Where Notch and Wnt signaling meet: The presenilin hub

Journal of Cell Biology

Volumn 152, Issue 4, 2001, Pages

  De Strooper, Bart ^a   Annaert, Wim ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2; WNT PROTEIN;

ALZHEIMER DISEASE; GENE OVEREXPRESSION; HUMAN; MEDICAL RESEARCH; MOLECULAR DYNAMICS; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0035911161     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.4.f17     Document Type: Note

References (15)

1. Presenilins: Molecular switches between proteolysis and signal transduction
2. Interaction between Wingless and Notch signaling pathways mediated by dishevelled
3. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
4. A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog
5. Presenilin 1 facilitates the constitutive turnover of beta-catenin: Differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway
6. Substitution of a GSK-3β phosphorylation site in presenilin 1 separates presenilin function from β-catenin signaling
7. A common enzyme connects notch signaling and Alzheimer's disease
8. A ubiquitin ligase complex essential for the NF-kappaB. Wnt/Wingless, and Hedgehog signaling pathways
9. Presenilin affects Arm/beta-catenin localization and function in Drosophila
10. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced a beta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants
11. Presenilin 1 negatively regulates β-catenin/LEF signaling independently of APP and Notch processing
12. Notch and wingless regulate expression of cuticle patterning genes
13. A family of mammalian F-box proteins
14. Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
15. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis