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Volumn 4, Issue 13, 2004, Pages 1385-1398

Pharmacogenetics of drug transporters and its impact on the pharmacotherapy

Author keywords

Disease risk; Expression; Function; Haplotype analysis; MDR1; P glycoprotein; Pharmacodynamics; Pharmacokinetics; Single nucleotide polymorphism (SNP)

Indexed keywords

ABC TRANSPORTER; ADEFOVIR; AMANTADINE; ANTINEOPLASTIC AGENT; BETA LACTAM ANTIBIOTIC; CIDOFOVIR; CIMETIDINE; CYCLOSPORIN A; DACTINOMYCIN; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOCETAXEL; DRUG METABOLIZING ENZYME; ETOPOSIDE; FEXOFENADINE; GENE PRODUCT; GLYCOPROTEIN P; GLYCOSYLATED PROTEIN; MEMBRANE PROTEIN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; PRAVASTATIN; PROSTAGLANDIN E2; QUINIDINE; SULINDAC; TOPOTECAN; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE;

EID: 4544373032     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568026043387692     Document Type: Review
Times cited : (105)

References (172)
  • 1
    • 49749154208 scopus 로고
    • Familial incidence of low pseudocholinesterase level
    • Kalow, W. Familial incidence of low pseudocholinesterase level. Lancet 1956, 2, 576.
    • (1956) Lancet , vol.2 , pp. 576
    • Kalow, W.1
  • 2
    • 0000616920 scopus 로고
    • Enzymatic deficiency in primaquine-sensitive erythrocytes
    • Carson, P.E.; Flanagan, C.L.; Ickes, C.E.; Alving, A.S. Enzymatic deficiency in primaquine-sensitive erythrocytes. Science 1956, 124, 484-485.
    • (1956) Science , vol.124 , pp. 484-485
    • Carson, P.E.1    Flanagan, C.L.2    Ickes, C.E.3    Alving, A.S.4
  • 3
    • 26444539817 scopus 로고
    • Genetic control of isoniazid metabolism in man
    • Evans, D.A.P.; Manley, K.A.; McKusick, V.A. Genetic control of isoniazid metabolism in man. Br. Med. J. 1960, 2, 485-491.
    • (1960) Br. Med. J. , vol.2 , pp. 485-491
    • Evans, D.A.P.1    Manley, K.A.2    McKusick, V.A.3
  • 4
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - Drug disposition, drug targets, and side effects
    • Evans, W.E.; McLeod, H.L. Pharmacogenomics - drug disposition, drug targets, and side effects. N. Engl. J. Med. 2003, 348, 538-549.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 6
    • 0036739611 scopus 로고    scopus 로고
    • SNPs and pharmacogenomics
    • Ambrose, H.J. SNPs and pharmacogenomics. Pharmacogenomics 2002, 3, 583-586.
    • (2002) Pharmacogenomics , vol.3 , pp. 583-586
    • Ambrose, H.J.1
  • 7
    • 0036433035 scopus 로고    scopus 로고
    • Pharmacogenetics and personalized medicine
    • Kalow, W. Pharmacogenetics and personalized medicine. Fundam. Clin. Pharmacol. 2002, 16, 337-342.
    • (2002) Fundam. Clin. Pharmacol. , vol.16 , pp. 337-342
    • Kalow, W.1
  • 8
    • 0031461131 scopus 로고    scopus 로고
    • Pharmacogenetics in biological perspective
    • Kalow, W. Pharmacogenetics in biological perspective. Pharmacol. Rev. 1997, 49, 369-379.
    • (1997) Pharmacol. Rev. , vol.49 , pp. 369-379
    • Kalow, W.1
  • 9
    • 0031826288 scopus 로고    scopus 로고
    • Hypothesis: Comparisons of inter- and intra-individual variations can substitute for twin studies in drug research
    • Kalow, W.; Tang, B.K.; Endrenyi, L. Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research. Pharmacogenetics 1998, 8, 283-289.
    • (1998) Pharmacogenetics , vol.8 , pp. 283-289
    • Kalow, W.1    Tang, B.K.2    Endrenyi, L.3
  • 10
    • 0035102719 scopus 로고    scopus 로고
    • CYP3A genetics in drug metabolism
    • Eichelbaum, M.; Burk, O. CYP3A genetics in drug metabolism. Nature Med. 2001, 7, 285-287.
    • (2001) Nature Med. , vol.7 , pp. 285-287
    • Eichelbaum, M.1    Burk, O.2
  • 11
    • 0032793249 scopus 로고    scopus 로고
    • Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment
    • Ingelman-Sundberg, M.; Oscarson, M.; McLellan, R.A. Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment. TiPS 1999, 20, 342-349.
    • (1999) TiPS , vol.20 , pp. 342-349
    • Ingelman-Sundberg, M.1    Oscarson, M.2    McLellan, R.A.3
  • 12
    • 0242584509 scopus 로고    scopus 로고
    • CYP3A4 and VDR gene polymorphisms and the risk of prostate cancer in men with benign prostate hyperplasia
    • Tayeb, M.T.; Clark, C.; Haites, N.E.; Sharp, L.; Murray, G.I.; McLeod, H.L. CYP3A4 and VDR gene polymorphisms and the risk of prostate cancer in men with benign prostate hyperplasia. Br. J. Cancer 2003, 88, 928-932.
    • (2003) Br. J. Cancer , vol.88 , pp. 928-932
    • Tayeb, M.T.1    Clark, C.2    Haites, N.E.3    Sharp, L.4    Murray, G.I.5    McLeod, H.L.6
  • 13
    • 85013917085 scopus 로고    scopus 로고
    • Genetic polymorphism of human cytochrome P450 involved in drug metabolism
    • Nagata, K.; Yamazoe, Y. Genetic polymorphism of human cytochrome P450 involved in drug metabolism. Drug Metabol. Pharmacokin. 2002, 17, 167-189.
    • (2002) Drug Metabol. Pharmacokin. , vol.17 , pp. 167-189
    • Nagata, K.1    Yamazoe, Y.2
  • 14
    • 0037131879 scopus 로고    scopus 로고
    • Genetic contribution to variable human CYP-3A-mediated metabolism
    • Lamba, J.K.; Lin, Y.S.; Schuetz, E.G.; Thummel, K.E. Genetic contribution to variable human CYP-3A-mediated metabolism. Adv. Drug Deliv. Rev. 2002, 54, 1271-1294.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1271-1294
    • Lamba, J.K.1    Lin, Y.S.2    Schuetz, E.G.3    Thummel, K.E.4
  • 15
    • 0037988709 scopus 로고    scopus 로고
    • Pharmacogenomics of ABC transporters and its role in cancer chemotherapy
    • Sparreboom, A.; Danesi, R.; Ando, Y.; Chan, J.; Figg, W.D. Pharmacogenomics of ABC transporters and its role in cancer chemotherapy. Drug Resist Updat. 2003, 6, 71-84.
