-
1
-
-
16044364385
-
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
-
Santana, P. et al. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86, 189-199 (1996).
-
(1996)
Cell
, vol.86
, pp. 189-199
-
-
Santana, P.1
-
2
-
-
0035183299
-
Biological factors influencing optimum fractionation in radiation therapy
-
Fowler, J. F. Biological factors influencing optimum fractionation in radiation therapy. Acta Oncol. 40, 712-717 (2001).
-
(2001)
Acta Oncol.
, vol.40
, pp. 712-717
-
-
Fowler, J.F.1
-
3
-
-
0035195557
-
The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
-
Wahl, G. M. & Carr, A. M. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nature Cell Biol. 3, E277-E286 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
-
-
Wahl, G.M.1
Carr, A.M.2
-
5
-
-
0023911085
-
Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor
-
Neta, R., Oppenheim, J. J. & Douches, S. D. Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor. J. Immunol. 140, 108-111 (1988).
-
(1988)
J. Immunol.
, vol.140
, pp. 108-111
-
-
Neta, R.1
Oppenheim, J.J.2
Douches, S.D.3
-
6
-
-
0035138823
-
p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent
-
Kemp, C. J., Sun, S. & Gurley, K. E. p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent. Cancer Res. 61, 327-332 (2001). Shows that the experimental mouse tumours that respond to cancer treatment by apoptosis originate from apoptosis-prone tissues.
-
(2001)
Cancer Res.
, vol.61
, pp. 327-332
-
-
Kemp, C.J.1
Sun, S.2
Gurley, K.E.3
-
7
-
-
0036121363
-
p53 regulation of DNA excision repair pathways
-
Smith, M. L. p53 regulation of DNA excision repair pathways. Mutagenesis 17, 149-156 (2002).
-
(2002)
Mutagenesis
, vol.17
, pp. 149-156
-
-
Smith, M.L.1
-
8
-
-
0033590179
-
DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
-
Dasika, G. K. et al. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene 18, 7883-7899 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 7883-7899
-
-
Dasika, G.K.1
-
9
-
-
0034057320
-
Apoptosis in cancer
-
Lowe, S. W. & Lin, A. W. Apoptosis in cancer. Carcinogenesis 21, 485-495 (2000).
-
(2000)
Carcinogenesis
, vol.21
, pp. 485-495
-
-
Lowe, S.W.1
Lin, A.W.2
-
10
-
-
0029972806
-
p53: Puzzle and paradigm
-
Ko, L. J. & Prives, C. p53: puzzle and paradigm. Genes Dev. 10, 1054-1072 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 1054-1072
-
-
Ko, L.J.1
Prives, C.2
-
11
-
-
0031987277
-
Regulation of p53 downstream genes Semin
-
el-Deiry, W. S. Regulation of p53 downstream genes Semin. Cancer Biol. 8, 345-357 (1998)
-
(1998)
Cancer Biol.
, vol.8
, pp. 345-357
-
-
El-Deiry, W.S.1
-
12
-
-
0036317093
-
The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA
-
Offer, H. et al. The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA. Carcinogenesis 23, 1025-1032 (2002).
-
(2002)
Carcinogenesis
, vol.23
, pp. 1025-1032
-
-
Offer, H.1
-
13
-
-
0034703742
-
p53: Death star
-
Vousden, K. H. p53: death star. Cell 103, 691-694 (2000).
-
(2000)
Cell
, vol.103
, pp. 691-694
-
-
Vousden, K.H.1
-
14
-
-
0033826530
-
Genetic analysis of chemoresistance in primary murine lymphomas
-
Schmitt, C. A., Rosenthal, C. T. & Lowe, S. W. Genetic analysis of chemoresistance in primary murine lymphomas. Nature Med. 6, 1029-1035 (2000).
-
(2000)
Nature Med.
, vol.6
, pp. 1029-1035
-
-
Schmitt, C.A.1
Rosenthal, C.T.2
Lowe, S.W.3
-
15
-
-
17944379798
-
ASPP proteins specifically stimulate the apoptotic function of p53
-
Samuels-Lev, Y. et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 8, 781-794 (2001).
-
(2001)
Mol. Cell
, vol.8
, pp. 781-794
-
-
Samuels-Lev, Y.1
-
16
-
-
0034664733
-
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
-
Oda, K. et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102, 849-862 (2000).
-
(2000)
Cell
, vol.102
, pp. 849-862
-
-
Oda, K.1
-
18
-
-
0031466618
-
Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
-
Shiloh, Y. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31, 635-662 (1997).
-
(1997)
Annu. Rev. Genet.
, vol.31
, pp. 635-662
-
-
Shiloh, Y.1
-
19
-
-
0031944906
-
DNA repair disorders
-
Woods, C. G. DNA repair disorders. Arch. Dis. Child. 78, 178-184 (1998).
-
(1998)
Arch. Dis. Child.
, vol.78
, pp. 178-184
-
-
Woods, C.G.1
-
23
-
-
0015846505
-
N-ethylmaleimide and the cyclic response to X-rays of synchronous Chinese hamster cells
-
Sinclair, W. K. N-ethylmaleimide and the cyclic response to X-rays of synchronous Chinese hamster cells. Radiat. Res. 55, 41-57 (1973).
