-
1
-
-
0029115555
-
The structure of the presenilin 1 (S.182) gene, and identification of six novel mutations in early onset AD families. Alzheimer's Disease Collaborative Group
-
Alzheimer's Disease Collaborative Group
-
Alzheimer's Disease Collaborative Group. The structure of the presenilin 1 (S.182) gene, and identification of six novel mutations in early onset AD families. Alzheimer's Disease Collaborative Group. Nat Genet 11: 219-222, 1995.
-
(1995)
Nat Genet
, vol.11
, pp. 219-222
-
-
-
2
-
-
34347250499
-
Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate
-
Baker RP, Young K, Feng L, Shi Y, Urban S. Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate. Proc Natl Acad Sci USA 104: 8257-8262, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8257-8262
-
-
Baker, R.P.1
Young, K.2
Feng, L.3
Shi, Y.4
Urban, S.5
-
3
-
-
33645105621
-
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms
-
Bentahir M, Nyabi O, Verhamme J, Tolia A, Horre K, Wiltfang J, Esselmann H, De Strooper B. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. J Neurochem 96: 732-742, 2006.
-
(2006)
J Neurochem
, vol.96
, pp. 732-742
-
-
Bentahir, M.1
Nyabi, O.2
Verhamme, J.3
Tolia, A.4
Horre, K.5
Wiltfang, J.6
Esselmann, H.7
De Strooper, B.8
-
4
-
-
0034681260
-
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown MS, Ye J, Rawson RB, Goldstein JL. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100: 391-398, 2000.
-
(2000)
Cell
, vol.100
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
5
-
-
0032488995
-
The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex
-
Capell A, Grunberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem 273: 3205-3211, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 3205-3211
-
-
Capell, A.1
Grunberg, J.2
Pesold, B.3
Diehlmann, A.4
Citron, M.5
Nixon, R.6
Beyreuther, K.7
Selkoe, D.J.8
Haass, C.9
-
6
-
-
0034674730
-
Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons
-
Chan SL, Mayne M, Holden CP, Geiger JD, Mattson MP. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem 275: 18195-18200, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 18195-18200
-
-
Chan, S.L.1
Mayne, M.2
Holden, C.P.3
Geiger, J.D.4
Mattson, M.P.5
-
7
-
-
50649119079
-
Glu 332 in the nicastrin ectodomain is essential for γ-secretase complex maturation but not for its activity
-
6a
-
6a. Chávez-Gutiérrez L, Tolia A, Maes E, Li T, Wong PC, de Strooper B. Glu 332 in the nicastrin ectodomain is essential for γ-secretase complex maturation but not for its activity. J Biol Chem 283:20096-20105, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 20096-20105
-
-
Chávez-Gutiérrez, L.1
Tolia, A.2
Maes, E.3
Li, T.4
Wong, P.C.5
de Strooper, B.6
-
8
-
-
44849120372
-
Membrane topology of gamma-secretase component PEN-2
-
Crystal AS, Morais VA, Pierson TC, Pijak DS, Carlin D, Lee VM, Doms RW. Membrane topology of gamma-secretase component PEN-2. J Biol Chem 14: 14, 2003.
-
(2003)
J Biol Chem
, vol.14
, pp. 14
-
-
Crystal, A.S.1
Morais, V.A.2
Pierson, T.C.3
Pijak, D.S.4
Carlin, D.5
Lee, V.M.6
Doms, R.W.7
-
9
-
-
0037431082
-
-
De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex. Neuron 38: 9-12, 2003.
-
De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex. Neuron 38: 9-12, 2003.
-
-
-
-
10
-
-
0035911161
-
Where Notch and Wnt signaling meet. The presenilin hub
-
De Strooper B, Annaert W. Where Notch and Wnt signaling meet. The presenilin hub. J Cell Biol 152: F17-F20, 2001.
-
(2001)
J Cell Biol
, vol.152
-
-
De Strooper, B.1
Annaert, W.2
-
11
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [see comments]
-
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [see comments]. Nature 398: 518-522, 1999.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goate, A.11
Kopan, R.12
-
12
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein [see comments]
-
De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein [see comments]. Nature 391: 387-390, 1998.
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
13
-
-
0036639707
-
Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease
-
Dominguez DI, De Strooper B. Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease. Trends Pharmacol Sci 23: 324-330, 2002.
-
(2002)
Trends Pharmacol Sci
, vol.23
, pp. 324-330
-
-
Dominguez, D.I.1
De Strooper, B.2
-
14
-
-
0037173115
-
Presenilin and nicastrin regulate each other and determine amyloid betapeptide production via complex formation
-
Edbauer D, Winkler E, Haass C, Steiner H. Presenilin and nicastrin regulate each other and determine amyloid betapeptide production via complex formation. Proc Natl Acad Sci USA 99: 8666-8671, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8666-8671
-
-
Edbauer, D.1
Winkler, E.2
Haass, C.3
Steiner, H.4
-
15
-
-
0142203285
-
Reconstitution of gamma-secretase activity
-
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Reconstitution of gamma-secretase activity. Nat Cell Biol 7: 7, 2003.
