The human ATP-binding cassette (ABC) transporter superfamily

Genome Research

Volumn 11, Issue 7, 2001, Pages 1156-1166

  Dean, Michael ^a   Rzhetsky, Andrey ^b,c   Allikmets, Rando ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Columbia University ^*  (United States)

^c The New York Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CHOLESTEROL; COLCHICINE; CYCLOSPORIN A; DAUNORUBICIN; DIGOXIN; DOXORUBICIN; ELACRIDAR; ETOPOSIDE; IRINOTECAN; MEMBRANE PROTEIN; METHOTREXATE; MITOXANTRONE; NUCLEOSIDE MONOPHOSPHATE KINASE; PACLITAXEL; RHODAMINE; SAQUINAVIR; SULFINPYRAZONE; TOPOTECAN; VALSPODAR; VERAPAMIL; VINBLASTINE; VINCRISTINE;

AMINO ACID SEQUENCE; ANEMIA; BILE; CELL MEMBRANE; CHROMOSOME MAP; CONTROLLED STUDY; CYSTIC FIBROSIS; DROSOPHILA; DRUG RESISTANCE; DRUG RESPONSE; EVOLUTION; GENE EXPRESSION; GENE LOCATION; GENE TRANSLOCATION; GENETIC VARIABILITY; HUMAN; INHERITANCE; MOLECULAR BIOLOGY; MULTIGENE FAMILY; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PHYLOGENY; PHYSIOLOGY; PRIORITY JOURNAL; RETINA DEGENERATION; REVIEW; SEQUENCE HOMOLOGY;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; EVOLUTION, MOLECULAR; GENETIC DISEASES, INBORN; HUMANS; MULTIGENE FAMILY; PHYLOGENY;

ARACHNIDA; HEXAPODA;

EID: 0034917716     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.GR-1649R     Document Type: Review

References (70)

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4. Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)
5. Histologic pathology of the liver in progressive familial intrahepatic cholestasis
6. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
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13. Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3
14. The MDR superfamily of genes and its biological implications
15. Identification of a sister gene to P-glycoprotein
16. Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis
17. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
18. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
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20. Multiple mutations in highly conserved residues are found in mildly affected cystic fibrosis patients
21. Complete inventory of the yeast ABC proteins
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23. Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: Evidence for a defect in protein trafficking
24. A multidrug resistance transporter from human MCF-7 breast cancer cells
25. Multiple alignment using hidden Markov models
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27. CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship
28. Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia
29. Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein
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31. Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
32. Crystal structure of the ATP-binding subunit of an ABC transporter
33. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
34. The rapid generation of mutation data matrices from protein sequences
35. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
36. The ABC transporter Atm1p is required for mitochondrial iron homeostasis
37. An inventory of the human ABC proteins
38. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport
39. Initial sequencing and analysis of the human genome. International Human Genome Sequencing Consortium
40. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): Evidence for sterol-dependent regulation in macrophages
41. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
42. Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux
43. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of elF2alpha kinase GCN2
44. Sequence comparison of yeast ATP binding cassette (ABC) proteins
45. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes
46. Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
47. A whole-genome assembly of Drosophila
48. Evolution by the birth-and-death process in multigene families of the vertebrate immune system
49. Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family
50. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
51. Salmonella typhi uses CFTR to enter epithelial cells
52. Increased incidence of cystic fibrosis gene mutations in adults with disseminated bronchiectasis
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54. Association of a variant in exon 31 of the sulfonylurea receptor 1 (SUR1) gene with type 2 diabetes mellitus in French Caucasians
55. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
56. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes
57. The neighbor-joining method: A new method for reconstructing phylogenetic trees
58. Peroxisomal ABC transporters
59. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis
60. Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease
61. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy
62. ABC50 interacts with eukaryotic initiation factor 2 and associates with the ribosome in an ATP-dependent manner
63. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
64. The sequence of the human genome
65. Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
66. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice
67. Isolation and characterization of Drosophilia multidrug resistance gene homologs
68. The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
69. The ABCs of cholesterol efflux
70. Evolutionary divergence and convergence in proteins