AID-Dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in Somatic hypermutation

Immunity

Volumn 18, Issue 6, 2003, Pages 727-738

  Zan, Hong ^a,c   Wu, Xiaoping ^a,c   Komori, Atsumasa ^a,c   Holloman, William K ^b   Casali, Paolo ^a,b,c  

^a Cornell University ^*  (United States)

^b Weill Cornell Medical Center   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD40 ANTIGEN; CYTIDINE DEAMINASE; DNA POLYMERASE; DOUBLE STRANDED DNA; IMMUNOGLOBULIN; KU ANTIGEN; PROTEIN; PROTEIN BCL 6; RAD51 PROTEIN; RAD52 PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CROSS LINKING; DNA REPAIR; DNA STRAND BREAKAGE; FREQUENCY ANALYSIS; GENE MUTATION; GENE REARRANGEMENT; GENETIC VARIABILITY; GERM LINE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOGENE C MYC; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; TRANSCRIPTION INITIATION SITE;

EID: 0038771252     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(03)00151-1     Document Type: Article

References (47)

1. H genes are transcribed by T cells in association with a new 5′ exon. J. Exp. Med. 167:1988;2011-2016.
2. Bemark M., Sale J.E., Kim H.J., Berek C., Cosgrove R.A., Neuberger M.S. Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity. J. Exp. Med. 192:2000;1509-1514.
3. H transcripts. J. Exp. Med. 173:1991;1529-1535.
4. Bross L., Fukita Y., McBlane F., Demolliere C., Rajewsky K., Jacobs H. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation. Immunity. 13:2000;589-597.
5. Bross L., Muramatsu K., Kinoshita K., Honjo H., Jacobs H. DNA double-strand breaks. prior to but not sufficient in targeting hypermutation J. Exp. Med. 195:2002;1187-1192.
6. H-Cμ locus. Proc. Natl. Acad. Sci. USA. 78:1981;3814-3818.
7. + B cell line. J. Immunol. 160:1998;2145-2157. a.
8. Cerutti A., Schaffer A., Shah S., Zan H., Liou H.C., Goodwin R.G., Casali P. CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells. Immunity. 9:1998;247-256. b.
9. H genes are inherently susceptible to amino acid replacement. Immunol. Today. 15:1994;367-373.
10. Chaudhuri J., Tian M., Khuong C., Chua K., Pinaud E., Alt F.W. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 422:2003;726-730.
11. D'Amours D., Jackson S.P. The Mre11 complex. at the crossroads of dna repair and checkpoint signalling Nat. Rev. Mol. Cell Biol. 3:2002;317-327.
12. Diaz M., Casali P. Somatic Ig hypermutation. Curr. Opin. Immunol. 14:2002;235-240.
13. Di Noia J., Neuberger M.S. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature. 419:2002;43-48.
14. Doi T., Kinoshita K., Ikegawa M., Muramatsu M., Honjo T. De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination. Proc. Natl. Acad. Sci. USA. 100:2003;2634-2638.
15. Essers J., van Steeg H., de Wit J., Swagemakers S.M., Vermeij M., Hoeijmakers J.H., Kanaar R. Homologous and non-homologous recombination differentially affect DNA damage repair in mice. EMBO J. 19:2000;1703-1710.
16. Faili A., Aoufouchi S., Gueranger Q., Zober C., Leon A., Bertocci B., Weill J.-C., Reynaud C.A. AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line. Nat. Immunol. 3:2002;815-821.
17. Fukita Y., Jacobs H., Rajewsky K. Somatic hypermutation in the heavy chain locus correlates with transcription. Immunity. 9:1998;105-114.
18. H gene diversification. J. Exp. Med. 196:2002;629-639.
19. Honjo T., Kinoshita K., Muramatsu M. Molecular mechanism of class switch recombination. linkage with somatic hypermutation Annu. Rev. Immunol. 20:2002;165-196.
20. Johnson R.E., Washington M.T., Haracska L., Prakash S., Prakash L. Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions. Nature. 406:2000;1015-1019.
21. H gene elements by normal human fetal liver. Mol. Immunol. 34:1997;333-341.
22. - germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts. Immunity. 4:1996;603-613.
