Effect of the mutation (C3435t) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects

Clinical Pharmacology and Therapeutics

Volumn 71, Issue 4, 2002, Pages 297-303

  Nakamura, Tsutomu ^a   Sakaeda, Toshiyuki ^a   Horinouchi, Masanori ^a   Tamura, Takao ^a   Aoyama, Nobuo ^a   Shirakawa, Toshiro ^a   Matsuo, Masafumi ^a   Kasuga, Masato ^a   Okumura, Katsuhiko ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DIGOXIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1;

ADULT; ALLELE; ARTICLE; DRUG BLOOD LEVEL; DUODENUM; EXON; GENE EXPRESSION; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN TISSUE; INTESTINE BIOPSY; INTESTINE CELL; JAPAN; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; ALLELES; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSINE; DIGOXIN; DNA-BINDING PROTEINS; DUODENUM; ENTEROCYTES; ENZYME INHIBITORS; EXONS; GENE EXPRESSION REGULATION; GENES, MDR; HUMANS; JAPAN; MALE; MITOCHONDRIAL PROTEINS; MIXED FUNCTION OXYGENASES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; P-GLYCOPROTEIN; RIBOSOMAL PROTEINS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE PROTEINS; THYMINE;

EID: 0036224114     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2002.122055     Document Type: Article

References (22)

1. Expression of a multidrug-resistance gene in human tumors and tissues
2. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
3. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
4. The gut as a barrier to drug absorption
5. Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of the one allele with P-glycoprotein expression and activity in vivo
6. Expression of P-glycoprotein in human placenta: Relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene
7. MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects
8. A novel method for real time quantitative RT-PCR
9. Localization of villin a cytoskeletal protein specific to microvilli, in human ileum and colon and in colonic neoplasms
10. Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel
11. Identification of functionally variant MDR1 alleles among European Americans and African Americans
12. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
13. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
14. Identification of rifampin-inducible P450-IIIA4 (CYP3A4) in human small bowel enterocytes
15. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
16. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
17. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
18. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A4 induction
19. SXR, a novel steroid and xenobiotic-sensing nuclear receptor
20. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
21. The effect of rifampin treatment on intestinal expression of human MRP transporters
22. Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2)