C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

Pharmacogenetics

Volumn 12, Issue 6, 2002, Pages 451-457

  Goto, Maki ^a   Masuda, Satohiro ^a   Saito, Hideyuki ^a   Uemoto, Shinji ^a   Kiuchi, Tetsuya ^a   Tanaka, Koichi ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Metabolic enzyme; Small intestine; SNP; Tacrolimus; Transporter

Indexed keywords

CYTOCHROME P450 3A4; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; TACROLIMUS; CYP3A PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; IMMUNOSUPPRESSIVE AGENT; MESSENGER RNA; PRIMER DNA;

ARTICLE; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; DOSE RESPONSE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTESTINE CELL; LIVER TRANSPLANTATION; LIVING DONOR; MAJOR CLINICAL STUDY; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIPIENT; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; ADOLESCENT; ADULT; CHEMISTRY; CHILD; ENZYMOLOGY; FEMALE; GENE; GENETICS; INFANT; INTESTINE; MALE; METABOLISM; MIDDLE AGED; PRESCHOOL CHILD; PROGNOSIS;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; ENTEROCYTES; FEMALE; GENE FREQUENCY; GENES, MDR; HUMAN; IMMUNOSUPPRESSIVE AGENTS; INFANT; INTESTINES; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGE; P-GLYCOPROTEIN; POLYMERASE CHAIN REACTION; POLYMORPHISM (GENETICS); POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROGNOSIS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TACROLIMUS; HUMANS; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 0036667953     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200208000-00005     Document Type: Article

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