AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: A post-cleavage role for AID

Molecular Immunology

Volumn 46, Issue 1, 2008, Pages 45-61

  Zan, Hong ^a   Casali, Paolo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Activation induced cytidine deaminase (AID); Antibody; B cell; Class switch DNA recombination (CSR); Double strand DNA break (DSB); Immunoglobulin (Ig); Knockout mice; Switch region; Uracil DNA glycosylase (Ung)

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; APURINIC ACID; DOUBLE STRANDED DNA; ENDONUCLEASE; ENZYME INHIBITOR; IMMUNOGLOBULIN; URACIL DNA GLYCOSIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DEAMINATION; DEGLYCOSYLATION; DNA RECOMBINATION; DOUBLE STRANDED DNA BREAK; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; GENE SWITCHING; HEAVY CHAIN; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CYTIDINE DEAMINASE; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; MICE; MODELS, IMMUNOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; RECOMBINATION, GENETIC; URACIL-DNA GLYCOSIDASE;

MUS;

EID: 52949100601     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.07.003     Document Type: Article

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