    • (2003) Drug Resist. Updat. , vol.6 , pp. 71-84
    • Sparreboom, A.1    Danesi, R.2    Ando, Y.3    Chan, J.4    Figg, W.D.5
  • 16
    • 0013095102 scopus 로고    scopus 로고
    • MDR1 genotype-related pharmacokinetics and pharmacodynamics
    • Sakaeda, T.; Nakamura, T.; Okumura, K. MDR1 genotype-related pharmacokinetics and pharmacodynamics. Biol. Pharm. Bull. 2002, 25, 1391-1400.
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 1391-1400
    • Sakaeda, T.1    Nakamura, T.2    Okumura, K.3
  • 17
    • 0038106665 scopus 로고    scopus 로고
    • Pharmacogenetics of MDR1 and its impact on pharmacokinetics and pharmcodynamics of drugs
    • Sakaeda, T.; Nakamura, T.; Okumura, K. Pharmacogenetics of MDR1 and its impact on pharmacokinetics and pharmcodynamics of drugs. Pharmacogenomics 2003, 4, 397-410.
    • (2003) Pharmacogenomics , vol.4 , pp. 397-410
    • Sakaeda, T.1    Nakamura, T.2    Okumura, K.3
  • 18
    • 0037131893 scopus 로고    scopus 로고
    • The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans
    • Fromm, M.F. The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans. Adv. Drug Deliv. Rev. 2002, 54, 1295-1310.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1295-1310
    • Fromm, M.F.1
  • 19
    • 0037968587 scopus 로고    scopus 로고
    • Pharmacogenomics of drug transporters
    • Licinio, J.; Wong, M.L.; Eds.; Wiley-VCH Verlag GmbH: Weinheim, Germany
    • Tirona, R.G.; Kim, R.B. Pharmacogenomics of drug transporters. In Pharmacogenomics. The Search for Individualized Therapies; Licinio, J.; Wong, M.L.; Eds.; Wiley-VCH Verlag GmbH: Weinheim, Germany, 2002; pp 179-213.
    • (2002) Pharmacogenomics. The Search for Individualized Therapies , pp. 179-213
    • Tirona, R.G.1    Kim, R.B.2
  • 20
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: The multidrug resistance-associated proteins
    • Borst, P.; Evers, R.; Kool, M.; Wijnholds, J. A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst. 2000, 92, 1295-1302.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 22
    • 0033938669 scopus 로고    scopus 로고
    • The multispecific organic anion transporter (OAT) family
    • Sekine, T.; Cha, S.H.; Endou, H. The multispecific organic anion transporter (OAT) family. Pflügers Arch. 2000, 440, 337-350.
    • (2000) Pflügers Arch. , vol.440 , pp. 337-350
    • Sekine, T.1    Cha, S.H.2    Endou, H.3
  • 23
    • 0033849976 scopus 로고    scopus 로고
    • Cellular and molecular aspects of drug transport in the kidney
    • Inui, K.I.; Masuda, S.; Saito, H. Cellular and molecular aspects of drug transport in the kidney. Kidney Int. 2000, 58, 944-958.
    • (2000) Kidney Int. , vol.58 , pp. 944-958
    • Inui, K.I.1    Masuda, S.2    Saito, H.3
  • 24
    • 0035066252 scopus 로고    scopus 로고
    • Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
    • Dresser, M.J.; Leabman, M.K.; Giacomini, K.M. Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J. Pharm. Sci. 2001, 90, 397-421.
    • (2001) J. Pharm. Sci. , vol.90 , pp. 397-421
    • Dresser, M.J.1    Leabman, M.K.2    Giacomini, K.M.3
  • 25
    • 0033756459 scopus 로고    scopus 로고
    • Transporter-mediated permeation of drugs across the blood-brain barrier
    • Tamai, I.; Tsuji, A. Transporter-mediated permeation of drugs across the blood-brain barrier. J. Pharm. Sci. 2000, 89, 1371-1388.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 1371-1388
    • Tamai, I.1    Tsuji, A.2
  • 26
    • 0002674396 scopus 로고    scopus 로고
    • Drug transporters: Their role and importamnce in the selection and development of new drugs
    • Mizuno, N.; Sugiyama, Y. Drug transporters: their role and importamnce in the selection and development of new drugs. Drug Metabol. Pharmacokin. 2002, 17, 93-108.
    • (2002) Drug Metabol. Pharmacokin. , vol.17 , pp. 93-108
    • Mizuno, N.1    Sugiyama, Y.2
  • 27
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in chinese hamster ovary cell mutants
    • Juliano, R.L.; Ling, V. A surface glycoprotein modulating drug permeability in chinese hamster ovary cell mutants. Biochim. Biophys. Acta 1976, 455, 152-162.
    • (1976) Biochim. Biophys. Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 29
    • 0022972654 scopus 로고
    • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
    • Chen, C.J.; Chin, J.E.; Ueda, K.; Clark, D.P.; Pastan, I; Gottesman, M.M.; Roninson, I.B. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 1986, 47, 381-389.
    • (1986) Cell , vol.47 , pp. 381-389
    • Chen, C.J.1    Chin, J.E.2    Ueda, K.3    Clark, D.P.4    Pastan, I.5    Gottesman, M.M.6    Roninson, I.B.7
  • 30
    • 0008632564 scopus 로고
    • Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicines, doxorubicin, and vinblastine
    • Ueda, K.; Cardarelli, C.; Gottesman, M.M.; Pastan, I. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicines, doxorubicin, and vinblastine. Proc. Natl. Acad. Sci. USA 1987, 84, 3004-3008.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 3004-3008
    • Ueda, K.1    Cardarelli, C.2    Gottesman, M.M.3    Pastan, I.4
  • 31
    • 0025191307 scopus 로고
    • Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins
    • Chen, C.; Clark, D.; Ueda, K.; Pastan, I.; Gottesman, M.M.; Roninson, I.B. Gpnomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J. Biol. Chem. 1990, 265, 506-514.