-
(1973)
Radiat. Res.
, vol.55
, pp. 41-57
-
-
Sinclair, W.K.1
-
24
-
-
0032480320
-
Stress-induced secretion of growth inhibitors: A novel tumor suppressor function of p53
-
Komarova, E. A. et al. Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53. Oncogene 17, 1089-1096 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 1089-1096
-
-
Komarova, E.A.1
-
25
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai, H. et al Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21, 5195-5205 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
-
26
-
-
0032701521
-
Disruption of p53 in human cancer cells alters the responses to therapeutic agents
-
Bunz, F. et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J. Clin. Invest. 104, 263-269 (1999).
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 263-269
-
-
Bunz, F.1
-
27
-
-
0030021996
-
Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents
-
Hawkins, D. S., Demers, G. W. & Galloway, D. A. Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents. Cancer Res. 56, 892-898 (1996). Inactivation of p53 might cause cell sensitization to treatment with anticancer agents.
-
(1996)
Cancer Res.
, vol.56
, pp. 892-898
-
-
Hawkins, D.S.1
Demers, G.W.2
Galloway, D.A.3
-
28
-
-
0034691676
-
The role of p53 in death of IL-3-dependent cells in response to cytotoxic drugs
-
Palacios, C., Gutierrez del Arroyo, A., Silva, A. & Collins, M. K. The role of p53 in death of IL-3-dependent cells in response to cytotoxic drugs. Oncogene 19, 3556-3559 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 3556-3559
-
-
Palacios, C.1
Gutierrez del Arroyo, A.2
Silva, A.3
Collins, M.K.4
-
29
-
-
0035132822
-
p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress
-
Offer, H. et al. p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress. Cancer Res. 61, 88-96 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 88-96
-
-
Offer, H.1
-
30
-
-
0028152718
-
Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance
-
Pardo, F. S. et al. Transfection of rat embryo cells with mutant p53 increases the intrinsic radiation resistance. Radiat. Res. 140, 180-185 (1994).
-
(1994)
Radiat. Res.
, vol.140
, pp. 180-185
-
-
Pardo, F.S.1
-
31
-
-
0029761030
-
Gamma-ray-induced cell killing and chromosome abnormalities in the bone marrow of p53-deficient mice
-
Wang, L. et al. Gamma-ray-induced cell killing and chromosome abnormalities in the bone marrow of p53-deficient mice. Radiat. Res. 146, 259-266 (1996).
-
(1996)
Radiat. Res.
, vol.146
, pp. 259-266
-
-
Wang, L.1
-
32
-
-
0032851826
-
Repair of DNA double-strand breaks and radiosensitivity to killing in an isogenic group of p53 mutant cell lines
-
DiBiase, S. J., Guan, J., Curran, W. J., Jr & Iliakis, G. Repair of DNA double-strand breaks and radiosensitivity to killing in an isogenic group of p53 mutant cell lines. Int. J. Radiat. Oncol. Biol. Phys. 45, 743-751 (1999).
-
(1999)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.45
, pp. 743-751
-
-
DiBiase, S.J.1
Guan, J.2
Curran W.J., Jr.3
Iliakis, G.4
-
33
-
-
0036852823
-
Converting p53 from a killer into a healer
-
Gudkov, A. V. Converting p53 from a killer into a healer. Nature Med. 8, 1196-1198 (2002).
-
(2002)
Nature Med.
, vol.8
, pp. 1196-1198
-
-
Gudkov, A.V.1
-
34
-
-
0037195158
-
Selenomethionine regulation of p53 by a ref-1-dependent redox mechanism
-
Seo, Y. R., Kelley, M. & Smith, M. L. Selenomethionine regulation of p53 by a ref-1-dependent redox mechanism. Proc. Natl Acad. Sci. USA 99, 13969-13971 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13969-13971
-
-
Seo, Y.R.1
Kelley, M.2
Smith, M.L.3
-
35
-
-
0028956722
-
Radiation response of the central nervous system
-
Schultheiss, T. E., Kun, L. E., Ang, K. K. & Stephens, L. C. Radiation response of the central nervous system. Int. J. Radiat. Oncol. Biol. Phys. 31, 1093-1112 (1995).
-
(1995)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.31
, pp. 1093-1112
-
-
Schultheiss, T.E.1
Kun, L.E.2
Ang, K.K.3
Stephens, L.C.4
-
36
-
-
0024562119
-
Radiation embryology
-
Michel, C. Radiation embryology. Experientia 45, 69-77 (1989).
-
(1989)
Experientia
, vol.45
, pp. 69-77
-
-
Michel, C.1
-
37
-
-
17444388849
-
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents
-
Chang, B. D. et al. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 59, 3761-3767 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 3761-3767
-
-
Chang, B.D.1
-
38
-
-
0034689774
-
p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
-
Chang, B. D. et al. p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 19, 2165-2170 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 2165-2170
-
-
Chang, B.D.1
-
39
-
-
0036566326
-
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence
-
Macip, S. et al. Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence. EMBO J. 21, 2180-2188 (2002). References 37-39 show that senescence-like permanent growth arrest can be an important type of tumour-cell response to treatment with DNA-damaging agents.
-
(2002)
EMBO J.
