The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells

Pharmacogenetics

Volumn 11, Issue 4, 2001, Pages 293-298

  Hitzl, M ^a   Drescher, S ^a   Van der Kuip, H ^a   Schaffeler E ^a   Fischer, J ^a   Schwab, M ^a   Eichelbaum, M ^a   Fromm, M F ^a  

^a ROBERT BOSCH GMBH   (Germany)

Author keywords

MDR1; P glycoprotein; Polymorphism; Rhodamine 123

Indexed keywords

CD56 ANTIGEN; CYCLOPHILIN; DIGOXIN; GLYCOPROTEIN P; MEMBRANE PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE 123;

ADULT; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG BLOOD LEVEL; DRUG DISPOSITION; EXON; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; GENE MUTATION; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; LEUKOCYTE; MALE; NATURAL KILLER CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT;

ADULT; ANTIGENS, CD56; BIOLOGICAL TRANSPORT, ACTIVE; FEMALE; FLUORESCENT DYES; GENE EXPRESSION; GENES, MDR; GENOTYPE; HUMANS; KILLER CELLS, NATURAL; MALE; P-GLYCOPROTEIN; POINT MUTATION; POLYMORPHISM, GENETIC; RHODAMINE 123; RNA, MESSENGER;

EID: 0034971274     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200106000-00003     Document Type: Article

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