    • (1990) J. Biol. Chem. , vol.265 , pp. 506-514
    • Chen, C.1    Clark, D.2    Ueda, K.3    Pastan, I.4    Gottesman, M.M.5    Roninson, I.B.6
  • 32
    • 0030971840 scopus 로고    scopus 로고
    • Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis
    • Rosenberg, M.F.; Callaghan, R.; Ford, R.C.; Higgins, C.F. Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis. J. Biol. Chem. 1997, 272, 10685-10694.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10685-10694
    • Rosenberg, M.F.1    Callaghan, R.2    Ford, R.C.3    Higgins, C.F.4
  • 35
    • 0007544439 scopus 로고    scopus 로고
    • MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
    • van Helvoort, A.; Smith, A.J.; Sprong, H.; Fritzsche, I.; Schinkel, A.H.; Borst, P.; van Meer, G. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 1996, 87, 507-517.
    • (1996) Cell , vol.87 , pp. 507-517
    • van Helvoort, A.1    Smith, A.J.2    Sprong, H.3    Fritzsche, I.4    Schinkel, A.H.5    Borst, P.6    van Meer, G.7
  • 37
    • 0031691234 scopus 로고    scopus 로고
    • The role of P-glycoprotein andcanalicular miultispecific organic anion transporter in the hepatobiliary excretion of drugs
    • Kusuhara, H.; Suzuki, H.; Sugiyama, Y. The role of P-glycoprotein andcanalicular miultispecific organic anion transporter in the hepatobiliary excretion of drugs. J. Pharm. Sci. 1998, 97, 1025-1040.
    • (1998) J. Pharm. Sci. , vol.97 , pp. 1025-1040
    • Kusuhara, H.1    Suzuki, H.2    Sugiyama, Y.3
  • 38
    • 0033975157 scopus 로고    scopus 로고
    • Role of P-glycoprotein in drug disposition
    • Tanigawara, Y. Role of P-glycoprotein in drug disposition. Ther. Drug Monit. 2000, 22, 137-140.
    • (2000) Ther. Drug Monit. , vol.22 , pp. 137-140
    • Tanigawara, Y.1
  • 40
    • 0342762062 scopus 로고    scopus 로고
    • The barrier function of CYP3A4 and P-glycoprotein in the small bowel
    • Watkins, P.B. The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Adv. Drug Deliv. Rev. 1997, 27, 161-170.
    • (1997) Adv. Drug Deliv. Rev. , vol.27 , pp. 161-170
    • Watkins, P.B.1
  • 42
    • 0034917716 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • Dean, M.; Rzhetsky, A.; Allikmets, R. The human ATP-binding cassette (ABC) transporter superfamily Genome Res. 2001, 11, 1156-1166.
    • (2001) Genome Res. , vol.11 , pp. 1156-1166
    • Dean, M.1    Rzhetsky, A.2    Allikmets, R.3
  • 43
    • 0034953105 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfarmly
    • Dean, M.; Hamon, Y.; Chimini, G. The human ATP-binding cassette (ABC) transporter superfarmly. J. Lipid Res. 2001, 42, 1007-1017.
    • (2001) J. Lipid Res. , vol.42 , pp. 1007-1017
    • Dean, M.1    Hamon, Y.2    Chimini, G.3
  • 44
    • 0034964222 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation
    • Matheny, C.J.; Lamb, M.W.; Brouwer, K.L.R.; Pollack, G.M. Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation. Pharmacotherapy 2001, 21, 778-796.
    • (2001) Pharmacotherapy , vol.21 , pp. 778-796
    • Matheny, C.J.1    Lamb, M.W.2    Brouwer, K.L.R.3    Pollack, G.M.4
  • 46
    • 0343488673 scopus 로고    scopus 로고
    • Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption
    • Hunter, J.; Hirst, B.H. Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption. Adv. Drug Deliv. Rev. 1997, 25, 129-157.
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 129-157
    • Hunter, J.1    Hirst, B.H.2
  • 47
    • 0037204543 scopus 로고    scopus 로고
    • Progress in understanding the structure-activity relationships of P-glycoprotein
    • Stouch, T.R.; Gudmundsson, O. Progress in understanding the structure-activity relationships of P-glycoprotein. Adv. Drug Deliv. Rev. 2002, 54, 315-328.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 315-328
    • Stouch, T.R.1    Gudmundsson, O.2
  • 48
    • 0001996676 scopus 로고    scopus 로고
    • The pharmacogenomics of human P-glycoprotein
    • Licinio, J.; Wong, M L.; Eds.; Wiley-VCH Verlag GmbH: Weinheim, Germany
    • Fromm, M.F.; Eichelbaum, M. The pharmacogenomics of human P-glycoprotein. In Pharmacogenomics. The Search for Individualized Therapies; Licinio, J.; Wong, M L.; Eds.; Wiley-VCH Verlag GmbH: Weinheim, Germany, 2002; pp 159-178.
    • (2002) Pharmacogenomics. The Search for Individualized Therapies , pp. 159-178
    • Fromm, M.F.1    Eichelbaum, M.2
  • 49
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher, V.J.; Wu, C.Y.; Benet, L.Z. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy. Mol. Carcinogen. 1995, 13, 129-134.
    • (1995) Mol. Carcinogen , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 50
    • 0141671688 scopus 로고    scopus 로고
    • Drug transporters in HIV therapy
    • Kim, R.B. Drug transporters in HIV therapy. Top. HIV Med. 2003, 11, 136-139.
    • (2003) Top. HIV Med. , vol.11 , pp. 136-139
    • Kim, R.B.1
  • 51
    • 0036128985 scopus 로고    scopus 로고
    • Role of multidrug transporters in pharmacoresistance to antiepileptic drugs
    • Löcher, W.; Potschka, H. Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol. Exp. Ther. 2002, 301, 7-14.
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 7-14
    • Löcher, W.1    Potschka, H.2
  • 52
    • 0031765907 scopus 로고    scopus 로고
    • Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
    • Wacher, V.J.; Silverman, J.A.; Zhang, Y.; Benet, L.Z. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J. Pharm. Sci. 1998, 87, 1322-1330.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 1322-1330
    • Wacher, V.J.1    Silverman, J.A.2    Zhang, Y.3    Benet, L.Z.4
  • 53
    • 0345411341 scopus 로고    scopus 로고
    • P-glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies
    • Wandel, C.; Kim, R.B.; Kajiji, S.; Guengerich, F.P.; Wilkinson, G.R.; Wood, A.J.J. P-glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies. Cancer Res. 1999, 59, 3944-3948.