, vol.21
, pp. 2180-2188
-
-
Macip, S.1
-
40
-
-
0035179555
-
Role of retinoblastoma tumor suppressor protein in DNA damage response
-
Wang, J. Y., Naderi, S. & Chen, T. T. Role of retinoblastoma tumor suppressor protein in DNA damage response. Acta Oncol. 40, 689-695 (2001). The role of RB is essential for the establishment of irreversible growth arrest in response to IR: inactivation of RB allows the cell to resume proliferation after prolonged p53-dependent growth arrest following severe DNA damage.
-
(2001)
Acta Oncol.
, vol.40
, pp. 689-695
-
-
Wang, J.Y.1
Naderi, S.2
Chen, T.T.3
-
41
-
-
0032864278
-
Different responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction
-
Song, S. & Lambert. P. F. Different responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction. Am. J. Pathol. 155, 1121-1127 (1999).
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 1121-1127
-
-
Song, S.1
Lambert, P.F.2
-
42
-
-
0031003552
-
Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo
-
Komarova, E. A. et al. Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J. 16, 1391-1400 (1997).
-
(1997)
EMBO J.
, vol.16
, pp. 1391-1400
-
-
Komarova, E.A.1
-
43
-
-
0034601420
-
Different impact of p53 and p21 on the radiation response of mouse tissues
-
Komarova, E. A., Christov, K., Faerman, A. I. & Gudkov, A. V. Different impact of p53 and p21 on the radiation response of mouse tissues. Oncogene 19, 3791-3798 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 3791-3798
-
-
Komarova, E.A.1
Christov, K.2
Faerman, A.I.3
Gudkov, A.V.4
-
44
-
-
0027319521
-
p53 is required for radiation-induced apoptosis in mouse thymocytes
-
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. & Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849 (1993).
-
(1993)
Nature
, vol.362
, pp. 847-849
-
-
Lowe, S.W.1
Schmitt, E.M.2
Smith, S.W.3
Osborne, B.A.4
Jacks, T.5
-
45
-
-
0030460978
-
The p53 response to ionising radiation in adult and developing murine tissues
-
MacCallum, D. E. et al. The p53 response to ionising radiation in adult and developing murine tissues. Oncogene 13, 2575-2587 (1996).
-
(1996)
Oncogene
, vol.13
, pp. 2575-2587
-
-
MacCallum, D.E.1
-
46
-
-
0030879563
-
Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity
-
Westphal, C. H. et al. Atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nature Genet 16, 397-401 (1997). References 41-46 illustrate the role of p53-dependent apoptosis in normal tissue damage by IR, indicating that p53 might be a determinant of the side effects of cancer treatment.
-
(1997)
Nature Genet.
, vol.16
, pp. 397-401
-
-
Westphal, C.H.1
-
47
-
-
0033543728
-
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
-
Komarov, P. G. et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285, 1733-1737 (1999). Identification (by chemical library screening) and in vivo and in vitro testing of a p53 inhibitor as an approach to reduce IR-induced tissue damage.
-
(1999)
Science
, vol.285
, pp. 1733-1737
-
-
Komarov, P.G.1
-
48
-
-
0027528673
-
High levels of p53 protein in UV-irradiated normal human skin
-
Hall, P.A., McKee, P.H., Menage, H. D., Dover, R. & Lane, D. P. High levels of p53 protein in UV-irradiated normal human skin. Oncogene 8, 203-207 (1993)
-
(1993)
Oncogene
, vol.8
, pp. 203-207
-
-
Hall, P.A.1
McKee, P.H.2
Menage, H.D.3
Dover, R.4
Lane, D.P.5
-
49
-
-
0027287748
-
Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation
-
Campbell, C., Quinn, A. G., Angus, B., Farr, P. M. & Rees, J. L. Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation. Cancer Res. 53, 2697-2699 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 2697-2699
-
-
Campbell, C.1
Quinn, A.G.2
Angus, B.3
Farr, P.M.4
Rees, J.L.5
-
50
-
-
0028047723
-
The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
-
Merritt, A. J. et al. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54, 614-617 (1994).
-
(1994)
Cancer Res.
, vol.54
, pp. 614-617
-
-
Merritt, A.J.1
-
51
-
-
0028301094
-
p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation
-
Clarke, A. R., Gledhill, S., Hooper, M. L., Bird, C. C. & Wyllie, A. H. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene 9, 1767-1773 (1994). References 50 and 51 describe the p53 dependence of IR-induced damage to the epithelium of the small intestine.
-
(1994)
Oncogene
, vol.9
, pp. 1767-1773
-
-
Clarke, A.R.1
Gledhill, S.2
Hooper, M.L.3
Bird, C.C.4
Wyllie, A.H.5
-
52
-
-
0029051336
-
Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo
-
Midgley C. A. et al. Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. J. Cell Sci. 108, 1843-1848 (1995).
-
(1995)
J. Cell Sci.
, vol.108
, pp. 1843-1848
-
-
Midgley, C.A.1
-
53
-
-
0022390692
-
p53 cellular tumor antigen: Analysis of mRNA levels in normal adult tissues, embryos, and tumors
-
Rogel, A., Popliker, M., Webb, C. G. & Oren, M. p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol. Cell. Biol. 5, 2851-2855 (1985).
-
(1985)
Mol. Cell. Biol.
