Two distinct modes of cell death induced by doxorubicin: Apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype

Oncogene

Volumn 24, Issue 30, 2005, Pages 4765-4777

  Eom, Young Woo ^a   Kim, Mi Ae ^a   Park, Seok Soon ^a   Goo, Mi Jin ^a   Kwon, Hyuk Jae ^a   Sohn, Seonghyang ^a   Kim, Wook Hwan ^a   Yoon, Gyesoon ^a   Choi, Kyeong Sook ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Apoptosis; Doxorubicin; Hepatocellular carcinoma cells; Mitotic catastrophe; Senescence like phenotype

Indexed keywords

BETA GALACTOSIDASE; BUB1 RELATED PROTEIN; CASPASE; CENTROMERE PROTEIN A; CHECKPOINT KINASE 1; CYTOCHROME C; DOXORUBICIN; PHOSPHATIDYLSERINE; PROPIDIUM IODIDE; PROTEIN MAD2; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAMIN B; MITOGEN ACTIVATED PROTEIN KINASE P38;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; HEPATOMA CELL; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; MITOSIS INHIBITION; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; BIOLOGICAL MODEL; CELL AGING; CELL MEMBRANE PERMEABILITY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; KINETICS; METABOLISM; MITOCHONDRION; MITOSIS; MITOSIS SPINDLE; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE;

APOPTOSIS; CASPASES; CELL AGING; CELL DEATH; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL NUCLEUS; CYTOCHROMES C; DNA; DOWN-REGULATION; DOXORUBICIN; ENZYME ACTIVATION; HUMANS; KINETICS; LAMIN TYPE B; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; MITOSIS; MITOTIC SPINDLE APPARATUS; MODELS, BIOLOGICAL; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 23044467656     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208627     Document Type: Article

References (47)