    • (1999) Cancer Res. , vol.59 , pp. 3944-3948
    • Wandel, C.1    Kim, R.B.2    Kajiji, S.3    Guengerich, F.P.4    Wilkinson, G.R.5    Wood, A.J.J.6
  • 55
    • 0036144831 scopus 로고    scopus 로고
    • Investigation of the coordinated functional activities of cytochrome P450 3A4 and P-glycoprotein in limiting the absorption of xenobiotics in Caco-2 cells
    • Tran, C.D.H.; Timmins, P.; Conway, B.R.; Irwin, W.J. Investigation of the coordinated functional activities of cytochrome P450 3A4 and P-glycoprotein in limiting the absorption of xenobiotics in Caco-2 cells. J. Pharm. Sci. 2002, 91, 117-128.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 117-128
    • Tran, C.D.H.1    Timmins, P.2    Conway, B.R.3    Irwin, W.J.4
  • 57
    • 0030935086 scopus 로고    scopus 로고
    • Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions
    • Bertz, R.J.; Granneman, G.R. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin. Pharmacokinet. 1997, 32, 210-258.
    • (1997) Clin. Pharmacokinet. , vol.32 , pp. 210-258
    • Bertz, R.J.1    Granneman, G.R.2
  • 58
    • 4544300546 scopus 로고    scopus 로고
    • The gut as a barrier to drug absorption
    • Zhang, Y.; Benet, L.Z. The gut as a barrier to drug absorption. Clin. Pharmacokinet. 2001, 40, 15-168.
    • (2001) Clin. Pharmacokinet. , vol.40 , pp. 15-168
    • Zhang, Y.1    Benet, L.Z.2
  • 63
    • 0023638508 scopus 로고
    • Localization of the human multiple drug resistance gene, MDR1, to 7q21.1
    • Callen, D.F.; Baker, E.; Simmers, R.N.; Seshadri, R.; Roninson, I.B. Localization of the human multiple drug resistance gene, MDR1, to 7q21.1. Hum. Genet. 1987, 77, 142-144.
    • (1987) Hum. Genet. , vol.77 , pp. 142-144
    • Callen, D.F.1    Baker, E.2    Simmers, R.N.3    Seshadri, R.4    Roninson, I.B.5
  • 64
    • 0024414605 scopus 로고
    • Structure and expression of the human MDR1 (P-glycoprotein) gene family
    • Chin, J.E.; Soffir, R.; Noonan, K.E.; Choi, K.; Roninson, I.B. Structure and expression of the human MDR1 (P-glycoprotein) gene family. Mol. Cell Biol. 1989, 9, 3808-3820.
    • (1989) Mol. Cell Biol. , vol.9 , pp. 3808-3820
    • Chin, J.E.1    Soffir, R.2    Noonan, K.E.3    Choi, K.4    Roninson, I.B.5
  • 66
    • 0028034123 scopus 로고
    • Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs
    • Stein, U.; Walther, W.; Wunderlich, V. Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs. Eur. J. Cancer 1994, 30A, 1541-1545.
    • (1994) Eur. J. Cancer , vol.30 A , pp. 1541-1545
    • Stein, U.1    Walther, W.2    Wunderlich, V.3
  • 67
    • 0032030654 scopus 로고    scopus 로고
    • Genetic polymorphism in MDR-1: A tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors
    • Mickley, L.A.; Lee, J.S.; Weng, Z.; Zhan, Z.; Alvarez, M.; Wilson, W.; Bates, S.E.; Fojo. T. Genetic polymorphism in MDR-1: A tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors. Blood 1998, 91, 1749-1756.
    • (1998) Blood , vol.91 , pp. 1749-1756
    • Mickley, L.A.1    Lee, J.S.2    Weng, Z.3    Zhan, Z.4    Alvarez, M.5    Wilson, W.6    Bates, S.E.7    Fojo, T.8
  • 70
    • 0000006828 scopus 로고    scopus 로고
    • Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)
    • Johne, A.; Brockmöller, J.; Bauer, S.; Maurer, A.; Langheinrich, M.; Roots, I. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum). Clin. Pharmacol. Ther. 1999, 66, 338-345.
    • (1999) Clin. Pharmacol. Ther. , vol.66 , pp. 338-345
    • Johne, A.1    Brockmöller, J.2    Bauer, S.3    Maurer, A.4    Langheinrich, M.5    Roots, I.6
  • 71
    • 0035103009 scopus 로고    scopus 로고
    • Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
    • Ito, S.; Ieiri, I.; Tanabe, M.; Suzuki, A.; Higuchi, S.; Otsubo, K. Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects. Pharmacogenetics 2001, 11, 175-184.
    • (2001) Pharmacogenetics , vol.11 , pp. 175-184
    • Ito, S.1    Ieiri, I.2    Tanabe, M.3    Suzuki, A.4    Higuchi, S.5    Otsubo, K.6
  • 79
    • 0037307357 scopus 로고    scopus 로고
    • Frequency distribution of C3435T mutation in exon 26 of the MDR1 gene in a Spanish population
    • Bernal, M.L.; Sinues, B.; Fanlo, A.; Mayayo, E. Frequency distribution of C3435T mutation in exon 26 of the MDR1 gene in a Spanish population. Ther. Drug Monit. 2003, 25, 107-111.
    • (2003) Ther. Drug Monit. , vol.25 , pp. 107-111
    • Bernal, M.L.1    Sinues, B.2    Fanlo, A.3    Mayayo, E.4
  • 80
    • 0038336616 scopus 로고    scopus 로고
    • Frequency of C3435T single nucleotide MDR1 genetic polymorphism in an Asian population: Phenotypic-genotypic correlates
    • Balram, C.; Sharma, A.; Sivathasan, C.; Lee, E.J. Frequency of C3435T single nucleotide MDR1 genetic polymorphism in an Asian population: phenotypic-genotypic correlates. Br. J. Clin. Pharmacol. 2003, 56, 78-83.
    • (2003) Br. J. Clin. Pharmacol. , vol.56 , pp. 78-83
    • Balram, C.1    Sharma, A.2    Sivathasan, C.3    Lee, E.J.4
  • 81
    • 0041625733 scopus 로고    scopus 로고
    • MDR1 and CYP3A4 polymorphisms among African, Indian, and white populations in KwaZulu-Natal, South Africa
    • Chelule, P.K.; Gordon, M.; Palanee, T.; Page, T.; Mosam, A.; Coovadia, H.M.; Cassol, S. MDR1 and CYP3A4 polymorphisms among African, Indian, and white populations in KwaZulu-Natal, South Africa. Clin. Pharmacol. Ther. 2003, 74, 195-196.