, vol.5
, pp. 2851-2855
-
-
Rogel, A.1
Popliker, M.2
Webb, C.G.3
Oren, M.4
-
54
-
-
0035797473
-
Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo
-
Burns, T. F., Bernhard, E. J. & El-Deiry, W. S. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 20, 4601-4612 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 4601-4612
-
-
Burns, T.F.1
Bernhard, E.J.2
El-Deiry, W.S.3
-
55
-
-
0033166086
-
Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells
-
Haks, M. C., Krimpenfort, P., van den Brakel, J. H. & Kruisbeek, A. M. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 91-101 (1999).
-
(1999)
Immunity
, pp. 91-101
-
-
Haks, M.C.1
Krimpenfort, P.2
Van den Brakel, J.H.3
Kruisbeek, A.M.4
-
56
-
-
0029858143
-
V(D)J recombination activates a p53-dependent DNA damage checkpoint in SCID lymphocyte precursors
-
Guidos, C. J. et al. V(D)J recombination activates a p53-dependent DNA damage checkpoint in SCID lymphocyte precursors. Genes Dev. 10, 2038-2054 (1996).
-
(1996)
Genes Dev.
, vol.10
, pp. 2038-2054
-
-
Guidos, C.J.1
-
57
-
-
0032191132
-
Surviving the cytochrome seas
-
Newmeyer, D. D. & Green, D. R. Surviving the cytochrome seas. Neuron 21, 653-655 (1998).
-
(1998)
Neuron
, vol.21
, pp. 653-655
-
-
Newmeyer, D.D.1
Green, D.R.2
-
58
-
-
0342978014
-
L has activity independent of cytochrome c release
-
L has activity independent of cytochrome c release. J. Biol. Chem. 272, 30299-30305 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30299-30305
-
-
Li, F.1
-
59
-
-
0032192529
-
Evidence of a novel event during neuronal death: Development of competence-to-die in response to cytoplasmic cytochrome c
-
Deshmukh, M. & Johnson, E. M. Jr. Evidence of a novel event during neuronal death: development of competence-to-die in response to cytoplasmic cytochrome c. Neuron 21, 695-705 (1998).
-
(1998)
Neuron
, vol.21
, pp. 695-705
-
-
Deshmukh, M.1
Johnson E.M., Jr.2
-
60
-
-
0032535715
-
Loss of Atm radiosensitizes multiple p53 null tissues
-
Westphal, C. H. et al. Loss of Atm radiosensitizes multiple p53 null tissues. Cancer Res. 58, 5637-5639 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 5637-5639
-
-
Westphal, C.H.1
-
61
-
-
0035854479
-
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice
-
Paris, F. et al. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293, 293-297 (2001). Tissue failure in response to IR can result from the selective damage of the most sensitive tissue component (in this case, the endothelium), leading to a chain reaction of pathological consequences.
-
(2001)
Science
, vol.293
, pp. 293-297
-
-
Paris, F.1
-
62
-
-
0033891414
-
Radiation-induced apoptosis in the adult central nervous system is p53-dependent
-
Chow, B. M., Li, Y. Q. & Wong, C. S. Radiation-induced apoptosis in the adult central nervous system is p53-dependent. Cell Death Differ. 7, 712-720 (2000).
-
(2000)
Cell Death Differ.
, vol.7
, pp. 712-720
-
-
Chow, B.M.1
Li, Y.Q.2
Wong, C.S.3
-
63
-
-
0017146236
-
In vitro radiosensitivity of human dipliod fibroblasts derived from patients with unusual clinical responses to radiation
-
Weichselbaum, R. R., Epstein, J. & Little, J. B. In vitro radiosensitivity of human dipliod fibroblasts derived from patients with unusual clinical responses to radiation. Radiology 121, 479-482 (1976).
-
(1976)
Radiology
, vol.121
, pp. 479-482
-
-
Weichselbaum, R.R.1
Epstein, J.2
Little, J.B.3
-
64
-
-
0027293946
-
Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland
-
Barcellos-Hoff, M. H. Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland. Cancer Res. 53, 3880-3886 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 3880-3886
-
-
Barcellos-Hoff, M.H.1
-
65
-
-
0036124599
-
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation
-
Flanders, K. C. et al. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation Am. J. Pathol. 160, 1057-1068 (2002).
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 1057-1068
-
-
Flanders, K.C.1
-
66
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone, R. W., Ruefli, A. A. & Lowe, S. W. Apoptosis: a link between cancer genetics and chemotherapy. Cell 108, 153-164 (2002).
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
67
-
-
0035049735
-
Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo
-
Schmitt, C. A. & Lowe, S. W. Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo. Blood Cells Mol. Dis. 27, 206-216 (2001).
-
(2001)
Blood Cells Mol. Dis.
, vol.27
, pp. 206-216
-
-
Schmitt, C.A.1
Lowe, S.W.2
-
68
-
-
0028250879
-
Ganetic alterations associated with bladder cancer
-
Cordon-Cardo, C., Dalbagni, G., Sarkis, A. S. & Reuter, V. E. Ganetic alterations associated with bladder cancer. Important Adv. Oncol. [vol?] 71-83 (1994).
-
(1994)
Important Adv. Oncol.