1. Acunas B and Rozanes I. (1999). Eur. J. Radiol., 32, 86-89.
2. Aebi U, Cohn J, Buhle L and Gerace L. (1986). Nature, 323, 560-564.
3. Baichwal VR and Baeuerle PA. (1997). Curr. Biol., 7, R94-R96.
4. Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R and Kroemer G. (2004). Oncogene, 23, 2825-2837.
5. Chan GK, Jablonski SA, Sudakin V, Hittle JC and Yen TJ. (1999). J. Cell. Biol., 146, 941-954.
6. Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel ES, Lausch E, Christov K and Roninson IB. (1999a). Cancer Res., 59, 3761-3767.
7. Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC and Roninson IB. (2000). Oncogene, 19, 2165-2170.
8. Chang BD, Swift ME, Shen M, Fang J, Broude EV and Roninson IB. (2002). Proc. Natl. Acad. Sci. USA, 99, 389-394.
9. Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J and Roninson IB. (1999b). Oncogene, 18, 4808-4818.
10. Chu K, Teele N, Dewey MW, Albright N and Dewey WC. (2004). Radiat. Res., 162, 270-286.
11. Davis RJ. (2000). Cell, 103, 239-252.
12. Decaudin D, Marzo I, Brenner C and Kroemer G. (1998). Int. J. Oncol., 12, 141-152.
13. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M and Campisi J. (1995). Proc. Natl. Acad. Sci. USA, 92, 9363-9367.
14. Dumont P, Burton M, Chen QM, Gonos ES, Frippiat C, Mazarati JB, Eliaers F, Remacle J and Toussaint O. (2000). Free Radic. Biol. Med., 28, 361-373.
15. Elmore LW, Rehder CW, Di X, McChesney PA, Jackson-Cook CK, Gewirtz DA and Holt SE. (2002). J. Biol. Chem., 277, 35509-35515.
16. Gamen S, Anel A, Perez-Galan P, Lasierra P, Johnson D, Pineiro A and Naval J. (2000). Exp. Cell Res., 258, 223-235.
17. Gewirtz DA. (1999). Biochem. Pharmacol., 57, 727-741.
18. Gupta S. (2001). Life Sci., 69, 2957-2964.
19. He QY, Liang YY, Wang DS and Li DD. (2002). Int. J. Oncol., 20, 261-266.
20. Hendry JH and West CM. (1997). Int. J. Radiat. Biol., 71, 709-719.
21. Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ and Mak TW. (2000). Science, 287, 1824-1827.
22. Hortobagyi GN. (1997). Drugs, 54, 1-7.
23. Hsu IC, Tokiwa T, Bennett W, Metcalf RA, Welsh JA, Sun T and Harris CC. (1993). Carcinogenesis, 14, 987-992.
24. Kalitsis P, MacDonald AC, Newson AJ, Hudson DF and Choo KH. (1998). Genomics, 47, 108-114.
25. Kang MS, Lee HJ, Lee JH, Ku JL, Lee KP, Kelley MJ, Won YJ, Kim ST and Park JG. (1996). Int. J. Cancer, 67, 898-902.
26. Lanni JS and Jacks T. (1998). Mol. Cell. Biol., 18, 1055-1064.
27. Li Y and Benezra R. (1996). Science, 274, 246-248.
28. Liu L, Kwak YT, Bex F, Garcia-Martinez LF, Li XH, Meek K, Lane WS and Gaynor RB. (1998). Mol. Cell. Biol., 18, 4221-4234.
29. Lock RB and Stribinskiene L. (1996). Cancer Res., 56, 4006-4012.
30. Lu W, Li YH, He XF, Chen Y, Zeng QL and Qiu YR. (2002). Di. Yi. Jun. Yi. Da. Xue. Xue. Bao., 22, 524-526.
31. Mantel C, Braun SE, Reid S, Henegariu O, Liu L, Hangoc G and Broxmeyer HE. (1999). Blood, 93, 1390-1398.
32. Miranda EI, Santana C, Rojas E, Hernandez S, Ostrosky-Wegman P and Garcia-Carranca A. (1996). Mutat. Res., 349, 173-182.
33. Nitta M, Kobayashi O, Honda S, Hirota T, Kuninaka S, Marumoto T, Ushio Y and Saya H. (2004). Oncogene, 23, 6548-6558.
34. Ono K and Han J. (2000). Cell Signal., 12, 1-13.
35. Park JG, Lee JH, Kang MS, Park KJ, Jeon YM, Lee HJ, Kwon HS, Park HS, Yeo KS, Lee KU, Kim ST, Chung JK, Hwang YJ, Lee HS, Kim CY, Lee YI, Chen TR, Hay RJ, Song SS, Kim WH, Kim CW and Kim YI. (1995). Int. J. Cancer, 62, 276-282.
36. Patt YZ, Claghorn L, Charnsangavej C, Soski M, Cleary K and Mavligit GM. (1988). Cancer, 61, 1884-1888.
37. Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B and Davis RJ. (1996). Mol. Cell. Biol., 16, 1247-1255.
38. Roninson IB, Broude EV and Chang BD. (2001). Drug Resist. Updat., 4, 303-313.
39. Ruth AC and Roninson IB. (2000). Cancer Res., 60, 2576-2578.
40. Sciarrino E, Simonetti RG, Le Moli S and Pagliaro L. (1985). Cancer, 56, 2751-2755.
41. Seong YS, Kamijo K, Lee JS, Fernandez E, Kuriyama R, Miki T and Lee KS. (2002). J. Biol Chem., 277, 32282-32293.
42. Serrano M, Lin AW, McCurrach ME, Beach D and Lowe SW. (1997). Cell, 88, 593-602.
43. Speth PA, Linssen PC, Boezeman JB, Wessels HM and Haanen C. (1987). Cancer Chemother. Pharmacol., 20, 305-310.
44. te Poele RH, Okorokov AL, Jardine L, Cummings J and Joel SP. (2002). Cancer Res., 62, 1876-1883.
45. Wang Y, Blandino G and Givol D. (1999). Oncogene, 18, 2643-2649.
46. Wang Y, Zhu S, Cloughesy TF, Liau LM and Mischel PS. (2004). Oncogene, 23, 1283-1290.
47. Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR and Templeton DJ. (1994). Nature, 372, 798-800.