    • (2003) Clin. Pharmacol. Ther. , vol.74 , pp. 195-196
    • Chelule, P.K.1    Gordon, M.2    Palanee, T.3    Page, T.4    Mosam, A.5    Coovadia, H.M.6    Cassol, S.7
  • 82
    • 0036400925 scopus 로고    scopus 로고
    • Distribution of allelic variants of functional C3435T polymorphisms of drug transporter MDR1 gene in a sample of polish population
    • Jamroziak, K.; Balcerczak, E.; Mlynarski, W.; Mirowski, M.; Robak, T. Distribution of allelic variants of functional C3435T polymorphisms of drug transporter MDR1 gene in a sample of polish population. Pol. J. Pharmacol. 2002, 54, 495-500.
    • (2002) Pol. J. Pharmacol. , vol.54 , pp. 495-500
    • Jamroziak, K.1    Balcerczak, E.2    Mlynarski, W.3    Mirowski, M.4    Robak, T.5
  • 84
    • 0036803396 scopus 로고    scopus 로고
    • Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: Functional relevance to pharmacokinetics of digoxin
    • Horinouchi, M.; Sakaeda, T.; Nakamura, T.; Morita, Y.; Tamura, T.; Aoyama, N.; Kasuga, M.; Okumura, K. Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677: Functional relevance to pharmacokinetics of digoxin. Pharm. Res. 2002, 19, 1581-1585.
    • (2002) Pharm. Res. , vol.19 , pp. 1581-1585
    • Horinouchi, M.1    Sakaeda, T.2    Nakamura, T.3    Morita, Y.4    Tamura, T.5    Aoyama, N.6    Kasuga, M.7    Okumura, K.8
  • 86
    • 0036729669 scopus 로고    scopus 로고
    • The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients
    • Zheng, H.; Webber, S.; Zeevi, A.; Schuetz, E.; Zhang, J.; Lamba, J.; Bowman, P.; Burckart, G.J. The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients. Hum. Immunol. 2002, 63, 765-770.
    • (2002) Hum. Immunol. , vol.63 , pp. 765-770
    • Zheng, H.1    Webber, S.2    Zeevi, A.3    Schuetz, E.4    Zhang, J.5    Lamba, J.6    Bowman, P.7    Burckart, G.J.8
  • 87
    • 0037330517 scopus 로고    scopus 로고
    • Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients
    • Chowbay, B.; Cumaraswamy, S.; Cheung, Y.B.; Zhou, Q.; Lee, E.J.D. Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients. Pharmacogenetics 2003, 13, 89-95.
    • (2003) Pharmacogenetics , vol.13 , pp. 89-95
    • Chowbay, B.1    Cumaraswamy, S.2    Cheung, Y.B.3    Zhou, Q.4    Lee, E.J.D.5
  • 90
    • 0037353758 scopus 로고    scopus 로고
    • Quantitative determination of MDR1 mRNA expression in peripheral blood lymphocytes: A possible role of genetic polymorphisms in the MDR1 gene
    • Oselin, K.; Nowakowski-Gashaw, I.; Mrozikiewicz, P.M.; Wolbergs, D.; Pahkla, R.; Roots, I. Quantitative determination of MDR1 mRNA expression in peripheral blood lymphocytes: a possible role of genetic polymorphisms in the MDR1 gene. Eur. J. Clin. Invest. 2003, 33, 261-267.
    • (2003) Eur. J. Clin. Invest. , vol.33 , pp. 261-267
    • Oselin, K.1    Nowakowski-Gashaw, I.2    Mrozikiewicz, P.M.3    Wolbergs, D.4    Pahkla, R.5    Roots, I.6
  • 91
    • 0041592734 scopus 로고    scopus 로고
    • MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes
    • Oselin, K.; Gerloff, T.; Mrozikiewicz, P.M.; Pahkla, R.; Roots, I. MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes. Fundam. Clin. Pharmacol. 2003, 17, 463-469.
    • (2003) Fundam. Clin. Pharmacol. , vol.17 , pp. 463-469
    • Oselin, K.1    Gerloff, T.2    Mrozikiewicz, P.M.3    Pahkla, R.4    Roots, I.5
  • 92
    • 0036224114 scopus 로고    scopus 로고
    • Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects
    • Nakamura, T.; Sakaeda, T.; Horinouchi, M.; Tamura, T.; Aoyama, N.; Shirakawa, T.; Matsuo, M.; Kasuga, M.; Okumura, K. Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects. Clin. Pharmacol. Ther. 2002, 71, 297-303.
    • (2002) Clin. Pharmacol. Ther. , vol.71 , pp. 297-303
    • Nakamura, T.1    Sakaeda, T.2    Horinouchi, M.3    Tamura, T.4    Aoyama, N.5    Shirakawa, T.6    Matsuo, M.7    Kasuga, M.8    Okumura, K.9
  • 93
    • 0036667953 scopus 로고    scopus 로고
    • C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation
    • Goto, M.; Masuda, S.; Saito, H.; Uemoto, S.; Kiuchi, T.; Tanaka, K.; Inui, K. C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation. Pharmacogenetics 2002, 12, 451-457.
    • (2002) Pharmacogenetics , vol.12 , pp. 451-457
    • Goto, M.1    Masuda, S.2    Saito, H.3    Uemoto, S.4    Kiuchi, T.5    Tanaka, K.6    Inui, K.7
  • 99
    • 0036082545 scopus 로고    scopus 로고
    • Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system
    • Kimchi-Sarfaty, C.; Gribar, J.J.; Gottesmann, M.M. Functional characterization of coding polymorphisms in the human MDR1 gene using a vaccinia virus expression system. Mol. Pharmacol. 2002, 62, 1-6.
    • (2002) Mol. Pharmacol. , vol.62 , pp. 1-6
    • Kimchi-Sarfaty, C.1    Gribar, J.J.2    Gottesmann, M.M.3
  • 100
    • 0038323843 scopus 로고    scopus 로고
    • Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities
    • Morita, N.; Yasumori, T.; Nakayama, K. Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities. Biochem. Pharmacol. 2003, 65, 1843-1852.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1843-1852
    • Morita, N.1    Yasumori, T.2    Nakayama, K.3
  • 101
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • Synold, T.W.; Dussault, I.; Forman, B.M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nature Med. 2001, 7, 584-590.
    • (2001) Nature Med. , vol.7 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 106
    • 0036904332 scopus 로고    scopus 로고
    • MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males
    • Gerloff, T.; Schaefer, M.; Johne, A.; Oselin, K.; Meisel, C.; Cascorbi, I.; Roots, I. MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males. Br. J. Clin. Pharmacol. 2002, 54, 610-616.