, pp. 71-83
-
-
Cordon-Cardo, C.1
Dalbagni, G.2
Sarkis, A.S.3
Reuter, V.E.4
-
69
-
-
0032054823
-
Prognostic value of p53 gene mutations in a large series of node-negative breast cancer patients
-
Falette, N. et al. Prognostic value of p53 gene mutations in a large series of node-negative breast cancer patients. Cancer Res. 58, 1451-1455 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 1451-1455
-
-
Falette, N.1
-
70
-
-
15444353870
-
p53 oncoprotein as a prognostic indicator in patients with breast cancer
-
Molina, R. et al. p53 oncoprotein as a prognostic indicator in patients with breast cancer. Anticancer Res. 18, 507-511 (1998).
-
(1998)
Anticancer Res.
, vol.18
, pp. 507-511
-
-
Molina, R.1
-
71
-
-
0034931001
-
Apoptosis: Mediator or mode of cell killing by anticancer agents?
-
Brown, J. M. & Wouters, B. G. Apoptosis: mediator or mode of cell killing by anticancer agents? Drug Resist. Update 4, 135-136 (2001).
-
(2001)
Drug Resist. Update
, vol.4
, pp. 135-136
-
-
Brown, J.M.1
Wouters, B.G.2
-
72
-
-
0033956925
-
The challenge of p53 as prognostic and predictive factor in gliomas
-
Nieder, C., Petersen, S., Petersen, C. & Thames, H. D. The challenge of p53 as prognostic and predictive factor in gliomas. Cancer Treat. Rev. 26, 67-73 (2000).
-
(2000)
Cancer Treat. Rev.
, vol.26
, pp. 67-73
-
-
Nieder, C.1
Petersen, S.2
Petersen, C.3
Thames, H.D.4
-
73
-
-
0034688878
-
Bcl-2 with loss of apoptosis allows accumulation of genetic alterations: A pathway to metastatic progression in human breast cancer
-
Sierra, A. et al. Bcl-2 with loss of apoptosis allows accumulation of genetic alterations: a pathway to metastatic progression in human breast cancer. Int. J. Cancer 89, 142-147 (2000).
-
(2000)
Int. J. Cancer
, vol.89
, pp. 142-147
-
-
Sierra, A.1
-
74
-
-
0032522738
-
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
-
Deveraux, Q. L. et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 17, 2215-2223 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 2215-2223
-
-
Deveraux, Q.L.1
-
75
-
-
0034253533
-
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
-
Beere, H. M. et al. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nature Cell Biol. 2, 469-475 (2000).
-
(2000)
Nature Cell Biol.
, vol.2
, pp. 469-475
-
-
Beere, H.M.1
-
76
-
-
0027944206
-
p53 status and the efficacy of cancer therapy in vivo
-
Lowe, S. W. et al. p53 status and the efficacy of cancer therapy in vivo. Science 266, 807-810 (1994). This paper had a very strong impact in the field by establishing the concept of p53-dependent apoptosis as the mechanism of treatment sensitivity of tumours.
-
(1994)
Science
, vol.266
, pp. 807-810
-
-
Lowe, S.W.1
-
77
-
-
0035754080
-
To cycle or not to cycle: A critical decision in cancer
-
Malumbres, M. & Barbacid, M. To cycle or not to cycle: a critical decision in cancer. Nature Rev. Cancer 1, 222-231 (2001).
-
(2001)
Nature Rev. Cancer
, vol.1
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
78
-
-
0035736138
-
If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
-
Roninson, I. B., Broude, E. V. & Chang, B. D. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist. Update 4, 303-313 (2001).
-
(2001)
Drug Resist. Update
, vol.4
, pp. 303-313
-
-
Roninson, I.B.1
Broude, E.V.2
Chang, B.D.3
-
79
-
-
0030875480
-
Apoptosis and mitotic cell death: Their relative contributions to normal-tissue and tumour radiation response
-
Hendry, J. H. & West, C. M. Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumour radiation response. Int. J. Radiat. Biol. 71, 709-719 (1997).
-
(1997)
Int. J. Radiat. Biol.
, vol.71
, pp. 709-719
-
-
Hendry, J.H.1
West, C.M.2
-
80
-
-
0031850793
-
Delayed DNA damage associated with mitotic catastrophe following X-irradiation of HeLa S3 cells
-
Ianzini, F. & Mackey, M. A. Delayed DNA damage associated with mitotic catastrophe following X-irradiation of HeLa S3 cells. Mutagenesis 13, 337-344 (1998)
-
(1998)
Mutagenesis
, vol.13
, pp. 337-344
-
-
Ianzini, F.1
Mackey, M.A.2
-
81
-
-
0029664460
-
Early and late G2 arrest of cells undergoing radiation-induced apoptosis or micronucleation
-
Abend, M., Gilbertz, K. P., Rhein, A. & van Beuningen, D. Early and late G2 arrest of cells undergoing radiation-induced apoptosis or micronucleation. Cell Prolif. 29, 101-113 (1996).
-
(1996)
Cell Prolif.
, vol.29
, pp. 101-113
-
-
Abend, M.1
Gilbertz, K.P.2
Rhein, A.3
Van Beuningen, D.4
-
82
-
-
0029923176
-
Multiple pathways for apoptotic nuclear fragmentation Exp
-
Dini, L., Coppola, S., Ruzittu, M. T. & Ghibelli, L. Multiple pathways for apoptotic nuclear fragmentation Exp. Cell Res. 223, 340-347 (1996).