-
(2003)
Nat Cell Biol
, vol.7
, pp. 7
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
16
-
-
15544380450
-
Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
-
Evin G, Canterford LD, Hoke DE, Sharples RA, Culvenor JG, Masters CL. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex. Biochemistry 44: 4332-4341, 2005.
-
(2005)
Biochemistry
, vol.44
, pp. 4332-4341
-
-
Evin, G.1
Canterford, L.D.2
Hoke, D.E.3
Sharples, R.A.4
Culvenor, J.G.5
Masters, C.L.6
-
17
-
-
36849037428
-
Structure of a site-2 protease family intramembrane metalloprotease
-
Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y. Structure of a site-2 protease family intramembrane metalloprotease. Science 318: 1608-1612, 2007.
-
(2007)
Science
, vol.318
, pp. 1608-1612
-
-
Feng, L.1
Yan, H.2
Wu, Z.3
Yan, N.4
Wang, Z.5
Jeffrey, P.D.6
Shi, Y.7
-
18
-
-
0942298101
-
Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex
-
Fortna RR, Crystal AS, Morais VA, Pijak DS, Lee VM, Doms RW. Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex. J Biol Chem 279: 3685-3693, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 3685-3693
-
-
Fortna, R.R.1
Crystal, A.S.2
Morais, V.A.3
Pijak, D.S.4
Lee, V.M.5
Doms, R.W.6
-
19
-
-
0347093518
-
Detergentdependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
-
Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS. Detergentdependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry 43: 323-333, 2004.
-
(2004)
Biochemistry
, vol.43
, pp. 323-333
-
-
Fraering, P.C.1
LaVoie, M.J.2
Ye, W.3
Ostaszewski, B.L.4
Kimberly, W.T.5
Selkoe, D.J.6
Wolfe, M.S.7
-
20
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D. Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 3: 85-97, 2002.
-
(2002)
Dev Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
Parks, A.L.11
Xu, W.12
Li, J.13
Gurney, M.14
Myers, R.L.15
Himes, C.S.16
Hiebsch, R.17
Ruble, C.18
Nye, J.S.19
Curtis, D.20
more..
-
21
-
-
0024474145
-
Universality and structure of the N-end rule
-
Gonda DK, Bachmair A, Wunning I, Tobias JW, Lane WS, Varshavsky A. Universality and structure of the N-end rule. J Biol Chem 264: 16700-16712, 1989.
-
(1989)
J Biol Chem
, vol.264
, pp. 16700-16712
-
-
Gonda, D.K.1
Bachmair, A.2
Wunning, I.3
Tobias, J.W.4
Lane, W.S.5
Varshavsky, A.6
-
22
-
-
0034080403
-
Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
-
Goutte C, Hepler W, Mickey KM, Priess JR. Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127: 2481-2492, 2000.
-
(2000)
Development
, vol.127
, pp. 2481-2492
-
-
Goutte, C.1
Hepler, W.2
Mickey, K.M.3
Priess, J.R.4
-
23
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte C, Tsunozaki M, Hale VA, Priess JR. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci USA 99: 775-779, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
Priess, J.R.4
-
24
-
-
0036628917
-
Novel class of polytopic proteins with domains associated with putative protease activity
-
Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI. Novel class of polytopic proteins with domains associated with putative protease activity. Biochemistry (Mosc) 67: 826-835, 2002.
-
(2002)
Biochemistry (Mosc)
, vol.67
, pp. 826-835
-
-
Grigorenko, A.P.1
Moliaka, Y.K.2
Korovaitseva, G.I.3
Rogaev, E.I.4
-
25
-
-
0027333557
-
Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
-
Haass C, Selkoe DJ. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 75: 1039-1042, 1993.
-
(1993)
Cell
, vol.75
, pp. 1039-1042
-
-
Haass, C.1
Selkoe, D.J.2
-
26
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
-
Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8: 101-112, 2007.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
27
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356, 2002.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
28
-
-
0037474505
-
Dimerization of presenilin-1 in vivo: Suggestion of novel regulatory mechanisms leading to higher order complexes
-
Hebert SS, Godin C, Tomiyama T, Mori H, Levesque G. Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes. Biochem Biophys Res Commun 301: 119-126, 2003.
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 119-126
-
-
Hebert, S.S.1
Godin, C.2
Tomiyama, T.3
Mori, H.4
Levesque, G.5
-
29
-
-
5144224126
-
Coordinated and widespread expression of gamma-secretase in vivo: Evidence for size and molecular heterogeneity
-
Hébert SS, Serneels L, Dejaegere T, Horré K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B. Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol Dis 17: 260-272, 2004.
