CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+ IgD+ B cell line

Journal of Immunology

Volumn 160, Issue 5, 1998, Pages 2145-2157

  Cerutti, Andrea ^a   Zan, Hong ^a   Schaffer, Andras ^a,b   Bergsagel, Leif ^a   Harindranath, Nagaradona ^c   Max, Edward E ^c   Casali, Paolo ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c Center for Biologics Evaluation/Res   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CD40 ANTIGEN; GLOBOTRIAOSYLCERAMIDE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; INTERLEUKIN 10; MONOCLONAL ANTIBODY;

ARTICLE; B LYMPHOCYTE; CELL MATURATION; GENE TARGETING; GENETIC TRANSCRIPTION; GERMINAL CENTER; HUMAN; HUMAN CELL; LIGAND BINDING; LYMPHOCYTE DIFFERENTIATION; PHENOTYPE; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; ANTIGENS, CD56; B-LYMPHOCYTE SUBSETS; BASE SEQUENCE; CD40 LIGAND; CELL DIFFERENTIATION; CELL LINE; CLONE CELLS; CYTOKINES; GENE REARRANGEMENT, B-LYMPHOCYTE; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPHENOTYPING; INTERLEUKIN-4; INTERLEUKIN-6; LIGANDS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; PLASMA CELLS; RECEPTORS, ANTIGEN, B-CELL; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION, GENETIC;

