Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation

Cancer Research

Volumn 60, Issue 10, 2000, Pages 2576-2578

  Ruth, Adam C ^a   Roninson, Igor B ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL DEATH; CELL FUNCTION; CELL SURVIVAL; DRUG EFFECT; GAMMA IRRADIATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOSENSITIVITY;

3T3 CELLS; ANIMALS; APOPTOSIS; CELL AGING; CELL SURVIVAL; HELA CELLS; HUMANS; MICE; MITOSIS; P-GLYCOPROTEIN; RADIATION, IONIZING;

EID: 0034657818     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Hendry, J. H., and West, C. M. L. Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumour radiation response. Int. J. Radiat. Biol., 71: 709-719, 1997.
2. Chang, B. D., Broude, E. V., Dokmanovic, M., Zhu, H., Ruth, A., Xuan, Y., Kandel, E. S., Lausch, E., Christov, K., and Roninson, J. B. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res., 59: 3761-3767, 1999.
3. Gottesman, M. M., and Pastan, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62: 385-427, 1993.
4. Hill, B. T., Deuchars, K., Hosking, L. K., Ling, V., and Whelan, R. D. H. Overexpression of P-glycoprotein in mammalian tumor cell lines after fractionated X-irradiation in vitro. J. Natl. Cancer Inst., 82: 607-611, 1990.
5. Cho, J., Lee, Y., Lutzky, J., Redpath, L., and Slater, L. Collateral sensitivity to radiation and cis-platinum in a multidrug-resistant human leukemia cell line. Cancer Chemother. Pharmacol., 37: 168-172, 1995.
6. Mazzanti, R., Fantappie, O., Fabrizio, P., Pacini, S., Relli, P., Casamassima, F., Milano, F., and Ruggiero, M. Conferring drug resistance by MDR1 gene transfection increases susceptibility to irradiation and lipid peroxidation in 3T3 cell line. Free Radic. Biol. Med., 20: 601-606, 1996.
7. Shimm, S. D., Olson, S., and Hill, A. B. Radiation resistance in a multidrug resistant human T-cell leukemia line. J. Radiat. Oncol. Biol. Phys., 15: 931-936, 1988.
8. Denecke, J., Fiedler, K., Hacker-Klom, U., Molenkamp, G., Jurgens, H., and Wolff, J. E. A. Multiple drug-resistant C6 glioma cells cross-resistant to irradiation. Anticancer Res., 17: 4531-4534, 1997.
9. Smyth, M. J., Krasovskis, E., Sutton, V. R., and Johnstone, R. W. The drug efflux protein P-glycoprotein additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc. Natl. Acad. Sci. USA, 95: 7024-7029, 1998.
10. Johnstone, R. W., Cretney, E., and Smyth, M. J. P-Glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood, 93: 1075-1085, 1999.
11. Kandel, E. S., Chang, B. D., Shott, B., Shtil, A. A., Gudkov, A. V., and Roninson, I. B. Applications of green fluorescent protein as a marker of retroviral vectors. Somat. Cell Mol. Genet., 23: 325-340, 1997.
12. Gossen, M., and Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA, 89: 5547-5551, 1992.
13. De Graaf, D., Sharma, R. C., Mechetner, E. B., Schimke, R. T., and Roninson, I. B. P-Glycoprotein confers resistance to methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proc. Natl. Acad. Sci. USA, 93: 1238-1242, 1996.
14. Mechetner, E. B., and Roninson, I. B. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc. Natl. Acad. Sci. USA, 89: 5824-5828, 1992.
15. Pellegata, N. S., Antoniono, R. J., Redpath, J. L., and Stanbridge, E. J. DNA damage and p53-mediated cell cycle arrest: a reevaluation. Proc. Natl. Acad. Sci. USA, 93: 15209-15214, 1996.
16. Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V., and Gudkov, A. V. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science (Washington DC), 285: 1733-1736.
17. Michael, J. M., Lavin, M. F., and Watters, D. J. Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling. Cancer Res., 57: 3600-3605, 1997.
18. Thevenod, F., Friedmann, J. M., Katzen, A. D., and Hauser, I. A. Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-κB activation protects kidney proximal tubule cells from cadmium and reactive oxygen species-induced apoptosis. J. Biol. Chem., 275: 1887-1896, 2000.
19. Kyprianou, N., King, E. D., Bradbury, D., and Rhee, J. G. Bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells. Int. J. Cancer, 70: 341-348, 1997.
20. Yin, D. X., and Schimke, R. T. BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells. Cancer Res., 55: 4922-4928, 1995.
21. Lock, R. B., and Stribinskiene, L. Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival. Cancer Res., 56: 4006-4012, 1996.