-
(2004)
Neurobiol Dis
, vol.17
, pp. 260-272
-
-
Hébert, S.S.1
Serneels, L.2
Dejaegere, T.3
Horré, K.4
Dabrowski, M.5
Baert, V.6
Annaert, W.7
Hartmann, D.8
De Strooper, B.9
-
30
-
-
20444481683
-
A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence
-
Henricson A, Kall L, Sonnhammer EL. A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence. Febs J 272: 2727-2733, 2005.
-
(2005)
Febs J
, vol.272
, pp. 2727-2733
-
-
Henricson, A.1
Kall, L.2
Sonnhammer, E.L.3
-
31
-
-
33845411954
-
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
-
Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 52: 831-843, 2006.
-
(2006)
Neuron
, vol.52
, pp. 831-843
-
-
Hsieh, H.1
Boehm, J.2
Sato, C.3
Iwatsubo, T.4
Tomita, T.5
Sisodia, S.6
Malinow, R.7
-
32
-
-
17844390391
-
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation
-
Huppert SS, Ilagan MX, De Strooper B, Kopan R. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell 8: 677-688, 2005.
-
(2005)
Dev Cell
, vol.8
, pp. 677-688
-
-
Huppert, S.S.1
Ilagan, M.X.2
De Strooper, B.3
Kopan, R.4
-
33
-
-
0034702303
-
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
-
Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature 405: 966-970, 2000.
-
(2000)
Nature
, vol.405
, pp. 966-970
-
-
Huppert, S.S.1
Le, A.2
Schroeter, E.H.3
Mumm, J.S.4
Saxena, M.T.5
Milner, L.A.6
Kopan, R.7
-
34
-
-
0027258525
-
The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
-
Jarrett JT, Berger EP, Lansbury PT Jr. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32: 4693-4697, 1993.
-
(1993)
Biochemistry
, vol.32
, pp. 4693-4697
-
-
Jarrett, J.T.1
Berger, E.P.2
Lansbury Jr., P.T.3
-
35
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R. APP processing and synaptic function. Neuron 37: 925-937, 2003.
-
(2003)
Neuron
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
Sisodia, S.7
Malinow, R.8
-
36
-
-
0037145062
-
Presenilin couples the paired phosphorylation of beta-catenin independent of axin. Implications for beta-catenin activation in tumorigenesis
-
Kang D, Soriano S, Xia X, Eberhart C, De Strooper B, Zheng H, Koo E. Presenilin couples the paired phosphorylation of beta-catenin independent of axin. Implications for beta-catenin activation in tumorigenesis. Cell 110: 751, 2002.
-
(2002)
Cell
, vol.110
, pp. 751
-
-
Kang, D.1
Soriano, S.2
Xia, X.3
Eberhart, C.4
De Strooper, B.5
Zheng, H.6
Koo, E.7
-
37
-
-
34548107607
-
Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved
-
Khandelwal A, Chandu D, Roe CM, Kopan R, Quatrano RS. Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved. Proc Natl Acad Sci USA 104: 13337-13342, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 13337-13342
-
-
Khandelwal, A.1
Chandu, D.2
Roe, C.M.3
Kopan, R.4
Quatrano, R.S.5
-
38
-
-
36048985389
-
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2
-
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci USA 9: 9, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.9
, pp. 9
-
-
Kimberly, W.T.1
LaVoie, M.J.2
Ostaszewski, B.L.3
Ye, W.4
Wolfe, M.S.5
Selkoe, D.J.6
-
39
-
-
34548572895
-
Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers
-
Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP, Dang TP. Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res 67: 8051-8057, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 8051-8057
-
-
Konishi, J.1
Kawaguchi, K.S.2
Vo, H.3
Haruki, N.4
Gonzalez, A.5
Carbone, D.P.6
Dang, T.P.7
-
40
-
-
2942557122
-
Gamma-secretase: Proteasome of the membrane?
-
Kopan R, Ilagan MX. Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 5: 499-504, 2004.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 499-504
-
-
Kopan, R.1
Ilagan, M.X.2
-
41
-
-
0036830947
-
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
-
LaFerla FM. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci 3: 862-872, 2002.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 862-872
-
-
LaFerla, F.M.1
-
42
-
-
57049116849
-
-
Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register B, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem 8: 8, 2003.
-
Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register B, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem 8: 8, 2003.
-
-
-
-
43
-
-
27444441308
-
A nine-transmembrane domain topology for presenilin 1
-
Laudon H, Hansson EM, Melen K, Bergman A, Farmery MR, Winblad B, Lendahl U, von Heijne G, Naslund J. A nine-transmembrane domain topology for presenilin 1. J Biol Chem 280: 35352-35360, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 35352-35360
-
-
Laudon, H.1
Hansson, E.M.2
Melen, K.3
Bergman, A.4
Farmery, M.R.5
Winblad, B.6
Lendahl, U.7
von Heijne, G.8
Naslund, J.9
-
44
-
-
0034657414
-
Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice
-
Leissring MA, Akbari Y, Fanger CM, Cahalan MD, Mattson MP, LaFerla FM. Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice. J Cell Biol 149: 793-798, 2000.