EID: 0032032241     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. MacLennan, I. C. 1994. Germinal centers. Annu. Rev. Immunol. 12:117.
2. Pascual, V., Y. J. Liu, A. Magalski, O. de Boutellier, J. Banchereau, and J. D. Capra. 1994. Analysis of somatic mutation in five B cell subsets of human tonsils. J. Exp. Med. 180:329.
3. Liu, Y. L., F. Malisan, O. de Bouteiller, C. Guret, S. Lebecque, J. Banchereau, F. C. Mills, E. E. Max, and H. Martinez-Valdez. 1996. Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation. Immunity 4:241.
4. + tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts. J. Exp. Med. 183:227.
5. Punnonen, J., G. Aversa, B. G. Cocks, A. N. McKenzie, S. Menon, G. Zurawski, R. de Waal Malefyt, and J. E. de Vries. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. USA 90:3730.
6. Jumper, M. D., J. B. Splawski, P. E. Lipsky, and K. Meek. 1994. Ligation of CD40 induces germline transcripts of multiple Ig H chain isotypes in human B cells. J. Immunol. 152:438.
7. Liu, Y. J., C. Barthélémy, O. de Boutellier, C. Arpin, I. Durand, and J. Banchereau. 1995. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 2:239.
8. Fujieda, S., K. Zhang, and A. Sason. 1995. IL-4 plus CD40 monoclonal antibody induces human B cells gamma subclass-specific isotype switch: switching to γ1, γ3 and γ4, but not γ2. J. Immunol. 155:2318.
9. Malisan, F., F. Brière, J. M. Bridon, N. Harindranath, F. C. Mills, E. E. Max, J. Banchereau, and H. Martinez-Valdez. 1996. Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes. J. Exp. Med. 183:937.
10. Galibert L., N. Burdin, B. de Saint-Vis, P. Garrone, C. Van Kooten, J. Banchereau, and F. Rousset. 1996. CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. J. Exp. Med. 183:77.
11. Stavnezer, J., S. Sirlin, and J. Abbott. 1985. Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells: characterization of the accompanying rearrangements of heavy chain genes. J. Exp. Med. 161:577.
12. Delphin, S., and J. Stavnezer. 1995. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline e promoter: regulation by NF-IL-4, a C/EBP family member and NF-κB/p50. J. Exp. Med. 181: 181.
13. Burrows, P. D., G. B. Beck-Engeser, and M. R. Wabl. 1983. Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement. Nature 306:243.
14. Lutzker, S., P. Rothman, R. Pollock, R. Coffman, and F. W. Alt. 1988. Mitogen-and IL-4-regulated expression of germ-line Ig γ2b transcripts: evidence for directed heavy chain class switching. Cell 53:177.
15. + cells. Int. Immunol. 8:193.
16. Spira, G., P. Gregor, H. L. Aguila, and M. D. Scharff. 1994. Clonal variants of hybridoma cells that switch isotype at a high frequency. Proc. Natl. Acad. Sci. USA 91:3423.
17. Sideras, P., T. R. Mizuta, H. Kanamori, N. Suzuki, M. Okamoto, K., Kuze, H. Ohno, S. Doi, S. Fukuhara, M. S. Hassan, L. Hammarstrom, E. Smith, A. Shimuzu, and T. Honjo. 1989. Production of germline transcripts of Cγ genes in an IgM-producing human neoplastic B cell line that switches to IgG-producing cells. Int. Immunol. 1:631.
18. Lederman, S., M. J. Yellin, A. M. Cleary, A. Pernis, G. Inghirami, L. E. Cohn, L. R. Covey, J. J. Lee, P. Rothman, and L. Chess. 1994. T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death. J. Immunol. 152:2163.
19. Ichiyoshi, Y., and P. Casali. 1994. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain variable segments. J. Exp. Med. 180:885.
20. McCaffrey, T. I., S. Consigli, B. Du, D. J. Falcone, T. A. Sanborn, A. M. Spokojny, and H. L. Bush, Jr. 1995. Decreased type II/type I TGF-β receptor ratio in cells derived from human atherosclerotic lesions: conversion from an antiproliferative to profibrotic response to TGF-β1. J. Clin. Invest. 96: 2667.
21. - B lymphocyte subset producing natural antibodies. J. Immunol. 148:2690.
22. Bergsagel, P. L., M. Chesi, E. Nardini, L. A. Brents, S. L. Kirby, and W. M. Kuehl. 1996. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma. Proc. Natl. Acad Sci. USA 93:13931.
23. Kitani, A., and W. Strober. 1994. Differential regulation of Cα1 and Cα2 germ-line and mature mRNA transcripts in human peripheral blood B cells. J. Immunol. 153:1466.
24. Nilsson, L., K. B. Islam, O. Olafsson, I. Zalcberg, C. Samakovlis, L. Hammarstrom, C. I. E. Smith, and P. Sideras. 1991. Structure of TGF-β1-induced human immunoglobulin Cα1 and Cα2 germ-line transcripts. Int. Immunol. 5:1107.
25. Stavnezer, J. 1996. Antibody class switching. Adv. Immunol. 61:79.
26. Snapper, C. M., K. B. Marcu, and P. Zelazowski. 1997. The immunoglobulin class switch: beyond "accessibility." Immunity 6:217.
27. Mills, F. C., F. Thyphronytis, F. Finkelman, and E. E. Max. 1992. Ig μ-∈ isotype switch in IL-4-treated human B lymphoblastoid cells: evidence for a sequential switching. J. Immunol. 149:1075.
28. Mills, F. C., M. P. Mitchell, N. Harindranath, and E. E. Max. 1995. Human Ig Sγ regions and their participation in sequential switching to IgE. J. Immunol. 155: 3021.
29. Fujieda, S., J. A. Waschek, K. Zhang, and A. Saxon. 1996. Vasoactive intestinal peptide induces Sα/Sμ. switch circular DNA in human B cells. J. Clin. Invest. 98:1527.
30. Arpin, C., J. Déchanet, C. Van Kooten, P. Merville, G. Grouard, F. Brière, J. Banchereau, and Y. J. Liu. 1995. Generation of memory B cells and plasma cells in vitro. Science 268:720.
31. + B cell subset with phenotypical and functional characteristics of germinal center B cells. Eur. J. Immunol. 26:1712.
32. Pellat-Deceunynck, C., R. Bataille, N. Robillard, J. L. Harousseau, M. J. Rapp, N. Juge-Morinau, J. Wjidenes, and M. Amiot. 1994. Expression of CD28 and CD40 in human myeloma cells: a comparative study with normal plasma cells. Blood 84:2597.
33. Lundgren, M., L. Strom, L. O. Bergqvist, S. Skog, T. Heiden, T. Stavnezer, and E. Severinson. 1995. Cell cycle regulation of germline immunoglobulin transcription: potential role of Ets family members. Eur. J. Immunol 25:2042.
34. Li, S. C., P. B. Rothman, J. Zhang, C. Chan, D. Hirsh, and F. W. Alt. 1994. Expression of Iμ-Cγ hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching. Int. Immunol. 6:491.
35. Matthes, T., C. Werner-Favre, H. Tang, X. Zhang, V. Kindler, and R. H. Zubler. 1993. Cytokine mRNA expression during an in vitro response of human B lymphocytes: kinetics of B cell tumor necrosis factor alpha, interleukin (IL)-6. IL-10, and transforming growth factor beta 1 mRNAs. J. Exp. Med. 178:521.
36. Burdin, N., C. Van Kooten, L. Galibert, J. S. Abrams, J. Wijdenes, J. Banchereau, and F. Rousset. 1995. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J. Immunol. 154:2533.
37. + B cells to secrete IgG1 and IgG3. J. Exp. Med. 179:757.
38. Liu, J. L., C. Arpin, O. de Bouteiller, C. Guret, J. Banchereau, H. Martinez-Valdez, and S. Lebecque. 1996. Sequential triggering of apoptosis. somatic mutation, and isotype switching during germinal center development. Semin. Immunol. 8:169.
39. Kremmidiotis, G., and H. Zola. 1995. Changes in CD44 expression during B cell differentiation in the human tonsil. Cell. Immunol. 161:147.
40. 53, and Bax but not the survival gene bcl-2. J. Exp. Med. 183:971.
41. Lagresle, C., C. Bella, P. T. Daniel, P. H. Krammer, and T. Defrance. 1995. Regulation of germinal center B cell differentiation: role of the human APO-1/Fas (CD95) molecule. J. Immunol. 154:5746.
42. Choe, J., H. S. Kim, X. Zhang, R. J. Armitage, and Y. S. Choi. 1996. Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. Anti-Ig down-regulates Fas expression on CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis. J. Immunol. 157: 1006.
43. INK4c and IL-6. Immunity 6:47.
44. Kälberg, E., S. Jainandunsing, D. Gray, and T. Leanderson. 1996. Somatic mutation of immunoglobulin V genes in vitro. Science 271:1285.