    • (2002) Br. J. Clin. Pharmacol. , vol.54 , pp. 610-616
    • Gerloff, T.1    Schaefer, M.2    Johne, A.3    Oselin, K.4    Meisel, C.5    Cascorbi, I.6    Roots, I.7
  • 107
    • 0036001238 scopus 로고    scopus 로고
    • C3435T mutation in exon 26 of the human MDR1 gene and cyclosporine pharmacokinetics in healthy subjects
    • Min, D.I.; Ellingrod, V.L. C3435T mutation in exon 26 of the human MDR1 gene and cyclosporine pharmacokinetics in healthy subjects. Ther. Drug Monit. 2002, 24, 400-404.
    • (2002) Ther. Drug Monit. , vol.24 , pp. 400-404
    • Min, D.I.1    Ellingrod, V.L.2
  • 111
    • 0034744113 scopus 로고    scopus 로고
    • No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients
    • von Ahsen, N.; Richter, M.; Grupp, C.; Ringe, B.; Oellerich, M., Armstrong, V.W. No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients. Clin. Chem. 2001, 47, 1048-1052.
    • (2001) Clin. Chem. , vol.47 , pp. 1048-1052
    • von Ahsen, N.1    Richter, M.2    Grupp, C.3    Ringe, B.4    Oellerich, M.5    Armstrong, V.W.6
  • 115
    • 0036731724 scopus 로고    scopus 로고
    • Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies
    • Goh, B.C.; Lee, S.C.; Wang, L.Z.; Fan, L.; Guo, J.Y.; Lamba, J.; Schuetz, E.; Lim, R.; Lim, H.L.; Ong, A.B.; Lee, H.S. Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies. J. Clin. Oncol. 2002, 20, 3683-3690.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3683-3690
    • Goh, B.C.1    Lee, S.C.2    Wang, L.Z.3    Fan, L.4    Guo, J.Y.5    Lamba, J.6    Schuetz, E.7    Lim, R.8    Lim, H.L.9    Ong, A.B.10    Lee, H.S.11
  • 117
  • 119
    • 0032927941 scopus 로고    scopus 로고
    • Cancer multidrug resistance
    • Persidis, A. Cancer multidrug resistance. Nature Biotechnol. 1999, 17, 94-95.
    • (1999) Nature Biotechnol. , vol.17 , pp. 94-95
    • Persidis, A.1
  • 120
    • 0034477126 scopus 로고    scopus 로고
    • Reversal of multidrug resistance of tumor cells
    • Szabo, D.; Keyzer, H.; Kaiser, H.E.; Molnar, J. Reversal of multidrug resistance of tumor cells. Anticancer Res. 2000, 20, 4261-4274.
    • (2000) Anticancer Res. , vol.20 , pp. 4261-4274
    • Szabo, D.1    Keyzer, H.2    Kaiser, H.E.3    Molnar, J.4
  • 121
    • 0031764330 scopus 로고    scopus 로고
    • Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance
    • Bradshaw, D.M.; Arceci, R.J. Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. J. Clin. Oncol. 1998, 16, 3674-3690.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 3674-3690
    • Bradshaw, D.M.1    Arceci, R.J.2
  • 122
    • 0036892827 scopus 로고    scopus 로고
    • MDR1 inhibition: Less resistance or less relevance?
    • Garraway, L.A.; Chabner, B. MDR1 inhibition: less resistance or less relevance? Eur. J. Cancer 2002, 38, 2337-2340.
    • (2002) Eur. J. Cancer , vol.38 , pp. 2337-2340
    • Garraway, L.A.1    Chabner, B.2
  • 123
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman, M.M.; Fojo, T.; Bates, S.E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer 2002, 2, 48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 124
    • 0038199888 scopus 로고    scopus 로고
    • Drug resistance in cancer: A multifactorial problem
    • Mattern, J. Drug resistance in cancer: a multifactorial problem. Anticancer Res. 2003, 23, 1769-1772.
    • (2003) Anticancer Res. , vol.23 , pp. 1769-1772
    • Mattern, J.1
  • 125
    • 0036591187 scopus 로고    scopus 로고
    • Reversers of the multidrug resistance transporter P-glycoprotein
    • Stein, W.D. Reversers of the multidrug resistance transporter P-glycoprotein. Curr. Opin. Investig. Drugs 2002, 3, 812-817.
    • (2002) Curr. Opin. Investig. Drugs , vol.3 , pp. 812-817
    • Stein, W.D.1
  • 130
    • 0032534043 scopus 로고    scopus 로고
    • A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis
    • Panwala, C.M.; Jones, J.C.; Viney, J.L. A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J. Immunol. 1998, 161, 5733-5744.
    • (1998) J. Immunol. , vol.161 , pp. 5733-5744
    • Panwala, C.M.1    Jones, J.C.2    Viney, J.L.3
  • 131
    • 0036169116 scopus 로고    scopus 로고
    • Helicobacter bilis infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1 a-1-) mice
    • Maggio-Price, L.; Shows, D.; Waggie, K.; Burich, A.; Zeng, W.; Escobar, S.; Morrissey, P.; Viney, J.L. Helicobacter bilis infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1 a-1-) mice. Am. J. Pathol. 2002, 160, 739-751.
    • (2002) Am. J. Pathol. , vol.160 , pp. 739-751
    • Maggio-Price, L.1    Shows, D.2    Waggie, K.3    Burich, A.4    Zeng, W.5    Escobar, S.6    Morrissey, P.7    Viney, J.L.8
  • 132
    • 0037624566 scopus 로고    scopus 로고
    • Multidrug resistance 1 gene (P-glycoprotein 170): An important determinant in gastrointestinal diseases?
    • Ho, G.T.; Moodie, F.M.; Satsangi, J. Multidrug resistance 1 gene (P-glycoprotein 170): An important determinant in gastrointestinal diseases? Gut 2003, 52, 759-766.
    • (2003) Gut , vol.52 , pp. 759-766
    • Ho, G.T.1    Moodie, F.M.2    Satsangi, J.3
  • 133
    • 0042807478 scopus 로고    scopus 로고
    • MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinoma detected by MALDI-TOF mass spectrometry
    • Humeny, A.; Rodel, F.; Rodel, C.; Sauer, R.; Fuzesi, L.; Becker, C.; Efferth, T. MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinoma detected by MALDI-TOF mass spectrometry. Anticancer Res. 2003, 23, 2735-2740.