-
(1996)
Cell Res.
, vol.223
, pp. 340-347
-
-
Dini, L.1
Coppola, S.2
Ruzittu, M.T.3
Ghibelli, L.4
-
83
-
-
0037013154
-
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
-
Schmitt, C. A. et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109, 335-346 (2002). Blocking the apoptotic programme in tumours of immunocyte origin causes a switch to an alternative type of p53-mediated response to treatment in vivo - senescence-like permanent arrest.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
-
84
-
-
0027893001
-
Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage
-
Slichenmyer, W. J., Nelson, W. G., Slebos, R. J. & Kastan, M. B. Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res. 53, 4164-4168 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 4164-4168
-
-
Slichenmyer, W.J.1
Nelson, W.G.2
Slebos, R.J.3
Kastan, M.B.4
-
85
-
-
0027176479
-
p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines
-
Brachman, D. G. et al. p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines. Cancer Res. 53, 3667-3669 (1993). References 84 and 85 show that wild-type p53 in the tumour is not necessarily associated with higher sensitivity to treatment.
-
(1993)
Cancer Res.
, vol.53
, pp. 3667-3669
-
-
Brachman, D.G.1
-
86
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
Graeber T. G. et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91 (1996).
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
-
87
-
-
0036044841
-
Apoptosis inhibitor as a suppressor of tumor progression: Expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor
-
discussion 45-46
-
Gurova, K. V. et al. Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor Cancer Biol. Ther. 1, 39-44; discussion 45-46 (2002).
-
(2002)
Cancer Biol. Ther.
, vol.1
, pp. 39-44
-
-
Gurova, K.V.1
-
88
-
-
0037216725
-
Paradoxical role of apoptosis in cancer progression
-
Gurova, K. & Gudkov, A. V. Paradoxical role of apoptosis in cancer progression. J. Cell Biochem. 88, 128-137 (2003).
-
(2003)
J. Cell Biochem.
, vol.88
, pp. 128-137
-
-
Gurova, K.1
Gudkov, A.V.2
-
89
-
-
0000051538
-
Could p53 be a target for therapeutic suppression?
-
Komarova, E. A. & Gudkov, A. V. Could p53 be a target for therapeutic suppression? Semin. Cancer Biol. 8, 389-400 (1998).
-
(1998)
Semin. Cancer Biol.
, vol.8
, pp. 389-400
-
-
Komarova, E.A.1
Gudkov, A.V.2
-
90
-
-
84892012518
-
-
(ed. Blagosklonny, M. V.) (Eurekah, Austin, Texas
-
Funk, J. O., Samuel, T. & Weber, H. O. in Cell Cycle Checkpoints and Cancer (ed. Blagosklonny, M. V.) 64-77 (Eurekah, Austin, Texas, 2001).
-
(2001)
Cell Cycle Checkpoints and Cancer
, pp. 64-77
-
-
Funk, J.O.1
Samuel, T.2
Weber, H.O.3
-
91
-
-
0035155661
-
ATM a central controller of cellular responses to DNA damage
-
Khanna, K. K., Lavin, M. F. Jackson, S. P. & Muthern, T. D. ATM, a central controller of cellular responses to DNA damage. Cell Death Differ. 8, 1052-1065 (2001).
-
(2001)
Cell Death Differ.
, vol.8
, pp. 1052-1065
-
-
Khanna, K.K.1
Lavin, M.F.2
Jackson, S.P.3
Muthern, T.D.4
-
92
-
-
0034952596
-
Unraveling DNA repair in human: Molecular mechanisms and consequences of repair defect
-
Tuteja, N. & Tutela, R. Unraveling DNA repair in human: molecular mechanisms and consequences of repair defect. Crit. Rev. Biochem. Mol. Biol. 36, 261-290 (2001).
-
(2001)
Crit. Rev. Biochem. Mol. Biol.
, vol.36
, pp. 261-290
-
-
Tuteja, N.1
Tutela, R.2
-
93
-
-
0032966188
-
The molecular and cellular basis of radiosensitivity: Implications for understanding how normal tissues and tumors respond to therapeutic radiation
-
Rosen, E. M., Fan, S., Rockwell, S. & Goldberg, I. D. The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation. Cancer Invest. 17, 56-72 (1999).
-
(1999)
Cancer Invest.
, vol.17
, pp. 56-72
-
-
Rosen, E.M.1
Fan, S.2
Rockwell, S.3
Goldberg, I.D.4
-
94
-
-
0036270993
-
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: Fail-safe protection against carcinogenesis
-
Bernstein, C., Bernstein, H., Payne, C. M. & Garewal, H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat. Res. 511, 145-178 (2002).
-
(2002)
Mutat. Res.