-
(2000)
J Cell Biol
, vol.149
, pp. 793-798
-
-
Leissring, M.A.1
Akbari, Y.2
Fanger, C.M.3
Cahalan, M.D.4
Mattson, M.P.5
LaFerla, F.M.6
-
45
-
-
0037007140
-
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP
-
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Muller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci USA 99: 4697-4702, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4697-4702
-
-
Leissring, M.A.1
Murphy, M.P.2
Mead, T.R.3
Akbari, Y.4
Sugarman, M.C.5
Jannatipour, M.6
Anliker, B.7
Muller, U.8
Saftig, P.9
De Strooper, B.10
Wolfe, M.S.11
Golde, T.E.12
LaFerla, F.M.13
-
46
-
-
0032704888
-
Presenilin-2 mutations modulate amplitude and kinetics of inositol 1,4,5-trisphosphate-mediated calcium signals
-
Leissring MA, Parker I, LaFerla FM. Presenilin-2 mutations modulate amplitude and kinetics of inositol 1,4,5-trisphosphate-mediated calcium signals. J Biol Chem 274: 32535-32538, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 32535-32538
-
-
Leissring, M.A.1
Parker, I.2
LaFerla, F.M.3
-
47
-
-
0032972683
-
Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes
-
Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM. Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J Neurochem 72: 1061-1068, 1999.
-
(1999)
J Neurochem
, vol.72
, pp. 1061-1068
-
-
Leissring, M.A.1
Paul, B.A.2
Parker, I.3
Cotman, C.W.4
LaFerla, F.M.5
-
48
-
-
35748982195
-
Cutting proteins within lipid bilayers: Rhomboid structure and mechanism
-
Lemberg MK, Freeman M. Cutting proteins within lipid bilayers: rhomboid structure and mechanism. Mol Cell 28: 930-940, 2007.
-
(2007)
Mol Cell
, vol.28
, pp. 930-940
-
-
Lemberg, M.K.1
Freeman, M.2
-
49
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
Levitan D, Greenwald I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377: 351-354, 1995.
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
50
-
-
35148844224
-
Moderate reduction of gammasecretase attenuates amyloid burden and limits mechanism-based liabilities
-
Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC. Moderate reduction of gammasecretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci 27: 10849-10859, 2007.
-
(2007)
J Neurosci
, vol.27
, pp. 10849-10859
-
-
Li, T.1
Wen, H.2
Brayton, C.3
Laird, F.M.4
Ma, G.5
Peng, S.6
Placanica, L.7
Wu, T.C.8
Crain, B.J.9
Price, D.L.10
Eberhart, C.G.11
Wong, P.C.12
-
51
-
-
0343819757
-
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
-
Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci USA 97: 6138-6143, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6138-6143
-
-
Li, Y.M.1
Lai, M.T.2
Xu, M.3
Huang, Q.4
DiMuzio-Mower, J.5
Sardana, M.K.6
Shi, X.P.7
Yin, K.C.8
Shafer, J.A.9
Gardell, S.J.10
-
52
-
-
0032981558
-
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
-
Lichtenthaler SF, Wang R, Grimm H, Uljon SN, Masters CL, Beyreuther K. Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein. Proc Natl Acad Sci USA 96: 3053-3058, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3053-3058
-
-
Lichtenthaler, S.F.1
Wang, R.2
Grimm, H.3
Uljon, S.N.4
Masters, C.L.5
Beyreuther, K.6
-
53
-
-
12144250683
-
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
-
Ma G, Li T, Price DL, Wong PC. APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J Neurosci 25: 192-198, 2005.
-
(2005)
J Neurosci
, vol.25
, pp. 192-198
-
-
Ma, G.1
Li, T.2
Price, D.L.3
Wong, P.C.4
-
54
-
-
18344380083
-
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
-
Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J 21: 1948-1956, 2002.
-
(2002)
EMBO J
, vol.21
, pp. 1948-1956
-
-
Marambaud, P.1
Shioi, J.2
Serban, G.3
Georgakopoulos, A.4
Sarner, S.5
Nagy, V.6
Baki, L.7
Wen, P.8
Efthimiopoulos, S.9
Shao, Z.10
Wisniewski, T.11
Robakis, N.K.12
-
55
-
-
5744242532
-
Presenilins in memory, Alzheimer's disease, and therapy
-
Marjaux E, Hartmann D, De Strooper B. Presenilins in memory, Alzheimer's disease, and therapy. Neuron 42: 189-192, 2004.
-
(2004)
Neuron
, vol.42
, pp. 189-192
-
-
Marjaux, E.1
Hartmann, D.2
De Strooper, B.3
-
56
-
-
0141994826
-
Intramembrane-cleaving aspartic proteases and disease: Presenilins, signal peptide peptidase and their homologs
-
Martoglio B, Golde TE. Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs. Hum Mol Genet 12: R201-R206, 2003.