    • (2003) Anticancer Res. , vol.23 , pp. 2735-2740
    • Humeny, A.1    Rodel, F.2    Rodel, C.3    Sauer, R.4    Fuzesi, L.5    Becker, C.6    Efferth, T.7
  • 134
    • 0038241171 scopus 로고    scopus 로고
    • Polymorphism in the P-glycoprotein drug transporter MDR1 gene: A possible link between environmental and genetic factors in Parkinson's disease
    • Drozdzik, M.; Bialecka, M.; Mysliwiec, K.; Honczarenko, K.; Stankiewicz, J.; Sych, Z. Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease. Pharmacogenetics 2003, 13, 259-263.
    • (2003) Pharmacogenetics , vol.13 , pp. 259-263
    • Drozdzik, M.1    Bialecka, M.2    Mysliwiec, K.3    Honczarenko, K.4    Stankiewicz, J.5    Sych, Z.6
  • 135
    • 18144437085 scopus 로고    scopus 로고
    • Genetically determined differences in P-glycoprotein function: Implications for disease risk
    • Fromm, M.F. Genetically determined differences in P-glycoprotein function: Implications for disease risk. Toxicology 2002, 181/182, 299-303.
    • (2002) Toxicology , vol.181-182 , pp. 299-303
    • Fromm, M.F.1
  • 136
    • 0033958086 scopus 로고    scopus 로고
    • Multiple physiological functions for multidrug trnsporter P-glycoprotein?
    • Johnstone, R.W.; Ruefli, A.A.; Smyth, M.J. Multiple physiological functions for multidrug trnsporter P-glycoprotein? Trends Biochem. Sci. 2000, 25, 1-6.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 1-6
    • Johnstone, R.W.1    Ruefli, A.A.2    Smyth, M.J.3
  • 138
    • 0032499771 scopus 로고    scopus 로고
    • The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis
    • Smyth, M.J.; Krasovskis, E.; Sutton, V.R.; Johnstone, R.W. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc. Natl. Acad. Sci. USA 1998, 95, 7024-7029.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7024-7029
    • Smyth, M.J.1    Krasovskis, E.2    Sutton, V.R.3    Johnstone, R.W.4
  • 139
    • 0032950954 scopus 로고    scopus 로고
    • P-Glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death
    • Johnstone, R.W.; Cretney, E.; Smyth, M.J. P-Glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood 1999, 93, 1075-1085.
    • (1999) Blood , vol.93 , pp. 1075-1085
    • Johnstone, R.W.1    Cretney, E.2    Smyth, M.J.3
  • 141
    • 0034057157 scopus 로고    scopus 로고
    • Effect of ABC transporters on HIV-1 infection: Inhibition of virus production by the MDR1 transporter
    • Lee, C.G.L.; Ramachandra, M.; Jeang, K.T.; Martin, M.A.; Pastan, I.; Gottesman, M.M. Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter. FASEB J. 2000, 14, 516-522.
    • (2000) FASEB J. , vol.14 , pp. 516-522
    • Lee, C.G.L.1    Ramachandra, M.2    Jeang, K.T.3    Martin, M.A.4    Pastan, I.5    Gottesman, M.M.6
  • 142
    • 0030922309 scopus 로고    scopus 로고
    • DNA elements recognizing NF-Y and Sp1 regulate the human multidrug-resistance gene promoter
    • Sundseth, R.; MacDonald, G.; Ting, J.; King, A.C. DNA elements recognizing NF-Y and Sp1 regulate the human multidrug-resistance gene promoter. Mol. Pharmacol. 1997, 51, 963-971.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 963-971
    • Sundseth, R.1    MacDonald, G.2    Ting, J.3    King, A.C.4
  • 143
    • 0027290898 scopus 로고
    • SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity
    • Cornwell, M.M.; Smith, D.E. SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity. J. Biol. Chem. 1993, 268, 19505-19511.
    • (1993) J. Biol. Chem. , vol.268 , pp. 19505-19511
    • Cornwell, M.M.1    Smith, D.E.2
  • 144
    • 0032513246 scopus 로고    scopus 로고
    • Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene
    • Ohga, T.; Uchiumi, T.; Makino, Y.; Koike, K.; Wada, M.; Kuwano, M.; Kohno, K. Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene. J. Biol. Chem. 1998, 273, 5997-6000.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5997-6000
    • Ohga, T.1    Uchiumi, T.2    Makino, Y.3    Koike, K.4    Wada, M.5    Kuwano, M.6    Kohno, K.7
  • 145
    • 0030825963 scopus 로고    scopus 로고
    • Nuclear translocation of the Y-box binding protein by ultraviolet irradiation
    • Koike, K.; Uchiumi, T.; Ohga, T.; Toh, S.; Wada, M.; Kohno, K.; Kuwano, M. Nuclear translocation of the Y-box binding protein by ultraviolet irradiation. FEBS Lett. 1997, 417, 390-394.
    • (1997) FEBS Lett. , vol.417 , pp. 390-394
    • Koike, K.1    Uchiumi, T.2    Ohga, T.3    Toh, S.4    Wada, M.5    Kohno, K.6    Kuwano, M.7
  • 146
    • 0031861729 scopus 로고    scopus 로고
    • Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y
    • Jin, S.; Scotto, K.W. Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. Mol. Cell Biol. 1998, 18, 4377-4384.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 4377-4384
    • Jin, S.1    Scotto, K.W.2
  • 147
    • 0036964795 scopus 로고    scopus 로고
    • Transcriptional regulation of the human MDR1 gene at the level of the inverted MED-1 promoter region
    • Labialle, S.; Gayet, L.; Marthinet, E.; Rigal, D.; Baggetto, L.G. Transcriptional regulation of the human MDR1 gene at the level of the inverted MED-1 promoter region. Ann. N. Y. Acad. Sci. 2002, 973, 468-471.
    • (2002) Ann. N. Y. Acad. Sci. , vol.973 , pp. 468-471
    • Labialle, S.1    Gayet, L.2    Marthinet, E.3    Rigal, D.4    Baggetto, L.G.5
  • 148
    • 0037648335 scopus 로고    scopus 로고
    • Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor (SXR) mRNA
    • Takara, K.; Takagi, K.; Tsujimoto, M.; Ohnishi, N.; Yokoyama, T. Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor (SXR) mRNA. Biochem. Biophys. Res. Commun. 2003, 306, 116-120.
    • (2003) Biochem. Biophys. Res. Commun. , vol.306 , pp. 116-120
    • Takara, K.1    Takagi, K.2    Tsujimoto, M.3    Ohnishi, N.4    Yokoyama, T.5
  • 149
    • 0038193551 scopus 로고    scopus 로고
    • P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation
    • Yagüe, E.; Armesilla, A.L.; Harrison, G.; Elliott, J.; Sardini, A.; Higgins, C.F.; Raguz, S. P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation. J. Biol. Chem. 2003, 278, 10344-10352.
