotic modifications and aberrations in cancer
95. Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells
96. Micronuclei and nuclear abnormalities observed in erythroblasts in myelodysplastic syndromes and in de novo acute leukemia after treatment
97. Predictive assays for the therapy of rectum carcinoma
98. Prediction of radiosensitivity of oral cancers by serial cytological assay of nuclear changes
99. Changes in S-phase fraction and micronucleus frequency as prognostic factors in radiotherapy of cervical carcinoma
100. The increment of micronucleus frequency in cervical carcinoma during irradiation in vivo and its prognostic value for tumour radiocurability
101. Do prostatic biopsies 12 months or more after external irradiation for adenocarcinoma, Stage III, predict long-term survival?
102. Desmoid tumors in adults: The role of radiotherapy in their management
103. A p53 and apoptotic independent role for p21Waf1 in tumour response to radiation therapy
104. Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment