Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: Definition of the requirements and modalities of hypermutation

Journal of Immunology

Volumn 162, Issue 6, 1999, Pages 3437-3447

  Zan, Hong ^a   Cerutti, Andrea ^a   Dramitinos, Patricia ^a   Schaffer, András ^a   Li, Zongdong ^a   Casali, Paolo ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; DINUCLEOTIDE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY;

ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CROSS LINKING; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GERMINAL CENTER; HUMAN; HUMAN CELL; LIGAND BINDING; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD40; ANTIGENS, CD80; B-LYMPHOCYTES; BASE COMPOSITION; BASE SEQUENCE; CD40 LIGAND; CELL LINE; CLONE CELLS; CODON; DNA MUTATIONAL ANALYSIS; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN J-CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; LIGANDS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; POINT MUTATION;

EID: 0033559138     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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