-
(2003)
Hum Mol Genet
, vol.12
-
-
Martoglio, B.1
Golde, T.E.2
-
57
-
-
21144447065
-
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases
-
Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St. George-Hyslop P, Carlson GA, Westaway D. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases. Proc Natl Acad Sci USA 102: 8972-8977, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8972-8977
-
-
Mastrangelo, P.1
Mathews, P.M.2
Chishti, M.A.3
Schmidt, S.D.4
Gu, Y.5
Yang, J.6
Mazzella, M.J.7
Coomaraswamy, J.8
Horne, P.9
Strome, B.10
Pelly, H.11
Levesque, G.12
Ebeling, C.13
Jiang, Y.14
Nixon, R.A.15
Rozmahel, R.16
Fraser, P.E.17
St. George-Hyslop, P.18
Carlson, G.A.19
Westaway, D.20
more..
-
58
-
-
34547094392
-
A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis
-
Narayanan S, Sato T, Wolfe MS. A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis. J Biol Chem 282: 20172-20179, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 20172-20179
-
-
Narayanan, S.1
Sato, T.2
Wolfe, M.S.3
-
59
-
-
0000138540
-
Effects of PS1 deficiency on membrane protein trafficking in neurons
-
Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21: 1213-1221, 1998.
-
(1998)
Neuron
, vol.21
, pp. 1213-1221
-
-
Naruse, S.1
Thinakaran, G.2
Luo, J.J.3
Kusiak, J.W.4
Tomita, T.5
Iwatsubo, T.6
Qian, X.7
Ginty, D.D.8
Price, D.L.9
Borchelt, D.R.10
Wong, P.C.11
Sisodia, S.S.12
-
61
-
-
0037370310
-
Notch1 functions as a tumor suppressor in mouse skin
-
Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M, Hui CC, Clevers H, Dotto GP, Radtke F. Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33: 416-421, 2003.
-
(2003)
Nat Genet
, vol.33
, pp. 416-421
-
-
Nicolas, M.1
Wolfer, A.2
Raj, K.3
Kummer, J.A.4
Mill, P.5
van Noort, M.6
Hui, C.C.7
Clevers, H.8
Dotto, G.P.9
Radtke, F.10
-
62
-
-
2442446430
-
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
-
Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE. Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. J Biol Chem 279: 15153-15160, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 15153-15160
-
-
Nyborg, A.C.1
Kornilova, A.Y.2
Jansen, K.3
Ladd, T.B.4
Wolfe, M.S.5
Golde, T.E.6
-
63
-
-
0036565893
-
Identification of a novel family of presenilin homologues
-
Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE. Identification of a novel family of presenilin homologues. Hum Mol Genet 11: 1037-1044, 2002.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1037-1044
-
-
Ponting, C.P.1
Hutton, M.2
Nyborg, A.3
Baker, M.4
Jansen, K.5
Golde, T.E.6
-
64
-
-
0043172415
-
The SREBP pathway: Insights from Insigs and insects
-
Rawson RB. The SREBP pathway: insights from Insigs and insects. Nat Rev Mol Cell Biol 4: 631-640, 2003.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 631-640
-
-
Rawson, R.B.1
-
65
-
-
28644437291
-
The amyloid-beta precursor protein: Integrating structure with biological function
-
Reinhard C, Hebert SS, De Strooper B. The amyloid-beta precursor protein: integrating structure with biological function. EMBO J 24: 3996-4006, 2005.
-
(2005)
EMBO J
, vol.24
, pp. 3996-4006
-
-
Reinhard, C.1
Hebert, S.S.2
De Strooper, B.3
-
66
-
-
34447640166
-
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice
-
Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Muller UC. The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27: 7817-7826, 2007.
-
(2007)
J Neurosci
, vol.27
, pp. 7817-7826
-
-
Ring, S.1
Weyer, S.W.2
Kilian, S.B.3
Waldron, E.4
Pietrzik, C.U.5
Filippov, M.A.6
Herms, J.7
Buchholz, C.8
Eckman, C.B.9
Korte, M.10
Wolfer, D.P.11
Muller, U.C.12
-
67
-
-
0031569390
-
-
Rogaev EI, Sherrington R, Wu C, Levesque G, Liang Y, Rogaeva EA, Ikeda M, Holman K, Lin C, Lukiw WJ, de Jong PJ, Fraser PE, Rommens JM, St. George-Hyslop P. Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease. Genomics 40: 415-424, 1997.
-
Rogaev EI, Sherrington R, Wu C, Levesque G, Liang Y, Rogaeva EA, Ikeda M, Holman K, Lin C, Lukiw WJ, de Jong PJ, Fraser PE, Rommens JM, St. George-Hyslop P. Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease. Genomics 40: 415-424, 1997.