, vol.511
, pp. 145-178
-
-
Bernstein, C.1
Bernstein, H.2
Payne, C.M.3
Garewal, H.4
-
95
-
-
0032931517
-
The p53 pathway
-
Prives, C. & Hall, P. A. The p53 pathway. J. Pathol. 187, 112-126 (1999)
-
(1999)
J. Pathol.
, vol.187
, pp. 112-126
-
-
Prives, C.1
Hall, P.A.2
-
96
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden, K. H. & Lu, X. Live or let die: the cell's response to p53. Nature Rev. Cancer 2, 594-604 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
97
-
-
0030853074
-
Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts
-
Ford, J. M. & Hanawalt, P. C. Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts. J. Biol. Chem. 272, 28073-28080 (1997). References 34 and 97 indicate a direct involvement of p53 in DNA repair.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28073-28080
-
-
Ford, J.M.1
Hanawalt, P.C.2
-
98
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell 88, 323-331 (1997).
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
99
-
-
0035206383
-
Mechanisms of p53-dependent apoptosis
-
Schuler, M. & Green, D. R. Mechanisms of p53-dependent apoptosis. Biochem. Soc. Trans. 29, 684-688 (2001).
-
(2001)
Biochem. Soc. Trans.
, vol.29
, pp. 684-688
-
-
Schuler, M.1
Green, D.R.2
-
100
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li, H., Zhu, H., Xu, C. J. & Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491-501 (1998).
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
101
-
-
0035921189
-
Ionizing radiation as a response-enhancing agent for CD95-mediated apoptosis
-
Sheard, M. A. Ionizing radiation as a response-enhancing agent for CD95-mediated apoptosis. Int. J. Cancer 96, 213-220 (2001).
-
(2001)
Int. J. Cancer
, vol.96
, pp. 213-220
-
-
Sheard, M.A.1
-
102
-
-
0036242549
-
Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis
-
Embree-Ku, M., Venturini, D. & Boekelheide, K. Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis. Biol. Reprod. 66, 1456-1461 (2002).
-
(2002)
Biol. Reprod.
, vol.66
, pp. 1456-1461
-
-
Embree-Ku, M.1
Venturini, D.2
Boekelheide, K.3
-
103
-
-
0035983264
-
Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor
-
McGowan, C. H. Checking in on Cds1 (Chk2): a checkpoint kinase and tumor suppressor Bioessays 24, 502-511 (2002).
-
(2002)
Bioessays
, vol.24
, pp. 502-511
-
-
McGowan, C.H.1
-
104
-
-
0033552636
-
Maintenance of genomic integrity by p53: Complementary roles for activated and non-activated p53
-
Albrechtsen, N. et al. Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53. Oncogene 18, 7706-7717 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 7706-7717
-
-
Albrechtsen, N.1
-
105
-
-
0025096056
-
Molecular cloning of the human DNA excision repair gene ERCC-6
-
Troelstra, C. et al. Molecular cloning of the human DNA excision repair gene ERCC-6. Mol. Cell. Biol. 10, 5806-5813 (1990).
-
(1990)
Mol. Cell. Biol.
, vol.10
, pp. 5806-5813
-
-
Troelstra, C.1
-
106
-
-
0030883593
-
Interaction of p53 with the human Rad51 protein
-
Buchhop, S. et al. Interaction of p53 with the human Rad51 protein. Nucleic Acids Res. 25, 3868-3874 (1997).
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3868-3874
-
-
Buchhop, S.1
-
107
-
-
0032411879
-
Stress signals for apoptosis: Ceramide and c-Jun kinase
-
Basu, S. & Kolesnick, R. Stress signals for apoptosis: ceramide and c-Jun kinase. Oncogene 17, 3277-3285 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 3277-3285
-
-
Basu, S.1
Kolesnick, R.2
-
108
-
-
0036303786
-
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
-
Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway J. Clin. Invest. 110, 3-8 (2002).
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 3-8
-
-
Kolesnick, R.1
-
109
-
-
0032576768
-
ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage
-
Aladjem, M. I. et al. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr. Biol. 8, 145-155 (1998).
-
(1998)
Curr. Biol.
, vol.8
, pp. 145-155
-
-
Aladjem, M.I.1
-
110
-
-
0029874308
-
p53-dependent apoptosis suppresses radiation-induced teratogenesis
-
Norimura, T., Nomoto, S., Katsuki, M., Gondo, Y. & Kondo, S. p53-dependent apoptosis suppresses radiation-induced teratogenesis. Nature Med. 2, 577-580 (1996). Loss of p53 in mice is associated with a marked increase in the teratogenic effect of IR, presumably because genetically damaged cells are no longer eliminated by p53-mediated apoptosis. These observations allowed David Lane to name p53 "a guardian of babies".
-
(1996)
Nature Med.
, vol.2
, pp. 577-580
-
-
Norimura, T.1
Nomoto, S.2
Katsuki, M.3
Gondo, Y.4
Kondo, S.5
-
111
-
-
0029875821
-
Cellular proofreading
-
Brash, D. E. Cellular proofreading. Nature Med. 2, 525-526 (1996).
-
(1996)
Nature Med.
, vol.2
, pp. 525-526
-
-
Brash, D.E.1
-
112
-
-
0030951637
-
Tumor suppressors: A developing role for p53?
-
Hall, P. A. & Lane, D. P. Tumor suppressors: a developing role for p53? Curr. Biol. 7, R144-R147 (1997).
-
(1997)
Curr. Biol.
, vol.7
-
-
Hall, P.A.1
Lane, D.P.2
-
113
-
-
0024679160
-
Effects and consequences of prenatal irradiation
-
Vos, O. Effects and consequences of prenatal irradiation. Boll. Soc. Ital. Biol. Sper. 65, 481-500 (1989).
