Presenilin clinical mutations can affect γ-secretase activity by different mechanisms

Journal of Neurochemistry

Volumn 96, Issue 3, 2006, Pages 732-742

  Bentahir, Mostafa ^a   Nyabi, Omar ^a   Verhamme, Jan ^a   Tolia, Alexandra ^a   Horré, Katrien ^a   Wiltfang, Jens ^b   Esselmann, Hermann ^c   De Strooper, Bart ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

secretase; Familial Alzheimer's disease; Presenilin

Indexed keywords

AMYLOID BETA PROTEIN; COMPLEMENTARY DNA; GAMMA SECRETASE; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; EMBRYO; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAMILIAL DISEASE; GEL ELECTROPHORESIS; GENE MUTATION; MISSENSE MUTATION; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CADHERINS; CELLS, CULTURED; DROSOPHILA PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EMBRYO; ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MUTAGENESIS; MUTATION; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PRESENILIN-1; PROTEIN ARRAY ANALYSIS; PROTEOGLYCANS; RECEPTORS, NOTCH; SYNDECANS;

EID: 33645105621     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03578.x     Document Type: Article

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