-
-
-
-
68
-
-
36349024875
-
Active gamma-secretase complexes contain only one of each component
-
Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. J Biol Chem 282: 33985-33993, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 33985-33993
-
-
Sato, T.1
Diehl, T.S.2
Narayanan, S.3
Funamoto, S.4
Ihara, Y.5
De Strooper, B.6
Steiner, H.7
Haass, C.8
Wolfe, M.S.9
-
69
-
-
11144354609
-
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
-
Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ 3rd, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42: 23-36, 2004.
-
(2004)
Neuron
, vol.42
, pp. 23-36
-
-
Saura, C.A.1
Choi, S.Y.2
Beglopoulos, V.3
Malkani, S.4
Zhang, D.5
Shankaranarayana Rao, B.S.6
Chattarji, S.7
Kelleher 3rd, R.J.8
Kandel, E.R.9
Duff, K.10
Kirkwood, A.11
Shen, J.12
-
70
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [see comments]
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease [see comments]. Nat Med 2: 864-870, 1996.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
71
-
-
0242331600
-
A presenilin dimer at the core of the gamma-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
-
Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, Shearman M, Kopan R. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci USA 100: 13075-13080, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 13075-13080
-
-
Schroeter, E.H.1
Ilagan, M.X.2
Brunkan, A.L.3
Hecimovic, S.4
Li, Y.M.5
Xu, M.6
Lewis, H.D.7
Saxena, M.T.8
De Strooper, B.9
Coonrod, A.10
Tomita, T.11
Iwatsubo, T.12
Moore, C.L.13
Goate, A.14
Wolfe, M.S.15
Shearman, M.16
Kopan, R.17
-
72
-
-
0242412482
-
-
Searfoss GH, Jordan WH, Calligaro DO, Galbreath EJ, Schirtzinger LM, Berridge BR, Gao H, Higgins MA, May PC, Ryan TP. Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. J Biol Chem 278: 46107-46116, 2003.
-
Searfoss GH, Jordan WH, Calligaro DO, Galbreath EJ, Schirtzinger LM, Berridge BR, Gao H, Higgins MA, May PC, Ryan TP. Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. J Biol Chem 278: 46107-46116, 2003.
-
-
-
-
73
-
-
57049151072
-
Cadherins mediate both the association between PS1 and betacatenin and the effects of PS1 on beta-catenin stability
-
Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK. Cadherins mediate both the association between PS1 and betacatenin and the effects of PS1 on beta-catenin stability. J Biol Chem 26: 26, 2005.
-
(2005)
J Biol Chem
, vol.26
, pp. 26
-
-
Serban, G.1
Kouchi, Z.2
Baki, L.3
Georgakopoulos, A.4
Litterst, C.M.5
Shioi, J.6
Robakis, N.K.7
-
74
-
-
13444268952
-
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo
-
Serneels L, Dejaegere T, Craessaerts K, Horre K, Jorissen E, Tousseyn T, Hebert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proc Natl Acad Sci USA 102: 1719-1724, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1719-1724
-
-
Serneels, L.1
Dejaegere, T.2
Craessaerts, K.3
Horre, K.4
Jorissen, E.5
Tousseyn, T.6
Hebert, S.7
Coolen, M.8
Martens, G.9
Zwijsen, A.10
Annaert, W.11
Hartmann, D.12
De Strooper, B.13
-
75
-
-
23744491374
-
Nicastrin functions as a gamma-secretase-substrate receptor
-
Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE 3rd, Sudhof T, Yu G. Nicastrin functions as a gamma-secretase-substrate receptor. Cell 122: 435-447, 2005.
-
(2005)
Cell
, vol.122
, pp. 435-447
-
-
Shah, S.1
Lee, S.F.2
Tabuchi, K.3
Hao, Y.H.4
Yu, C.5
LaPlant, Q.6
Ball, H.7
Dann 3rd, C.E.8
Sudhof, T.9
Yu, G.10
-
76
-
-
0030779784
-
Skeletal and CNS defects in presenilin-1-deficient mice
-
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in presenilin-1-deficient mice. Cell 89: 629-639, 1997.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
77
-
-
4744375540
-
Identification of distinct gamma -secretase complexes with different APH-1 variants
-
Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H. Identification of distinct gamma -secretase complexes with different APH-1 variants. J Biol Chem 279: 41340-41345, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 41340-41345
-
-
Shirotani, K.1
Edbauer, D.2
Prokop, S.3
Haass, C.4
Steiner, H.5
-
78
-
-
34250328818
-
Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes
-
Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiol Dis 27: 102-107, 2007.
