Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects

Clinical Pharmacology and Therapeutics

Volumn 69, Issue 3, 2001, Pages 169-174

  Cascorbi, Ingolf ^a,b,c,d   Gerloff, Thomas ^a,b,c,d   Johne, Andreas ^a,b,c,d   Meisel, Christian ^a,b,c,d   Hoffmeyer, Sven ^a,b,c,d   Schwab, Matthias ^a,b,c,d   Schaeffeler, Elke ^a,b,c,d   Eichelbaum, Michel ^a,b,c,d   Brinkmann, Ulrich ^a,b,c,d   Roots, Ivar ^a,b,c,d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Epidauros Biotechnology AG   (Germany)

^c DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^d UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; COST EFFECTIVENESS ANALYSIS; FEMALE; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MULTIDRUG RESISTANCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; AGED; ALLELES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENES, MDR; GENOTYPE; HUMANS; MALE; MIDDLE AGED; P-GLYCOPROTEIN; PHARMACOGENETICS; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 0035104031     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2001.114164     Document Type: Article

References (23)

1. ABC transporters: From microorganisms to man
2. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside digoxin
3. P-glycoprotein: A mediator of multidrug resistance in tumor cells
4. The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
5. Human P-glycoprotein transports cyclosporin A and FK506
6. P-glycoprotein and multidrug resistance
7. Biochemical, cellular, and pharmacological aspects of the multidrug transporter
8. Role of P-glycoprotein in drug disposition
9. Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier
10. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
11. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
12. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
13. Low bioavailability of cyclosporine microemulsion and tacrolimus in a small bowel transplant recipient: Possible relationship to intestinal P-glycoprorein activity
14. Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
15. Genetic polymorphism in MDR-1: A tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors
16. A SNPshot: Pharmacogenetics and the future of drug therapy
17. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)
18. Acute heart transplant rejection due to Saint John's wort
19. Multidrug resistance-I (MDR-I) in rheumatic autoimmune disorders; part I: Increased P-glycoprotein activity in lymphocytes from rheumatoid arthritis patients might influence disease outcome
20. High multidrug resistance (P-glycoprorein 170) expression in inflammatory bowel disease patients who fail medical therapy
21. P-glycoprotein: A defense mechanism limiting oral bioavailability and CNS accumulation of drugs
22. High expression of multidrug resistance-1 (MDR-1) and its relationship with multiple prognostic factors in gastric carcinomas in patients in Turkey
23. Expression of the multidrug resistance P-glycoprotein and its relationship to hematological characteristics and response to treatment in myelodysplastic syndromes