Simultaneous genotyping of seven single-nucleotide polymorphisms in the MDR1 gene by single-tube multiplex minisequencing

Clinical Chemistry

Volumn 49, Issue 4, 2003, Pages 672-676

  Gwee, Pai Chung ^a   Tang, Kun ^a   Chua, John M Z ^a,b   Lee, Edmund J D ^a   Chong, Samuel S ^a,c   Lee, Caroline G L ^a,b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MULTIDRUG RESISTANCE PROTEIN 1;

ALGORITHM; ARTICLE; CAPILLARY ELECTROPHORESIS; CORRELATION ANALYSIS; COST EFFECTIVENESS ANALYSIS; DNA TEMPLATE; DRUG METABOLISM; ETHNIC DIFFERENCE; EVALUATION; EXON; GENE FREQUENCY; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MUTATIONAL ANALYSIS; PHARMACOGENETICS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN VARIANT; SINGLE NUCLEOTIDE POLYMORPHISM; SINGLE TUBE MULTIPLEX MINISEQUENCING; TECHNIQUE;

GENES, MDR; GENOTYPE; HUMANS; P-GLYCOPROTEIN; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA;

EID: 0037381013     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/49.4.672     Document Type: Article

References (11)

1. Tang K, Ngoi SM, Gwee PC, Chua JMZ, Lee EJD, Chong SC, et al. Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populations. Pharmacogenetics 2002;12:437-50.
2. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A 2000;97:3473-8.
3. Kim RB, Leake BF, Choo EF, Dresser GK, Kubba SV, Schwarz UI, et al. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther 2001;70:189-99.
4. Sakaeda T, Nakamura T, Horinouchi M, Kakumoto M, Ohmoto N, Sakai T, et al. MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects. Pharm Res 2001;18:1400-4.
5. Hitzl M, Drescher S, van der Kuip H, Schaffeler E, Fischer J, Schwab M, et al. The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells. Pharmacogenetics 2001;11:293-8.
6. Roberts R, Joyce P, Mulder R, Begg E, Kennedy M. A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated with major depression. Pharmacogenomics J 2002;2:191-6.
7. Fellay J, Marzolini C, Meadon E, Back D, Buclin T, Chave J, et al. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetic study. Lancet 2002;359:30-6.
8. Tanabe M, Ieiri I, Nagata N, Inoue K, Ito S, Kanamori Y, et al. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene. J Pharmacol Exp Ther 2001;297:1137-43.
9. Furuno T, Landi MT, Ceroni M, Caporaso N, Bernucci I, Nappi G, et al. Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease. Pharmacogenetics 2002;12:529-34.
10. von Ahsen N, Richter M, Grupp C, Ringe B, Oellerich M, Armstrong VW. No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients. Clin Chem 2001;47:1048-52.
11. Min DI, Ellingrod VL. C3435T mutation in exon 26 of the human MDR1 gene and cyclosporine pharmacokinetics in healthy subjects. Ther Drug Monit 2002;24:400-4.