-
(2007)
Neurobiol Dis
, vol.27
, pp. 102-107
-
-
Shirotani, K.1
Tomioka, M.2
Kremmer, E.3
Haass, C.4
Steiner, H.5
-
79
-
-
33748746861
-
Presenilin-1 maintains a nine transmembrane topology throughout the secretory pathway
-
Spasic D, Tolia A, Dillen K, Baert V, De Strooper B, Vrijens S, Annaert W. Presenilin-1 maintains a nine transmembrane topology throughout the secretory pathway. J Biol Chem 281: 26569-26577, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 26569-26577
-
-
Spasic, D.1
Tolia, A.2
Dillen, K.3
Baert, V.4
De Strooper, B.5
Vrijens, S.6
Annaert, W.7
-
80
-
-
0033778262
-
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
-
Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat Cell Biol 2: 848-851, 2000.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 848-851
-
-
Steiner, H.1
Kostka, M.2
Romig, H.3
Basset, G.4
Pesold, B.5
Hardy, J.6
Capell, A.7
Meyn, L.8
Grim, M.L.9
Baumeister, R.10
Fechteler, K.11
Haass, C.12
-
81
-
-
0033639117
-
Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
-
Struhl G, Adachi A. Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. Mol Cell 6: 625-636, 2000.
-
(2000)
Mol Cell
, vol.6
, pp. 625-636
-
-
Struhl, G.1
Adachi, A.2
-
82
-
-
0033535508
-
Presenilin is required for activity and nuclear access of Notch in Drosophila
-
Struhl G, Greenwald I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398: 522-525, 1999.
-
(1999)
Nature
, vol.398
, pp. 522-525
-
-
Struhl, G.1
Greenwald, I.2
-
83
-
-
37549016046
-
Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1
-
Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M. Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1. Mol Cell Biol 28: 165-176, 2008.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 165-176
-
-
Tagami, S.1
Okochi, M.2
Yanagida, K.3
Ikuta, A.4
Fukumori, A.5
Matsumoto, N.6
Ishizuka-Katsura, Y.7
Nakayama, T.8
Itoh, N.9
Jiang, J.10
Nishitomi, K.11
Kamino, K.12
Morihara, T.13
Hashimoto, R.14
Tanaka, T.15
Kudo, T.16
Chiba, S.17
Takeda, M.18
-
84
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature 422: 438-441, 2003.
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
Thinakaran, G.7
Iwatsubo, T.8
-
85
-
-
33748140720
-
2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations
-
2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126: 981-993, 2006.
-
(2006)
Cell
, vol.126
, pp. 981-993
-
-
Tu, H.1
Nelson, O.2
Bezprozvanny, A.3
Wang, Z.4
Lee, S.F.5
Hao, Y.H.6
Serneels, L.7
De Strooper, B.8
Yu, G.9
Bezprozvanny, I.10
-
86
-
-
33751246749
-
Rhomboid proteins: Conserved membrane proteases with divergent biological functions
-
Urban S. Rhomboid proteins: conserved membrane proteases with divergent biological functions. Genes Dev 20: 3054-3068, 2006.
-
(2006)
Genes Dev
, vol.20
, pp. 3054-3068
-
-
Urban, S.1
-
87
-
-
20544460148
-
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435: 959-963, 2005.
-
(2005)
Nature
, vol.435
, pp. 959-963
-
-
van Es, J.H.1
van Gijn, M.E.2
Riccio, O.3
van den Born, M.4
Vooijs, M.5
Begthel, H.6
Cozijnsen, M.7
Robine, S.8
Winton, D.J.9
Radtke, F.10
Clevers, H.11
-
88
-
-
31044438340
-
Regulation of tyrosinase trafficking and processing by presenilins: Partial loss of function by familial Alzheimer's disease mutation
-
Wang R, Tang P, Wang P, Boissy RE, Zheng H. Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc Natl Acad Sci USA 103: 353-358, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 353-358
-
-
Wang, R.1
Tang, P.2
Wang, P.3
Boissy, R.E.4
Zheng, H.5
-
89
-
-
33750886311
-
Crystal structure of a rhomboid family intramembrane protease
-
Wang Y, Zhang Y, Ha Y. Crystal structure of a rhomboid family intramembrane protease. Nature 444: 179-180, 2006.
-
(2006)
Nature
, vol.444
, pp. 179-180
-
-
Wang, Y.1
Zhang, Y.2
Ha, Y.3
-
90
-
-
0037150672
-
Identification of signal peptide peptidase, a presenilin-type aspartic protease
-
Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B. Identification of signal peptide peptidase, a presenilin-type aspartic protease. Science 296: 2215-2218, 2002.
-
(2002)
Science
, vol.296
, pp. 2215-2218
-
-
Weihofen, A.1
Binns, K.2
Lemberg, M.K.3
Ashman, K.4
Martoglio, B.5
-
91
-
-
0037930851
-
Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors
-
Weihofen A, Lemberg MK, Friedmann E, Rueeger H, Schmitz A, Paganetti P, Rovelli G, Martoglio B. Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors. J Biol Chem 278: 16528-16533, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 16528-16533
-
-
Weihofen, A.1
Lemberg, M.K.2
Friedmann, E.3
Rueeger, H.4
Schmitz, A.5
Paganetti, P.6
Rovelli, G.7
Martoglio, B.8
-
92
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, Morris JPt Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306: 269-271, 2004.