    • (2003) J. Biol. Chem. , vol.278 , pp. 10344-10352
    • Yagüe, E.1    Armesilla, A.L.2    Harrison, G.3    Elliott, J.4    Sardini, A.5    Higgins, C.F.6    Raguz, S.7
  • 154
    • 0037938688 scopus 로고    scopus 로고
    • Effects of continuous exposure to digoxin on MDR1 function and expression in Caco-2 cells
    • Takara, K.; Tsujimoto, M.; Ohnishi, N.; Yokoyama, N. Effects of continuous exposure to digoxin on MDR1 function and expression in Caco-2 cells. J. Pharm. Pharmacol. 2003, 55, 675-681.
    • (2003) J. Pharm. Pharmacol. , vol.55 , pp. 675-681
    • Takara, K.1    Tsujimoto, M.2    Ohnishi, N.3    Yokoyama, N.4
  • 155
    • 0029916534 scopus 로고    scopus 로고
    • P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans
    • Schuetz, E.G.; Schinkel, A.H.; Relling, M.V.; Schuetz, J.D. P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc. Natl. Acad. Sci. USA 1996, 93, 4001-4005.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4001-4005
    • Schuetz, E.G.1    Schinkel, A.H.2    Relling, M.V.3    Schuetz, J.D.4
  • 156
    • 0036135007 scopus 로고    scopus 로고
    • Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin
    • Asghar, A.; Gorski, J.C.; Haehner-Naniels, B.; Hall, S.D. Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin. Drug Metabol. Dispos. 2002, 30, 20-26.
    • (2002) Drug Metabol. Dispos. , vol.30 , pp. 20-26
    • Asghar, A.1    Gorski, J.C.2    Haehner-Naniels, B.3    Hall, S.D.4
  • 157
    • 0035805536 scopus 로고    scopus 로고
    • Nuclear receptor response elements mediate induction of intestinal MDR by rifampin
    • Geick, A.; Eichelbaum, M.; Burk, O. Nuclear receptor response elements mediate induction of intestinal MDR by rifampin. J. Biol. Chem. 2001, 276, 14581-14587.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14581-14587
    • Geick, A.1    Eichelbaum, M.2    Burk, O.3
  • 161
    • 0034185251 scopus 로고    scopus 로고
    • Regulation of the multidrug resistance genes by stress signals
    • Sukhal, M.; Piquette-Miller, M. Regulation of the multidrug resistance genes by stress signals. J. Pharm. Pharmacuet. Sci. 2000, 3, 268-280.
    • (2000) J. Pharm. Pharmacuet. Sci. , vol.3 , pp. 268-280
    • Sukhal, M.1    Piquette-Miller, M.2
  • 162
    • 0037442092 scopus 로고    scopus 로고
    • Population stratification and squrious allelic association
    • Cardon, L.R.; Palmer, L.J. Population stratification and squrious allelic association. Lancet 2003, 361, 598-604.
    • (2003) Lancet , vol.361 , pp. 598-604
    • Cardon, L.R.1    Palmer, L.J.2
  • 164
    • 0033626025 scopus 로고    scopus 로고
    • Pharmacogenetics - A tool for individualizing antineoplastic therapy
    • Innocenti, F.; Iyer, L.; Ratain, M.J. Pharmacogenetics - A tool for individualizing antineoplastic therapy. Clin. Pharmacokinet. 2000, 39, 315-325.
    • (2000) Clin. Pharmacokinet. , vol.39 , pp. 315-325
    • Innocenti, F.1    Iyer, L.2    Ratain, M.J.3
  • 165
    • 0036202663 scopus 로고    scopus 로고
    • Update on pharmacogenetics in cancer chemotherapy
    • Innocenti, F.; Ratain, M.J. Update on pharmacogenetics in cancer chemotherapy. Eur. J. Cancer 2002, 38, 639-644.
    • (2002) Eur. J. Cancer , vol.38 , pp. 639-644
    • Innocenti, F.1    Ratain, M.J.2
  • 166
    • 0035692767 scopus 로고    scopus 로고
    • Polymorphisms of metabolizing enzymes and transporter proteins involved in the clearance of anticancer agents
    • Sekine, I.; Saijo, N. Polymorphisms of metabolizing enzymes and transporter proteins involved in the clearance of anticancer agents, Ann. Oncol. 2001, 12, 1515-1525.
    • (2001) Ann. Oncol. , vol.12 , pp. 1515-1525
    • Sekine, I.1    Saijo, N.2
  • 169
    • 0037381013 scopus 로고    scopus 로고
    • Simulatneous genotyping of seven single-nucleotide polymorphisms in the MDR1 gene by single-tube multiplex minisequencing
    • Gwee, P.C.; Tang, K.; Chua, J.M.Z.; Lee, E.J.D., Chong, S.S. Lee, C.G.L. Simulatneous genotyping of seven single-nucleotide polymorphisms in the MDR1 gene by single-tube multiplex minisequencing. Clin. Chem. 2003, 49, 672-676.
    • (2003) Clin. Chem. , vol.49 , pp. 672-676
    • Gwee, P.C.1    Tang, K.2    Chua, J.M.Z.3    Lee, E.J.D.4    Chong, S.S.5    Lee, C.G.L.6
  • 170
    • 85046915075 scopus 로고    scopus 로고
    • Detection of MDR1 single nucleotide polymorphisms C3435T and G2677T using real-time polymerase chain reaction: MDR1 single nucleotide polymorphism genotyping assay
    • Song, P.; Li, S.; Meibohm, B.; Gaber, A.O.; Honaker, M.R.; Kotb, M.; Yates, C.R. Detection of MDR1 single nucleotide polymorphisms C3435T and G2677T using real-time polymerase chain reaction: MDR1 single nucleotide polymorphism genotyping assay. AAPS. Pharm. Sci. 2002, 4, A29.
    • (2002) AAPS Pharm. Sci. , vol.4
    • Song, P.1    Li, S.2    Meibohm, B.3    Gaber, A.O.4    Honaker, M.R.5    Kotb, M.6    Yates, C.R.7
  • 172
    • 0034745462 scopus 로고    scopus 로고
    • High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC
    • Schaeffeler, E.; Lang, T.; Zanger, U.M.; Eichelbaum, M.; Schwab, M. High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC. Clin. Chem. 2001, 47, 548-555.
    • (2001) Clin. Chem. , vol.47 , pp. 548-555
    • Schaeffeler, E.1    Lang, T.2    Zanger, U.M.3    Eichelbaum, M.4    Schwab, M.5


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