-
(1989)
Boll. Soc. Ital. Biol. Sper.
, vol.65
, pp. 481-500
-
-
Vos, O.1
-
114
-
-
0030779865
-
p53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine
-
Hendry, J. H., Cai, W. B., Roberts, S. A. & Potten, C. S. p53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine. Radiat. Res. 148, 254-259 (1997).
-
(1997)
Radiat. Res.
, vol.148
, pp. 254-259
-
-
Hendry, J.H.1
Cai, W.B.2
Roberts, S.A.3
Potten, C.S.4
-
115
-
-
0031892878
-
Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice
-
Hasegawa, M., Zhang, Y., Niibe, H., Terry, N. H. & Meistrich, M. L. Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice. Radiat. Res. 149, 263-270 (1998)
-
(1998)
Radiat. Res.
, vol.149
, pp. 263-270
-
-
Hasegawa, M.1
Zhang, Y.2
Niibe, H.3
Terry, N.H.4
Meistrich, M.L.5
-
116
-
-
0031828874
-
p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes
-
Tron, V. A. et al. p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes. Am. J. Pathol. 153, 579-585 (1998).
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 579-585
-
-
Tron, V.A.1
-
117
-
-
0033529123
-
Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress
-
Frenkel, J. et al. Accentuated apoptosis in normally developing p53 knockout mouse embryos following genotoxic stress. Oncogene 18, 2901-2907 (1999)
-
(1999)
Oncogene
, vol.18
, pp. 2901-2907
-
-
Frenkel, J.1
-
118
-
-
0033544023
-
Epithelial cells of different organs exhibit distinct patterns of p53-dependent and p53-independent apoptosis following DNA insult
-
Uberti, D. et al Epithelial cells of different organs exhibit distinct patterns of p53-dependent and p53-independent apoptosis following DNA insult. Exp. Cell Res. 252, 123-133 (1999).
-
(1999)
Exp. Cell Res.
, vol.252
, pp. 123-133
-
-
Uberti, D.1
-
119
-
-
0030453081
-
p53 deficiency produces fewer regenerating spermatogenic tubules after irradiation
-
Hendry, J. H., Adeeko, A., Potten, C. S. & Morris, I. D. p53 deficiency produces fewer regenerating spermatogenic tubules after irradiation. Int. J. Radiat. Biol. 70, 677-682 (1996).
-
(1996)
Int. J. Radiat. Biol.
, vol.70
, pp. 677-682
-
-
Hendry, J.H.1
Adeeko, A.2
Potten, C.S.3
Morris, I.D.4
-
120
-
-
0024578370
-
Modifiers of radiosensitivity
-
Rojas, A. & Denekamp, J. Modifiers of radiosensitivity. Experientia 45, 41-52 (1989).
-
(1989)
Experientia
, vol.45
, pp. 41-52
-
-
Rojas, A.1
Denekamp, J.2
-
121
-
-
0037096740
-
Insulin increases the sensitivity of tumors to irradiation: Involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption
-
Jordan, B. F. et al. Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption. Cancer Res. 62, 3555-3561 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 3555-3561
-
-
Jordan, B.F.1
-
122
-
-
0022649840
-
Interleukin 1 is a radioprotector
-
Neta, R., Douches, S. & Oppenheim, J. J. Interleukin 1 is a radioprotector. J. Immunol. 136, 2483-2485 (1986).
-
(1986)
J. Immunol.
, vol.136
, pp. 2483-2485
-
-
Neta, R.1
Douches, S.2
Oppenheim, J.J.3
-
123
-
-
0026767362
-
Radioprotection of mice by recombinant rat stem cell factor
-
Zsebo, K. M. et al. Radioprotection of mice by recombinant rat stem cell factor. Proc. Natl Acad. Sci. USA 89, 9464-9468 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 9464-9468
-
-
Zsebo, K.M.1
-
124
-
-
0028109722
-
IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation
-
Neta, R., Stiefel, S. M., Finkelman, F., Herrmann, S. & Ali, N. IL-12 protects bone marrow from and sensitizes intestinal tract to ionizing radiation. J. Immunol. 153, 4230-4237 (1994).
-
(1994)
J. Immunol.
, vol.153
, pp. 4230-4237
-
-
Neta, R.1
Stiefel, S.M.2
Finkelman, F.3
Herrmann, S.4
Ali, N.5
-
125
-
-
0034042294
-
Molecular genetics of circadian rhythms in mammals
-
King, D. P. & Takahashi, J. S. Molecular genetics of circadian rhythms in mammals. Annu. Rev. Neurosci. 23, 713-742 (2000).
-
(2000)
Annu. Rev. Neurosci.
, vol.23
, pp. 713-742
-
-
King, D.P.1
Takahashi, J.S.2
-
126
-
-
0036223532
-
Chronobiology of the mammalian response to ionizing radiation potential applications in oncology
-
Haus, E. Chronobiology of the mammalian response to ionizing radiation potential applications in oncology. Chronobiol. Int. 19, 77-100 (2002).
-
(2002)
Chronobiol. Int.
, vol.19
, pp. 77-100
-
-
Haus, E.1
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