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris, J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
Blacklow, S.C.7
Look, A.T.8
Aster, J.C.9
-
93
-
-
0033621152
-
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
-
Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry 38: 11223-11230, 1999.
-
(1999)
Biochemistry
, vol.38
, pp. 11223-11230
-
-
Wolfe, M.S.1
De Los Angeles, J.2
Miller, D.D.3
Xia, W.4
Selkoe, D.J.5
-
94
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398: 513-517, 1999.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
95
-
-
17744401440
-
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm
-
Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJ, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LH, Sisodia SS. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 387: 288-292, 1997.
-
(1997)
Nature
, vol.387
, pp. 288-292
-
-
Wong, P.C.1
Zheng, H.2
Chen, H.3
Becher, M.W.4
Sirinathsinghji, D.J.5
Trumbauer, M.E.6
Chen, H.Y.7
Price, D.L.8
Van der Ploeg, L.H.9
Sisodia, S.S.10
-
96
-
-
33845365770
-
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry
-
Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol 13: 1084-1091, 2006.
-
(2006)
Nat Struct Mol Biol
, vol.13
, pp. 1084-1091
-
-
Wu, Z.1
Yan, N.2
Feng, L.3
Oberstein, A.4
Yan, H.5
Baker, R.P.6
Gu, L.7
Jeffrey, P.D.8
Urban, S.9
Shi, Y.10
-
97
-
-
0035845481
-
Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis
-
Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, Wang XJ, Koo EH, Wu X, Zheng H. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci USA 98: 10863-10868, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10863-10868
-
-
Xia, X.1
Qian, S.2
Soriano, S.3
Wu, Y.4
Fletcher, A.M.5
Wang, X.J.6
Koo, E.H.7
Wu, X.8
Zheng, H.9
-
98
-
-
0033535555
-
Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants [see comments]
-
Ye Y, Lukinova N, Fortini ME. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants [see comments]. Nature 398: 525-529, 1999.
-
(1999)
Nature
, vol.398
, pp. 525-529
-
-
Ye, Y.1
Lukinova, N.2
Fortini, M.E.3
-
99
-
-
0033712477
-
Presenilin-mediated modulation of capacitative calcium entry
-
Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of capacitative calcium entry. Neuron 27: 561-572, 2000.
-
(2000)
Neuron
, vol.27
, pp. 561-572
-
-
Yoo, A.S.1
Cheng, I.2
Chung, S.3
Grenfell, T.Z.4
Lee, H.5
Pack-Chung, E.6
Handler, M.7
Shen, J.8
Xia, W.9
Tesco, G.10
Saunders, A.J.11
Ding, K.12
Frosch, M.P.13
Tanzi, R.E.14
Kim, T.W.15
-
100
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
Yu G, Chen F, Levesque G, Nishimura M, Zhang DM, Levesque L, Rogaeva E, Xu D, Liang Y, Duthie M, St. George-Hyslop PH, Fraser PE. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J Biol Chem 273: 16470-16475, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
Nishimura, M.4
Zhang, D.M.5
Levesque, L.6
Rogaeva, E.7
Xu, D.8
Liang, Y.9
Duthie, M.10
St. George-Hyslop, P.H.11
Fraser, P.E.12
-
101
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St. George-Hyslop P. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407: 48-54, 2000.
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
Nishimura, M.2
Arawaka, S.3
Levitan, D.4
Zhang, L.5
Tandon, A.6
Song, Y.Q.7
Rogaeva, E.8
Chen, F.9
Kawarai, T.10
Supala, A.11
Levesque, L.12
Yu, H.13
Yang, D.S.14
Holmes, E.15
Milman, P.16
Liang, Y.17
Zhang, D.M.18
Xu, D.H.19
Sato, C.20
Rogaev, E.21
Smith, M.22
Janus, C.23
Zhang, Y.24
Aebersold, R.25
Farrer, L.S.26
Sorbi, S.27
Bruni, A.28
Fraser, P.29
St. George-Hyslop, P.30
more..
-
102
-
-
0032531793
-
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
-
Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395: 698-702, 1998.
-
(1998)
Nature
, vol.395
, pp. 698-702
-
-
Zhang, Z.1
Hartmann, H.2
Do, V.M.3
Abramowski, D.4
Sturchler-Pierrat, C.5
Staufenbiel, M.6
Sommer, B.7
van de Wetering, M.8
Clevers, H.9
Saftig, P.10
De Strooper, B.11
He, X.12
Yankner, B.A.13
-
103
-
-
0030788767
-
Presenilin 1 interaction in the brain with a novel member of the Armadillo family
-
Zhou J, Liyanage U, Medina M, Ho C, Simmons AD, Lovett M, Kosik KS. Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport 8: 1489-1494, 1997.
-
(1997)
Neuroreport
, vol.8
, pp. 1489-1494
-
-
Zhou, J.1
Liyanage, U.2
Medina, M.3
Ho, C.4
Simmons, A.D.5
Lovett, M.6
Kosik, K.S.7
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