23. Martin A., Bardwell P.D., Woo C.J., Fan M., Shulman M.J., Scharff M.D. Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature. 415:2002;802-806.
24. Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 102:2000;553-563.
25. Okazaki I.M., Kinoshita K., Muramatsu M., Yoshikawa K., Honjo T. The AID enzyme induces class switch recombination in fibroblasts. Nature. 416:2002;340-345.
26. Papavasiliou F.N., Schatz D.G. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature. 408:2000;216-221.
27. Papavasiliou F.N., Schatz D.G. Somatic hypermutation of immunoglobulin genes; merging mechanisms for genetic diversity. Cell. 109:2002;s35-s44. a.
28. Papavasiliou F.N., Schatz D.G. The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J. Exp. Med. 195:2002;1193-1198. b.
29. Pascual V., Liu Y.J., Magalski A., de Bouteiller O., Banchereau J., Capra J.D. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180:1994;329-339.
30. Picard D., Schaffner W. Unrearranged immunoglobulin lambda variable region is transcribed in kappa-producing myelomas. EMBO J. 3:1984;3031-3035.
31. Pierce A.J., Hu P., Han M., Ellis N., Jasin M. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15:2001;3237-3242.
32. Sale J.E., Neuberger M.S. TdT-accessibe breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity. 9:1998;859-869.
33. Schaffer A., Cerutti A., Shah S., Zan H., Casali P. The evolutionary conserved sequence upstream of the human Ig Sγ3 region is an inducible promoter. synergistic activation by CD40 ligand and IL-4 via cooperative NF-κB and STAT-6 binding sites J. Immunol. 162:1999;5327-5336.
34. Schaffer A., Kim E., Wu X., Zan H., Testoni L., Salamon S., Cerutti A., Casali P. Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements. J. Biol. Chem. 278:2003;23141-23150.
35. Schlissel M., Constantinescu A., Morrow T., Baxter M., Peng A. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:1993;2520-2532.
36. Shinohara A., Ogawa T. Stimulation by Rad52 of yeast Rad51-mediated recombination. Nature. 391:1998;404-407.
37. Song B., Sung P. Functional interactions among yeast Rad51 recombinase, Rad52 mediator, and replication protein A in DNA strand exchange. J. Biol. Chem. 275:2000;15895-15904.
38. Storb U., Shen H.M., Michael N., Kim N. Somatic hypermutation of immunoglobulin and non-immunoglobulin genes. Philos. Trans. R. Soc. Lond. B Biol. Sci. 356:2001;13-19.
39. Takata M., Sasaki M.S., Sonoda E., Morrison C., Hashimoto M., Utsumi H., Yamaguchi-Iwai Y., Shinohara A., Takeda S. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17:1998;5497-5508.
40. van Gent D.C., Hoeijmakers J.H., Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat. Rev. Genet. 2:2001;196-206.
41. Wilson P.C., Wilson K., Liu Y.J., Banchereau J., Pascual V., Capra J.D. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J. Exp. Med. 91:2000;1881-1894.
42. Wu X., Zan H., Komori A., Feng J., Kim E.C., Casali P. Immunoglobulin somatic hypermutation. double-strand DNA breaks, AID and error-prone DNA repair J. Clin. Immunol. 23:2003;235-246.
43. H gene segments. Cell. 40:1985;271-281.
44. Zan H., Cerutti A., Schaffer A., Dramitinos P., Casali P. CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-β. Evidence for TGF-β but not IL-10-dependent direct SμøSα and sequential SμøSγ, SγøSα DNA recombination. J. Immunol. 161:1998;5217-5225.
45. + cell line in vitro. Definition of the requirements and the modalities of hypermutation J. Immunol. 162:1999;3437-3447.
46. Zan H., Li Z., Yamaji K., Dramitinos P., Cerutti A., Casali P. BCR engagement and T cell contact induce bcl-6 hypermutation in human B cells. association with initiation of transcription and identity with Ig hypermutation J. Immunol. 165:2000;830-839.
47. Zan H., Komori A., Li Z., Cerutti A., Schaffer A., Flajnik M.F., Diaz M., Casali P. The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation. Immunity. 14:2001;643-653.